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Gene Review

BGLAP  -  bone gamma-carboxyglutamate (gla) protein

Bos taurus

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Disease relevance of BGLAP


High impact information on BGLAP


Biological context of BGLAP


Anatomical context of BGLAP


Associations of BGLAP with chemical compounds


Physical interactions of BGLAP


Other interactions of BGLAP


Analytical, diagnostic and therapeutic context of BGLAP


  1. New biochemical marker for bone metabolism. Measurement by radioimmunoassay of bone GLA protein in the plasma of normal subjects and patients with bone disease. Price, P.A., Parthemore, J.G., Deftos, L.J. J. Clin. Invest. (1980) [Pubmed]
  2. Effect of acute increases in bone matrix degradation on circulating levels of bone-Gla protein. Riggs, B.L., Tsai, K.S., Mann, K.G. J. Bone Miner. Res. (1986) [Pubmed]
  3. Measurement of serum bone gla-protein (BGP) in humans with an ovine BGP-based radioimmunoassay. Pastoureau, P., Delmas, P.D. Clin. Chem. (1990) [Pubmed]
  4. Primary structure of the gamma-carboxyglutamic acid-containing protein from bovine bone. Price, P.A., Poser, J.W., Raman, N. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  5. Isolation and characterization of native adult osteonectin. Romberg, R.W., Werness, P.G., Lollar, P., Riggs, B.L., Mann, K.G. J. Biol. Chem. (1985) [Pubmed]
  6. Primary structure of bovine matrix Gla protein, a new vitamin K-dependent bone protein. Price, P.A., Williamson, M.K. J. Biol. Chem. (1985) [Pubmed]
  7. Role of gamma-carboxyglutamic acid. Cation specificity of prothrombin and factor X-phospholipid binding. Nelsestuen, G.L., Broderius, M., Martin, G. J. Biol. Chem. (1976) [Pubmed]
  8. Immunochemical studies of conformational alterations in bone gamma-carboxyglutamic acid containing protein. Delmas, P.D., Stenner, D.D., Romberg, R.W., Riggs, B.L., Mann, K.G. Biochemistry (1984) [Pubmed]
  9. Cultured bovine bone cells synthesize basic fibroblast growth factor and store it in their extracellular matrix. Globus, R.K., Plouet, J., Gospodarowicz, D. Endocrinology (1989) [Pubmed]
  10. Osteonectin and Gla-protein in calf bone: ultrastructural immunohistochemical localization using the Protein A-gold method. Bianco, P., Hayashi, Y., Silvestrini, G., Termine, J.D., Bonucci, E. Calcif. Tissue Int. (1985) [Pubmed]
  11. Assessment of bone turnover in the dry period of dairy cows by measurement of plasma bone GLA protein, total plasma alkaline phosphatase activity and urinary hydroxyproline. van Mosel, M., Corlett, S.C. Exp. Physiol. (1990) [Pubmed]
  12. Measurement of plasma osteocalcin in sheep: assessment of circadian variation, the effects of age and nutritional status and the response to perturbation of the adrenocortical axis. Corlett, S.C., Couch, M., Care, A.D., Sykes, A.R. Exp. Physiol. (1990) [Pubmed]
  13. Fourier-transform infrared spectroscopic study of Ca2+-binding to osteocalcin. Mizuguchi, M., Fujisawa, R., Nara, M., Nitta, K., Kawano, K. Calcif. Tissue Int. (2001) [Pubmed]
  14. Calcification inhibitors and wnt signaling proteins are implicated in bovine artery smooth muscle cell calcification in the presence of phosphate and vitamin d sterols. Shalhoub, V., Shatzen, E., Henley, C., Boedigheimer, M., McNinch, J., Manoukian, R., Damore, M., Fitzpatrick, D., Haas, K., Twomey, B., Kiaei, P., Ward, S., Lacey, D.L., Martin, D. Calcif. Tissue Int. (2006) [Pubmed]
  15. Matrix Gla protein, a new gamma-carboxyglutamic acid-containing protein which is associated with the organic matrix of bone. Price, P.A., Urist, M.R., Otawara, Y. Biochem. Biophys. Res. Commun. (1983) [Pubmed]
  16. Determination of site-specific gamma-carboxyglutamic acid formation by vitamin K-dependent carboxylase utilizing De-gamma-carboxy bone Gla protein as substrate. Benton, M.E., Suttie, J.W. Meth. Enzymol. (1997) [Pubmed]
  17. Specific radioimmunoassay for ovine bone gla-protein (osteocalcin). Pastoureau, P., Merle, B., Delmas, P.D. Acta Endocrinol. (1988) [Pubmed]
  18. Regulation of bovine bone cell proliferation by fibroblast growth factor and transforming growth factor beta. Globus, R.K., Patterson-Buckendahl, P., Gospodarowicz, D. Endocrinology (1988) [Pubmed]
  19. A simple enzyme-linked immunosorbent assay of human osteocalcin. Rosenquist, C., Bonde, M., Fledelius, C., Qvist, P. Clin. Chem. (1994) [Pubmed]
  20. The presence of gamma-carboxyglutamic acid-containing protein in atheromatous aortae. Deyl, Z., Macek, K., Vancikova, O., Adam, M. Biochim. Biophys. Acta (1979) [Pubmed]
  21. Laser Raman spectroscopy of calf bone Gla protein. Dendramis, A.L., Poser, J.W., Schwinn, E.W. Biochim. Biophys. Acta (1983) [Pubmed]
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