Disease relevance of SLA2

• Extracorporeal liver support with MARS in liver failure: has it a role in the treatment of severe alcoholic hepatitis [1]?
• METHODS: Eight patients (all encephalopathic; hepatorenal syndrome: Type 1, five patients; Type 2, two patients) were treated with MARS [2].
• It was observed that patients developed episodes of hypoglycemia during molecular adsorbent recycling system (MARS) treatment [3].
• Our data indicate that MARS is an effective therapeutic option for patients with intractable cholestatic pruritus [4].
• Bilirubin levels and hepatic encephalopathy improved under MARS therapy [5].

Psychiatry related information on SLA2

• Planetary protection, legal ambiguity and the decision making process for Mars sample return [6].
• OBJECTIVE: The science fiction film Invaders From Mars is used to teach principles of child development; clinical features of separation anxiety and nightmares; and clinical interventions, including child psychotherapy, child protective issues, and crisis management [7].

High impact information on SLA2

• The observation of gullies on Mars indicates the presence of liquid water near the surface in recent times, which is difficult to reconcile with the current cold climate [8].
• The high-pressure, high-temperature data presented here show conclusively that potassium enters iron sulphide melts in a strongly temperature-dependent fashion and that (40)K can serve as a substantial heat source in the cores of the Earth and Mars [9].
• Costs increased for Mars Express, not just Beagle [10].
• But material from the Earth, Mars, comets and various meteorites have Mg/Si and Al/Si ratios, oxygen-isotope ratios, osmium-isotope ratios and D/H, Ar/H2O and Kr/Xe ratios such that no primitive material similar to the Earth's mantle is currently represented in our meteorite collections [11].
• For example, they might have formed through slow erosion by water running across the surface, either early or late in Mars' history, possibly protected from harsh conditions by ice cover [12].

Chemical compound and disease context of SLA2

• Mean glucose removal rate was 6.20 +/- 0.93 g/h. In addition to a maintenance drip supporting the caloric requirement of patients, a dextrose replacement drip that paralleled the rate of glucose removal would prevent patients from experiencing episodes of hypoglycemia during MARS treatment [3].

Biological context of SLA2

• Our identification of the negative regulator SLAP-2 demonstrates that a retroviral-based screening strategy may be an efficient way to identify and characterize the function of key components of many signal transduction systems [13].
• The SLAP-2 protein contains an NH2-terminal myristoylation consensus sequence and SH3 and SH2 Src homology domains, but lacks a tyrosine kinase domain [13].
• Overexpression of SLAP-2 in B and T cell lines specifically impaired antigen receptor-mediated signaling events, including CD69 surface marker upregulation, nuclear factor of activated T cells (NFAT) promoter activation and calcium influx [13].
• The human SLAP-2 gene is located on chromosome 20q, and the SLAP-2 coding region consists of seven exons [14].
• RESULTS: Real-time PCR showed significant (P<0.001) increases in ALP gene expression in osteoblasts grown on SLA-2, relative to all other surfaces [15].

Anatomical context of SLA2

• Northern blot analysis indicates that SLAP-2 is predominantly expressed in the immune system [16].
• The SLAP3 transcript was ubiquitously expressed, whereas SLAP1 and SLAP2 transcripts were predominantly expressed in cardiac, soleus, and smooth muscle [17].
• Similar to its murine counterpart, two human SLAP-2 protein isoforms exist because of alternative translation initiation, and SLAP-2 protein expression is observed in a variety of hematopoietic cell lines of both lymphoid and myeloid lineages [14].
• SLAP-2 is most closely related to SLAP and contains a Src homology 3 (SH3) domain and an SH2 domain, as well as an amino-terminal myristoylation site that mediates SLAP-2 association with membranes [18].
• RT-PCR analysis revealed constitutive expression of the SLAP-2 gene in bone marrow macrophages [19].

Associations of SLA2 with chemical compounds

• In antigen receptor-stimulated cells, SLAP-2 associated with several tyrosine phosphorylated proteins, including the ubiquitin ligase Cbl [13].
• Signaling induced by phorbol myristate acetate (PMA) and ionomycin was not significantly reduced, suggesting SLAP-2 functions proximally in the antigen receptor signaling cascade [13].
• METHODS: Osteoblasts were cultured on titanium disks prepared with a titanium dioxide grit blasting (TiOBlast) or grit blasted and etched with hydrofluoric acid (Osseospeed), grit blasted and etched (SLA-1), or grit blasted, etched and rinsed with N2 protection and stored in isotonic NaCl (SLA-2) commercially pure titanium implant discs [15].
• On the basis of this model, the primordial atmospheric pressure on Mars must have been in the vicinity of 1 bar, barring other sources or sinks of CO2 [20].
• O2- ions and the Mars labeled release response [21].

Other interactions of SLA2

• In addition to known regulators of antigen receptor signaling, we identified a novel adaptor protein, SLAP-2 which shares 36% sequence similarity with the known Src-like adaptor protein, SLAP [13].

Analytical, diagnostic and therapeutic context of SLA2

• MARS (for molecular adsorbent recirculating system) and the transjugular intrahepatic portosystemic shunt may also improve renal function in these patients [22].
• The mean total serum bilirubin in patients who responded to therapy declined from 19.11 +/- 16.96 mg/dL (SD) before MARS therapy to 9.24 +/- 3.52 mg/dL after treatment [4].
• Gas chromatography has proven to be a very useful analytical technique for in situ analysis of extraterrestrial environments as demonstrated by its successful operation on spacecraft missions to Mars and Venus [23].
• RESULTS: A total of 18 MARS sessions and 4 plasma exchange sessions were performed [5].
• Minor complications in colonoscopy: Mars versus Venus, and preps matter too [24].

References