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Gene Review

Ppp1r1a  -  protein phosphatase 1, regulatory...

Rattus norvegicus

Synonyms: I-1, IPP-1, Ipp1, Protein phosphatase 1 regulatory subunit 1A, Protein phosphatase inhibitor 1
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Disease relevance of Ppp1r1a


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Biological context of Ppp1r1a


Anatomical context of Ppp1r1a


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Enzymatic interactions of Ppp1r1a


Regulatory relationships of Ppp1r1a


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Analytical, diagnostic and therapeutic context of Ppp1r1a


  1. Protein kinase and phosphatase activity regulate the form of synaptic plasticity expressed. Coussens, C.M., Teyler, T.J. Synapse (1996) [Pubmed]
  2. Protein phosphatase inhibitor-1 mRNA expression correlates with neoplastic transformation of epithelial liver cells and progression of hepatocellular carcinomas. Aleem, E., Flohr, T., Thielmann, H.W., Bannasch, P., Mayer, D. Int. J. Oncol. (2004) [Pubmed]
  3. Reversible hyperphosphorylation and reorganization of vimentin intermediate filaments by okadaic acid in 9L rat brain tumor cells. Lee, W.C., Yu, J.S., Yang, S.D., Lai, Y.K. J. Cell. Biochem. (1992) [Pubmed]
  4. Hepatic oxidative stress following prolonged sublethal microcystin LR exposure. Guzman, R.E., Solter, P.F. Toxicologic pathology. (1999) [Pubmed]
  5. Differential activation of caspase-3 at two maturational stages during okadaic acid-induced rat neuronal death. Hong, H.N., Yoon, S.Y., Suh, J., Lee, J.H., Kim, D. Neurosci. Lett. (2002) [Pubmed]
  6. Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. Haystead, T.A., Sim, A.T., Carling, D., Honnor, R.C., Tsukitani, Y., Cohen, P., Hardie, D.G. Nature (1989) [Pubmed]
  7. An essential role for protein phosphatases in hippocampal long-term depression. Mulkey, R.M., Herron, C.E., Malenka, R.C. Science (1993) [Pubmed]
  8. The phosphoprotein DARPP-32 mediates cAMP-dependent potentiation of striatal N-methyl-D-aspartate responses. Blank, T., Nijholt, I., Teichert, U., Kügler, H., Behrsing, H., Fienberg, A., Greengard, P., Spiess, J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  9. Ca(2+)-induced rebound potentiation of gamma-aminobutyric acid-mediated currents requires activation of Ca2+/calmodulin-dependent kinase II. Kano, M., Kano, M., Fukunaga, K., Konnerth, A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  10. Phosphorylated Mr 32,000 dopamine- and cAMP-regulated phosphoprotein inhibits Na+,K(+)-ATPase activity in renal tubule cells. Aperia, A., Fryckstedt, J., Svensson, L., Hemmings, H.C., Nairn, A.C., Greengard, P. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  11. Molecular cloning of protein phosphatase inhibitor-1 and its expression in rat and rabbit tissues. Elbrecht, A., DiRenzo, J., Smith, R.G., Shenolikar, S. J. Biol. Chem. (1990) [Pubmed]
  12. Detection and quantification of protein phosphatase inhibitor-1 gene expression in total rat liver and isolated hepatocytes. Aleem, E.A., Flohr, T., Hunziker, A., Mayer, D., Bannasch, P., Thielmann, H.W. Mol. Cell. Biochem. (2001) [Pubmed]
  13. Protection by naringin and some other flavonoids of hepatocytic autophagy and endocytosis against inhibition by okadaic acid. Gordon, P.B., Holen, I., Seglen, P.O. J. Biol. Chem. (1995) [Pubmed]
  14. Okadaic acid, cAMP, and selected nutrients inhibit hepatocyte proliferation at different stages in G1: modulation of the cAMP effect by phosphatase inhibitors and nutrients. Mellgren, G., Vintermyr, O.K., Døskeland, S.O. J. Cell. Physiol. (1995) [Pubmed]
  15. Phosphorylation of DARPP-32 and protein phosphatase inhibitor-1 in rat choroid plexus: regulation by factors other than dopamine. Snyder, G.L., Girault, J.A., Chen, J.Y., Czernik, A.J., Kebabian, J.W., Nathanson, J.A., Greengard, P. J. Neurosci. (1992) [Pubmed]
  16. Tyrosine hydroxylase in rat brain dopaminergic nerve terminals. Multiple-site phosphorylation in vivo and in synaptosomes. Haycock, J.W., Haycock, D.A. J. Biol. Chem. (1991) [Pubmed]
  17. Hormonal regulation of protein dephosphorylation. Identification and hormonal regulation of protein phosphatase inhibitor-1 in rat adipose tissue. Nemenoff, R.A., Blackshear, P.J., Avruch, J. J. Biol. Chem. (1983) [Pubmed]
  18. An elevation of cytosolic protein phosphorylation modulates trimeric G-protein regulation of secretory vesicle formation from the trans-Golgi network. Ohashi, M., Huttner, W.B. J. Biol. Chem. (1994) [Pubmed]
  19. Adrenal glucocorticoid permissive regulation of muscle glycogenolysis: action on protein phosphatase(s) and its inhibitor(s). Green, G.A., Chenoweth, M., Dunn, A. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  20. Involvement of phosphorylation in doxorubicin-mediated myofibril degeneration. An immunofluorescence microscopy analysis. Sussman, M.A., Hamm-Alvarez, S.F., Vilalta, P.M., Welch, S., Kedes, L. Circ. Res. (1997) [Pubmed]
  21. G(i) protein-mediated functional compartmentalization of cardiac beta(2)-adrenergic signaling. Kuschel, M., Zhou, Y.Y., Cheng, H., Zhang, S.J., Chen, Y., Lakatta, E.G., Xiao, R.P. J. Biol. Chem. (1999) [Pubmed]
  22. Protein phosphatase-1 and -2A activities in heart, liver, and skeletal muscle extracts from control and diabetic rats. Foulkes, J.G., Jefferson, L.S. Diabetes (1984) [Pubmed]
  23. Tyrosine phosphorylation of the metabotropic glutamate receptor mGluR5 in striatal neurons. Orlando, L.R., Dunah, A.W., Standaert, D.G., Young, A.B. Neuropharmacology (2002) [Pubmed]
  24. Activation of PP2A-like phosphatase and modulation of tau phosphorylation accompany stress-induced apoptosis in cultured oligodendrocytes. Goldbaum, O., Richter-Landsberg, C. Glia (2002) [Pubmed]
  25. Dopamine and glutamate agonists stimulate neuron-specific expression of Fos-like protein in the striatum. Berretta, S., Robertson, H.A., Graybiel, A.M. J. Neurophysiol. (1992) [Pubmed]
  26. Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP-activated protein kinase. A sensitive mechanism to protect the cell against ATP depletion. Moore, F., Weekes, J., Hardie, D.G. Eur. J. Biochem. (1991) [Pubmed]
  27. Protein phosphatase inhibitor cantharidin inhibits steroidogenesis and steroidogenic acute regulatory protein expression in cultured rat preovulatory follicles. Yu, C.C., Chen, W.Y., Li, P.S. Life Sci. (2001) [Pubmed]
  28. Sustained ERK-2 activation in rat glomerular mesangial cells: differential regulation by protein phosphatases. Schramek, H., Schumacher, M., Pfaller, W. Am. J. Physiol. (1996) [Pubmed]
  29. A role for protein kinase C-mediated phosphorylation in eliciting glucagon desensitization in rat hepatocytes. Savage, A., Zeng, L., Houslay, M.D. Biochem. J. (1995) [Pubmed]
  30. Developmental regulation of tyrosine phosphorylation of the NR2D NMDA glutamate receptor subunit in rat central nervous system. Dunah, A.W., Yasuda, R.P., Wolfe, B.B. J. Neurochem. (1998) [Pubmed]
  31. Divergent kinase signaling mediates agonist-induced phosphorylation of phosphatase inhibitory proteins PHI-1 and CPI-17 in vascular smooth muscle cells. Pang, H., Guo, Z., Xie, Z., Su, W., Gong, M.C. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  32. Regulation of the transmodulated epidermal growth factor receptor by cholera toxin and the protein phosphatase inhibitor okadaic acid. Winston, J.T., Olashaw, N.E., Pledger, W.J. J. Cell. Biochem. (1991) [Pubmed]
  33. Antagonistic effects of insulin and beta-adrenergic agonists on the activity of protein phosphatase inhibitor-1 in skeletal muscle of the perfused rat hemicorpus. Foulkes, J.G., Cohen, P., Strada, S.J., Everson, W.V., Jefferson, L.S. J. Biol. Chem. (1982) [Pubmed]
  34. Distribution of dopamine- and cAMP-dependent phosphoprotein (DARPP-32) in the developing and mature kidney. Fryckstedt, J., Aperia, A., Snyder, G., Meister, B. Kidney Int. (1993) [Pubmed]
  35. Localization of phosphatase inhibitor-1 mRNA in the developing and adult rat brain in comparison with that of protein phosphatase-1 mRNAs. Sakagami, H., Ebina, K., Kondo, H. Brain Res. Mol. Brain Res. (1994) [Pubmed]
  36. Induction of c-fos in rat brain by acute cocaine and fenfluramine exposure: a comparison study. Torres, G., Rivier, C. Brain Res. (1994) [Pubmed]
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