Gene Review:
MCM3 - minichromosome maintenance complex...
Homo sapiens
Synonyms:
DNA polymerase alpha holoenzyme-associated protein P1, DNA replication licensing factor MCM3, HCC5, P1-MCM3, P1.h, ...
- Minichromosome maintenance protein 3 elicits a cancer-restricted immune response in patients with brain malignancies and is a strong independent predictor of survival in patients with anaplastic astrocytoma. Söling, A., Sackewitz, M., Volkmar, M., Schaarschmidt, D., Jacob, R., Holzhausen, H.J., Rainov, N.G. Clin. Cancer Res. (2005)
- Cancer-associated expression of minichromosome maintenance 3 gene in several human cancers and its involvement in tumorigenesis. Ha, S.A., Shin, S.M., Namkoong, H., Lee, H., Cho, G.W., Hur, S.Y., Kim, T.E., Kim, J.W. Clin. Cancer Res. (2004)
- Genomic structure of the gene for the human P1 protein (MCM3) and its exclusion as a candidate for autosomal recessive polycystic kidney disease. Hofmann, Y., Becker, J., Wright, F., Avner, E.D., Mrug, M., Guay-Woodford, L.M., Somlo, S., Zerres, K., Germino, G.G., Onuchic, L.F. Eur. J. Hum. Genet. (2000)
- Cell cycle regulation of chromatin at an origin of DNA replication. Zhou, J., Chau, C.M., Deng, Z., Shiekhattar, R., Spindler, M.P., Schepers, A., Lieberman, P.M. EMBO J. (2005)
- An episomal mammalian replicon: sequence-independent binding of the origin recognition complex. Schaarschmidt, D., Baltin, J., Stehle, I.M., Lipps, H.J., Knippers, R. EMBO J. (2004)
- Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals. Natale, D.A., Li, C.J., Sun, W.H., DePamphilis, M.L. EMBO J. (2000)
- Magnetic resonance imaging (MRI) of primary liver cancer--MRI-pathologic correlation. Ohtomo, K., Itai, Y., Furui, S., Yoshikawa, K., Yashiro, N., Iio, M. Radiation medicine. (1985)
- A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication. Kuwahara, K., Yoshida, M., Kondo, E., Sakata, A., Watanabe, Y., Abe, E., Kouno, Y., Tomiyasu, S., Fujimura, S., Tokuhisa, T., Kimura, H., Ezaki, T., Sakaguchi, N. Blood (2000)
- Structure, expression, and chromosomal localization of the human gene encoding a germinal center-associated nuclear protein (GANP) that associates with MCM3 involved in the initiation of DNA replication. Abe, E., Kuwahara, K., Yoshida, M., Suzuki, M., Terasaki, H., Matsuo, Y., Takahashi, E.I., Sakaguchi, N. Gene (2000)
- Identification of Carboxyl-terminal MCM3 Phosphorylation Sites Using Polyreactive Phosphospecific Antibodies. Shi, Y., Dodson, G.E., Mukhopadhyay, P.S., Shanware, N.P., Trinh, A.T., Tibbetts, R.S. J. Biol. Chem. (2007)
- The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3. Takei, Y., Assenberg, M., Tsujimoto, G., Laskey, R. J. Biol. Chem. (2002)
- Expression of replication-licensing factors MCM2 and MCM3 in normal, hyperplastic, and carcinomatous endometrium: correlation with expression of Ki-67 and estrogen and progesterone receptors. Kato, K., Toki, T., Shimizu, M., Shiozawa, T., Fujii, S., Nikaido, T., Konishi, I. Int. J. Gynecol. Pathol. (2003)
- Enhanced expression of Mcm proteins in cancer cells derived from uterine cervix. Ishimi, Y., Okayasu, I., Kato, C., Kwon, H.J., Kimura, H., Yamada, K., Song, S.Y. Eur. J. Biochem. (2003)
- Fusion between human and Drosophila melanogaster cells induced by polyethylene glycol. Halfer, C., Del Pin, D., Dell'Oro, A. Genetica (1987)
- Differential binding of replication proteins across the human c-myc replicator. Ghosh, M., Kemp, M., Liu, G., Ritzi, M., Schepers, A., Leffak, M. Mol. Cell. Biol. (2006)
- In vitro phosphorylation of phosphoenolpyruvate carboxylase from the green alga Selenastrum minutum. Rivoal, J., Turpin, D.H., Plaxton, W.C. Plant Cell Physiol. (2002)
- Functional interaction between the glucocorticoid receptor and GANP/MCM3AP. Osman, W., Laine, S., Zilliacus, J. Biochem. Biophys. Res. Commun. (2006)
- Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. Cortez, D., Glick, G., Elledge, S.J. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization. Takei, Y., Tsujimoto, G. J. Biol. Chem. (1998)
- Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma. DaFonseca, C.J., Shu, F., Zhang, J.J. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Characterization of apoptosis-induced Mcm3 and Cdc6 cleavage reveals a proapoptotic effect for one Mcm3 fragment. Schories, B., Engel, K., Dörken, B., Gossen, M., Bommert, K. Cell Death Differ. (2004)
- Interaction of hRad51 and hRad52 with MCM complex: a cross-talk between recombination and replication proteins. Shukla, A., Navadgi, V.M., Mallikarjuna, K., Rao, B.J. Biochem. Biophys. Res. Commun. (2005)
- Involvement of cyclin D1-cdk5 overexpression and MCM3 cleavage in bax-associated spontaneous apoptosis and differentiation in an A253 human head and neck carcinoma xenograft model. Yin, M.B., Tóth, K., Cao, S., Guo, B., Frank, C., Slocum, H.K., Rustum, Y.M. Int. J. Cancer (1999)
- Long-term survival and pattern of recurrence after resection of small hepatocellular carcinoma in patients with preserved liver function: implications for a strategy of salvage transplantation. Poon, R.T., Fan, S.T., Lo, C.M., Liu, C.L., Wong, J. Ann. Surg. (2002)