The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Sbp  -  spermine binding protein

Mus musculus

Synonyms: AV082137, AV082259, Major prostatic secretory glycoprotein, P25, Prostatic spermine-binding protein, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Sbp

  • Hepatitis B surface antigen (HBsAg) particles are composed of a major polypeptide, p25, and additional polypeptides of higher m.w., namely p33 and p39, are variably present [1].
  • These results suggest that p25 may be necessary for the specific kinase inhibitory activity detected in vaccinia virus-infected cells [2].
  • All of the SBP subfractions were confirmed to be reactive to IgE antibodies from patients with Japanese cedar pollinosis, and also to mouse anti-SBP monoclonal antibodies [3].
  • From the results obtained, it is concluded that p25 is a mammalian stress protein, the abundance of which is related to growth characteristics of the Ehrlich ascites tumor [4].
  • High-level expression of p25 in Escherichia coli has been established by oligonucleotide-directed mutagenesis of cDNA and insertion of the mutated cDNA into a T7-promoter expression vector [4].
 

Psychiatry related information on Sbp

 

High impact information on Sbp

  • We demonstrate here that treatment of murine T cell hybridomas with phorbol 12-myristate 13-acetate results in phosphorylation of p25 and gp21 on serine residues [6].
  • Moreover, p25 expression increased the number of dendritic spines and synapses [7].
  • Using region-specific and inducible transgenic mice, we show that transiently increased p25 expression in the hippocampus enhanced long-term potentiation (LTP) and facilitated hippocampus-dependent memory [7].
  • Neither peak I nor peak II protein resembled the serotonin binding protein (SBP) that is found in serotonergic neurons of the brain and gut [8].
  • The presence of 5-HT uptake sites in epithelia and adjacent sites of SBP in the underlying mesenchyme raises the possibility that 5-HT might be involved in those epithelial-mesenchymal interactions known to be important for the development of structures in the craniofacial region [9].
 

Chemical compound and disease context of Sbp

 

Biological context of Sbp

 

Anatomical context of Sbp

  • We found that p25 is a non-membrane-bound fragment of Ii with an N terminus beginning at Met98 of the Ii sequence. p25 is formed at a very early stage of Ii synthesis in the rough endoplasmic reticulum rather than in a post-Golgi Ag-processing compartment [14].
  • Hybridoma clones were produced by fusing P3 X 63Ag8.653 mouse myeloma cells with spleen cells from a mouse that had been immunized with 45-kDa or 56-kDa SBP [15].
  • Serotonin binding protein (SBP) is a constituent of the synaptic vesicles of serotonergic neurons [15].
  • The protein is designated as ram (ras-related gene from megakaryocyte) protein (ram p25) [16].
  • Although an SBP-binding activity has been found in every non-pituitary tissue or cell line tested, no such activity could be detected in either rat pituitaries or rat pituitary GH4C1 cells [17].
 

Associations of Sbp with chemical compounds

  • A full length cDNA (MP25) encoding the major mouse prostatic secretory glycoprotein (p25), whose expression is androgen dependent, has been cloned and characterised [11].
  • The MALDI in-source decay measurements combined with nanoESI (nanoelectrospay ionization) MS/MS measurements obtained after specific proteolysis of SBP, allowed the exact positioning of a single N-linked carbohydrate group, and the identification of a pyroglutamate residue at the sequence N-terminus [12].
  • The N-terminal amino acid sequence of SBP was identical to the reported sequence of an allergen of mountain cedar which vegetated in North America [3].
  • In the presence of cytosine arabinoside p25 synthesis did not decrease at late times postinfection [2].
  • Kinase inhibitory activity copurified with p25, through gel filtration, and Cibacron blue-affinity chromatography [2].
 

Other interactions of Sbp

 

Analytical, diagnostic and therapeutic context of Sbp

References

  1. Immune response to the pre-S(1) region of the hepatitis B surface antigen (HBsAg): a pre-S(1)-specific T cell response can bypass nonresponsiveness to the pre-S(2) and S regions of HBsAg. Milich, D.R., McLachlan, A., Chisari, F.V., Kent, S.B., Thorton, G.B. J. Immunol. (1986) [Pubmed]
  2. Characterization of a vaccinia virus-encoded double-stranded RNA-binding protein that may be involved in inhibition of the double-stranded RNA-dependent protein kinase. Watson, J.C., Chang, H.W., Jacobs, B.L. Virology (1991) [Pubmed]
  3. N-terminal amino acid sequence of a major allergen of Japanese cedar pollen (Cry j I). Taniai, M., Ando, S., Usui, M., Kurimoto, M., Sakaguchi, M., Inouye, S., Matuhasi, T. FEBS Lett. (1988) [Pubmed]
  4. Molecular cloning, sequencing and expression in Escherichia coli of the 25-kDa growth-related protein of Ehrlich ascites tumor and its homology to mammalian stress proteins. Gaestel, M., Gross, B., Benndorf, R., Strauss, M., Schunk, W.H., Kraft, R., Otto, A., Böhm, H., Stahl, J., Drabsch, H. Eur. J. Biochem. (1989) [Pubmed]
  5. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? Leclerc, S., Garnier, M., Hoessel, R., Marko, D., Bibb, J.A., Snyder, G.L., Greengard, P., Biernat, J., Wu, Y.Z., Mandelkow, E.M., Eisenbrand, G., Meijer, L. J. Biol. Chem. (2001) [Pubmed]
  6. Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor. Samelson, L.E., Patel, M.D., Weissman, A.M., Harford, J.B., Klausner, R.D. Cell (1986) [Pubmed]
  7. Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Fischer, A., Sananbenesi, F., Pang, P.T., Lu, B., Tsai, L.H. Neuron (2005) [Pubmed]
  8. Serotonin storage pools in basophil leukemia and mast cells: characterization of two types of serotonin binding protein and radioautographic analysis of the intracellular distribution of [3H]serotonin. Tamir, H., Theoharides, T.C., Gershon, M.D., Askenase, P.W. J. Cell Biol. (1982) [Pubmed]
  9. Serotonin and morphogenesis. I. Sites of serotonin uptake and -binding protein immunoreactivity in the midgestation mouse embryo. Lauder, J.M., Tamir, H., Sadler, T.W. Development (1988) [Pubmed]
  10. Purification of the growth-related protein p25 of the Ehrlich ascites tumor and analysis of its isoforms. Benndorf, R., Kraft, R., Otto, A., Stahl, J., Böhm, H., Bielka, H. Biochem. Int. (1988) [Pubmed]
  11. Androgen regulated expression of a spermine binding protein gene in mouse ventral prostate. Mills, J.S., Needham, M., Parker, M.G. Nucleic Acids Res. (1987) [Pubmed]
  12. Strain-based sequence variations and structure analysis of murine prostate specific spermine binding protein using mass spectrometry. Chaurand, P., DaGue, B.B., Ma, S., Kasper, S., Caprioli, R.M. Biochemistry (2001) [Pubmed]
  13. Mouse liver selenium-binding protein decreased in abundance by peroxisome proliferators. Giometti, C.S., Liang, X., Tollaksen, S.L., Wall, D.B., Lubman, D.M., Subbarao, V., Rao, M.S. Electrophoresis (2000) [Pubmed]
  14. Characterization of fragments of the murine Ia-associated invariant chain. Mehringer, J.H., Harris, M.R., Kindle, C.S., McCourt, D.W., Cullen, S.E. J. Immunol. (1991) [Pubmed]
  15. Preparation and characterization of monoclonal antibodies to serotonin binding protein. Liu, K.P., Yu, P.Y., Hsiung, S.H., Kirchgessner, A.L., Gershon, M.D., Tamir, H. J. Neurochem. (1990) [Pubmed]
  16. The ram: a novel low molecular weight GTP-binding protein cDNA from a rat megakaryocyte library. Nagata, K., Satoh, T., Itoh, H., Kozasa, T., Okano, Y., Doi, T., Kaziro, Y., Nozawa, Y. FEBS Lett. (1990) [Pubmed]
  17. The rat growth hormone proximal silencer contains a novel DNA-binding site for multiple nuclear proteins that represses basal promoter activity. Roy, R.J., Vallières, L., Leclerc, S., Guérin, S.L. Eur. J. Biochem. (1994) [Pubmed]
  18. Identification of prostatic-secreted proteins in mice by mass spectrometric analysis and evaluation of lobe-specific and androgen-dependent mRNA expression. Fujimoto, N., Akimoto, Y., Suzuki, T., Kitamura, S., Ohta, S. J. Endocrinol. (2006) [Pubmed]
  19. Correction of the cDNA-derived protein sequence of prostatic spermine binding protein: pivotal role of tandem mass spectrometry in sequence analysis. Anderegg, R.J., Carr, S.A., Huang, I.Y., Hiipakka, R.A., Chang, C.S., Liao, S.T. Biochemistry (1988) [Pubmed]
  20. Androgen-regulated expression of secretory protein synthesis in mouse ventral prostate. Mills, J.S., Needham, M., Thompson, T.C., Parker, M.G. Mol. Cell. Endocrinol. (1987) [Pubmed]
 
WikiGenes - Universities