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Gene Review

SEPSECS  -  Sep (O-phosphoserine) tRNA:Sec...

Homo sapiens

Synonyms: LP, Liver-pancreas antigen, O-phosphoseryl-tRNA(Sec) selenium transferase, PCH2D, SLA, ...
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Disease relevance of SEPSECS

  • Identification of target antigen for SLA/LP autoantibodies in autoimmune hepatitis [1].
  • Methods We tested 2000 serum samples from patients with various liver diseases and controls for SLA autoantibodies by inhibition ELISA [1].
  • Expressed in Escherichia coli, SLA-p35 showed dose-dependent and complete blocking of reactivity to native SLA antigen after preabsorption with the 35-kd recombinant protein [2].
  • Autoantibodies against a soluble liver antigen (SLA) were detected in 23 patients with HBsAg-negative chronic active hepatitis (CAH) but not in 502 patients with various other hepatic and non-hepatic disorders or 165 healthy blood donors [3].
  • All individuals presented with the cutaneous clinical form of leishmaniasis and were analyzed for proliferative responses to LACK antigen and SLA, frequency of lymphocyte subpopulations (analyzed ex vivo), and antigen-induced (LACK and SLA) cytokine production at the single-cell level (determined by flow cytometry) [4].

High impact information on SEPSECS

  • Autoantibodies to soluble liver antigen (SLA) and to liver and pancreas antigen (LP) have been described as disease specific, occurring in about 30% of all patients with autoimmune hepatitis, but no standardised assays are available [1].
  • Identified clones were tested against a panel of serum samples positive for SLA and LP autoantibodies and control serum samples, and the epitope mapped by deletion mutants and exonuclease digestion [1].
  • CONCLUSIONS: Glutathione S-transferase subunit proteins represent the major autoantigen in anti-SLA-positive AIH [5].
  • The insertion of the putative retrotransposon was shown to interfere with gene expression, with no SLA transcripts being detected by RNA gel blot analysis in a self-incompatible B. oleracea var botrytis line carrying an interrupted SLA gene [6].
  • However, analysis of seven B. oleracea var botrytis lines exhibiting both self-compatible and self-incompatible phenotypes showed that these lines carry an S allele very similar or identical to that of the B. oleracea var acephala line and that the SLA gene is interrupted by an insert in all seven lines [6].

Chemical compound and disease context of SEPSECS


Biological context of SEPSECS


Anatomical context of SEPSECS


Associations of SEPSECS with chemical compounds

  • Therefore we used a new theoretical method called fold recognition and could show that the SLA/LP sequence is compatible with the architecture of the superfamily of pyridoxal phosphate (PLP; vitamin B6)-dependent transferases [17].
  • PBSCs mobilized with pSCF/pIL-3 were infused into an SLA-matched recipient conditioned with cyclophosphamide (50 mg/kg) and total body irradiation 1150 cGy [18].
  • To study the biological implications of this modification, CaCo-2 cells were incubated with either LA or sulphated lithocholic acid (3-sulpholithocholic acid, SLA), and in some experiments with taurine-conjugated lithocholic acid [19].
  • Patients treated with gemcitabine had a similar 10-month LP rate (62% vs. 61%), 10-month DM rate (55% vs. 47%), 1-year OS rate (42% vs. 28%), and median OS duration (11 months vs. 9 months) to patients treated with 5 FU (all p = NS) [20].
  • Altrenogest (ALT), a synthetic progestogen, and exogenous gonadotropins were administered to the Swine Leukocyte Antigen (SLA) inbred miniature pig that typically has a reduced ovulation rate and small litter size [21].

Other interactions of SEPSECS

  • In conclusion, the exquisite epitope specificity and IgG subtype are evidence for the maturity of the SLA/LP autoantibody response; a specific autoantigen-driven process underlying the immunopathogenesis is likely [11].

Analytical, diagnostic and therapeutic context of SEPSECS

  • Autoantibodies to soluble liver antigen and liver pancreas (SLA/LP) have been described as specific markers for Autoimmune Hepatitis (AIH), occurring in about 20% of patients with AIH [11].
  • Anti-SLA cannot be detected by immunofluorescence [3].
  • The immunoprecipitation of the SLA RNA by antibodies against common proteins does not require an association between the SLA RNA and the SL RNP [22].
  • The SLA antigens were reduced and alkylated, and the component heavy and light chains were isolated by gel filtration under dissociating conditions [23].
  • CONCLUSIONS: Antibodies to SLA/LP can be reliably detected by these standardised immunoassays based on recombinant antigen [24].


  1. Identification of target antigen for SLA/LP autoantibodies in autoimmune hepatitis. Wies, I., Brunner, S., Henninger, J., Herkel, J., Kanzler, S., Meyer zum Büschenfelde, K.H., Lohse, A.W. Lancet (2000) [Pubmed]
  2. Soluble liver antigen: isolation of a 35-kd recombinant protein (SLA-p35) specifically recognizing sera from patients with autoimmune hepatitis. Volkmann, M., Martin, L., Bäurle, A., Heid, H., Strassburg, C.P., Trautwein, C., Fiehn, W., Manns, M.P. Hepatology (2001) [Pubmed]
  3. Characterisation of a new subgroup of autoimmune chronic active hepatitis by autoantibodies against a soluble liver antigen. Manns, M., Gerken, G., Kyriatsoulis, A., Staritz, M., Meyer zum Büschenfelde, K.H. Lancet (1987) [Pubmed]
  4. Flow cytometric determination of cellular sources and frequencies of key cytokine-producing lymphocytes directed against recombinant LACK and soluble Leishmania antigen in human cutaneous leishmaniasis. Bottrel, R.L., Dutra, W.O., Martins, F.A., Gontijo, B., Carvalho, E., Barral-Netto, M., Barral, A., Almeida, R.P., Mayrink, W., Locksley, R., Gollob, K.J. Infect. Immun. (2001) [Pubmed]
  5. Members of the glutathione S-transferase gene family are antigens in autoimmune hepatitis. Wesierska-Gadek, J., Grimm, R., Hitchman, E., Penner, E. Gastroenterology (1998) [Pubmed]
  6. A functional S locus anther gene is not required for the self-incompatibility response in Brassica oleracea. Pastuglia, M., Ruffio-Châble, V., Delorme, V., Gaude, T., Dumas, C., Cock, J.M. Plant Cell (1997) [Pubmed]
  7. Isolation and characterization of cDNA encoding the antigenic protein of the human tRNP(Ser)Sec complex recognized by autoantibodies from patients withtype-1 autoimmune hepatitis. Costa, M., Rodríguez-Sánchez, J.L., Czaja, A.J., Gelpí, C. Clin. Exp. Immunol. (2000) [Pubmed]
  8. Autoantibodies against CYP2D6 and other drug-metabolizing enzymes in autoimmune hepatitis type 2. Mizutani, T., Shinoda, M., Tanaka, Y., Kuno, T., Hattori, A., Usui, T., Kuno, N., Osaka, T. Drug Metab. Rev. (2005) [Pubmed]
  9. Anti-soluble liver antigen (SLA) antibodies in chronic HCV infection. Vitozzi, S., Lapierre, P., Djilali-Saiah, I., Marceau, G., Beland, K., Alvarez, F. Autoimmunity (2004) [Pubmed]
  10. Effect of lactoperoxidase system on glucosyltransferase D of Streptococcus mutans. Yu, X., Loimaranta, V., Lenander-Lumikari, M., Wunder, D., Bowen, W.H., Tenuvuo, J. The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA). (2000) [Pubmed]
  11. Fine specificity of autoantibodies to soluble liver antigen and liver/pancreas. Herkel, J., Heidrich, B., Nieraad, N., Wies, I., Rother, M., Lohse, A.W. Hepatology (2002) [Pubmed]
  12. Recognition of xeno-(HLA, SLA) major histocompatibility complex antigens by mouse cytotoxic T cells is not H-2 restricted: a study with transgenic mice. Kievits, F., Wijffels, J., Lokhorst, W., Ivanyi, P. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  13. The major histocompatibility complex in swine. Chardon, P., Renard, C., Vaiman, M. Immunol. Rev. (1999) [Pubmed]
  14. Characterization and clinical relevance of liver-pancreas antibodies in autoimmune hepatitis. Stechemesser, E., Klein, R., Berg, P.A. Hepatology (1993) [Pubmed]
  15. Neonatal porcine islet cells induce human CD4+, but not CD8+, lymphocyte proliferation and resist cell-mediated cytolytic injury in vitro. Murray, A.G., Nelson, R.C., Rayat, G.R., Elliott, J.F., Korbutt, G.S. Diabetes (1999) [Pubmed]
  16. Rapid transbilayer movement of spin-labeled steroids in human erythrocytes and in liposomes. Müller, P., Herrmann, A. Biophys. J. (2002) [Pubmed]
  17. A bioinformatical approach suggests the function of the autoimmune hepatitis target antigen soluble liver antigen/liver pancreas. Kernebeck, T., Lohse, A.W., Grötzinger, J. Hepatology (2001) [Pubmed]
  18. Cytokine-mobilized peripheral blood progenitor cells for allogeneic reconstitution of miniature swine. Colby, C., Chang, Q., Fuchimoto, Y., Ferrara, V., Murphy, M., Sackstein, R., Spitzer, T.R., White-Scharf, M.E., Sachs, D.H. Transplantation (2000) [Pubmed]
  19. Lithocholic acid and sulphated lithocholic acid differ in the ability to promote matrix metalloproteinase secretion in the human colon cancer cell line CaCo-2. Halvorsen, B., Staff, A.C., Ligaarden, S., Prydz, K., Kolset, S.O. Biochem. J. (2000) [Pubmed]
  20. Is the therapeutic index better with gemcitabine-based chemoradiation than with 5-fluorouracil-based chemoradiation in locally advanced pancreatic cancer? Crane, C.H., Abbruzzese, J.L., Evans, D.B., Wolff, R.A., Ballo, M.T., Delclos, M., Milas, L., Mason, K., Charnsangavej, C., Pisters, P.W., Lee, J.E., Lenzi, R., Vauthey, J.N., Wong, A.B., Phan, T., Nguyen, Q., Janjan, N.A. Int. J. Radiat. Oncol. Biol. Phys. (2002) [Pubmed]
  21. Effects of altrenogest and exogenous gonadotropins on ovarian function and embryo recovery in swine leukocyte antigen inbred miniature swine as influenced by cystic endometrial hyperplasia. Diehl, J.R., Stuart, L.D., Goodrowe, K.L., Wildt, D.E. Biol. Reprod. (1986) [Pubmed]
  22. Spliced leader-associated RNA of trypanosomes. Sequence conservation and association with protein components common to trans-spliceosomal ribonucleoproteins. Palfi, Z., Xu, G.L., Bindereif, A. J. Biol. Chem. (1994) [Pubmed]
  23. Transplantation in miniature swine. XII. N-terminal sequences of class I histocompatibility antigens (SLA) and beta 2-microglobulin. Metzger, J.J., Lunney, J.K., Sachs, D.H., Rudikoff, S. J. Immunol. (1982) [Pubmed]
  24. Establishment of standardised SLA/LP immunoassays: specificity for autoimmune hepatitis, worldwide occurrence, and clinical characteristics. Baeres, M., Herkel, J., Czaja, A.J., Wies, I., Kanzler, S., Cancado, E.L., Porta, G., Nishioka, M., Simon, T., Daehnrich, C., Schlumberger, W., Galle, P.R., Lohse, A.W. Gut (2002) [Pubmed]
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