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MeSH Review

Scutellaria baicalensis

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Disease relevance of Scutellaria baicalensis


High impact information on Scutellaria baicalensis


Chemical compound and disease context of Scutellaria baicalensis


Biological context of Scutellaria baicalensis

  • The Scutellariae radix extracts at high dose were observed to cause damage at the bile duct and expression change of a number of proteins including some involved in catabolism of triglyceride-rich particles, carbohydrate metabolism, regulators of cell signaling processes, and enzymes involved in biotransformation [7].
  • San'o-shashin-to, composed of Scutellariae Radix, Coptidis Rhizoma and Rhei Rhizoma (volume ratio = 1:1:1), reduced an increase in arterial blood pressure of anesthetized rats induced by theophylline (5 mg/kg, i.v.). The hypotensive effect of San'o-shashin-to was produced in a dose dependent manner and was maximum at its 0.5 g/kg [8].

Anatomical context of Scutellaria baicalensis


Associations of Scutellaria baicalensis with chemical compounds

  • A rapid and sensitive method, using electrochemical detection, has been developed for the determination of baicalin and baicalein, the flavonoid of Scutellariae radix, in rat plasma [12].
  • A structure-activity study was carried out to determine the important regions of baicalein and oroxylin A, two flavones isolated from the Chinese herb Scutellariae radix, in inhibiting NAD(P)H:quinone acceptor oxidoreductase (EC; DT-diaphorase) [13].
  • These results suggest that the gastric mucosal protection of Coptidis rhizoma and Phellodendri cortex may be ascribed to the reinforcement of mucosal barrier resistance through endogenous sulfhydryl compounds and DDC-sensitive compounds, but those of Gardeniae fructus and Scutellariae radix may be independent of NEM- or DDC-sensitive compounds [14].
  • A significant and dose-dependent induction of QR activity was observed in the methanol extract of scutellariae radix and baicalin [15].
  • We previously reported that Oren (Coptidis rhizoma) and Ogon (Scutellariae radix) inhibit azoxymethane (AOM)-induced aberrant crypt foci (ACF) formation [16].

Gene context of Scutellaria baicalensis


Analytical, diagnostic and therapeutic context of Scutellaria baicalensis


  1. Effects of Sho-saiko-to, San'o-shashin-to and Scutellariae Radix on intracellular Ca2+ mobilization in C6 rat glioma cells. Kyo, R., Nakahata, N., Sakakibara, I., Kubo, M., Ohizumi, Y. Biol. Pharm. Bull. (1998) [Pubmed]
  2. Effects of scutellariae radix extract and its components (baicalein, baicalin, and wogonin) on the experimental elevation of aqueous flare in pigmented rabbits. Nagaki, Y., Hayasaka, S., Kadoi, C., Nakamura, N., Hayasaka, Y. Jpn. J. Ophthalmol. (2001) [Pubmed]
  3. Cellular mechanism for potentiation of Ca2+-mediated Cl- secretion by the flavonoid baicalein in intestinal epithelia. Yue, G.G., Yip, T.W., Huang, Y., Ko, W.H. J. Biol. Chem. (2004) [Pubmed]
  4. Inhibition of rat liver NAD(P)H:quinone acceptor oxidoreductase (DT-diaphorase) by flavonoids isolated from the Chinese herb scutellariae radix (Huang Qin). Liu, X.F., Liu, M.L., Iyanagi, T., Legesse, K., Lee, T.D., Chen, S.A. Mol. Pharmacol. (1990) [Pubmed]
  5. Scutellariae radix extracts suppress ethanol-induced caspase-11 expression and cell death in N(2)a cells. Kang, K., Oh, Y.K., Choue, R., Kang, S.J. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  6. Analysis of inhibitory effects of scutellariae radix and baicalein on prostaglandin E2 production in rat C6 glioma cells. Nakahata, N., Kutsuwa, M., Kyo, R., Kubo, M., Hayashi, K., Ohizumi, Y. Am. J. Chin. Med. (1998) [Pubmed]
  7. Proteomic analysis of mouse liver for the evaluation of effects of Scutellariae radix by liquid chromatography with tandem mass spectrometry. Ong, E.S., Len, S.M., Lee, A.C., Chui, P., Chooi, K.F. Rapid Commun. Mass Spectrom. (2004) [Pubmed]
  8. Effects of San'o-shashin-to and the constituent herbal medicines on theophylline-induced increase in arterial blood pressure of rats. Sanae, F., Komatsu, Y., Chisaki, K., Kido, T., Ishige, A., Hayashi, H. Biol. Pharm. Bull. (2001) [Pubmed]
  9. Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines. Ikemoto, S., Sugimura, K., Yoshida, N., Yasumoto, R., Wada, S., Yamamoto, K., Kishimoto, T. Urology (2000) [Pubmed]
  10. Hwangryun-Hae-Dok-tang (Huanglian-Jie-Du-Tang) extract and its constituents reduce ischemia-reperfusion brain injury and neutrophil infiltration in rats. Hwang, Y.S., Shin, C.Y., Huh, Y., Ryu, J.H. Life Sci. (2002) [Pubmed]
  11. Effects of flavonoids isolated from Scutellariae radix on cytochrome P-450 activities in human liver microsomes. Kim, J.Y., Lee, S., Kim, D.H., Kim, B.R., Park, R., Lee, B.M. J. Toxicol. Environ. Health Part A (2002) [Pubmed]
  12. Determination of baicalin and baicalein in rat plasma by high-performance liquid chromatography with electrochemical detection. Wakui, Y., Yanagisawa, E., Ishibashi, E., Matsuzaki, Y., Takeda, S., Sasaki, H., Aburada, M., Oyama, T. J. Chromatogr. (1992) [Pubmed]
  13. Inhibition of NAD(P)H:quinone acceptor oxidoreductase by flavones: a structure-activity study. Chen, S., Hwang, J., Deng, P.S. Arch. Biochem. Biophys. (1993) [Pubmed]
  14. Roles of sulfhydryl compounds in the gastric mucosal protection of the herb drugs composing oren-gedoku-to (a traditional herbal medicine). Takase, H., Inoue, O., Saito, Y., Yumioka, E., Suzuki, A. Jpn. J. Pharmacol. (1991) [Pubmed]
  15. Induction of quinone reductase by a methanol extract of Scutellaria baicalensis and its flavonoids in murine Hepa 1c1c7 cells. Park, H.J., Lee, Y.W., Park, H.H., Lee, Y.S., Kwon, I.B., Yu, J.H. Eur. J. Cancer Prev. (1998) [Pubmed]
  16. Suppressive effect of the herbal medicine Oren-gedoku-to on cyclooxygenase-2 activity and azoxymethane-induced aberrant crypt foci development in rats. Fukutake, M., Miura, N., Yamamoto, M., Fukuda, K., Iijima, O., Ishikawa, H., Kubo, M., Okada, M., Komatsu, Y., Sasaki, H., Wakabayashi, K., Ishige, A., Amagaya, S. Cancer Lett. (2000) [Pubmed]
  17. Mechanisms by which Hange-shashin-to reduces prostaglandin E2 levels. Kase, Y., Saitoh, K., Ishige, A., Komatsu, Y. Biol. Pharm. Bull. (1998) [Pubmed]
  18. Effects of flavonoids isolated from scutellariae radix on the production of tissue-type plasminogen activator and plasminogen activator inhibitor-1 induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells. Kimura, Y., Yokoi, K., Matsushita, N., Okuda, H. J. Pharm. Pharmacol. (1997) [Pubmed]
  19. Inhibitory effect of Coptidis Rhizoma and Scutellariae Radix on azoxymethane-induced aberrant crypt foci formation in rat colon. Fukutake, M., Yokota, S., Kawamura, H., Iizuka, A., Amagaya, S., Fukuda, K., Komatsu, Y. Biol. Pharm. Bull. (1998) [Pubmed]
  20. Study of major flavonoids in crude Scutellariae Radix by micellar electrokinetic capillary chromatography. Qi, L., Zhou, R., Wang, Y.F., Zhu, Y.C. Journal of capillary electrophoresis. (1998) [Pubmed]
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