Disease relevance of calcium dioxido-oxo-silane

• Wollastonite exposure and lung fibrosis [1].
• Pulmonary toxicity of wollastonite in vivo and in vitro [2].
• The epidemiological evidence for wollastonite is limited, but does not suggest that workers are at significant risk of an increased incidence of pulmonary fibrosis, lung cancer, or mesothelioma [3].
• We have produced a ferromagnetic glass-ceramic composed of magnetite and wollastonite as a thermoseed for interstitial hyperthermia [4].
• That influenza virus multiplied in wollastonite-treated cells to a level that was sevenfold less than that in normal cells was associated with increased interferon production [5].

High impact information on calcium dioxido-oxo-silane

• We found that the patterns of time-dependent increase of CL (sigmoid type) were similar for each sample except wollastonite [6].
• Instillation of RPMI 1640 medium or wollastonite for 24 h induced apoptosis in 0.1 +/- 0 [7].
• Results demonstrated that chrysotile and crocidolite asbestos, as well as crystalline silica, but not titanium dioxide or wollastonite, increased the RFD1+ phenotype (inducer or immune activator macrophages) and decreased the RFD1+ RFD7+ phenotype (suppressor macrophages) [8].
• The elimination kinetics of wollastonite fibers from the lung were relatively fast, with half-times of 15 to 21 days [9].
• The behaviour of bone tissue around wollastonite coatings were examined by histological and SEM observation [10].

Chemical compound and disease context of calcium dioxido-oxo-silane

• In the present paper, the toxicity of three samples of Indian wollastonite was compared to that of chrysotile [11].
• The group of wollastonite workers with radiological signs of pulmonary fibrosis had activities of serum angiotensin-converting enzyme that were similar to those of wollastonite workers without fibrosis [12].
• Rats with experimental osteopenia, which was induced by resecting both ovaries and sciatic nerves (OVX + NX), were used to evaluate osteoconduction of an apatite and wollastonite-containing glass-ceramic (designated A-W.GC) and an alumina ceramic [13].

Biological context of calcium dioxido-oxo-silane

• The in vivo rat absorption study showed that Florite RE 10 mg preparation had the highest C(max) (2.14+/-0.67 microg/ml) and AUC (4.74+/-1.21 microg h/ml) [14].
• The test in marrow indicated that wollastonite coatings could induce new bone formation on their surface showing good bone inductivity property [10].
• The aim of the present study was to improve the solubility and oral bioavailability of a poorly water-soluble drug, 3-bis(4-methoxyphenyl) methylene-2-indolinone (TAS-301), by its melt-adsorption on a porous calcium silicate, Florite RE (FLR), without any solvents [15].
• We conclude that there is inadequate evidence for the carcinogenicity of wollastonite in animals and, based on strong evidence that wollastonite is not biopersistent, believe that a well-designed animal inhalation bioassay would have a negative result [3].
• A review of the toxicology and epidemiology of wollastonite [3].

Anatomical context of calcium dioxido-oxo-silane

• Mechanism of apatite formation on wollastonite coatings in simulated body fluids [16].
• Wollastonite fibers were also analyzed for their ability to lyse erythrocytes and activate complement [17].
• Bonding behavior of a glass-ceramic containing apatite and wollastonite in segmental replacement of the rabbit tibia under load-bearing conditions [18].
• Effects of apatite and wollastonite containing glass-ceramic powder and two types of alumina powder in composites on osteoblastic differentiation of bone marrow cells [19].
• We examined the behavior of fetal rat chondrocytes cultured on a bioactive glass-ceramic containing apatite and wollastonite (A.W.G.C.). Biomaterial surface topography and profiles were evaluated by bidimensional profilometry and revealed a rough surface for the glass-ceramic compared to the plastic coverslips used as controls [20].

Associations of calcium dioxido-oxo-silane with other chemical compounds

• Other preparations had C(max) and AUC of 0.69+/-0.10 microg/ml and 1.56+/-0.43 microg h/ml for Florite RE 20 mg, 1.07+/-0.31 microg/ml and 1.80+/-0.33 microg h/ml for Neusilin US2, and 0.99+/-0.21 microg/ml and 1.77+/-0.50 micorg h/ml for Sylysia 320, respectively [14].
• The microporous calcium silicate preparation using Florite RE 10 mg was evaluated in dogs after oral administration in an enteric capsule, Eudragit S100 (50 mg/dog) [14].
• Carbonate-containing hydroxyapatite (CHA) layer was formed on the surface of the wollastonite and W7T3 coatings soaked in simulated body fluid, while was not formed on the surface of the TiO2 and W3T7 coatings after immersion [21].
• Preparation, characterization and in vitro release of gentamicin from PHBV/wollastonite composite microspheres [22].
• The results showed a carbonate-containing hydroxyapatite layer formed on the surface of a plasma-sprayed wollastonite coating soaked in simulated body fluids, and a silica-rich layer appeared on the surface of the coating before the formation of the carbonate-containing hydroxyapatite layer [23].

Gene context of calcium dioxido-oxo-silane

• Wollastonite decreased only the activity of gamma-glutamyl transpeptidase and glutathione peroxidase [2].
• We investigated the differences between the lavage parameters -- including tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) release by lavage leukocytes -- in control rats and in animals intratracheally instilled with short and long amosite and wollastonite fibres [24].
• Composites of PBT with wollastonite in two different proportions, viz [25].
• The (29)Si MAS NMR spectra of rankinite and wollastonite clearly resolve manifolds of spinning sidebands from two and three Si sites, respectively, allowing the CSA parameters to be obtained with high precision for each site [26].
• Meloxicam was adsorbed on the Florite RE (FLR) by fast evaporation of solvent from drug solution containing dispersed FLR [27].

Analytical, diagnostic and therapeutic context of calcium dioxido-oxo-silane

• Bioactive glass-ceramic containing crystalline apatite and wollastonite initiates biomineralization in bone cell cultures [28].
• Mono-phase glass-ceramics of akermanite were successfully produced from a Ca-mica and wollastonite via low-temperature sintering and crystallization [29].
• Composite microspheres have been prepared from bioactive wollastonite (W) and biodegradable poly (hydroxybutyrate-polyhydroxyvalerate) (PHBV) in the present study [22].
• The scanning electron microscopy observation showed that the addition of wollastonite promote the proliferation of osteoblast [21].
• The surface structures of wollastonite coatings immersed in simulated body fluids were analyzed with scanning electron microscopy, Auger electron spectroscopy, and transmission electron microscopy [23].

References