Gene Review:
RPS6KA1 - ribosomal protein S6 kinase, 90kDa,...
Homo sapiens
Synonyms:
90 kDa ribosomal protein S6 kinase 1, HU-1, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1a, MAPKAP kinase 1a, ...
- The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation. Clark, D.E., Errington, T.M., Smith, J.A., Frierson, H.F., Weber, M.J., Lannigan, D.A. Cancer Res. (2005)
- Mitogen-activated protein kinase pathway-dependent tumor-specific survival signaling in melanoma cells through inactivation of the proapoptotic protein bad. Eisenmann, K.M., VanBrocklin, M.W., Staffend, N.A., Kitchen, S.M., Koo, H.M. Cancer Res. (2003)
- S6 kinase p90rsk in granulocyte-macrophage colony-stimulating factor-stimulated proliferative and mature hematopoietic cells. Joseph, D.E., Paul, C.C., Baumann, M.A., Gomez-Cambronero, J. J. Biol. Chem. (1996)
- Human rsk isoforms: cloning and characterization of tissue-specific expression. Moller, D.E., Xia, C.H., Tang, W., Zhu, A.X., Jakubowski, M. Am. J. Physiol. (1994)
- Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Smith, J.A., Poteet-Smith, C.E., Xu, Y., Errington, T.M., Hecht, S.M., Lannigan, D.A. Cancer Res. (2005)
- Dysregulation of the TSC-mTOR pathway in human disease. Inoki, K., Corradetti, M.N., Guan, K.L. Nat. Genet. (2005)
- Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Chung, J., Kuo, C.J., Crabtree, G.R., Blenis, J. Cell (1992)
- Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome. Trivier, E., De Cesare, D., Jacquot, S., Pannetier, S., Zackai, E., Young, I., Mandel, J.L., Sassone-Corsi, P., Hanauer, A. Nature (1996)
- Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Ding, Q., Xia, W., Liu, J.C., Yang, J.Y., Lee, D.F., Xia, J., Bartholomeusz, G., Li, Y., Pan, Y., Li, Z., Bargou, R.C., Qin, J., Lai, C.C., Tsai, F.J., Tsai, C.H., Hung, M.C. Mol. Cell (2005)
- Nuclear actin and myosin I are required for RNA polymerase I transcription. Philimonenko, V.V., Zhao, J., Iben, S., Dingová, H., Kyselá, K., Kahle, M., Zentgraf, H., Hofmann, W.A., de Lanerolle, P., Hozák, P., Grummt, I. Nat. Cell Biol. (2004)
- Estradiol prevents the injury-induced decrease of 90 ribosomal S6 kinase (p90RSK) and Bad phosphorylation. Koh, P.O. Neurosci. Lett. (2007)
- Effect of clarithromycin on Pseudomonas aeruginosa biofilms. Tanaka, G., Shigeta, M., Komatsuzawa, H., Sugai, M., Suginaka, H., Usui, T. Chemotherapy. (2000)
- Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors. Ballif, B.A., Roux, P.P., Gerber, S.A., MacKeigan, J.P., Blenis, J., Gygi, S.P. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Characterization of regulatory events associated with membrane targeting of p90 ribosomal S6 kinase 1. Richards, S.A., Dreisbach, V.C., Murphy, L.O., Blenis, J. Mol. Cell. Biol. (2001)
- Leukotriene D4 mediates survival and proliferation via separate but parallel pathways in the human intestinal epithelial cell line Int 407. Paruchuri, S., Sjölander, A. J. Biol. Chem. (2003)
- Extracellular signal-regulated kinase/90-KDA ribosomal S6 kinase/nuclear factor-kappa B pathway mediates phorbol 12-myristate 13-acetate-induced megakaryocytic differentiation of K562 cells. Kim, K.W., Kim, S.H., Lee, E.Y., Kim, N.D., Kang, H.S., Kim, H.D., Chung, B.S., Kang, C.D. J. Biol. Chem. (2001)
- Activation of p90RSK and cAMP response element binding protein in stimulated neutrophils: novel effects of the pyridinyl imidazole SB 203580 on activation of the extracellular signal-regulated kinase cascade. Lian, J.P., Huang, R., Robinson, D., Badwey, J.A. J. Immunol. (1999)
- Nonclassical action of retinoic acid on the activation of the cAMP response element-binding protein in normal human bronchial epithelial cells. Aggarwal, S., Kim, S.W., Cheon, K., Tabassam, F.H., Yoon, J.H., Koo, J.S. Mol. Biol. Cell (2006)
- Intracellular network of phosphatidylinositol 3-kinase, mammalian target of the rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen-activated protein kinases pathways for regulating mycobacteria-induced IL-23 expression in human macrophages. Yang, C.S., Song, C.H., Lee, J.S., Jung, S.B., Oh, J.H., Park, J., Kim, H.J., Park, J.K., Paik, T.H., Jo, E.K. Cell. Microbiol. (2006)
- Bacterial heat shock protein-60 increases epithelial cell proliferation through the ERK1/2 MAP kinases. Zhang, L., Pelech, S.L., Mayrand, D., Grenier, D., Heino, J., Uitto, V.J. Exp. Cell Res. (2001)
- Rsk1 mediates a MEK-MAP kinase cell survival signal. Shimamura, A., Ballif, B.A., Richards, S.A., Blenis, J. Curr. Biol. (2000)
- Activation of MAP2-kinase in B lymphocytes by calcium ionophores. Franklin, R.A., Tordai, A., Mazer, B., Terada, N., Lucas, J.J., Gelfand, E.W. J. Immunol. (1994)
- Divergent functional roles for p90rsk kinase domains. Bjørbaek, C., Zhao, Y., Moller, D.E. J. Biol. Chem. (1995)
- Role of p90 ribosomal S6-kinase-1 in oltipraz-induced specific phosphorylation of CCAAT/enhancer binding protein-beta for GSTA2 gene transactivation. Lee, S.J., Kim, S.G. Mol. Pharmacol. (2006)
- 90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling. Hu, Y., Fang, X., Dunham, S.M., Prada, C., Stachowiak, E.K., Stachowiak, M.K. J. Biol. Chem. (2004)
- Induction of MUC8 gene expression by interleukin-1 beta is mediated by a sequential ERK MAPK/RSK1/CREB cascade pathway in human airway epithelial cells. Song, K.S., Seong, J.K., Chung, K.C., Lee, W.J., Kim, C.H., Cho, K.N., Kang, C.D., Koo, J.S., Yoon, J.H. J. Biol. Chem. (2003)
- Ribosomal S6 kinase-1 modulates interleukin-1beta-induced persistent activation of NF-{kappa}B through phosphorylation of I{kappa}Bbeta. Xu, S., Bayat, H., Hou, X., Jiang, B. Am. J. Physiol., Cell Physiol. (2006)
- The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IkappaBalpha and stimulates its degradation in vitro. Ghoda, L., Lin, X., Greene, W.C. J. Biol. Chem. (1997)
- T cell receptor activation of a ribosomal S6 kinase activity. Calvo, V., Bierer, B.E., Vik, T.A. Eur. J. Immunol. (1992)
- Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. Roux, P.P., Richards, S.A., Blenis, J. Mol. Cell. Biol. (2003)
- The yersinia virulence factor YopM forms a novel protein complex with two cellular kinases. McDonald, C., Vacratsis, P.O., Bliska, J.B., Dixon, J.E. J. Biol. Chem. (2003)
- Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site. Woo, M.S., Ohta, Y., Rabinovitz, I., Stossel, T.P., Blenis, J. Mol. Cell. Biol. (2004)
- Cloning and characterization of Xenopus Rsk2, the predominant p90 Rsk isozyme in oocytes and eggs. Bhatt, R.R., Ferrell, J.E. J. Biol. Chem. (2000)
- RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK). Pierrat, B., Correia, J.S., Mary, J.L., Tomás-Zuber, M., Lesslauer, W. J. Biol. Chem. (1998)
- Stimulation of insulin-like growth factor binding protein-1 synthesis by interleukin-1beta: requirement of the mitogen-activated protein kinase pathway. Frost, R.A., Nystrom, G.J., Lang, C.H. Endocrinology (2000)
- p90 RSK-1 associates with and inhibits neuronal nitric oxide synthase. Song, T., Sugimoto, K., Ihara, H., Mizutani, A., Hatano, N., Kume, K., Kambe, T., Yamaguchi, F., Tokuda, M., Watanabe, Y. Biochem. J. (2007)
- Acetaldehyde promotes rapamycin-dependent activation of p70(S6K) and glucose uptake despite inhibition of Akt and mTOR in dopaminergic SH-SY5Y human neuroblastoma cells. Fang, C.X., Yang, X., Sreejayan, N., Ren, J. Exp. Neurol. (2007)