Gene Review:
Bglap - bone gamma carboxyglutamate protein
Mus musculus
Synonyms:
BGP, Bglap1, Bone Gla protein, Gamma-carboxyglutamic acid-containing protein, OC, ...
- Interleukin 10-deficient mice develop osteopenia, decreased bone formation, and mechanical fragility of long bones. Dresner-Pollak, R., Gelb, N., Rachmilewitz, D., Karmeli, F., Weinreb, M. Gastroenterology (2004)
- Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones. Celeste, A.J., Rosen, V., Buecker, J.L., Kriz, R., Wang, E.A., Wozney, J.M. EMBO J. (1986)
- Type X collagen gene expression in mouse chondrocytes immortalized by a temperature-sensitive simian virus 40 large tumor antigen. Lefebvre, V., Garofalo, S., de Crombrugghe, B. J. Cell Biol. (1995)
- Synergistic induction of osteocalcin gene expression: identification of a bipartite element conferring fibroblast growth factor 2 and cyclic AMP responsiveness in the rat osteocalcin promoter. Boudreaux, J.M., Towler, D.A. J. Biol. Chem. (1996)
- Regulation of osteocalcin production and bone resorption by 1,25-dihydroxyvitamin D3 in mouse long bones: interaction with the bone-derived growth factors TGF-beta and IGF-I. Staal, A., Geertsma-Kleinekoort, W.M., Van Den Bemd, G.J., Buurman, C.J., Birkenhäger, J.C., Pols, H.A., Van Leeuwen, J.P. J. Bone Miner. Res. (1998)
- Leptin prevents the fall in plasma osteocalcin during starvation in male mice. Goldstone, A.P., Howard, J.K., Lord, G.M., Ghatei, M.A., Gardiner, J.V., Wang, Z.L., Wang, R.M., Girgis, S.I., Bailey, C.J., Bloom, S.R. Biochem. Biophys. Res. Commun. (2002)
- Mice deficient in Abl are osteoporotic and have defects in osteoblast maturation. Li, B., Boast, S., de los Santos, K., Schieren, I., Quiroz, M., Teitelbaum, S.L., Tondravi, M.M., Goff, S.P. Nat. Genet. (2000)
- Increased bone formation in osteocalcin-deficient mice. Ducy, P., Desbois, C., Boyce, B., Pinero, G., Story, B., Dunstan, C., Smith, E., Bonadio, J., Goldstein, S., Gundberg, C., Bradley, A., Karsenty, G. Nature (1996)
- Increased bone formation and decreased osteocalcin expression induced by reduced Twist dosage in Saethre-Chotzen syndrome. Yousfi, M., Lasmoles, F., Lomri, A., Delannoy, P., Marie, P.J. J. Clin. Invest. (2001)
- Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis. Chen, L., Adar, R., Yang, X., Monsonego, E.O., Li, C., Hauschka, P.V., Yayon, A., Deng, C.X. J. Clin. Invest. (1999)
- Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. Weinstein, R.S., Jilka, R.L., Parfitt, A.M., Manolagas, S.C. J. Clin. Invest. (1998)
- Osteocalcin promoter-based toxic gene therapy for the treatment of osteosarcoma in experimental models. Ko, S.C., Cheon, J., Kao, C., Gotoh, A., Shirakawa, T., Sikes, R.A., Karsenty, G., Chung, L.W. Cancer Res. (1996)
- Melatonin promotes osteoblast differentiation and bone formation. Roth, J.A., Kim, B.G., Lin, W.L., Cho, M.I. J. Biol. Chem. (1999)
- Picomolar norethindrone in vitro stimulates the cell proliferation and activity of a human osteosarcoma cell line and increases bone collagen synthesis without an effect on bone resorption. Lau, K.H., Wang, S.P., Linkhart, T.A., Demarest, K.T., Baylink, D.J. J. Bone Miner. Res. (1994)
- Imbalance of local bone metabolism in inflammatory arthritis and its reversal upon tumor necrosis factor blockade: direct analysis of bone turnover in murine arthritis. Zwerina, J., Tuerk, B., Redlich, K., Smolen, J.S., Schett, G. Arthritis Res. Ther. (2006)
- Functional hierarchy between two OSE2 elements in the control of osteocalcin gene expression in vivo. Frendo, J.L., Xiao, G., Fuchs, S., Franceschi, R.T., Karsenty, G., Ducy, P. J. Biol. Chem. (1998)
- The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression. Desbois, C., Hogue, D.A., Karsenty, G. J. Biol. Chem. (1994)
- 1,25-dihydroxyvitamin D3 inhibits Osteocalcin expression in mouse through an indirect mechanism. Zhang, R., Ducy, P., Karsenty, G. J. Biol. Chem. (1997)
- MINT, the Msx2 interacting nuclear matrix target, enhances Runx2-dependent activation of the osteocalcin fibroblast growth factor response element. Sierra, O.L., Cheng, S.L., Loewy, A.P., Charlton-Kachigian, N., Towler, D.A. J. Biol. Chem. (2004)
- Role of the alpha2-integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor. Xiao, G., Wang, D., Benson, M.D., Karsenty, G., Franceschi, R.T. J. Biol. Chem. (1998)
- Stimulus-selective inhibition of rat osteocalcin promoter induction and protein-DNA interactions by the homeodomain repressor Msx2. Newberry, E.P., Boudreaux, J.M., Towler, D.A. J. Biol. Chem. (1997)
- Reciprocal temporospatial patterns of Msx2 and Osteocalcin gene expression during murine odontogenesis. Bidder, M., Latifi, T., Towler, D.A. J. Bone Miner. Res. (1998)
- Does adult fracture repair recapitulate embryonic skeletal formation? Ferguson, C., Alpern, E., Miclau, T., Helms, J.A. Mech. Dev. (1999)
- Employing a transgenic animal model to obtain cementoblasts in vitro. D'Errico, J.A., Berry, J.E., Ouyang, H., Strayhorn, C.L., Windle, J.J., Somerman, M.J. J. Periodontol. (2000)
- Glucocorticoids inhibit osteocalcin transcription in osteoblasts by suppressing Egr2/Krox20-binding enhancer. Leclerc, N., Noh, T., Khokhar, A., Smith, E., Frenkel, B. Arthritis Rheum. (2005)
- Activation of peroxisome proliferator-activated receptor-gamma inhibits the Runx2-mediated transcription of osteocalcin in osteoblasts. Jeon, M.J., Kim, J.A., Kwon, S.H., Kim, S.W., Park, K.S., Park, S.W., Kim, S.Y., Shin, C.S. J. Biol. Chem. (2003)
- Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation. Lee, M.H., Javed, A., Kim, H.J., Shin, H.I., Gutierrez, S., Choi, J.Y., Rosen, V., Stein, J.L., van Wijnen, A.J., Stein, G.S., Lian, J.B., Ryoo, H.M. J. Cell. Biochem. (1999)
- Insulin-like growth factor I production is essential for anabolic effects of thyroid hormone in osteoblasts. Huang, B.K., Golden, L.A., Tarjan, G., Madison, L.D., Stern, P.H. J. Bone Miner. Res. (2000)
- Ascorbic acid induces collagenase-1 in human periodontal ligament cells but not in MC3T3-E1 osteoblast-like cells: potential association between collagenase expression and changes in alkaline phosphatase phenotype. Shiga, M., Kapila, Y.L., Zhang, Q., Hayami, T., Kapila, S. J. Bone Miner. Res. (2003)
- Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene. Hassan, M.Q., Javed, A., Morasso, M.I., Karlin, J., Montecino, M., van Wijnen, A.J., Stein, G.S., Stein, J.L., Lian, J.B. Mol. Cell. Biol. (2004)
- Medium perfusion enhances osteogenesis by murine osteosarcoma cells in three-dimensional collagen sponges. Mueller, S.M., Mizuno, S., Gerstenfeld, L.C., Glowacki, J. J. Bone Miner. Res. (1999)
- Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription. Javed, A., Guo, B., Hiebert, S., Choi, J.Y., Green, J., Zhao, S.C., Osborne, M.A., Stifani, S., Stein, J.L., Lian, J.B., van Wijnen, A.J., Stein, G.S. J. Cell. Sci. (2000)
- Chondrocytes provide morphogenic signals that selectively induce osteogenic differentiation of mesenchymal stem cells. Gerstenfeld, L.C., Cruceta, J., Shea, C.M., Sampath, K., Barnes, G.L., Einhorn, T.A. J. Bone Miner. Res. (2002)