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Chemical Compound Review

cefmetazole     (6R,7R)-7-[2- (cyanomethylsulfanyl) ethanoyl...

Synonyms: Cefmetazolo, Cefmetazolum, SureCN147832, CHEBI:3489, CHEMBL1201195, ...
 
 
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Disease relevance of CS 1170

 

High impact information on CS 1170

 

Chemical compound and disease context of CS 1170

 

Biological context of CS 1170

 

Anatomical context of CS 1170

  • Persistent infection was documented in lymph nodes of untreated rabbits; no evidence of latent infection was found in penicillin- or cefmetazole-treated animals [18].
  • The mean plasma levels of cefmetazole at the start and end of surgery (8.9 +/- 2.4 and 31.7 +/- 6.4 min after dosage) were 21.1 and 59.0 micrograms/ml, respectively; concentrations of the drug were 14.6 and 4,486.9 micrograms/g in skin, 9,165.0 and 1,756.4 micrograms/g in subcutaneous tissue, and 8,669.6 and 2,022.9 micrograms/g in muscle [19].
  • This study evaluated the pharmacokinetics of cefmetazole, including its intravascular and interstitial fluid distribution, by using the skin window (SW) technique [14].
  • The effects produced by three beta-lactamic antibiotics (N-formimidoyl thienamycin or imipenem, cefmetazole and cefoxitin) in vitro on protein carboxylmethylation, cAMP and cGMP levels in human polymorphonuclear neutrophils were studied [20].
  • As well as drug metabolism, the drug excretion was demonstrated to be humanized because cefmetazole was mainly excreted in urine both in the chimeric mice and human but in feces in control uPA-/-/SCID mice [21].
 

Associations of CS 1170 with other chemical compounds

 

Gene context of CS 1170

  • In six subjects with creatinine clearance (CLCR) of greater than 90 ml/min per 1.73 m2 (group 1), the terminal elimination half-life (t1/2 beta) was 1.31 +/- 0.54 h (mean +/- standard deviation), cefmetazole total body clearance (CLP) was 132.8 +/- 25.1 ml/min per 1.73 m2, and volume of distribution at steady state was 0.165 +/- 0.025 liter/kg [26].
  • The principal adverse effect noted in the adult rats receiving the largest doses (2000 and 2500 mg/kg/day) of cefmetazole was slight elevation of serum alanine aminotransferase [16].
  • Cefmetazole is also active against beta-lactamase-producing organisms that are resistant to first-generation cephalosporins or penicillins [27].
  • The bioavailability of cefmetazole, determined by area under the blood concentration curve method, increased 20 to 30% by the coadministration of calmodulin inhibitors [28].
  • Isolation of enterotoxin-producing Clostridium sporogenes from cefmetazole-associated diarrheic rabbit [29].
 

Analytical, diagnostic and therapeutic context of CS 1170

References

  1. Sub-minimal inhibitory concentrations of cefmetazole enhance serum bactericidal activity in vitro by amplifying poly-C9 deposition. Schweinle, J.E., Nishiyasu, M. J. Clin. Invest. (1992) [Pubmed]
  2. Activity of cefmetazole against anaerobic bacteria. Cornick, N.A., Jacobus, N.V., Gorbach, S.L. Antimicrob. Agents Chemother. (1987) [Pubmed]
  3. Use of cephalosporins for prophylaxis and therapy of polymicrobial infection in mice. Brook, I. Antimicrob. Agents Chemother. (1993) [Pubmed]
  4. Biliary excretion and choleretic effect of cefmetazole in rats. Gonzalez, J., Fernandez, C., Marińo, E., Morales, A., Jimenez, R. Antimicrob. Agents Chemother. (1989) [Pubmed]
  5. Peptidoglycan synthetic activities in membranes of Escherichia coli caused by overproduction of penicillin-binding protein 2 and rodA protein. Ishino, F., Park, W., Tomioka, S., Tamaki, S., Takase, I., Kunugita, K., Matsuzawa, H., Asoh, S., Ohta, T., Spratt, B.G. J. Biol. Chem. (1986) [Pubmed]
  6. beta-Lactamase-mediated inactivation and efficacy of cefazolin and cefmetazole in Staphylococcus aureus abscesses. Fields, M.T., Herndon, B.L., Bamberger, D.M. Antimicrob. Agents Chemother. (1993) [Pubmed]
  7. Inhibition of biliary cholesterol and phospholipid secretion by cefmetazole. The role of vesicular transport and of canalicular events. Cava, F., Gonzalez, J., Gonzalez-Buitrago, J.M., Muriel, C., Jimenez, R. Biochem. J. (1991) [Pubmed]
  8. Susceptibility to cephalosporins of penicillin-susceptible and penicillin-resistant strains of Neisseria gonorrhoeae from Philadelphia. Fekete, T., Serfass, D.A., Lafredo, S.C., Cundy, K.R. Antimicrob. Agents Chemother. (1989) [Pubmed]
  9. Significance of inducible cephalosporinase remaining in the experimentally infected rat granuloma pouch after beta-lactam therapy. Araki, H., Minami, S., Watanabe, Y., Yasuda, T. Antimicrob. Agents Chemother. (1991) [Pubmed]
  10. In vitro and in vivo antibacterial activity of T-1982, a new semisynthetic cephamycin antibiotic. Tai, M., Fukuoka, Y., Yotsuji, A., Kumano, K., Takahata, M., Mikami, H., Yasuda, T., Saikawa, I., Mitsuhashi, S. Antimicrob. Agents Chemother. (1982) [Pubmed]
  11. Susceptibilities of species of the Bacteroides fragilis group to 10 antimicrobial agents. Betriu, C., Campos, E., Cabronero, C., Rodriguez-Avial, C., Picazo, J.J. Antimicrob. Agents Chemother. (1990) [Pubmed]
  12. Quality control guidelines for cefdinir, cefepime, cefetamet, cefmetazole, cefpodoxime, cefprozil, and clinafloxacin (CI-960) for various National Committee for Clinical Laboratory Standards susceptibility testing methods. Quality Control Study Group. Bale, M.J., Jones, R.N. J. Clin. Microbiol. (1993) [Pubmed]
  13. Pharmacokinetics of cefmetazole administered intramuscularly and intravenously to healthy adults. Rodriguez-Barbero, J., Mariño, E.L., Dominguez-Gil, A. Antimicrob. Agents Chemother. (1985) [Pubmed]
  14. Pharmacokinetics of intravenous cefmetazole with emphasis on comparison between predicted theoretical levels in tissue and actual skin window fluid levels. Tan, J.S., Salstrom, S.J., Signs, S.A., Hoffman, H.E., File, T.M. Antimicrob. Agents Chemother. (1989) [Pubmed]
  15. Cefmetazole treatment of intra-abdominal infection. Holloway, W.J., Winslow, D.L., Reinhardt, J.F. J. Antimicrob. Chemother. (1989) [Pubmed]
  16. Preclinical safety studies of cefmetazole. Moe, J.B., Piper, R.C., Tanase, H., Sotani, K., Manabe, J. J. Antimicrob. Chemother. (1989) [Pubmed]
  17. Influence of timing of antibiotic administration on tissue concentrations during surgery. Wong-Beringer, A., Corelli, R.L., Schrock, T.R., Guglielmo, B.J. Am. J. Surg. (1995) [Pubmed]
  18. Efficacy of cefmetazole in the treatment of active syphilis in the rabbit model. Baker-Zander, S.A., Lukehart, S.A. Antimicrob. Agents Chemother. (1989) [Pubmed]
  19. Concentrations of cefmetazole in plasma and tissue resulting from peri-incisional administration before appendectomy. Rodríguez, J.R., Mariño, E.L., Otero, M.J., Commes, J.R., Garcia, J., Rodriguez, J.M., Lozano, F., Dominguez-Gil, A., Alonso, A.G. Antimicrob. Agents Chemother. (1984) [Pubmed]
  20. Mechanisms of action involved in the chemoattractant activity of three beta-lactamic antibiotics upon human neutrophils. Rodriguez, A.B., Barriga, C., De la Fuente, M. Biochem. Pharmacol. (1991) [Pubmed]
  21. Application of chimeric mice with humanized liver for predictive ADME. Katoh, M., Yokoi, T. Drug Metab. Rev. (2007) [Pubmed]
  22. Pharmacokinetics of intravenously administered cefmetazole and cefoxitin and effects of probenecid on cefmetazole elimination. Ko, H., Cathcart, K.S., Griffith, D.L., Peters, G.R., Adams, W.J. Antimicrob. Agents Chemother. (1989) [Pubmed]
  23. Production of low-affinity penicillin-binding protein by low- and high-resistance groups of methicillin-resistant Staphylococcus aureus. Murakami, K., Nomura, K., Doi, M., Yoshida, T. Antimicrob. Agents Chemother. (1987) [Pubmed]
  24. Comparison of single-dose cefmetazole and cefotetan prophylaxis in women undergoing primary caesarean section. Galask, R.P., Weiner, C., Petzold, C.R. J. Antimicrob. Chemother. (1989) [Pubmed]
  25. The effects of cefmetazole and latamoxef on platelet function in healthy human volunteers. Peters, G.R., Metzler, C.M. J. Antimicrob. Chemother. (1989) [Pubmed]
  26. Disposition of cefmetazole in healthy volunteers and patients with impaired renal function. Halstenson, C.E., Guay, D.R., Opsahl, J.A., Hirata, C.A., Olanoff, L.S., Novak, E., Ko, H., Cathcart, K.S., Matzke, G.R. Antimicrob. Agents Chemother. (1990) [Pubmed]
  27. Cefmetazole sodium: pharmacology, pharmacokinetics, and clinical trials. Schentag, J.J. Pharmacotherapy (1991) [Pubmed]
  28. Effects of phenothiazines and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide on rat colonic absorption of cefmetazole. Suzuka, T., Furuya, A., Kamada, A., Nishihata, T. J. Pharmacobio-dyn. (1986) [Pubmed]
  29. Isolation of enterotoxin-producing Clostridium sporogenes from cefmetazole-associated diarrheic rabbit. Hara, Y., Igimi, S., Kasuga, F., Ogura, A., Nagaoka, Y., Takahashi, S., Mizuno, S. J. Vet. Med. Sci. (1991) [Pubmed]
  30. High-performance liquid chromatographic method for determination of cefmetazole in human serum. Sekine, M., Sasahara, K., Kojima, T., Morioka, T. Antimicrob. Agents Chemother. (1982) [Pubmed]
  31. Pharmacokinetics and dose proportionality of cefmetazole in healthy young and elderly volunteers. Borin, M.T., Peters, G.R., Smith, T.C. Antimicrob. Agents Chemother. (1990) [Pubmed]
 
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