Gene Review:
Slc6a3 - solute carrier family 6 (neurotransmitter...
Rattus norvegicus
Synonyms:
DA transporter, DAT, Sodium-dependent dopamine transporter, Solute carrier family 6 member 3
- The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines. Loder, M.K., Melikian, H.E. J. Biol. Chem. (2003)
- The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons. Nirenberg, M.J., Vaughan, R.A., Uhl, G.R., Kuhar, M.J., Pickel, V.M. J. Neurosci. (1996)
- Modification of dopaminergic markers expression in the striatum by neonatal exposure to glutamate during development. López-Pérez, S.J., Vergara, P., Ventura-Valenzuela, J.P., Ureña-Guerrero, M.E., Segovia, J., Beas-Zárate, C. Int. J. Dev. Neurosci. (2005)
- In vivo regulation of central nervous system progesterone receptors: cocaine induces steroid-dependent behavior through dopamine transporter modulation of D5 receptors in rats. Apostolakis, E.M., Garai, J., Clark, J.H., O'Malley, B.W. Mol. Endocrinol. (1996)
- Anoxia-induced dopamine release from rat striatal slices: involvement of reverse transport mechanism. Büyükuysal, R.L., Mete, B. J. Neurochem. (1999)
- Valproate attenuates hyperactive and perseverative behaviors in mutant mice with a dysregulated dopamine system. Ralph-Williams, R.J., Paulus, M.P., Zhuang, X., Hen, R., Geyer, M.A. Biol. Psychiatry (2003)
- Chemistry and pharmacology of the piperidine-based analogues of cocaine. Identification of potent DAT inhibitors lacking the tropane skeleton. Kozikowski, A.P., Araldi, G.L., Boja, J., Meil, W.M., Johnson, K.M., Flippen-Anderson, J.L., George, C., Saiah, E. J. Med. Chem. (1998)
- Differential nigral expression of Bcl-2 protein family in chronically haloperidol and clozapine-treated rats: Role in neurotoxicity and stereotyped behavior. Saldaña, M., Bonastre, M., Aguilar, E., Marin, C. Exp. Neurol. (2007)
- Modulation of amphetamine-stimulated [3H]dopamine release from rat pheochromocytoma (PC12) cells by sigma type 2 receptors. Weatherspoon, J.K., Werling, L.L. J. Pharmacol. Exp. Ther. (1999)
- Bupropion inhibits nicotine-evoked [(3)H]overflow from rat striatal slices preloaded with [(3)H]dopamine and from rat hippocampal slices preloaded with [(3)H]norepinephrine. Miller, D.K., Sumithran, S.P., Dwoskin, L.P. J. Pharmacol. Exp. Ther. (2002)
- Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA. Shimada, S., Kitayama, S., Lin, C.L., Patel, A., Nanthakumar, E., Gregor, P., Kuhar, M., Uhl, G. Science (1991)
- Dopamine transporter-mediated conductances increase excitability of midbrain dopamine neurons. Ingram, S.L., Prasad, B.M., Amara, S.G. Nat. Neurosci. (2002)
- Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding. Kitayama, S., Shimada, S., Xu, H., Markham, L., Donovan, D.M., Uhl, G.R. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions. Murer, M.G., Dziewczapolski, G., Menalled, L.B., García, M.C., Agid, Y., Gershanik, O., Raisman-Vozari, R. Ann. Neurol. (1998)
- Phosphatidylinositol 3-kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites. Lin, Z., Zhang, P.W., Zhu, X., Melgari, J.M., Huff, R., Spieldoch, R.L., Uhl, G.R. J. Biol. Chem. (2003)
- Heteroaromatic analogs of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as high-affinity dopamine reuptake inhibitors. Matecka, D., Lewis, D., Rothman, R.B., Dersch, C.M., Wojnicki, F.H., Glowa, J.R., DeVries, A.C., Pert, A., Rice, K.C. J. Med. Chem. (1997)
- Methylenedioxymethamphetamine decreases plasmalemmal and vesicular dopamine transport: mechanisms and implications for neurotoxicity. Hansen, J.P., Riddle, E.L., Sandoval, V., Brown, J.M., Gibb, J.W., Hanson, G.R., Fleckenstein, A.E. J. Pharmacol. Exp. Ther. (2002)
- Psychostimulants and vesicle trafficking: a novel mechanism and therapeutic implications. Hanson, G.R., Sandoval, V., Riddle, E., Fleckenstein, A.E. Ann. N. Y. Acad. Sci. (2004)
- Multiple molecular determinants in the carboxyl terminus regulate dopamine transporter export from endoplasmic reticulum. Miranda, M., Sorkina, T., Grammatopoulos, T.N., Zawada, W.M., Sorkin, A. J. Biol. Chem. (2004)
- Dopamine transporters are dephosphorylated in striatal homogenates and in vitro by protein phosphatase 1. Foster, J.D., Pananusorn, B., Cervinski, M.A., Holden, H.E., Vaughan, R.A. Brain Res. Mol. Brain Res. (2003)
- Restricted feeding with scheduled sucrose access results in an upregulation of the rat dopamine transporter. Bello, N.T., Sweigart, K.L., Lakoski, J.M., Norgren, R., Hajnal, A. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2003)
- Strain differences in the distribution of dopamine transporter sites in rat brain. Jiao, X., Paré, W.P., Tejani-Butt, S. Prog. Neuropsychopharmacol. Biol. Psychiatry (2003)
- Environmental enrichment decreases cell surface expression of the dopamine transporter in rat medial prefrontal cortex. Zhu, J., Apparsundaram, S., Bardo, M.T., Dwoskin, L.P. J. Neurochem. (2005)
- Dopamine efflux via wild-type and mutant dopamine transporters: alanine substitution for proline-572 enhances efflux and reduces dependence on extracellular dopamine, sodium and chloride concentrations. Itokawa, M., Lin, Z., Uhl, G.R. Brain Res. Mol. Brain Res. (2002)
- Effect of 1,2,3,4,-tetrahydroisoquinoline administration under conditions of CYP2D inhibition on dopamine metabolism, level of tyrosine hydroxylase protein and the binding of [3H]GBR 12,935 to dopamine transporter in the rat nigrostriatal, dopaminergic system. Lorenc-Koci, E., Antkiewicz-Michaluk, L., Wardas, J., Zapała, M., Wierońska, J. Brain Res. (2004)
- Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicity. Nakajima, A., Yamada, K., Nagai, T., Uchiyama, T., Miyamoto, Y., Mamiya, T., He, J., Nitta, A., Mizuno, M., Tran, M.H., Seto, A., Yoshimura, M., Kitaichi, K., Hasegawa, T., Saito, K., Yamada, Y., Seishima, M., Sekikawa, K., Kim, H.C., Nabeshima, T. J. Neurosci. (2004)
- Regional and subcellular compartmentation of the dopamine transporter and tyrosine hydroxylase in the rat ventral pallidum. Mengual, E., Pickel, V.M. J. Comp. Neurol. (2004)
- Differentiation of mesencephalic progenitor cells into dopaminergic neurons by cytokines. Ling, Z.D., Potter, E.D., Lipton, J.W., Carvey, P.M. Exp. Neurol. (1998)
- Ontogeny of dopamine transporter mRNA expression in the rat brain. Fujita, M., Shimada, S., Nishimura, T., Uhl, G.R., Tohyama, M. Brain Res. Mol. Brain Res. (1993)
- The zitter mutant rat exhibits loss of D3 receptors with degeneration of the dopamine system. Joyce, J.N., Yoshimoto, K., Ueda, S. Neuroreport (2000)
- Methamphetamine-induced rapid and reversible reduction in the activities of tryptophan hydroxylase and dopamine transporters: oxidative consequences? Hanson, G.R., Gibb, J.W., Metzger, R.R., Kokoshka, J.M., Fleckenstein, A.E. Ann. N. Y. Acad. Sci. (1998)
- Cell-type-specific expression of catecholamine transporters in the rat brain. Lorang, D., Amara, S.G., Simerly, R.B. J. Neurosci. (1994)
- The dopamine transporter: immunochemical characterization and localization in brain. Ciliax, B.J., Heilman, C., Demchyshyn, L.L., Pristupa, Z.B., Ince, E., Hersch, S.M., Niznik, H.B., Levey, A.I. J. Neurosci. (1995)