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MFP2  -  fatty acid beta-oxidation multifunctional...

Arabidopsis thaliana

Synonyms: ATMFP2, F3E22.20, MULTIFUNCTIONAL PROTEIN 2, multifunctional protein 2
 
 
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Disease relevance of MFP2

 

High impact information on MFP2

 

Chemical compound and disease context of MFP2

 

Biological context of MFP2

 

Anatomical context of MFP2

 

Associations of MFP2 with chemical compounds

  • Cloning and functional expression of the corresponding cDNA verified that the new methyltransferase is a multifunctional 26.6-kDa Mg(2+)-dependent enzyme, which shows a significant sequence similarity to the cluster of caffeoyl coenzyme A-methylating enzymes [21].
  • Calmodulin (CaM), a ubiquitous and multifunctional Ca(2+) sensor, interacts with a wide variety of cellular proteins and modulates their activity/function in regulating diverse cellular processes [22].
  • Seedlings of mfp2 require an exogenous supply of sucrose for seedling establishment to occur [23].
  • Despite a reduction in the rate of beta-oxidation, mfp2 seedlings are not resistant to the herbicide 2,4-dichlorophenoxybutyric acid, which is catabolized to the auxin 2,4-dichlorophenoxyacetic acid by beta-oxidation [23].
  • In this respect the organization of these three plant purine biosynthesis genes is fundamentally different from the multifunctional purine biosynthesis enzymes characteristic of other eucaryotes and instead resembles the one gene, one enzyme relationship found in procaryotes [24].
 

Other interactions of MFP2

 

Analytical, diagnostic and therapeutic context of MFP2

References

  1. Lambda YES: a multifunctional cDNA expression vector for the isolation of genes by complementation of yeast and Escherichia coli mutations. Elledge, S.J., Mulligan, J.T., Ramer, S.W., Spottswood, M., Davis, R.W. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  2. The Nanovirus-Encoded Clink Protein Affects Plant Cell Cycle Regulation through Interaction with the Retinoblastoma-Related Protein. Lageix, S., Catrice, O., Deragon, J.M., Gronenborn, B., Pélissier, T., Ramírez, B.C. J. Virol. (2007) [Pubmed]
  3. Formation of surface tubules and fluorescent foci in Arabidopsis thaliana protoplasts expressing a fusion between the green fluorescent protein and the cauliflower mosaic virus movement protein. Huang, Z., Han, Y., Howell, S.H. Virology (2000) [Pubmed]
  4. Multiple resistance phenotypes to Lettuce mosaic virus among Arabidopsis thaliana accessions. Revers, F., Guiraud, T., Houvenaghel, M.C., Mauduit, T., Le Gall, O., Candresse, T. Mol. Plant Microbe Interact. (2003) [Pubmed]
  5. Arabidopsis STERILE APETALA, a multifunctional gene regulating inflorescence, flower, and ovule development. Byzova, M.V., Franken, J., Aarts, M.G., de Almeida-Engler, J., Engler, G., Mariani, C., Van Lookeren Campagne, M.M., Angenent, G.C. Genes Dev. (1999) [Pubmed]
  6. A defect in beta-oxidation causes abnormal inflorescence development in Arabidopsis. Richmond, T.A., Bleecker, A.B. Plant Cell (1999) [Pubmed]
  7. NDP kinase 2 interacts with two oxidative stress-activated MAPKs to regulate cellular redox state and enhances multiple stress tolerance in transgenic plants. Moon, H., Lee, B., Choi, G., Shin, D., Prasad, D.T., Lee, O., Kwak, S.S., Kim, D.H., Nam, J., Bahk, J., Hong, J.C., Lee, S.Y., Cho, M.J., Lim, C.O., Yun, D.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  8. Molecular cloning and functional expression of gibberellin 2- oxidases, multifunctional enzymes involved in gibberellin deactivation. Thomas, S.G., Phillips, A.L., Hedden, P. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  9. The GA5 locus of Arabidopsis thaliana encodes a multifunctional gibberellin 20-oxidase: molecular cloning and functional expression. Xu, Y.L., Li, L., Wu, K., Peeters, A.J., Gage, D.A., Zeevaart, J.A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  10. Molybdenum co-factor biosynthesis: the Arabidopsis thaliana cDNA cnx1 encodes a multifunctional two-domain protein homologous to a mammalian neuroprotein, the insect protein Cinnamon and three Escherichia coli proteins. Stallmeyer, B., Nerlich, A., Schiemann, J., Brinkmann, H., Mendel, R.R. Plant J. (1995) [Pubmed]
  11. The Arabidopsis thaliana apurinic endonuclease Arp reduces human transcription factors Fos and Jun. Babiychuk, E., Kushnir, S., Van Montagu, M., Inzé, D. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  12. Analysis of an essential requirement for the poly(A) binding protein function using cross-species complementation. Chekanova, J.A., Shaw, R.J., Belostotsky, D.A. Curr. Biol. (2001) [Pubmed]
  13. XMog1, a nuclear ran-binding protein in Xenopus, is a functional homologue of Schizosaccharomyces pombe mog1p that co-operates with RanBP1 to control generation of Ran-GTP. Nicolás, F.J., Moore, W.J., Zhang, C., Clarke, P.R. J. Cell. Sci. (2001) [Pubmed]
  14. Multifunctional acetyl-CoA carboxylase 1 is essential for very long chain fatty acid elongation and embryo development in Arabidopsis. Baud, S., Guyon, V., Kronenberger, J., Wuillème, S., Miquel, M., Caboche, M., Lepiniec, L., Rochat, C. Plant J. (2003) [Pubmed]
  15. A complex and mobile structure forms a distinct subregion within the continuous vacuolar membrane in young cotyledons of Arabidopsis. Saito, C., Ueda, T., Abe, H., Wada, Y., Kuroiwa, T., Hisada, A., Furuya, M., Nakano, A. Plant J. (2002) [Pubmed]
  16. Arabidopsis peroxin 16 coexists at steady state in peroxisomes and endoplasmic reticulum. Karnik, S.K., Trelease, R.N. Plant Physiol. (2005) [Pubmed]
  17. Phylogenetic analyses and expression studies reveal two distinct groups of calreticulin isoforms in higher plants. Persson, S., Rosenquist, M., Svensson, K., Galvão, R., Boss, W.F., Sommarin, M. Plant Physiol. (2003) [Pubmed]
  18. Fatty acid biosynthesis in mitochondria of grasses: malonyl-coenzyme A is generated by a mitochondrial-localized acetyl-coenzyme A carboxylase. Focke, M., Gieringer, E., Schwan, S., Jänsch, L., Binder, S., Braun, H.P. Plant Physiol. (2003) [Pubmed]
  19. Metabolic compartmentation of plastid prenyllipid biosynthesis--evidence for the involvement of a multifunctional geranylgeranyl reductase. Keller, Y., Bouvier, F., d'Harlingue, A., Camara, B. Eur. J. Biochem. (1998) [Pubmed]
  20. Over-expression of Arabidopsis CAP causes decreased cell expansion leading to organ size reduction in transgenic tobacco plants. Barrero, R.A., Umeda, M., Yamamura, S., Uchimiya, H. Ann. Bot. (2003) [Pubmed]
  21. A novel Mg(2+)-dependent O-methyltransferase in the phenylpropanoid metabolism of Mesembryanthemum crystallinum. Ibdah, M., Zhang, X.H., Schmidt, J., Vogt, T. J. Biol. Chem. (2003) [Pubmed]
  22. Genes encoding calmodulin-binding proteins in the Arabidopsis genome. Reddy, V.S., Ali, G.S., Reddy, A.S. J. Biol. Chem. (2002) [Pubmed]
  23. The Arabidopsis thaliana multifunctional protein gene (MFP2) of peroxisomal beta-oxidation is essential for seedling establishment. Rylott, E.L., Eastmond, P.J., Gilday, A.D., Slocombe, S.P., Larson, T.R., Baker, A., Graham, I.A. Plant J. (2006) [Pubmed]
  24. Molecular characterization of Arabidopsis thaliana cDNAs encoding three purine biosynthetic enzymes. Schnorr, K.M., Nygaard, P., Laloue, M. Plant J. (1994) [Pubmed]
  25. A multifunctional acyl-acyl carrier protein desaturase from Hedera helix L. (English ivy) can synthesize 16- and 18-carbon monoene and diene products. Whittle, E., Cahoon, E.B., Subrahmanyam, S., Shanklin, J. J. Biol. Chem. (2005) [Pubmed]
  26. Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana. Husselstein-Muller, T., Schaller, H., Benveniste, P. Plant Mol. Biol. (2001) [Pubmed]
  27. A transgene encoding a blue-light receptor, phot1, restores blue-light responses in the Arabidopsis phot1 phot2 double mutant. Doi, M., Shigenaga, A., Emi, T., Kinoshita, T., Shimazaki, K. J. Exp. Bot. (2004) [Pubmed]
  28. Transgenic tobacco and Arabidopsis plants expressing the two multifunctional sorghum cytochrome P450 enzymes, CYP79A1 and CYP71E1, are cyanogenic and accumulate metabolites derived from intermediates in Dhurrin biosynthesis. Bak, S., Olsen, C.E., Halkier, B.A., Møller, B.L. Plant Physiol. (2000) [Pubmed]
  29. Pseudomonas aeruginosa-plant root interactions. Pathogenicity, biofilm formation, and root exudation. Walker, T.S., Bais, H.P., Déziel, E., Schweizer, H.P., Rahme, L.G., Fall, R., Vivanco, J.M. Plant Physiol. (2004) [Pubmed]
 
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