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MeSH Review

CD4-CD8 Ratio

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Disease relevance of CD4-CD8 Ratio


Psychiatry related information on CD4-CD8 Ratio


High impact information on CD4-CD8 Ratio


Chemical compound and disease context of CD4-CD8 Ratio


Biological context of CD4-CD8 Ratio

  • In contrast, the other MHC haplotypes (h, l, u) associated with low CD4/CD8 ratios and mRNA expression for TGF-beta and IL-10, but not for IFN-gamma [13].
  • Above findings suggested that SLE cells showed abnormally high apoptosis of T lymphocytes, especially of the CD4+ subpopulation, resulting in a decreased CD4/CD8 ratio [14].
  • Increased ADCC levels corresponding with a slight increase in CD4+ and CD8+ fractions were observed after the first injection, while the CD4/CD8 ratio and the levels of CD25 remained unchanged. c-MOv18 did not have a mitogenic effect on patients' PBMC and adding IL-2 did not change the degree of proliferation [15].
  • Impairment of cellular immunity such as lowered T4/T8 ratio, depressed lymphocyte response to mitogen and NK activity, and negative PPD skin reaction was evident in both patients [16].

Anatomical context of CD4-CD8 Ratio


Associations of CD4-CD8 Ratio with chemical compounds

  • The serum IL-2R levels were reflective of the classification of HIV-induced diseases by the Centers for Disease Control. Moreover, the IL-2R levels were negatively correlated most prominently with CD4 cell counts, with lymphocyte counts, and with a decrease in the CD4-CD8 ratio but not with either WBC counts or B cell counts [22].
  • In addition, ATG and cyclosporine had a more selective ablation of the T4 subset, resulting in a reversal of the T4/T8 ratios [23].
  • The CD4/CD8 ratio was similar between control and treated cells for each phase of cycle (G0----G1, S, G2 + M), suggesting that calcitriol did not selectively block proliferation of either T cell subpopulation [24].
  • The inverted CD4/CD8 ratio in the intraepithelial compartment suggests that cytotoxic/suppressor T cells are the first line of defense against luminal foreign agents reaching the prostate through retrograde flow [25].
  • Ethanol significantly increased the percentage population of CD4 (T-helper cell) in males (p = 0.017), but not in females, and promoted an apparent, although nonsignificant, increase in the CD4/CD8 ratio in both sexes [26].

Gene context of CD4-CD8 Ratio

  • These effects were associated with decreased peripheral and intrahepatic CD4/CD8 ratios and decreased interleukin 10 levels [27].
  • Both CD4+ and CD8+ T-cell subsets responded to this cytokine as shown by phenotype-depletion experiments and constancy in the CD4/CD8 ratios after culture with IL-7 [28].
  • According to our results, the evidences of increased cellular immune response in ARF are increased percentages CD4+ and CD25+ cells, CD4/CD8 ratio, and increased plasma concentrations of IL-1 alpha and IL-2 [29].
  • Also, a significant decrease of CD4/CD8 ratio was observed in the course of GvH caused by the iv transfer of cells from MRL/lpr mice [30].
  • RESULTS: A high percentage of CD3+ cells, CD4+ cells expressing HLA-DR antigen, and a high CD4/CD8 ratio were detected in the BAL fluid of patients compared with normal subjects [31].

Analytical, diagnostic and therapeutic context of CD4-CD8 Ratio



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  2. Suppressor of cytokine signaling 1 regulates IL-15 receptor signaling in CD8+CD44high memory T lymphocytes. Ilangumaran, S., Ramanathan, S., La Rose, J., Poussier, P., Rottapel, R. J. Immunol. (2003) [Pubmed]
  3. A novel case of immunodeficiency, centromeric instability, and facial anomalies (the ICF syndrome): immunologic and cytogenetic studies. Pezzolo, A., Prigione, I., Chiesa, S., Castellano, E., Gimelli, G., Pistoia, V. Haematologica (2002) [Pubmed]
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  5. Increased gamma/delta-positive T-cells in blood and bronchoalveolar lavage of patients with sarcoidosis and hypersensitivity pneumonitis. Raulf, M., Liebers, V., Steppert, C., Baur, X. Eur. Respir. J. (1994) [Pubmed]
  6. Individual differences in peripheral blood immunological and hormonal measures in adult male rhesus macaques (Macaca mulatta): evidence for temporal and situational consistency. Capitanio, J.P., Mendoza, S.P., Lerche, N.W. Am. J. Primatol. (1998) [Pubmed]
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  8. T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells. Zhu, J., Liu, X., Xie, C., Yan, M., Yu, Y., Sobel, E.S., Wakeland, E.K., Mohan, C. J. Clin. Invest. (2005) [Pubmed]
  9. Decreased 5' nucleotidase activity in lymphocytes from asymptomatic sexually active homosexual men and patients with the acquired immune deficiency syndrome. Murray, J.L., Reuben, J.M., Munn, C.G., Mansell, P.W., Newell, G.R., Hersh, E.M. Blood (1984) [Pubmed]
  10. Requirement for Jak3 in mature T cells: its role in regulation of T cell homeostasis. Sohn, S.J., Forbush, K.A., Nguyen, N., Witthuhn, B., Nosaka, T., Ihle, J.N., Perlmutter, R.M. J. Immunol. (1998) [Pubmed]
  11. Thymic skewing of the CD4/CD8 ratio maps with the T-cell receptor alpha-chain locus. Sim, B.C., Aftahi, N., Reilly, C., Bogen, B., Schwartz, R.H., Gascoigne, N.R., Lo, D. Curr. Biol. (1998) [Pubmed]
  12. Neuroimmunomodulation in cancer patients: correlations between melatonin and beta-endorphin blood levels and T helper/suppressor ratio. Barni, S., Lissoni, P., Crispino, S., Cattaneo, G., Rovelli, F., Fumagalli, G., Tancini, G. Int. J. Biol. Markers (1988) [Pubmed]
  13. Genetic analysis of inflammation, cytokine mRNA expression and disease course of relapsing experimental autoimmune encephalomyelitis in DA rats. Lorentzen, J.C., Andersson, M., Issazadeh, S., Dahlman, I., Luthman, H., Weissert, R., Olsson, T. J. Neuroimmunol. (1997) [Pubmed]
  14. The abnormal apoptosis of T cell subsets and possible involvement of IL-10 in systemic lupus erythematosus. Wang, H., Xu, J., Ji, X., Yang, X., Sun, K., Liu, X., Shen, Y. Cell. Immunol. (2005) [Pubmed]
  15. Cellular and humoral responses after multiple injections of unconjugated chimeric monoclonal antibody MOv18 in ovarian cancer patients: a pilot study. van Zanten-Przybysz, I., Molthoff, C., Gebbinck, J.K., von Mensdorff-Pouilly, S., Verstraeten, R., Kenemans, P., Verheijen, R. J. Cancer Res. Clin. Oncol. (2002) [Pubmed]
  16. Clinical, immunological, and virological aspects in Japanese hemophiliacs and AIDS patients. Abe, T. AIDS research. (1986) [Pubmed]
  17. The role of interleukin-2 in proliferative responses in vitro of T cells from patients after bone marrow transplantation. Evidence that minor defects can lead to in vitro unresponsiveness. Roosnek, E.E., Brouwer, M.C., Vossen, J.M., Roos, M.T., Schellekens, P.T., Zeijlemaker, W.P., Aarden, L.A. Transplantation (1987) [Pubmed]
  18. Phenotypic analysis of lymphocytes and monocytes/macrophages in peripheral blood and bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis. Wahlström, J., Berlin, M., Sköld, C.M., Wigzell, H., Eklund, A., Grunewald, J. Thorax (1999) [Pubmed]
  19. Distribution of T cell subsets in follicular fluid. Droesch, K., Fulgham, D.L., Liu, H.C., Rosenwaks, Z., Alexander, N.J. Fertil. Steril. (1988) [Pubmed]
  20. Immunophenotyping of inflammatory cells in lesional skin of the extrinsic and intrinsic types of atopic dermatitis. Rho, N.K., Kim, W.S., Lee, D.Y., Lee, J.H., Lee, E.S., Yang, J.M. Br. J. Dermatol. (2004) [Pubmed]
  21. Therapeutic effect of repeated natural killer T cell stimulation in mouse cholangitis complicated by colitis. Numata, Y., Tazuma, S., Ueno, Y., Nishioka, T., Hyogo, H., Chayama, K. Dig. Dis. Sci. (2005) [Pubmed]
  22. Soluble IL-2 receptor in AIDS. Correlation of its serum level with the classification of HIV-induced diseases and its characterization. Honda, M., Kitamura, K., Matsuda, K., Yokota, Y., Yamamoto, N., Mitsuyasu, R., Chermann, J.C., Tokunaga, T. J. Immunol. (1989) [Pubmed]
  23. T-lymphocyte subsets in renal allograft recipients treated with cyclosporine and azathioprine. Sumpio, B.E., Dwyer, J.M., Flye, M.W. Ann. Surg. (1987) [Pubmed]
  24. Comparison of the effects of 1,25-dihydroxyvitamin D3 on T lymphocyte subpopulations. Rigby, W.F., Yirinec, B., Oldershaw, R.L., Fanger, M.W. Eur. J. Immunol. (1987) [Pubmed]
  25. Intraepithelial and stromal lymphocytes in the normal human prostate. Bostwick, D.G., de la Roza, G., Dundore, P., Corica, F.A., Iczkowski, K.A. Prostate (2003) [Pubmed]
  26. Sex differences and the effects of alcohol on immune response in male and female rats. Grossman, C.J., Nienaber, M., Mendenhall, C.L., Hurtubise, P., Roselle, G.A., Rouster, S., Weber, N., Schmitt, G., Gartside, P.S. Alcohol. Clin. Exp. Res. (1993) [Pubmed]
  27. Adoptive transfer of regulatory NKT lymphocytes ameliorates non-alcoholic steatohepatitis and glucose intolerance in ob/ob mice and is associated with intrahepatic CD8 trapping. Elinav, E., Pappo, O., Sklair-Levy, M., Margalit, M., Shibolet, O., Gomori, M., Alper, R., Thalenfeld, B., Engelhardt, D., Rabbani, E., Ilan, Y. J. Pathol. (2006) [Pubmed]
  28. Interleukin-7 activates intestinal lymphocytes. Bilenker, M., Roberts, A.I., Brolin, R.E., Ebert, E.C. Dig. Dis. Sci. (1995) [Pubmed]
  29. Lymphocyte subsets and plasma IL-1 alpha, IL-2, and TNF-alpha concentrations in acute rheumatic fever and chronic rheumatic heart disease. Narin, N., Kütükçüler, N., Ozyürek, R., Bakiler, A.R., Parlar, A., Arcasoy, M. Clin. Immunol. Immunopathol. (1995) [Pubmed]
  30. Induction of graft versus host disease in SCID mice by MRL/lpr cell transfer. Fraziano, M., Montesano, C., Sammarco, I., di Cesare, S., Caroleo, M.C., Mattei, M., Cannata, S., Poccia, F., Bellavia, A., Salerno, A. Clin. Immunol. Immunopathol. (1994) [Pubmed]
  31. Analysis of T cell subsets and beta chemokines in patients with pulmonary sarcoidosis. Iida, K., Kadota, J., Kawakami, K., Matsubara, Y., Shirai, R., Kohno, S. Thorax (1997) [Pubmed]
  32. Recovery of T-lymphocytes for adoptive immunotherapy by lymphapheresis of HIV-infected patients without alterations of virological, immunological or clinical parameters. van Lunzen, J., Schmitz, J., Dengler, K., Schmidt, L., Schmitz, H., Dietrich, M. Br. J. Haematol. (1994) [Pubmed]
  33. Different rates of CD4+ and CD8+ T-cell proliferation in interleukin-2-treated human immunodeficiency virus-positive subjects. Caggiari, L., Zanussi, S., Crepaldi, C., Bortolin, M.T., Caffau, C., D'Andrea, M., De Paoli, P. Cytometry. (2001) [Pubmed]
  34. Influence of cyclic interferon gamma on lymphocytes and their subpopulations in patients with renal carcinoma. Grups, J.W., Frohmüller, H.G. Urology (1990) [Pubmed]
  35. Detection of circulating T cells with CD4+CD7- immunophenotype in patients with benign and malignant lymphoproliferative dermatoses. Harmon, C.B., Witzig, T.E., Katzmann, J.A., Pittelkow, M.R. J. Am. Acad. Dermatol. (1996) [Pubmed]
  36. Influence of laparoscopy and laparotomy on systemic and peritoneal T lymphocytes in a rat model. Gutt, C.N., Hollander, D., Brier, C.H., Kim, Z.G., Lorenz, M. International journal of colorectal disease. (2001) [Pubmed]
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