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Gene Review

MSLN  -  mesothelin

Homo sapiens

Synonyms: CAK1, CAK1 antigen, MPF, Mesothelin, Pre-pro-megakaryocyte-potentiating factor, ...
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Disease relevance of MSLN


Psychiatry related information on MSLN

  • In the present investigation we determined metabolic rate during sleep (SMR) as a function of physical activity (PA) in normal daily life [5].
  • Analysis of all certified deaths from dementia during 1968-78 by place of residence shows that areas with a significantly high SMR usually contain a large psychiatric hospital [6].
  • For mild mental retardation (MMR; that is, IQ = 50 to 75), prevalence was 3.54/1000, and for severe mental retardation (SMR; that is, IQ < 50), it was 3.64/1000 [7].
  • There was an increase in SMRs with longer latency periods and years of exposure, with the greatest risk found in those who had worked for 30 or more years after more than 30 years since first exposed (SMR 3.07, based on 16 deaths) [8].
  • RESULTS: Protocol-specific effects were obtained in that SMR training was associated with increased perceptual sensitivity 'd prime' (d'), and reduced omission errors and reaction time variability [9].

High impact information on MSLN

  • The nuclear envelope is a dynamic structure that completely disassembles in response to MPF/cdc2 activity in mitosis [10].
  • Bacterially expressed human nuclear lamin C, assembled in vitro into filaments, showed increased phosphorylation on specific sites in the extract in response to MPF [11].
  • The mechanism by which MPF induces nuclear lamin disassembly and nuclear envelope breakdown during mitosis was studied in a frog egg extract in which the transition from interphase to mitosis can be induced by the addition of MPF [11].
  • MPF extracted from starfish oocytes copurifies with an M phase-specific H1 histone kinase encoded by a homolog of the fission yeast cell cycle control gene cdc2+ [12].
  • In vertebrate cells, the nuclear entry of Cdc2-cyclin B1 (MPF) during prophase is thought to be essential for the induction and coordination of M-phase events [13].

Chemical compound and disease context of MSLN


Biological context of MSLN


Anatomical context of MSLN


Associations of MSLN with chemical compounds

  • PURPOSE: Mesothelin is a glycosyl-phosphatidylinositol-anchored glycoprotein present on the cell surface [2].
  • In this study we have shown that during the maturation of Xenopus laevis oocytes induced by progesterone, phosphorylation of MPM-2 antigens coincided with the appearance of MPF activity [15].
  • Furthermore, this activation correlated with the biochemical regulation of the maturation-promoting factor (MPF, cdc2/cyclin B), as both DRB and antisense depletion of CK2, as well as SB203580 were associated with an inhibition of its activation in response to nocodazole [26].
  • Components of the signaling pathway linking the 1-methyladenine receptor to MPF activation and maturation in starfish oocytes [27].
  • From immunoblot experiments and survey of the relevant literature it has been argued that OA may modulate both a tyrosine kinase and a tyrosine phosphatase activity to override the S-phase checkpoint and accelerate the activation of MPF in cells in G2-phase, respectively [28].

Other interactions of MSLN


Analytical, diagnostic and therapeutic context of MSLN


  1. Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. Chang, K., Pastan, I. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients. Ho, M., Hassan, R., Zhang, J., Wang, Q.C., Onda, M., Bera, T., Pastan, I. Clin. Cancer Res. (2005) [Pubmed]
  3. Mesothelin: a new target for immunotherapy. Hassan, R., Bera, T., Pastan, I. Clin. Cancer Res. (2004) [Pubmed]
  4. Large-scale molecular and tissue microarray analysis of mesothelin expression in common human carcinomas. Frierson, H.F., Moskaluk, C.A., Powell, S.M., Zhang, H., Cerilli, L.A., Stoler, M.H., Cathro, H., Hampton, G.M. Hum. Pathol. (2003) [Pubmed]
  5. Physical activity and sleeping metabolic rate. Westerterp, K.R., Meijer, G.A., Saris, W.H., Soeters, P.B., Winants, Y., ten Hoor, F. Medicine and science in sports and exercise. (1991) [Pubmed]
  6. Usefulness of mortality data in determining the geography and time trends of dementia. Martyn, C.N., Pippard, E.C. Journal of epidemiology and community health. (1988) [Pubmed]
  7. Mental retardation in teenagers: prevalence data from the Niagara region, Ontario. Bradley, E.A., Thompson, A., Bryson, S.E. Canadian journal of psychiatry. Revue canadienne de psychiatrie. (2002) [Pubmed]
  8. Mortality of a cohort of men in a silicosis register: further evidence of an association with lung cancer. Ng, T.P., Chan, S.L., Lee, J. Am. J. Ind. Med. (1990) [Pubmed]
  9. EEG biofeedback of low beta band components: frequency-specific effects on variables of attention and event-related brain potentials. Egner, T., Gruzelier, J.H. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. (2004) [Pubmed]
  10. Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis. Heald, R., McKeon, F. Cell (1990) [Pubmed]
  11. Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C. Ward, G.E., Kirschner, M.W. Cell (1990) [Pubmed]
  12. Purification of MPF from starfish: identification as the H1 histone kinase p34cdc2 and a possible mechanism for its periodic activation. Labbe, J.C., Picard, A., Peaucellier, G., Cavadore, J.C., Nurse, P., Doree, M. Cell (1989) [Pubmed]
  13. Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase. Toyoshima-Morimoto, F., Taniguchi, E., Shinya, N., Iwamatsu, A., Nishida, E. Nature (2001) [Pubmed]
  14. Cloning and expression of the recombinant FAb fragment of monoclonal antibody K1 that reacts with mesothelin present on mesotheliomas and ovarian cancers. Brinkmann, U., Webber, K., Di Carlo, A., Beers, R., Chowdhury, P., Chang, K., Chaudhary, V., Gallo, M., Pastan, I. Int. J. Cancer (1997) [Pubmed]
  15. Mitosis-specific monoclonal antibody MPM-2 inhibits Xenopus oocyte maturation and depletes maturation-promoting activity. Kuang, J., Zhao, J., Wright, D.A., Saunders, G.F., Rao, P.N. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  16. Characterization of the antigen (CAK1) recognized by monoclonal antibody K1 present on ovarian cancers and normal mesothelium. Chang, K., Pai, L.H., Batra, J.K., Pastan, I., Willingham, M.C. Cancer Res. (1992) [Pubmed]
  17. Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis. Hassan, R., Laszik, Z.G., Lerner, M., Raffeld, M., Postier, R., Brackett, D. Am. J. Clin. Pathol. (2005) [Pubmed]
  18. Effects of thiopental (Trapanal) on coronary blood flow and myocardial metabolism in man. Sonntag, H., Hellberg, K., Schenk, H.D., Donath, U., Regensburger, D., Kettler, D., Duchanova, H., Larsen, R. Acta anaesthesiologica Scandinavica. (1975) [Pubmed]
  19. Characterization of human mesothelin transcripts in ovarian and pancreatic cancer. Muminova, Z.E., Strong, T.V., Shaw, D.R. BMC Cancer (2004) [Pubmed]
  20. Mesothelin-mediated targeting of adenoviral vectors for ovarian cancer gene therapy. Breidenbach, M., Rein, D.T., Everts, M., Glasgow, J.N., Wang, M., Passineau, M.J., Alvarez, R.D., Korokhov, N., Curiel, D.T. Gene Ther. (2005) [Pubmed]
  21. Development of a CA125-mesothelin cell adhesion assay as a screening tool for biologics discovery. Scholler, N., Garvik, B., Hayden-Ledbetter, M., Kline, T., Urban, N. Cancer Lett. (2007) [Pubmed]
  22. Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors. Gubbels, J.A., Belisle, J., Onda, M., Rancourt, C., Migneault, M., Ho, M., Bera, T.K., Connor, J., Sathyanarayana, B.K., Lee, B., Pastan, I., Patankar, M.S. Mol. Cancer (2006) [Pubmed]
  23. Frequent expression of the tumor antigen CAK1 in squamous-cell carcinomas. Chang, K., Pastan, I., Willingham, M.C. Int. J. Cancer (1992) [Pubmed]
  24. Cell-cycle related regulation of poly(A) polymerase by phosphorylation. Colgan, D.F., Murthy, K.G., Prives, C., Manley, J.L. Nature (1996) [Pubmed]
  25. Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients. Thomas, A.M., Santarsiero, L.M., Lutz, E.R., Armstrong, T.D., Chen, Y.C., Huang, L.Q., Laheru, D.A., Goggins, M., Hruban, R.H., Jaffee, E.M. J. Exp. Med. (2004) [Pubmed]
  26. Protein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cells. Sayed, M., Pelech, S., Wong, C., Marotta, A., Salh, B. Oncogene (2001) [Pubmed]
  27. Components of the signaling pathway linking the 1-methyladenine receptor to MPF activation and maturation in starfish oocytes. Sadler, K.C., Ruderman, J.V. Dev. Biol. (1998) [Pubmed]
  28. Okadaic acid overrides the S-phase check point and accelerates progression of G2-phase to induce premature mitosis in HeLa cells. Ghosh, S., Schroeter, D., Paweletz, N. Exp. Cell Res. (1996) [Pubmed]
  29. Isolation and characterization of a monoclonal antibody, K1, reactive with ovarian cancers and normal mesothelium. Chang, K., Pastan, I., Willingham, M.C. Int. J. Cancer (1992) [Pubmed]
  30. The diagnostic utility of immunohistochemistry in distinguishing between mesothelioma and renal cell carcinoma: a comparative study. Ordóñez, N.G. Hum. Pathol. (2004) [Pubmed]
  31. Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver. Hornick, J.L., Lauwers, G.Y., Odze, R.D. Am. J. Surg. Pathol. (2005) [Pubmed]
  32. Forced expression of deltaN-TCF-1B in colon cancer derived cell lines is accompanied by the induction of CEACAM5/6 and mesothelin. Liebig, B., Brabletz, T., Staege, M.S., Wulfänger, J., Riemann, D., Burdach, S., Ballhausen, W.G. Cancer Lett. (2005) [Pubmed]
  33. Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer. Hassan, R., Remaley, A.T., Sampson, M.L., Zhang, J., Cox, D.D., Pingpank, J., Alexander, R., Willingham, M., Pastan, I., Onda, M. Clin. Cancer Res. (2006) [Pubmed]
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