Gene Review:
Rdh5 - retinol dehydrogenase 5
Mus musculus
Synonyms:
11-cis RDH, 11-cis RoDH, 11-cis retinol dehydrogenase, 9-cis, 9-cis retinol dehydrogenase, ...
- Targeted disruption of the mouse cis-retinol dehydrogenase gene: visual and nonvisual functions. Shang, E., Lai, K., Packer, A.I., Paik, J., Blaner, W.S., de Morais Vieira, M., Gouras, P., Wolgemuth, D.J. J. Lipid Res. (2002)
- 9-cis-retinoids: biosynthesis of 9-cis-retinoic acid. Paik, J., Vogel, S., Piantedosi, R., Sykes, A., Blaner, W.S., Swisshelm, K. Biochemistry (2000)
- Inhibitory effects of 9-cis and all-trans retinoic acid on 1,25(OH)2 vitamin D3-induced bone resorption. Kindmark, A., Melhus, H., Ljunghall, S., Ljunggren, O. Calcif. Tissue Int. (1995)
- The low-toxicity 9-cis UAB30 novel retinoid down-regulates the DNA methyltransferases and has anti-telomerase activity in human breast cancer cells. Hansen, N.J., Wylie, R.C., Phipps, S.M., Love, W.K., Andrews, L.G., Tollefsbol, T.O. Int. J. Oncol. (2007)
- Efficacy of all-trans-beta-carotene, canthaxanthin, and all-trans-, 9-cis-, and 4-oxoretinoic acids in inducing differentiation of an F9 embryonal carcinoma RAR beta-lacZ reporter cell line. Nikawa, T., Schulz, W.A., van den Brink, C.E., Hanusch, M., van der Saag, P., Stahl, W., Sies, H. Arch. Biochem. Biophys. (1995)
- Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Mangelsdorf, D.J., Borgmeyer, U., Heyman, R.A., Zhou, J.Y., Ong, E.S., Oro, A.E., Kakizuka, A., Evans, R.M. Genes Dev. (1992)
- Effect of dietary 18-carbon fatty acids on growth of transplantable mammary adenocarcinomas in mice. Abraham, S., Hillyard, L.A. J. Natl. Cancer Inst. (1983)
- Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos. Fujii, H., Sato, T., Kaneko, S., Gotoh, O., Fujii-Kuriyama, Y., Osawa, K., Kato, S., Hamada, H. EMBO J. (1997)
- Characterization of a premeiotic germ cell-specific cytoplasmic protein encoded by Stra8, a novel retinoic acid-responsive gene. Oulad-Abdelghani, M., Bouillet, P., Décimo, D., Gansmuller, A., Heyberger, S., Dollé, P., Bronner, S., Lutz, Y., Chambon, P. J. Cell Biol. (1996)
- Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity. Durand, B., Saunders, M., Gaudon, C., Roy, B., Losson, R., Chambon, P. EMBO J. (1994)
- The identification of a 9-cis retinol dehydrogenase in the mouse embryo reveals a pathway for synthesis of 9-cis retinoic acid. Romert, A., Tuvendal, P., Simon, A., Dencker, L., Eriksson, U. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivo. Kim, T.S., Maeda, A., Maeda, T., Heinlein, C., Kedishvili, N., Palczewski, K., Nelson, P.S. J. Biol. Chem. (2005)
- Biochemical properties, tissue expression, and gene structure of a short chain dehydrogenase/ reductase able to catalyze cis-retinol oxidation. Gamble, M.V., Shang, E., Zott, R.P., Mertz, J.R., Wolgemuth, D.J., Blaner, W.S. J. Lipid Res. (1999)
- Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo. Maeda, T., Van Hooser, J.P., Driessen, C.A., Filipek, S., Janssen, J.J., Palczewski, K. J. Neurochem. (2003)
- Gene structure, expression analysis, and membrane topology of RDH4. Romert, A., Tuvendal, P., Tryggvason, K., Dencker, L., Eriksson, U. Exp. Cell Res. (2000)
- Quantitative axial profiles of retinoic acid in the embryonic mouse spinal cord: 9-cis retinoic acid only detected after all-trans-retinoic acid levels are super-elevated experimentally. Ulven, S.M., Gundersen, T.E., Sakhi, A.K., Glover, J.C., Blomhoff, R. Dev. Dyn. (2001)
- Modulation of resistin expression by retinoic acid and vitamin A status. Felipe, F., Bonet, M.L., Ribot, J., Palou, A. Diabetes (2004)
- Identification and characterization of a stereospecific human enzyme that catalyzes 9-cis-retinol oxidation. A possible role in 9-cis-retinoic acid formation. Mertz, J.R., Shang, E., Piantedosi, R., Wei, S., Wolgemuth, D.J., Blaner, W.S. J. Biol. Chem. (1997)
- Distinct binding determinants for 9-cis retinoic acid are located within AF-2 of retinoic acid receptor alpha. Tate, B.F., Allenby, G., Janocha, R., Kazmer, S., Speck, J., Sturzenbecker, L.J., Abarzúa, P., Levin, A.A., Grippo, J.F. Mol. Cell. Biol. (1994)
- Cloning of a cDNA encoding rat aldehyde dehydrogenase with high activity for retinal oxidation. Bhat, P.V., Labrecque, J., Boutin, J.M., Lacroix, A., Yoshida, A. Gene (1995)
- The oxidation of 9-cis-retinol: a possible synthesis pathway for 9-cis-retinoic acid. Wolf, G. Nutr. Rev. (2000)
- 9-cis-retinoic acid regulates the expression of the muscle determination gene Myf5. Carnac, G., Albagli-Curiel, O., Levin, A., Bonnieu, A. Endocrinology (1993)
- Characterization of synthetic retinoids with selectivity for retinoic acid or retinoid X nuclear receptors. LeMotte, P.K., Keidel, S., Apfel, C.M. Biochim. Biophys. Acta (1996)
- Role of FXR in regulating bile acid homeostasis and relevance for human diseases. Rizzo, G., Renga, B., Mencarelli, A., Pellicciari, R., Fiorucci, S. Curr. Drug Targets Immune Endocr. Metabol. Disord. (2005)
- Targeted disruption of the murine retinal dehydrogenase gene rdh12 does not limit visual cycle function. Kurth, I., Thompson, D.A., Rüther, K., Feathers, K.L., Chrispell, J.D., Schroth, J., McHenry, C.L., Schweizer, M., Skosyrski, S., Gal, A., Hübner, C.A. Mol. Cell. Biol. (2007)
- Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid. Ulven, S.M., Gundersen, T.E., Weedon, M.S., Landaas, V.O., Sakhi, A.K., Fromm, S.H., Geronimo, B.A., Moskaug, J.O., Blomhoff, R. Dev. Biol. (2000)
- Ligand-dependent activation of transcription in vitro by retinoic acid receptor alpha/retinoid X receptor alpha heterodimers that mimics transactivation by retinoids in vivo. Dilworth, F.J., Fromental-Ramain, C., Remboutsika, E., Benecke, A., Chambon, P. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway. Stephensen, C.B., Rasooly, R., Jiang, X., Ceddia, M.A., Weaver, C.T., Chandraratna, R.A., Bucy, R.P. J. Immunol. (2002)
- Vitamin A down-regulation of IFN-gamma synthesis in cloned mouse Th1 lymphocytes depends on the CD28 costimulatory pathway. Cantorna, M.T., Nashold, F.E., Chun, T.Y., Hayes, C.E. J. Immunol. (1996)
- Effect of all-trans and 9-cis retinoic acid on growth and metastasis of xenotransplanted canine osteosarcoma cells in athymic mice. Hong, S.H., Kadosawa, T., Mochizuki, M., Matsunaga, S., Nishimura, R., Sasaki, N. Am. J. Vet. Res. (2000)