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TCF19  -  transcription factor 19

Homo sapiens

Synonyms: SC1, TCF-19, Transcription factor 19, Transcription factor SC1
 
 
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Disease relevance of TCF19

 

Psychiatry related information on TCF19

  • RESULTS: the discharge rates decreased from SC1 to SC2, with higher values quantified during NREM sleep (mean, 2.8) compared with REM sleep (mean, 0.8) [5].
 

High impact information on TCF19

  • Transfection of SC1 cDNA into mammalian cells leads to cell surface expression of SC1 antigen and a subsequent increase in cell-cell adhesion [2].
  • SC1, an integral membrane glycoprotein of 100 kd, is uniquely and transiently expressed on spinal cord motoneurons early in development and appears in peripheral neurons and several other tissues during development [2].
  • Long-term SC1-expanded murine ES cells can be differentiated into cells of the three primary germ layers in vitro and also can generate chimeric mice and contribute to the germ line in vivo [6].
  • In addition to three known genes, POU5F1, TCF19 and S, this 111 kb fragment contains four new, expressed genes identified in the course of our genomic sequencing of the entire HLA class I region [7].
  • A similar myoblast fusion defect is observed when the Drosophila homologs of DM-GRASP/BEN/SC1 (irregular chiasm-roughest and dumbfounded) are deleted together [8].
 

Biological context of TCF19

  • Complete sequencing of a 5.5-kb EcoRI fragment containing the TCF19 gene revealed that it is composed of three exons, bounded by consensus splice signals [9].
  • Among them, SC1 (TCF19) is the cell growth regulated gene possibly with trans-activator activity [10].
  • A number of potential new class I region genes were identified, including a cDNA with similarity to the tre oncogene, the trans-activating factor SC1 (TCF19), and a member of the interferon inducible 1 - 8 gene family [11].
  • In bacteria, the SC1 cDNA clone makes a protein of Mr 39,000, in agreement with the putative reading frame [12].
  • The SC1 gene localizes to human chromosome 6p21-22 [12].
 

Anatomical context of TCF19

 

Associations of TCF19 with chemical compounds

  • Its kinetics of growth regulation (time of increase in mRNA levels, sensitivity to cycloheximide, behavior in G1-specific temperature-sensitive mutants) classify the SC1 gene as a late growth-regulated gene, like the histone genes and the genes coding for the proteins of the DNA synthesis apparatus [12].
  • Long polysialic acid units composed of alpha-(2,8)-linked N-acetylneuraminic acid units, which in mammals are found exclusively on NCAM, were present on SC-1 antigens in SCLC [15].
 

Other interactions of TCF19

  • Feature mapping of the HLA class I region: localization of the POU5F1 and TCF19 genes [9].
 

Analytical, diagnostic and therapeutic context of TCF19

  • Molecular cloning and expression of a novel adhesion molecule, SC1 [2].
  • Density gradient centrifugation followed by immunopanning using SC1 antibody allowed us to purify two size classes of motoneuron [16].
  • RESULTS: Coculture of T84 cells with SC1 produced a significant fall in TER as did exposure of T84 monolayers to IEL derived supernatant [14].
  • Furthermore, Northern blot analysis also showed expression of the SC1 gene in rat ovaries, and the level of expression was affected during eCG/hCG-induced ovulation [3].
  • Southern blot analysis showed SC1 to be endogenous in the rat and absent in mouse and human cell genomes [3].

References

  1. Genome sequencing analysis of the 1.8 Mb entire human MHC class I region. Shiina, T., Tamiya, G., Oka, A., Takishima, N., Inoko, H. Immunol. Rev. (1999) [Pubmed]
  2. Molecular cloning and expression of a novel adhesion molecule, SC1. Tanaka, H., Matsui, T., Agata, A., Tomura, M., Kubota, I., McFarland, K.C., Kohr, B., Lee, A., Phillips, H.S., Shelton, D.L. Neuron (1991) [Pubmed]
  3. Identification of a novel retrovirus expressed in rat Sertoli cells and granulosa cells. Anway, M.D., Johnston, D.S., Crawford, D., Griswold, M.D. Biol. Reprod. (2001) [Pubmed]
  4. Antibacterial effects of N-sulfonated and N-sulfobenzoyl chitosan and application to oyster preservation. Chen, C.S., Liau, W.Y., Tsai, G.J. J. Food Prot. (1998) [Pubmed]
  5. Combined influence of cyclic arousability and EEG synchrony on generalized interictal discharges within the sleep cycle. Parrino, L., Smerieri, A., Terzano, M.G. Epilepsy Res. (2001) [Pubmed]
  6. Self-renewal of embryonic stem cells by a small molecule. Chen, S., Do, J.T., Zhang, Q., Yao, S., Yan, F., Peters, E.C., Sch??ler, H.R., Schultz, P.G., Ding, S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  7. Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene. Oka, A., Tamiya, G., Tomizawa, M., Ota, M., Katsuyama, Y., Makino, S., Shiina, T., Yoshitome, M., Iizuka, M., Sasao, Y., Iwashita, K., Kawakubo, Y., Sugai, J., Ozawa, A., Ohkido, M., Kimura, M., Bahram, S., Inoko, H. Hum. Mol. Genet. (1999) [Pubmed]
  8. Characterization of Drosophila hibris, a gene related to human nephrin. Dworak, H.A., Charles, M.A., Pellerano, L.B., Sink, H. Development (2001) [Pubmed]
  9. Feature mapping of the HLA class I region: localization of the POU5F1 and TCF19 genes. Krishnan, B.R., Jamry, I., Chaplin, D.D. Genomics (1995) [Pubmed]
  10. Genetic polymorphisms in the cell growth regulated gene, SC1 telomeric of the HLA-C gene and lack of association of psoriasis vulgaris. Teraoka, Y., Naruse, T.K., Oka, A., Matsuzawa, Y., Shiina, T., Iizuka, M., Iwashita, K., Ozawa, A., Inoko, H. Tissue Antigens (2000) [Pubmed]
  11. Identification of new HLA class I region genes by sample sequencing. Goldsworthy, M., Sampath, A., Wilkinson, J.M., Powis, S.H. Immunogenetics (1997) [Pubmed]
  12. A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor. Ku, D.H., Chang, C.D., Koniecki, J., Cannizzaro, L.A., Boghosian-Sell, L., Alder, H., Baserga, R. Cell Growth Differ. (1991) [Pubmed]
  13. Synovial fluid lymphocytes differ from peripheral blood lymphocytes in patients with rheumatoid arthritis. Fox, R.I., Fong, S., Sabharwal, N., Carstens, S.A., Kung, P.C., Vaughan, J.H. J. Immunol. (1982) [Pubmed]
  14. Changes in barrier function of a model intestinal epithelium by intraepithelial lymphocytes require new protein synthesis by epithelial cells. Taylor, C.T., Murphy, A., Kelleher, D., Baird, A.W. Gut (1997) [Pubmed]
  15. Expression of neural cell adhesion molecule-related sialoglycoprotein in small cell lung cancer and neuroblastoma cell lines H69 and CHP-212. Moolenaar, C.E., Muller, E.J., Schol, D.J., Figdor, C.G., Bock, E., Bitter-Suermann, D., Michalides, R.J. Cancer Res. (1990) [Pubmed]
  16. Survival of newly postmitotic motoneurons is transiently independent of exogenous trophic support. Mettling, C., Gouin, A., Robinson, M., el M'Hamdi, H., Camu, W., Bloch-Gallego, E., Buisson, B., Tanaka, H., Davies, A.M., Henderson, C.E. J. Neurosci. (1995) [Pubmed]
 
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