Gene Review:
Chat - choline O-acetyltransferase
Rattus norvegicus
Synonyms:
CHOACTase, ChAT, Choline O-acetyltransferase, Choline acetylase
- Disturbance of the cortical cholinergic innervation in Borna disease prior to encephalitis. Gies, U., Bilzer, T., Stitz, L., Staiger, J.F. Brain Pathol. (1998)
- Acetylcholine levels and choline acetyltransferase activity in rat cerebrovascular bed after uni- or bilateral sphenopalatine ganglionectomy. Dauphin, F., Richard, J.W., Seylaz, J., Quirion, R., Hamel, E. J. Cereb. Blood Flow Metab. (1991)
- Transcriptional regulation of choline acetyltransferase gene by cyclic AMP. Misawa, H., Takahashi, R., Deguchi, T. J. Neurochem. (1993)
- High-level synthesis and fate of acetylcholine in baculovirus-infected cells: characterization and purification of recombinant rat choline acetyltransferase. Habert, E., Birman, S., Mallet, J. J. Neurochem. (1992)
- Thyroid hormone causes sexually distinct neurochemical and morphological alterations in rat septal-diagonal band neurons. Westlind-Danielsson, A., Gould, E., McEwen, B.S. J. Neurochem. (1991)
- Age-impaired impulse flow from nucleus basalis to cortex. Aston-Jones, G., Rogers, J., Shaver, R.D., Dinan, T.G., Moss, D.E. Nature (1985)
- Cloning of the rat gene encoding choline acetyltransferase, a cholinergic neuron-specific marker. Hahn, M., Hahn, S.L., Stone, D.M., Joh, T.H. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Spatial discrimination learning and choline acetyltransferase activity in streptozotocin-treated rats: effects of chronic treatment with acetyl-L-carnitine. Prickaerts, J., Blokland, A., Honig, W., Meng, F., Jolles, J. Brain Res. (1995)
- Differential effects of typical and atypical antipsychotics on nerve growth factor and choline acetyltransferase expression in the cortex and nucleus basalis of rats. Parikh, V., Khan, M.M., Terry, A., Mahadik, S.P. Journal of psychiatric research. (2004)
- Firing properties of anatomically identified neurons in the medial septum of anesthetized and unanesthetized restrained rats. Simon, A.P., Poindessous-Jazat, F., Dutar, P., Epelbaum, J., Bassant, M.H. J. Neurosci. (2006)
- Two types of cholinergic innervation in cortex, one co-localized with vasoactive intestinal polypeptide. Eckenstein, F., Baughman, R.W. Nature (1984)
- Rescue of motoneurons from cell death by a purified skeletal muscle polypeptide: effects of the ChAT development factor, CDF. McManaman, J.L., Oppenheim, R.W., Prevette, D., Marchetti, D. Neuron (1990)
- Choline acetyltransferase structure reveals distribution of mutations that cause motor disorders. Cai, Y., Cronin, C.N., Engel, A.G., Ohno, K., Hersh, L.B., Rodgers, D.W. EMBO J. (2004)
- Inability to produce a model of dialysis encephalopathy in the rat by aluminum administration. Perry, T.L., Yong, V.W., Godolphin, W.J., Sutter, M., Hansen, S., Kish, S.J., Foulks, J.G., Ito, M. Neurochem. Res. (1987)
- Membrane-bound choline-O-acetyltransferase in rat hippocampal tissue is anchored by glycosyl-phosphatidylinositol. Smith, L.K., Carroll, P.T. Brain Res. (1993)
- Sparing by rasagiline (TVP-1012) of cholinergic functions and behavior in the postnatal anoxia rat. Speiser, Z., Katzir, O., Rehavi, M., Zabarski, T., Cohen, S. Pharmacol. Biochem. Behav. (1998)
- Peripheral Choline Acetyltransferase is Expressed by Monocytes and Upregulated During Renal Allograft Rejection in Rats. Hecker, A., Lips, K.S., Pfeil, U., Kummer, W., Padberg, W., Grau, V. J. Mol. Neurosci. (2006)
- Cholinergic metabolism and synapse formation by a rat nerve cell line. Schubert, D., Heinemann, S., Kidokoro, Y. Proc. Natl. Acad. Sci. U.S.A. (1977)
- Regulatory region in choline acetyltransferase gene directs developmental and tissue-specific expression in transgenic mice. Lönnerberg, P., Lendahl, U., Funakoshi, H., Arhlund-Richter, L., Persson, H., Ibáñez, C.F. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Toll-Like Receptor Ligands and CD154 Stimulate Microglia to Produce a Factor(s) That Promotes Excess Cholinergic Differentiation in the Developing Rat Basal Forebrain: Implications for Neurodevelopmental Disorders. Ni, L., Acevedo, G., Muralidharan, B., Padala, N., To, J., Jonakait, G.M. Pediatr. Res. (2007)
- Complementary DNAs for choline acetyltransferase from spinal cords of rat and mouse: nucleotide sequences, expression in mammalian cells, and in situ hybridization. Ishii, K., Oda, Y., Ichikawa, T., Deguchi, T. Brain Res. Mol. Brain Res. (1990)
- Effects of aging and amyloid-beta peptides on choline acetyltransferase activity in rat brain. Zambrzycka, A., Alberghina, M., Strosznajder, J.B. Neurochem. Res. (2002)
- The effects of ovariectomy and estrogen replacement on trkA and choline acetyltransferase mRNA expression in the basal forebrain of the adult female Sprague-Dawley rat. McMillan, P.J., Singer, C.A., Dorsa, D.M. J. Neurosci. (1996)
- Effects of excitotoxic lesions of the septum and vertical limb nucleus of the diagonal band of Broca on conditional visual discrimination: relationship between performance and choline acetyltransferase activity in the cingulate cortex. Marston, H.M., West, H.L., Wilkinson, L.S., Everitt, B.J., Robbins, T.W. J. Neurosci. (1994)
- Identification of central cholinergic neurons containing both choline acetyltransferase and acetylcholinesterase and of central neurons containing only acetylcholinesterase. Eckenstein, F., Sofroniew, M.V. J. Neurosci. (1983)
- Studies on the alkylation of choline acetyltransferase by choline mustard aziridinium ion. Rylett, R.J., Colhoun, E.H. J. Neurochem. (1985)
- Acetyl-CoA synthesizing enzymes in cholinergic nerve terminals. Sterri, S.H., Fonnum, F. J. Neurochem. (1980)
- Neurotrophins differentially enhance acetylcholine release, acetylcholine content and choline acetyltransferase activity in basal forebrain neurons. Auld, D.S., Mennicken, F., Day, J.C., Quirion, R. J. Neurochem. (2001)
- Parallel postnatal development of choline acetyltransferase activity and muscarinic acetylcholine receptors in the rat olfactory bulb. Large, T.H., Lambert, M.P., Gremillion, M.A., Klein, W.L. J. Neurochem. (1986)
- Transforming growth factor-alpha expands progenitor cells of the basal forebrain, but does not promote cholinergic differentiation. Jonakait, G.M., Luskin, M.B., Ni, L. J. Neurobiol. (1998)
- Embryonic development of rat sympathetic preganglionic neurons: possible migratory substrates. Phelps, P.E., Barber, R.P., Vaughn, J.E. J. Comp. Neurol. (1993)
- Expression of choline acetyltransferase mRNA in spermatogenic cells results in an accumulation of the enzyme in the postacrosomal region of mature spermatozoa. Ibáñez, C.F., Pelto-Huikko, M., Söder, O., Ritzèn, E.M., Hersh, L.B., Hökfelt, T., Persson, H. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Nerve growth factor-independent reduction in choline acetyltransferase activity in PC12 cells expressing mutant presenilin-1. Pedersen, W.A., Guo, Q., Hartman, B.K., Mattson, M.P. J. Biol. Chem. (1997)
- Activation of rat choline acetyltransferase by limited proteolysis. Wu, D., Ahmed, S.N., Lian, W., Hersh, L.B. J. Biol. Chem. (1995)
- Age and sex-dependent decreases in ChAT in basal forebrain nuclei. Luine, V.N., Renner, K.J., Heady, S., Jones, K.J. Neurobiol. Aging (1986)