Gene Review:
PSMC4 - proteasome (prosome, macropain) 26S...
Homo sapiens
Synonyms:
26S protease regulatory subunit 6B, 26S proteasome AAA-ATPase subunit RPT3, MB67-interacting protein, MGC13687, MGC23214, ...
- Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma. El-Hashemite, N., Zhang, H., Henske, E.P., Kwiatkowski, D.J. Lancet (2003)
- Genomic sequence analyses of segments 1 to 6 of Dendrolimus punctatus cytoplasmic polyhedrosis virus. Zhao, S.L., Liang, C.Y., Hong, J.J., Peng, H.Y. Arch. Virol. (2003)
- Stimulation of ribosomal protein S6 kinase activity by pp60v-src or by serum: dissociation from phorbol ester-stimulated activity. Blenis, J., Erikson, R.L. Proc. Natl. Acad. Sci. U.S.A. (1986)
- Activation of Akt predicts poor outcome in neuroblastoma. Opel, D., Poremba, C., Simon, T., Debatin, K.M., Fulda, S. Cancer Res. (2007)
- Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies. Bowen, D.M., Smith, C.B., White, P., Davison, A.N. Brain (1976)
- Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Chung, J., Kuo, C.J., Crabtree, G.R., Blenis, J. Cell (1992)
- p70 S6 kinase: an enigma with variations. Proud, C.G. Trends Biochem. Sci. (1996)
- SPKK, a new nucleic acid-binding unit of protein found in histone. Suzuki, M. EMBO J. (1989)
- 'SPKK' motifs prefer to bind to DNA at A/T-rich sites. Churchill, M.E., Suzuki, M. EMBO J. (1989)
- Immunohistochemical analysis of S6K1 and S6K2 expression in endometrial adenocarcinomas. Lyzogubov, V.V., Lytvyn, D.I., Dudchenko, T.M., Lubchenko, N.V., Pogrybniy, P.V., Nespryadko, S.V., Vinnitska, A.B., Usenko, V.S., Gout, I.T., Filonenko, V.V. Experimental oncology. (2004)
- Gankyrin is an ankyrin-repeat oncoprotein that interacts with CDK4 kinase and the S6 ATPase of the 26 S proteasome. Dawson, S., Apcher, S., Mee, M., Higashitsuji, H., Baker, R., Uhle, S., Dubiel, W., Fujita, J., Mayer, R.J. J. Biol. Chem. (2002)
- p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation. Papkoff, J., Chen, R.H., Blenis, J., Forsman, J. Mol. Cell. Biol. (1994)
- Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). Goncharova, E.A., Goncharov, D.A., Eszterhas, A., Hunter, D.S., Glassberg, M.K., Yeung, R.S., Walker, C.L., Noonan, D., Kwiatkowski, D.J., Chou, M.M., Panettieri, R.A., Krymskaya, V.P. J. Biol. Chem. (2002)
- Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton. Burnett, P.E., Blackshaw, S., Lai, M.M., Qureshi, I.A., Burnett, A.F., Sabatini, D.M., Snyder, S.H. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Tat-binding protein 7 is a subunit of the 26S protease. Dubiel, W., Ferrell, K., Rechsteiner, M. Biol. Chem. Hoppe-Seyler (1994)
- Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck. Amornphimoltham, P., Patel, V., Sodhi, A., Nikitakis, N.G., Sauk, J.J., Sausville, E.A., Molinolo, A.A., Gutkind, J.S. Cancer Res. (2005)
- Identification of phosphoprotein NP33 as a nucleus-associated ribosomal S6 protein and its phosphorylation in hematopoietic cells. Macfarlane, D.E., Gailani, D. Cancer Res. (1990)
- Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II. Landry, J., Lambert, H., Zhou, M., Lavoie, J.N., Hickey, E., Weber, L.A., Anderson, C.W. J. Biol. Chem. (1992)
- Ribosomal protein S6 phosphorylation and function during late gestation liver development in the rat. Boylan, J.M., Anand, P., Gruppuso, P.A. J. Biol. Chem. (2001)
- Molecular cloning, developmental expression, and phosphorylation of ribosomal protein S6 in the endocrine gland responsible for insect molting. Song, Q., Gilbert, L.I. J. Biol. Chem. (1997)
- Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6. Kimball, S.R., Shantz, L.M., Horetsky, R.L., Jefferson, L.S. J. Biol. Chem. (1999)
- Monoclonal antibodies mimic insulin activation of ribosomal protein S6 kinase without activation of insulin receptor tyrosine kinase. Studies in cells transfected with normal and mutant human insulin receptors. Sung, C.K., Maddux, B.A., Hawley, D.M., Goldfine, I.D. J. Biol. Chem. (1989)
- Protein kinase C-dependent and -independent pathways of proto-oncogene induction in human astrocytoma cells. Blackshear, P.J., Stumpo, D.J., Huang, J.K., Nemenoff, R.A., Spach, D.H. J. Biol. Chem. (1987)
- The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53. Higashitsuji, H., Higashitsuji, H., Itoh, K., Sakurai, T., Nagao, T., Sumitomo, Y., Sumitomo, H., Masuda, T., Dawson, S., Shimada, Y., Mayer, R.J., Fujita, J. Cancer Cell (2005)
- Activator complexes containing the proteasomal regulatory ATPases S10b (SUG2) and S6 (TBP1) in different tissues and organisms. Hastings, R., Walker, G., Eyheralde, I., Dawson, S., Billett, M., Mayer, R.J. Mol. Biol. Rep. (1999)
- Specific interactions between ATPase subunits of the 26 S protease. Richmond, C., Gorbea, C., Rechsteiner, M. J. Biol. Chem. (1997)
- Localisation of 26S proteasomes with different subunit composition in insect muscles undergoing programmed cell death. Löw, P., Hastings, R.A., Dawson, S.P., Sass, M., Billett, M.A., Mayer, R.J., Reynolds, S.E. Cell Death Differ. (2000)
- Activation of the pp90rsk and mitogen-activated serine/threonine protein kinases by ionizing radiation. Kharbanda, S., Saleem, A., Shafman, T., Emoto, Y., Weichselbaum, R., Kufe, D. Proc. Natl. Acad. Sci. U.S.A. (1994)
- The primary structure of the human ribosomal protein S6 derived from a cloned cDNA. Heinze, H., Arnold, H.H., Fischer, D., Kruppa, J. J. Biol. Chem. (1988)