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SKIV2L  -  superkiller viralicidic activity 2-like...

Homo sapiens

Synonyms: 170A, DDX13, HLP, Helicase SKI2W, Helicase-like protein, ...
 
 
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Disease relevance of SKIV2L

  • The human SKI2W is located between the RD and RP1 genes in the class III region of the major histocompatibility complex (MHC) on chromosome 6, a genomic region associated with many malignant, genetic and autoimmune diseases [1].
  • Human SKI2W fusion protein expressed in insect cells using a baculovirus vector has ATPase activity [1].
  • The DNA binding domain of the vaccinia virus early transcription factor small subunit is an extended helicase-like motif [2].
  • As suggested from the high level of sequence similarity of these viral proteins with the recently described superfamilies of helicase-like proteins (3-5), the NTBM-containing cylindrical inclusion (CI) protein from plum pox virus (PPV), which belongs to the potyvirus group of positive strand RNA viruses, is shown to be able to unwind RNA duplexes [3].
  • Type III hyperlipoproteinemia (type III HLP) is an atherogenic disorder of lipoprotein metabolism characterized by the accumulation of cholesterol-enriched VLDL and is usually associated with homozygosity for a normal variant of apoE, apoE2 [4].
 

Psychiatry related information on SKIV2L

  • These findings suggest that the hW gene may be an important gene in the control of mood and anxiety as well as one of the genetic factors related to mood disorders and panic disorder in males [5].
 

High impact information on SKIV2L

  • BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function [6].
  • A human RNA helicase-like protein, HRH1, facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome [7].
  • Intron binding protein (IBP) 160, a helicase-like protein previously detected in the spliceosomal C1 complex, binds the pre-mRNA in a sequence-independent manner, contacting nucleotides 33-40 upstream of the intron branch site, regardless of whether a snoRNA is present [8].
  • In that Xrn1p and Ski2p are cytoplasmic and Dbr1p localizes to both the nucleus and the cytoplasm, these data suggest that this decay pathway occurs within the cytoplasm [9].
  • Thus, comparisons between the 2/2 and 3/3 mice unequivocally demonstrate that a single amino acid difference (Arg158 Cys) in the apoE protein is sufficient to cause type III HLP and spontaneous atherosclerosis in mice [10].
 

Chemical compound and disease context of SKIV2L

 

Biological context of SKIV2L

 

Anatomical context of SKIV2L

  • The present study examined the effect of HLP on angioplasty-induced restenosis in carotid arteries of atherosclerotic rabbits [14].
  • Destruction of DCs and, in some cases, interdigitating cell hyperplasia might be associated with the variable clinical course of HLP [15].
  • The rabbits were intravenously infused with HLP (1.6 mg/(kg/h)) or saline (n=7 per group) for 4 h started before angioplasty which dilated atherosclerotic lesions in right common carotid artery [14].
  • Taken together, we propose that HLP may play an important role in chick sensory ganglia at relatively late stages of development [16].
  • These results suggested that promotion of long neurite extension and migration depends on activities of HLP through its receptor/Ron [16].
 

Associations of SKIV2L with chemical compounds

  • After the HLP-meal, ACTH tended to similarly but insignificantly increase in all groups, whereas cortisol increased significantly (P < 0.05) in the P-BFD group and insignificantly in the other groups [17].
  • This study was performed to investigate hydroxy-L-proline (HLP), a common ingredient of many diets, as a hyperoxaluria-inducing agent [18].
  • The results suggest that parallel disturbances in the regulation of cholesterol, bile acid, and lipoprotein metabolism occur in some patients with type IV HLP [19].
  • Lung permeability to Evans Blue was decreased from 9.5 +/- 2 to 4.1 +/- 0.7% (p = 0.036.). SKI-2 did not cause hemodynamic instability or alter resuscitation requirements [20].
  • The LCAT rate, VLDL triglyceride turnover, and bile acid kinetics were determined under standardized conditions in 10 patients with primary type IV HLP [19].
 

Other interactions of SKIV2L

 

Analytical, diagnostic and therapeutic context of SKIV2L

References

  1. Human helicase gene SKI2W in the HLA class III region exhibits striking structural similarities to the yeast antiviral gene SKI2 and to the human gene KIAA0052: emergence of a new gene family. Dangel, A.W., Shen, L., Mendoza, A.R., Wu, L.C., Yu, C.Y. Nucleic Acids Res. (1995) [Pubmed]
  2. The DNA binding domain of the vaccinia virus early transcription factor small subunit is an extended helicase-like motif. Li, J., Broyles, S.S. Nucleic Acids Res. (1995) [Pubmed]
  3. RNA helicase: a novel activity associated with a protein encoded by a positive strand RNA virus. Laín, S., Riechmann, J.L., García, J.A. Nucleic Acids Res. (1990) [Pubmed]
  4. The apolipoprotein E2 (Arg145Cys) mutation causes autosomal dominant type III hyperlipoproteinemia with incomplete penetrance. de Villiers, W.J., van der Westhuyzen, D.R., Coetzee, G.A., Henderson, H.E., Marais, A.D. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  5. Polymorphisms of the human homologue of the Drosophila white gene are associated with mood and panic disorders. Nakamura, M., Ueno, S., Sano, A., Tanabe, H. Mol. Psychiatry (1999) [Pubmed]
  6. BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cantor, S.B., Bell, D.W., Ganesan, S., Kass, E.M., Drapkin, R., Grossman, S., Wahrer, D.C., Sgroi, D.C., Lane, W.S., Haber, D.A., Livingston, D.M. Cell (2001) [Pubmed]
  7. A human RNA helicase-like protein, HRH1, facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. Ohno, M., Shimura, Y. Genes Dev. (1996) [Pubmed]
  8. A spliceosomal intron binding protein, IBP160, links position-dependent assembly of intron-encoded box C/D snoRNP to pre-mRNA splicing. Hirose, T., Ideue, T., Nagai, M., Hagiwara, M., Shu, M.D., Steitz, J.A. Mol. Cell (2006) [Pubmed]
  9. Cytoplasmic degradation of splice-defective pre-mRNAs and intermediates. Hilleren, P.J., Parker, R. Mol. Cell (2003) [Pubmed]
  10. Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2. Sullivan, P.M., Mezdour, H., Quarfordt, S.H., Maeda, N. J. Clin. Invest. (1998) [Pubmed]
  11. Microvascular reactivity in patients with hypercholesterolemia: effect of lipid lowering treatment. Stulc, T., Kasalová, Z., Prázný, M., Vrablík, M., Skrha, J., Ceska, R. Physiological research / Academia Scientiarum Bohemoslovaca. (2003) [Pubmed]
  12. Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA. Yang, Z., Shen, L., Dangel, A.W., Wu, L.C., Yu, C.Y. Genomics (1998) [Pubmed]
  13. The human DEVH-box protein Ski2w from the HLA is localized in nucleoli and ribosomes. Qu, X., Yang, Z., Zhang, S., Shen, L., Dangel, A.W., Hughes, J.H., Redman, K.L., Wu, L.C., Yu, C.Y. Nucleic Acids Res. (1998) [Pubmed]
  14. Hirulog-like peptide reduces restenosis and expression of tissue factor and transforming growth factor-beta in carotid artery of atherosclerotic rabbits. Chen, X., Ren, S., Ma, M.G., Dharmalingam, S., Lu, L., Xue, M., Ducas, J., Shen, G.X. Atherosclerosis (2003) [Pubmed]
  15. The role of follicular and interdigitating dendritic cells in HIV-related lymphoid hyperplasia: localization of fascin. Said, J.W., Pinkus, J.L., Yamashita, J., Mishalani, S., Matsumura, F., Yamashiro, S., Pinkus, G.S. Mod. Pathol. (1997) [Pubmed]
  16. Identification of HGF-like protein as a novel neurotrophic factor for avian dorsal root ganglion sensory neurons. Funakoshi, H., Nakamura, T. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  17. Comment: response of the hypothalamic-pituitary-adrenocortical axis to high-protein/fat and high-carbohydrate meals in women with different obesity phenotypes. Vicennati, V., Ceroni, L., Gagliardi, L., Gambineri, A., Pasquali, R. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  18. Modeling of hyperoxaluric calcium oxalate nephrolithiasis: experimental induction of hyperoxaluria by hydroxy-L-proline. Khan, S.R., Glenton, P.A., Byer, K.J. Kidney Int. (2006) [Pubmed]
  19. Plasma cholesterol esterification rate in type IV hyperlipoproteinemia. Relation to bile acid kinetics and triglyceride metabolism. Angelin, B., Einarsson, K., Leijd, B., Wallentin, L. J. Lab. Clin. Med. (1981) [Pubmed]
  20. Attenuation of shock-induced acute lung injury by sphingosine kinase inhibition. Lee, C., Xu, D.Z., Feketeova, E., Kannan, K.B., Yun, J.K., Deitch, E.A., Fekete, Z., Livingston, D.H., Hauser, C.J. The Journal of trauma. (2004) [Pubmed]
  21. Genomic structure of the human BCCIP gene and its expression in cancer. Meng, X., Liu, J., Shen, Z. Gene (2003) [Pubmed]
  22. Down-regulation in human cancers of DRHC, a novel helicase-like gene from 17q25.1 that inhibits cell growth. Nagai, H., Yabe, A., Mine, N., Mikami, I., Fujiwara, H., Terada, Y., Hirano, A., Tsuneizumi, M., Yokota, T., Emi, M. Cancer Lett. (2003) [Pubmed]
  23. Musing on the structural organization of the exosome complex. Mitchell, P., Tollervey, D. Nat. Struct. Biol. (2000) [Pubmed]
  24. Identification and characterization of a bidirectional promoter from the intergenic region between the human DDX13 and RD genes. Lee, S.G., Song, K. Mol. Cells (2000) [Pubmed]
  25. Molecular cloning of mouse p47, a second group mammalian RuvB DNA helicase-like protein: homology with those from human and Saccharomyces cerevisiae. Gohshi, T., Shimada, M., Kawahire, S., Imai, N., Ichimura, T., Omata, S., Horigome, T. J. Biochem. (1999) [Pubmed]
 
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