The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SH3BP5  -  SH3-domain binding protein 5 (BTK-associated)

Homo sapiens

Synonyms: SAB, SH3 domain-binding protein 5, SH3 domain-binding protein that preferentially associates with BTK, SH3BP-5, Sab
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SH3BP5

  • Protein interaction cloning method was used to identify a novel molecule, Sab, which binds to the SH3 domain of Bruton's tyrosine kinase (Btk), the deficient cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia and murine X-linked immunodeficiency [1].
  • We studied 53 male patients who had 57 episodes of S. aureus bacteremia (SAB) [2].
  • The highly pathogenic Tacaribe complex arenaviruses (GUA, JUN, MAC, SAB) were all members of lineage B, suggesting the possibility that the highly pathogenic phenotype is the result of evolutionary radiation from a common ancestor [3].
  • Analysis of small-subunit rRNA partial sequences indicated that DhA-33 was most closely related to Sphingomonas yanoikuyae (Sab = 0.875) and that DhA-35 was most closely related to Zoogloea ramigera (Sab = 0.849) [4].
  • Distinguishing patients with S. aureus infective endocarditis (IE) from those with uncomplicated SAB is essential, but often difficult [5].

High impact information on SH3BP5

  • Analysis of in vitro supramolecular assemblies showed that gelation activity of SAB peptides correlates with their ability to recruit a critical amount of spectrin into the complex to cross-link actin filaments [6].
  • Recent identification of a number of scaffold proteins (AKAP, PICK, Sab) that bring specific kinases to the cytoplasmic surface of mitochondria further emphasizes the importance of mitochondrial kinase signaling [7].
  • Studies were performed using chloroform, methanol, and benzene as the solvent, and both at neutral pH and at a pH of approximately 5.5, as used in SAB synthesis [8].
  • A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria [9].
  • After 15 mins, they received HbV/rHSA, shed autologous blood (SAB), washed homologous red blood cells (wRBC) suspended in rHSA (wRBC/rHSA, [Hb] = 8.6 g/dL), or rHSA alone [10].

Chemical compound and disease context of SH3BP5


Biological context of SH3BP5

  • The present study and previously reported work may suggest a possible role for Sab in targeting JNK to this subcellular compartment and/or mediating crosstalk between different signal-transduction pathways [13].
  • A better understanding of the epidemiology and clinical manifestations of SAB in HIV-positive patients will offer important opportunities for prevention of this frequent complication [2].
  • The medical records of 50 consecutive children having open heart surgery with SAB or EPID and general anesthesia between September 1996 and December 1997 were reviewed [14].
  • 1. The effect of chronic treatment with epanolol, a new cardioselective beta-adrenoreceptor antagonist with moderate beta 1-selective intrinsic sympathomimetic activity (ISA), on 24 h ambulatory intra-arterial blood pressure (24 h IABP) and the sino-aortic baroreceptor heart rate (SAB/HR) reflex was investigated in six hypertensive subjects [15].
  • 17 unique genotypes were generated by RAPD and the mean SAB value of all isolates was 0.891+/-0.002 [16].

Anatomical context of SH3BP5

  • After 6 hrs, the rHSA group showed significant ischemic changes in the right cerebral hemisphere relating to the ligation of the right carotid artery followed by cannulation, whereas the HbV/rHSA, SAB, and wRBC/rHSA groups showed less changes [10].
  • Virulent Mah type 1 poliovirus and the attenuated Sab types 1, 2 and 3 poliovirus do not efficiently produce plaques or grow as efficiently with Vero cells as with HeLa cells [17].
  • In the remaining patients (20 SASP, 17 SAB), stool frequency, stool consistency and macroscopic appearance as well as histology of the diseased mucosa were improved within 6 weeks, with no significant difference between the two groups with respect to any of the parameters recorded [12].
  • In the close examination of the intramuscular distribution of the nerve to the SAB, the region innervated by the anterior branch of the obturator nerve could clearly be distinguished from that innervated by the posterior branch [18].
  • Sab and Scd spermatids were the most common cells observed in group I, whereas Scd and primary spermatocytes were the most common in group II, and Scd and secondary spermatocytes were the most common in group III [19].

Associations of SH3BP5 with chemical compounds

  • Lineage A contained Flexal, Parana, Pichinde, and Tamiami viruses; lineage B contained Amapari, Guanarito (GUA), Junin (JUN), Machupo (MAC), Sabia (SAB), and Tacaribe viruses [3].
  • In addition, patients assigned to the SAB+REMI group received SAB with tetracaine (0.5-2.0 mg/kg) and morphine (7 mug/kg) [20].
  • There was no change in SAB/HR reflex set point, sensitivity or latency with epanolol [15].
  • Three different anaesthetic techniques were selected by random and draw; spinal anaesthesia (SAB) with plain 0.5% bupivacaine (15 mg) and 0.2 mg epinephrine added, lumbar epidural anaesthesia (EA) with 2% mepivacaine and 1:200,000 epinephrine added, and epidural anaesthesia (AEA) with the same solution alkalinized with bicarbonate [21].
  • METHODS: Rat's HSC-T6 were cultured and treated by SAB or curcumin [22].

Other interactions of SH3BP5


Analytical, diagnostic and therapeutic context of SH3BP5

  • Immunoprecipitation using the anti-Sab antibody identified the protein product of the gene as a 70 kDa molecule [1].
  • This clearly demonstrates that both the GAB and SAB are in vitro bioassays and do not fully reflect in vivo activity.(ABSTRACT TRUNCATED AT 250 WORDS)[23]
  • Computer-assisted methods (Dendron) were developed for storage of Ca3 patterns in data files, calculation of similarity (SAB) values between strains based upon band positions and intensities, and generation of histograms and dendrograms based on SAB values for all strains or any subset of strains in large epidemiological studies [24].
  • The SAB is shown to be relatively inaccurate with a wide range of variance, while the SAC is demonstrated to be an accurate, reliable, and safe method of continuous ICP measurement and an acceptable alternative to ventriculostomy [25].
  • After operation, the incidence of deep vein thrombosis (DVT), assessed by venography, was found to be 40% in the SAB group, which was significantly lower than the incidence (76.2%) in the GA group [26].


  1. Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (BtK). Matsushita, M., Yamadori, T., Kato, S., Takemoto, Y., Inazawa, J., Baba, Y., Hashimoto, S., Sekine, S., Arai, S., Kunikata, T., Kurimoto, M., Kishimoto, T., Tsukada, S. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  2. Increased incidence of Staphylococcus aureus bacteremia in hospitalized patients with acquired immunodeficiency syndrome. Senthilkumar, A., Kumar, S., Sheagren, J.N. Clin. Infect. Dis. (2001) [Pubmed]
  3. The phylogeny of New World (Tacaribe complex) arenaviruses. Bowen, M.D., Peters, C.J., Nichol, S.T. Virology (1996) [Pubmed]
  4. Bacteria obtained from a sequencing batch reactor that are capable of growth on dehydroabietic acid. Mohn, W.W. Appl. Environ. Microbiol. (1995) [Pubmed]
  5. Staphylococcus aureus bacteremia and endocarditis. Petti, C.A., Fowler, V.G. Infect. Dis. Clin. North Am. (2002) [Pubmed]
  6. Mechanochemistry of protein 4.1's spectrin-actin-binding domain: ternary complex interactions, membrane binding, network integration, structural strengthening. Discher, D.E., Winardi, R., Schischmanoff, P.O., Parra, M., Conboy, J.G., Mohandas, N. J. Cell Biol. (1995) [Pubmed]
  7. Kinase signaling cascades in the mitochondrion: a matter of life or death. Horbinski, C., Chu, C.T. Free Radic. Biol. Med. (2005) [Pubmed]
  8. Radiopharmaceutical chemistry of targeted radiotherapeutics, part 1: effects of solvent on the degradation of radiohalogenation precursors by 211At alpha-particles. Pozzi, O.R., Zalutsky, M.R. J. Nucl. Med. (2005) [Pubmed]
  9. A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria. Wiltshire, C., Matsushita, M., Tsukada, S., Gillespie, D.A., May, G.H. Biochem. J. (2002) [Pubmed]
  10. Hemoglobin-vesicles suspended in recombinant human serum albumin for resuscitation from hemorrhagic shock in anesthetized rats. Sakai, H., Masada, Y., Horinouchi, H., Yamamoto, M., Ikeda, E., Takeoka, S., Kobayashi, K., Tsuchida, E. Crit. Care Med. (2004) [Pubmed]
  11. Clinical and economic impact of methicillin resistance in patients with Staphylococcus aureus bacteremia. Lodise, T.P., McKinnon, P.S. Diagn. Microbiol. Infect. Dis. (2005) [Pubmed]
  12. Prospective, randomized, double-blind comparison of benzalazine and sulfasalazine in the treatment of active ulcerative colitis. Fleig, W.E., Laudage, G., Sommer, H., Wellmann, W., Stange, E.F., Riemann, J. Digestion (1988) [Pubmed]
  13. Sab (SH3BP5), a novel mitochondria-localized JNK-interacting protein. Wiltshire, C., Gillespie, D.A., May, G.H. Biochem. Soc. Trans. (2004) [Pubmed]
  14. A retrospective examination of regional plus general anesthesia in children undergoing open heart surgery. Hammer, G.B., Ngo, K., Macario, A. Anesth. Analg. (2000) [Pubmed]
  15. The effect of epanolol on intra-arterial ambulatory blood pressure and baroreceptor heart rate reflex in essential hypertension. Smith, S.A., Littler, W.A. Clin. Exp. Pharmacol. Physiol. (1988) [Pubmed]
  16. Epidemiological study on vaginal Candida glabrata isolated from pregnant women. Wenjin, Q., Yifu, S. Scand. J. Infect. Dis. (2006) [Pubmed]
  17. Attachment, uncoating and blockage of cell protein synthesis by Sabin derivatives of poliovirus in HeLa and Vero cells. Tershak, D.R., Makkar, R. Intervirology (1988) [Pubmed]
  18. The true nature of the adductor brevis dually innervated by the anterior and posterior branches of the obturator nerve in humans. Miura, M., Nakamura, E., Kato, S., Usui, T., Miyauchi, R. Okajimas folia anatomica Japonica. (1994) [Pubmed]
  19. Immature spermatogenic cells and leucocytes in normal and abnormal semen. Bassol, S., Recio, R., de la Cruz, D.L. Arch. Androl. (1990) [Pubmed]
  20. Postoperative analgesia after spinal blockade in infants and children undergoing cardiac surgery. Hammer, G.B., Ramamoorthy, C., Cao, H., Williams, G.D., Boltz, M.G., Kamra, K., Drover, D.R. Anesth. Analg. (2005) [Pubmed]
  21. Regional anaesthetic technique and the incidence of tourniquet pain. Tetzlaff, J.E., Yoon, H.J., Walsh, M. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (1993) [Pubmed]
  22. Study on Effects of Extracts from Salvia Miltiorrhiza and Curcuma Longa in Inhibiting Phosphorylated Extracellular Signal Regulated Kinase Expression in Rat's Hepatic Stellate Cells. Cheng, Y., Ping, J., Liu, C., Tan, Y.Z., Chen, G.F. Chinese journal of integrative medicine. (2006) [Pubmed]
  23. Bioassays of follicle stimulating hormone. Wang, C. Endocr. Rev. (1988) [Pubmed]
  24. Computer-assisted methods for assessing strain relatedness in Candida albicans by fingerprinting with the moderately repetitive sequence Ca3. Schmid, J., Voss, E., Soll, D.R. J. Clin. Microbiol. (1990) [Pubmed]
  25. A clinical comparison of subarachnoid catheters to ventriculostomy and subarachnoid bolts: a prospective study. Mollman, H.D., Rockswold, G.L., Ford, S.E. J. Neurosurg. (1988) [Pubmed]
  26. Effects of anaesthetic technique on deep vein thrombosis. A comparison of subarachnoid and general anaesthesia. McKenzie, P.J., Wishart, H.Y., Gray, I., Smith, G. British journal of anaesthesia. (1985) [Pubmed]
WikiGenes - Universities