Chemical Compound Review:
Nepadutant (2S)-2-[[(3S,6S,9S,12S)-12- [[(2S)-3-[[(2R...
Synonyms:
MEN-11,420, LS-55819, DCL000894, DNC000550, MEN 11420, ...
- Effect of nepadutant, a neurokinin 2 tachykinin receptor antagonist, on immediate-early gene expression after trinitrobenzenesulfonic acid-induced colitis in the rat. Birder, L.A., Kiss, S., de Groat, W.C., Lecci, A., Maggi, C.A. J. Pharmacol. Exp. Ther. (2003)
- Evidence of a peripheral role of neurokinins in detrusor hyperreflexia: a further study of selective tachykinin antagonists in chronic spinal injured rats. Abdel-Gawad, M., Dion, S.B., Elhilali, M.M. J. Urol. (2001)
- Protective effect of the tachykinin NK2 receptor antagonist nepadutant in acute rectocolitis induced by diluted acetic acid in guinea-pigs. Cutrufo, C., Evangelista, S., Cirillo, R., Ciucci, A., Conte, B., Lopez, G., Manzini, S., Maggi, C.A. Neuropeptides (2000)
- Tachykinin receptors antagonists: from research to clinic. Quartara, L., Altamura, M. Current drug targets. (2006)
- Excitatory motor and electrical effects produced by tachykinins in the human and guinea-pig isolated ureter and guinea-pig renal pelvis. Patacchini, R., Santicioli, P., Zagorodnyuk, V., Lazzeri, M., Turini, D., Maggi, C.A. Br. J. Pharmacol. (1998)
- Role of NK2 receptors in gastric barosensitivity and in experimental ileus in rats. Toulouse, M., Fioramonti, J., Maggi, C., Buéno, L. Neurogastroenterol. Motil. (2001)
- Monocyclic human tachykinin NK-2 receptor antagonists as evolution of a potent bicyclic antagonist: QSAR and site-directed mutagenesis studies. Giolitti, A., Altamura, M., Bellucci, F., Giannotti, D., Meini, S., Patacchini, R., Rotondaro, L., Zappitelli, S., Maggi, C.A. J. Med. Chem. (2002)
- Tachykinin NK2 receptor antagonists for the treatment of irritable bowel syndrome. Lecci, A., Capriati, A., Maggi, C.A. Br. J. Pharmacol. (2004)
- Hydrogen sulfide (H2S) stimulates capsaicin-sensitive primary afferent neurons in the rat urinary bladder. Patacchini, R., Santicioli, P., Giuliani, S., Maggi, C.A. Br. J. Pharmacol. (2004)
- Nepadutant pharmacokinetics and dose-effect relationships as tachykinin NK2 receptor antagonist are altered by intestinal inflammation in rodent models. Lecci, A., Carini, F., Tramontana, M., D'Aranno, V., Marinoni, E., Crea, A., Bueno, L., Fioramonti, J., Criscuoli, M., Giuliani, S., Maggi, C.A. J. Pharmacol. Exp. Ther. (2001)
- Characterization of receptors mediating contraction induced by tachykinins in the guinea-pig isolated common bile duct. Patacchini, R., Barthó, L., Maggi, C.A. Br. J. Pharmacol. (1997)
- A novel tachykinin NK2 receptor antagonist prevents motility-stimulating effects of neurokinin A in small intestine. Lördal, M., Navalesi, G., Theodorsson, E., Maggi, C.A., Hellström, P.M. Br. J. Pharmacol. (2001)
- MEN 11420 (Nepadutant), a novel glycosylated bicyclic peptide tachykinin NK2 receptor antagonist. Catalioto, R.M., Criscuoli, M., Cucchi, P., Giachetti, A., Gianotti, D., Giuliani, S., Lecci, A., Lippi, A., Patacchini, R., Quartara, L., Renzetti, A.R., Tramontana, M., Arcamone, F., Maggi, C.A. Br. J. Pharmacol. (1998)
- Effect of tachykinin NK2 receptor blockade on detrusor hyperreflexia induced by bacterial toxin in rats. Lecci, A., Tramontana, M., Giuliani, S., Criscuoli, M., Maggi, C.A. J. Urol. (1998)
- Characterization of the antibronchoconstrictor activity of MEN 11420, a tachykinin NK2 receptor antagonist, in guinea-pigs. Tramontana, M., Patacchini, R., Giuliani, S., Lippi, A., Lecci, A., Santicioli, P., Criscuoli, M., Maggi, C.A. Eur. J. Pharmacol. (1998)
- Role of prostanoids in the contraction induced by a tachykinin NK2 receptor agonist in the hamster urinary bladder. Tramontana, M., Catalioto, R.M., Lecci, A., Maggi, C.A. Naunyn Schmiedebergs Arch. Pharmacol. (2000)
- MEN 11420, a potent and selective tachykinin NK2 receptor antagonist in the guinea-pig and human colon. Santicioli, P., Giuliani, S., Patacchini, R., Tramontana, M., Criscuoli, M., Maggi, C.A. Naunyn Schmiedebergs Arch. Pharmacol. (1997)
- Functional characterisation of tachykinin receptors in the circular muscle layer of the mouse ileum. De Schepper, H.U., De Winter, B.Y., Seerden, T.C., Herman, A.G., Pelckmans, P.A., De Man, J.G. Regul. Pept. (2005)
- Impaired response to chemical irritation of the urinary tract in mice with disruption of the preprotachykinin gene. Kiss, S., Yoshiyama, M., Cao, Y.Q., Basbaum, A.I., de Groat, W.C., Lecci, A., Maggi, C.A., Birder, L.A. Neurosci. Lett. (2001)
- MEN 11,420, a peptide tachykinin NK2 receptor antagonist, reduces motor responses induced by the intravesical administration of capsaicin in vivo. Lecci, A., Giuliani, S., Tramontana, M., Criscuoli, M., Maggi, C.A. Naunyn Schmiedebergs Arch. Pharmacol. (1997)