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Chemical Compound Review

AC1L41UT     ethene; ethenyl ethanoate

Synonyms: 340502_ALDRICH, 437220_ALDRICH, 437239_ALDRICH, 437247_ALDRICH, 24937-78-8, ...
This record was replaced with 7904.
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Disease relevance of vinyl acetate


High impact information on vinyl acetate

  • A novel chemical sensor has been developed in which the polymer ethylene-vinyl acetate is used as a controlled-release system to deliver reagents to the sensing region of an optical fiber for a homogeneous competitive immunoassay based on fluorescence energy transfer [6].
  • In the present study, inhibition of the calcification of bioprosthetic heart valve cusps implanted subcutaneously in rats was achieved through the adjacent implantation of controlled-release matrices containing the anticalcification agent ethanehydroxydiphosphonate dispersed in a copolymer of ethylene-vinyl acetate [7].
  • We entrapped these migratory LCs by subcutaneous implantation of ethylene-vinyl-acetate (EVA) polymer rods releasing macrophage inflammatory protein (MIP)-3beta (to create an artificial gradient of an LC-attracting chemokine) and topical application of hapten (to trigger LC emigration from epidermis) [8].
  • Intracerebral microdialysis was used to evaluate the long-term in vivo release of dopamine from ethylene-vinyl acetate (EVAc)-dopamine copolymer matrix discs for up to 65 days following striatal implantation [9].
  • RESULTS: Postdeglycerolization in vitro RBC mass recoveries (mean +/- SD) were 96.8 +/- 5.7 and 94.7 +/- 5.6% for EVA LR and NLR units, respectively, and 97.3 +/- 6.2 and 94.7 +/- 6.2% for PVC LR and NLR units, based on unit weight and hematocrit after sampling for in vitro testing, immediately before glycerolization [2].

Biological context of vinyl acetate


Anatomical context of vinyl acetate

  • We manipulated the development of these currents in vivo by implanting a drug-infused slice of the ethylene-vinyl acetate copolymer Elvax over the superior colliculus of P8 rats to chronically release from this plastic low levels of N-methyl-D-aspartate (NMDA) [14].
  • Using computer-assisted epifluorescence microscopy, we have examined the local distribution of fluorescently labelled macromolecules released from an ethylene-vinyl acetate copolymer matrix into unstirred layers of phosphate-buffered water and mid-cycle human cervical mucus [15].
  • In the present study, we investigated the effect of dms released from ethylene vinyl acetate (EVAc) rods placed in acrylic copolymer capsules and implanted in the peritoneal cavity of rats [16].
  • When implanted intraperitoneally into rats, polymer capsules containing EVAc/dms rods generated a tissue reaction that was significantly thinner and featured fewer fibroblast and collagen layers than that around capsules containing pure EVAc rods at all time points studied [16].
  • The purpose of this work was (1) to develop extrudable ethylene-vinyl acetate (EVA) copolymer delivery systems capable of sustained release of bioactive proteins and (2) to determine the effect of platelet-derived growth factor (PDGF-BB) and/or transforming growth factor-beta2 (TGF-beta2) on human osteoblast proliferation and differentiation [17].

Associations of vinyl acetate with other chemical compounds


Gene context of vinyl acetate

  • We sought to investigate this issue by implanting ethylene-vinyl acetate copolymer pellets that slowly release VEGF into the vitreous cavity of rabbits and primates [22].
  • Ethylene-vinyl-acetate copolymer slow-release pellets containing either 250 ng, 500 ng or 1 microgram of hEGF or 250 ng of bovine serum albumin (BSA) were implanted into rabbit corneal stroma, and the corneas were examined by slitlamp biomicroscope for 3 weeks [23].
  • Continuous local application of exogenous IGF-I to the mouse cerebellum by means of ethylene-vinyl acetate copolymer (Elvax) significantly increased the degree of multiple CF innervation, when the IGF-I containing Elvax was implanted at postnatal day 8 (P8) [24].
  • CONCLUSION: With processing on the ACP 215 system, CPD/AS-5 LR and NLR thawed RBC units can be stored for up to 14 days after frozen storage at -65 degrees C or colder in EVA or PVC bags with acceptable in vivo and in vitro RBC quality [2].
  • The migration of active ingredients (AI) from conventional wettable powder formulations was complete within 1 day, while the migration from ethylene-vinyl acetate copolymeric matrix (EVA) lasted significantly longer due to low diffusion coefficients of monomeric pesticides in polymeric matrices Do = 10(-8)-10(-12) (cm2 X sec-1) [25].

Analytical, diagnostic and therapeutic context of vinyl acetate


  1. B16 melanoma metastasis to an "artificial organ" implant. Stackpole, C.W., Valle, E.F., Alterman, A.L. Cancer Res. (1991) [Pubmed]
  2. Successful in vivo recovery and extended storage of additive solution (AS)-5 red blood cells after deglycerolization and resuspension in AS-3 for 15 days with an automated closed system. Bandarenko, N., Cancelas, J., Snyder, E.L., Hay, S.N., Rugg, N., Corda, T., Joines, A.D., Gormas, J.F., Pratt, G.P., Kowalsky, R., Rose, M., Rose, L., Foley, J., Popovsky, M.A. Transfusion (2007) [Pubmed]
  3. Interstitial delivery of dexamethasone in the brain for the reduction of peritumoral edema. Tamargo, R.J., Sills, A.K., Reinhard, C.S., Pinn, M.L., Long, D.M., Brem, H. J. Neurosurg. (1991) [Pubmed]
  4. Effect of gonadal steroids on bone and other physiological parameters of male broiler chickens. Rath, N.C., Huff, W.E., Balog, J.M., Bayyari, G.R. Poult. Sci. (1996) [Pubmed]
  5. Mobilization of chrysene from soil in a model digestive system. Minhas, J.K., Vasiluk, L., Pinto, L.J., Gobas, F.A., Moore, M.M. Environ. Toxicol. Chem. (2006) [Pubmed]
  6. Chemical sensors based on controlled-release polymer systems. Barnard, S.M., Walt, D.R. Science (1991) [Pubmed]
  7. Inhibition of calcification of bioprosthetic heart valves by local controlled-release diphosphonate. Levy, R.J., Wolfrum, J., Schoen, F.J., Hawley, M.A., Lund, S.A., Langer, R. Science (1985) [Pubmed]
  8. Induction of tumor-specific protective immunity by in situ Langerhans cell vaccine. Kumamoto, T., Huang, E.K., Paek, H.J., Morita, A., Matsue, H., Valentini, R.F., Takashima, A. Nat. Biotechnol. (2002) [Pubmed]
  9. Controlled release of dopamine from a polymeric brain implant: in vivo characterization. During, M.J., Freese, A., Sabel, B.A., Saltzman, W.M., Deutch, A., Roth, R.H., Langer, R. Ann. Neurol. (1989) [Pubmed]
  10. Effect of plastic containers on liquid preservation of human granulocytes. I. With and without deoxyribonuclease and hydrocortisone. Contreras, T.J., Jemionek, J.F., French, J.E., Shields, L.J. Transfusion (1980) [Pubmed]
  11. Bioavailability studies of theophylline ethylcellulose microcapsules prepared by using ethylene-vinyl acetate copolymer as a coacervation-inducing agent. Lin, S.Y., Yang, J.C. Journal of pharmaceutical sciences. (1987) [Pubmed]
  12. Effects of atmospheric plasma treatment on the interfacial characteristics of ethylene-vinyl acetate/polyurethane composites. Kim, J.S., Kim, Y.K., Lee, K.H. Journal of colloid and interface science. (2004) [Pubmed]
  13. Enhanced transdermal delivery of atenolol from the ethylene-vinyl acetate matrix. Cho, C.W., Shin, S.C. International journal of pharmaceutics. (2004) [Pubmed]
  14. Chronic NMDA exposure accelerates development of GABAergic inhibition in the superior colliculus. Aamodt, S.M., Shi, J., Colonnese, M.T., Veras, W., Constantine-Paton, M. J. Neurophysiol. (2000) [Pubmed]
  15. Macromolecules released from polymers: diffusion into unstirred fluids. Radomsky, M.L., Whaley, K.J., Cone, R.A., Saltzman, W.M. Biomaterials (1990) [Pubmed]
  16. Mast cells and tissue reaction to intraperitoneally implanted polymer capsules. Christenson, L., Wahlberg, L., Aebischer, P. J. Biomed. Mater. Res. (1991) [Pubmed]
  17. Human osteoblast response in vitro to platelet-derived growth factor and transforming growth factor-beta delivered from controlled-release polymer rods. Kim, H.D., Valentini, R.F. Biomaterials (1997) [Pubmed]
  18. A type of esophageal stent coating composed of one 5-fluorouracil-containing EVA layer and one drug-free protective layer: In vitro release, permeation and mechanical properties. Guo, Q., Guo, S., Wang, Z. Journal of controlled release : official journal of the Controlled Release Society (2007) [Pubmed]
  19. Mouthguards in sport activities : history, physical properties and injury prevention effectiveness. Knapik, J.J., Marshall, S.W., Lee, R.B., Darakjy, S.S., Jones, S.B., Mitchener, T.A., Delacruz, G.G., Jones, B.H. Sports medicine (Auckland, N.Z.) (2007) [Pubmed]
  20. Calibration models for the vinyl acetate concentration in ethylene-vinyl acetate copolymers and its on-line monitoring by near-infrared spectroscopy and chemometrics: use of band shifts associated with variations in the vinyl acetate concentration to improve the models. Watari, M., Ozaki, Y. Applied spectroscopy. (2005) [Pubmed]
  21. Interaction between polymeric materials and tissue -- biodeterioration of polymeric materials. Kojima, K. Bull. Tokyo Med. Dent. Univ. (1975) [Pubmed]
  22. Intravitreal sustained release of VEGF causes retinal neovascularization in rabbits and breakdown of the blood-retinal barrier in rabbits and primates. Ozaki, H., Hayashi, H., Vinores, S.A., Moromizato, Y., Campochiaro, P.A., Oshima, K. Exp. Eye Res. (1997) [Pubmed]
  23. Recombinant human epidermal growth factor and corneal neovascularization. Nezu, E., Ohashi, Y., Kinoshita, S., Manabe, R. Jpn. J. Ophthalmol. (1992) [Pubmed]
  24. Effects of insulin-like growth factor I on climbing fibre synapse elimination during cerebellar development. Kakizawa, S., Yamada, K., Iino, M., Watanabe, M., Kano, M. Eur. J. Neurosci. (2003) [Pubmed]
  25. A comparative study on pesticide formulations for application in running waters. Bahadir, M., Pfister, G. Ecotoxicol. Environ. Saf. (1985) [Pubmed]
  26. Local delivery of the topoisomerase I inhibitor camptothecin sodium prolongs survival in the rat intracranial 9L gliosarcoma model. Weingart, J.D., Thompson, R.C., Tyler, B., Colvin, O.M., Brem, H. Int. J. Cancer (1995) [Pubmed]
  27. Ethylene-vinyl acetate copolymer microspheres for controlled release of macromolecules. Sefton, M.V., Brown, L.R., Langer, R.S. Journal of pharmaceutical sciences. (1984) [Pubmed]
  28. Mechanism of diffusion of monosubstituted benzoic acids through ethylene-vinyl acetate copolymers. Maurin, M.B., Dittert, L.W., Hussain, A.A. Journal of pharmaceutical sciences. (1992) [Pubmed]
  29. Control of n-alkanes crystallization by ethylene-vinyl acetate copolymers. Marie, E., Chevalier, Y., Eydoux, F., Germanaud, L., Flores, P. Journal of colloid and interface science. (2005) [Pubmed]
  30. Clinical acceptability of an ethylene-vinyl-acetate nonmedicated vaginal ring. Roumen, F.J., Dieben, T.O. Contraception. (1999) [Pubmed]
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