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Gene Review

UBXN11  -  UBX domain protein 11

Homo sapiens

Synonyms: COA-1, Colorectal tumor-associated antigen COA-1, PP2243, SOC, SOCI, ...
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Disease relevance of UBXD5

  • That biologically active and full-length foreign proteins can be displayed by fusion to SOC and HOC on the T4 capsid is demonstrated in this report [1].
  • The rank order of potency for SOC inhibition by these compounds closely correlated with their inhibitory properties on depolarization-induced [3H]NE release from SH-SY5Y human neuroblastoma cells [2].
  • The number of molecules of each protein (10-40) bound per phage and their activity suggest that proteins can fold to native conformation and be displayed by HOC and SOC to allow binding and protein-protein interactions on the capsid [1].
  • They suggest that combining guanylyl cyclase C agonists and SOC inhibitors offers a novel paradigm for cGMP-directed therapy and prevention for colorectal tumors [3].
  • In one implementation, SOC and its fusion derivatives are expressed at high levels in Escherichia coli, purified in high yield, and then bound in vitro to separately isolated polyheads [4].

Psychiatry related information on UBXD5

  • RESULTS: Of 72 children, 18 months to 5 years old, 19 met modified SOC criteria (8 met DSM-IV criteria SOC also), 29 met modified GAD criteria (5 met DSM-IV criteria GAD also), and 35 met no anxiety disorder criteria [5].
  • OBJECTIVE: This research examined the validity of criteria for diagnosing social phobia (SOC) and generalized anxiety disorder (GAD), where the DSM-IV criteria were modified to better identify toddlers who could have these disorders [5].
  • RESULTS: Most of the psychopathology, adaptive functioning and SOC scales were associated with a variety of psychiatric disorders at follow-up [6].
  • METHODS: Sixty-nine liver transplant candidates were asked about their psychosocial well-being, quality of life, spirituality, and need for counselling assessed by interview and questionnaire (HADS-D, FLZ, LOT, SOC, SF-36, SBI-15R) during the initial evaluation procedure for organ transplantation as well as 3 and 6 months after listing [7].
  • METHODS: The authors asked patients with progressive nonfluent aphasia (PNFA), patients with semantic dementia (SemD), and nonaphasic patients with a disorder of social comportment and executive functioning (SOC/EXEC) to narrate the story of a wordless children's picture book [8].

High impact information on UBXD5

  • In this study, we analyzed the immunophenotype of solitary oval cell-like cells (SOC), intralobular groups of cuboidal cells that might represent lining cells of CoH, bile ductular cells (BDC), bile duct epithelial cells (BEC), and hepatocytes [9].
  • In aggregate, the data presented here reveal that all three proteins are essential for generation of I(SOC) in these cells and that dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in activation of SOC channel in response to internal Ca(2+) store depletion [10].
  • Small differences between SOC and GEA3162-activated Ba(2+) entry and sensitivity to blockade by La(3+) were observed, and in HEK293 cells SOC activity was observed without a response to thiol modification [11].
  • Calyculin A-induced reorganization of the actin cytoskeleton prevented SOC but had no effect on GEA3162-induced Ca(2+) entry [11].
  • In DDT(1)MF-2 smooth muscle cells and DC-3F fibroblasts, Ca(2+) entry activated by the lipophilic NO donor, GEA3162 (5-amino-3-(3, 4-dichlorophenyl)1,2,3,4-oxatriazolium), or the alkylator, N-ethylmaleimide, was observed to be strongly activated by transient external Ca(2+) removal, closely resembling activation of SOC activity in the same cells [11].

Chemical compound and disease context of UBXD5

  • The system is demonstrated as applied to C-terminal fusions to SOC of (1) a tetrapeptide; (2) the 43-residue V3 loop domain of gp120, the human immunodeficiency virus type-1 (HIV-1) envelope glycoprotein; and (3) poliovirus VP1 capsid protein (312 residues) [4].
  • The specific oxygen consumption (SOC, average +/- SD) of the survivors from the UVA population during temperature stress was 0.21 +/- 0.05 mg O2 h-1 g body weight (BW)-1, while it was 0.54 +/- 0.11 mg O2 h-1 g BW-1 in the reference population [12].

Biological context of UBXD5

  • Eight relatives of 478 (1.7% of SOC) expressed a transient autoantibody, and none had the high risk genotype DR3/4(DQ2/8) [13].
  • To test this hypothesis, we prospectively evaluated sera from 478 relatives (SOC: sibling-offspring cohort) of patients with type 1 diabetes as well as 793 newborns from the general population (NEC: newborn nonrelative cohort) selected for expression of specific human leukocyte antigen haplotypes [13].
  • The prototype members of this family, cytokine-inducible Src homology 2-containing protein and suppressors of cytokine signaling SOC was cloned as cytokine-inducible immediate early gene that could inhibit the activation of signal transducer and activator of transcription factors and block biological responses to several cytokines [14].
  • Differentiation of LNCaP cells to an androgen-insensitive, apoptotic-resistant neuroendocrine phenotype downregulates SOC current [15].
  • We reviewed published results to estimate no-till effects on SOC and denitrification in the Argentine Pampas and the potential of no-till to mitigate the global warming effect [16].

Anatomical context of UBXD5

  • Concomitantly, SOC I activity appeared in the plasma membranes of PMA-treated cells [17].
  • Components of this enzyme system include cytochrome b558, and three soluble oxidase components (SOC I, SOC II, and SOC III) found in the cytosol of resting cells [17].
  • Second, the IC projects to the SOC and, in particular, to the source of olivocochlear efferent neurons [18].
  • Immunoblotting with antiserum B-1 (Volpp, B. D., Nauseef, W. M., and Clark, R. A. (1988) Science 242, 1295-1297), directed against a cytosolic complex capable of activating latent membranes in the cell-free system, showed a 47-kDa protein in SOC II and a 67-kDa protein in SOC III [19].
  • Cytosol from human neutrophils was separated in three different soluble oxidase components (SOC I, SOC II, and SOC III) [19].

Associations of UBXD5 with chemical compounds

  • The nonadditivity of SOC and NO donor-activated Ca(2+) entry suggested a single entry mechanism [11].
  • The reciprocal connectivity between any two of either the IC, SOC or the CN, again, affords to the auditory system remarkable parallel processing capabilities [18].
  • This activity is independent of GTP gamma S. Addition of SOC I increases this activity 3-4-fold, only when GTP gamma S is present [19].
  • Plasma membranes, incubated with SOC I plus GTP gamma S and re-isolated, showed a similar 3-4-fold enhanced O2 consumption with SOC II and SOC III [19].
  • These findings indicate that silver evokes the release of ROS and oxidation of thiols critical for the activation of a Ca2+ channel other than SOC [20].

Analytical, diagnostic and therapeutic context of UBXD5

  • 3. For the first time we have identified and characterized the SOC-mediated membrane current (Istore) in prostate cells using whole-cell, cell-attached, and perforated patch-clamp techniques, combined with fura-2 microspectrofluorimetric and Ca2+-imaging measurements [21].
  • In dynamic animations virtual characters then showed socially relevant facial expressions as they would appear in greeting and approach situations (SOC) or arbitrary facial movements (ARB) [22].
  • A 271-residue heavy and light chain fused IgG anti-EWL (egg white lysozyme) antibody was displayed in active form attached to the COOH-terminus of the SOC capsid protein, as demonstrated by lysozyme-agarose affinity chromatography (>100-fold increase in specific titer) [1].
  • To investigate the effect of hypophyseal transection (HST) on GH secretagogue activity of the non-peptidyl GH secretagogue L-692,585 in the conscious pig, male castrated swine were randomly assigned to either a hypophyseal stalk transection group (HST; n = 3) or to a sham-operated control group (SOC; n = 3) [23].
  • Such a triple assessment of the determinants, together with a thorough physical examination, brings the SOC into the diagnostic category of hypochondria [24].


  1. Phage T4 SOC and HOC display of biologically active, full-length proteins on the viral capsid. Ren, Z., Black, L.W. Gene (1998) [Pubmed]
  2. Inhibition of depolarization-induced [3H]noradrenaline release from SH-SY5Y human neuroblastoma cells by some second-generation H(1) receptor antagonists through blockade of store-operated Ca(2+) channels (SOCs). Taglialatela, M., Secondo, A., Fresi, A., Rosati, B., Pannaccione, A., Castaldo, P., Giorgio, G., Wanke, E., Annunziato, L. Biochem. Pharmacol. (2001) [Pubmed]
  3. Proliferative signaling by store-operated calcium channels opposes colon cancer cell cytostasis induced by bacterial enterotoxins. Kazerounian, S., Pitari, G.M., Shah, F.J., Frick, G.S., Madesh, M., Ruiz-Stewart, I., Schulz, S., Hajnóczky, G., Waldman, S.A. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  4. Phage display of intact domains at high copy number: a system based on SOC, the small outer capsid protein of bacteriophage T4. Ren, Z.J., Lewis, G.K., Wingfield, P.T., Locke, E.G., Steven, A.C., Black, L.W. Protein Sci. (1996) [Pubmed]
  5. Toddler anxiety disorders: a pilot study. Warren, S.L., Umylny, P., Aron, E., Simmens, S.J. Journal of the American Academy of Child and Adolescent Psychiatry. (2006) [Pubmed]
  6. Self-reported psychopathology, adaptive functioning and sense of coherence, and psychiatric diagnosis among young men : A population-based study. Ristkari, T., Sourander, A., Ronning, J., Helenius, H. Social psychiatry and psychiatric epidemiology. (2006) [Pubmed]
  7. Waiting for a liver transplant: psychosocial well-being, spirituality, and need for counselling. Goetzmann, L., Wagner-Huber, R., Klaghofer, R., Muellhaupt, B., Clavien, P.A., Buddeberg, C., Scheuer, E. Transplant. Proc. (2006) [Pubmed]
  8. Trying to tell a tale: discourse impairments in progressive aphasia and frontotemporal dementia. Ash, S., Moore, P., Antani, S., McCawley, G., Work, M., Grossman, M. Neurology (2006) [Pubmed]
  9. Expression of anti-OV6 antibody and anti-N-CAM antibody along the biliary line of normal and diseased human livers. Van Den Heuvel, M.C., Slooff, M.J., Visser, L., Muller, M., De Jong, K.P., Poppema, S., Gouw, A.S. Hepatology (2001) [Pubmed]
  10. Dynamic Assembly of TRPC1-STIM1-Orai1 Ternary Complex Is Involved in Store-operated Calcium Influx: EVIDENCE FOR SIMILARITIES IN STORE-OPERATED AND CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL COMPONENTS. Ong, H.L., Cheng, K.T., Liu, X., Bandyopadhyay, B.C., Paria, B.C., Soboloff, J., Pani, B., Gwack, Y., Srikanth, S., Singh, B.B., Gill, D., Ambudkar, I.S. J. Biol. Chem. (2007) [Pubmed]
  11. Ca(2+) entry activated by S-nitrosylation. Relationship to store-operated ca(2+) entry. Ma, H.T., Favre, C.J., Patterson, R.L., Stone, M.R., Gill, D.L. J. Biol. Chem. (1999) [Pubmed]
  12. Combined effects of constant sublethal UVA irradiation and elevated temperature on the survival and general metabolism of the convict-cichlid fish, Cichlasoma nigrofasciatum. Winckler, K., Fidhiany, L. Photochem. Photobiol. (1996) [Pubmed]
  13. Transient antiislet autoantibodies: infrequent occurrence and lack of association with "genetic" risk factors. Yu, J., Yu, L., Bugawan, T.L., Erlich, H.A., Barriga, K., Hoffman, M., Rewers, M., Eisenbarth, G.S. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  14. Are SOCS suppressors, regulators, and degraders? Johnston, J.A. J. Leukoc. Biol. (2004) [Pubmed]
  15. Store-operated Ca2+ channels in prostate cancer epithelial cells: function, regulation, and role in carcinogenesis. Vanden Abeele, F., Shuba, Y., Roudbaraki, M., Lemonnier, L., Vanoverberghe, K., Mariot, P., Skryma, R., Prevarskaya, N. Cell Calcium (2003) [Pubmed]
  16. Changes in soil organic carbon contents and nitrous oxide emissions after introduction of no-till in Pampean agroecosystems. Steinbach, H.S., Alvarez, R. J. Environ. Qual. (2006) [Pubmed]
  17. Assembly and activation of the NADPH:O2 oxidoreductase in human neutrophils after stimulation with phorbol myristate acetate. Ambruso, D.R., Bolscher, B.G., Stokman, P.M., Verhoeven, A.J., Roos, D. J. Biol. Chem. (1990) [Pubmed]
  18. The descending auditory pathway and acousticomotor systems: connections with the inferior colliculus. Huffman, R.F., Henson, O.W. Brain Res. Brain Res. Rev. (1990) [Pubmed]
  19. The activity of one soluble component of the cell-free NADPH:O2 oxidoreductase of human neutrophils depends on guanosine 5'-O-(3-thio)triphosphate. Bolscher, B.G., Denis, S.W., Verhoeven, A.J., Roos, D. J. Biol. Chem. (1990) [Pubmed]
  20. Silver activates mast cells through reactive oxygen species production and a thiol-sensitive store-independent Ca2+ influx. Yoshimaru, T., Suzuki, Y., Inoue, T., Niide, O., Ra, C. Free Radic. Biol. Med. (2006) [Pubmed]
  21. Store depletion and store-operated Ca2+ current in human prostate cancer LNCaP cells: involvement in apoptosis. Skryma, R., Mariot, P., Bourhis, X.L., Coppenolle, F.V., Shuba, Y., Vanden Abeele, F., Legrand, G., Humez, S., Boilly, B., Prevarskaya, N. J. Physiol. (Lond.) (2000) [Pubmed]
  22. Being with virtual others: Neural correlates of social interaction. Schilbach, L., Wohlschlaeger, A.M., Kraemer, N.C., Newen, A., Shah, N.J., Fink, G.R., Vogeley, K. Neuropsychologia. (2006) [Pubmed]
  23. Mediation by the central nervous system is critical to the in vivo activity of the GH secretagogue L-692,585. Hickey, G.J., Drisko, J., Faidley, T., Chang, C., Anderson, L.L., Nicolich, S., McGuire, L., Rickes, E., Krupa, D., Feeney, W., Friscino, B., Cunningham, P., Frazier, E., Chen, H., Laroque, P., Smith, R.G. J. Endocrinol. (1996) [Pubmed]
  24. The syndrome of oral complaints: etiology and therapy. Lowental, U., Pisanti, S. Oral Surg. Oral Med. Oral Pathol. (1978) [Pubmed]
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