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Gene Review

Prkcb  -  protein kinase C, beta

Mus musculus

Synonyms: A130082F03Rik, PKC-B, PKC-Beta, PKC-beta, Pkcb, ...
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Disease relevance of Prkcb1


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Chemical compound and disease context of Prkcb1


Biological context of Prkcb1


Anatomical context of Prkcb1


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Regulatory relationships of Prkcb1


Other interactions of Prkcb1


Analytical, diagnostic and therapeutic context of Prkcb1


  1. PKCbeta regulates ischemia/reperfusion injury in the lung. Fujita, T., Asai, T., Andrassy, M., Stern, D.M., Pinsky, D.J., Zou, Y.S., Okada, M., Naka, Y., Schmidt, A.M., Yan, S.F. J. Clin. Invest. (2004) [Pubmed]
  2. Reduction of Diabetes-Induced Oxidative Stress, Fibrotic Cytokine Expression, and Renal Dysfunction in Protein Kinase C{beta}-Null Mice. Ohshiro, Y., Ma, R.C., Yasuda, Y., Hiraoka-Yamamoto, J., Clermont, A.C., Isshiki, K., Yagi, K., Arikawa, E., Kern, T.S., King, G.L. Diabetes (2006) [Pubmed]
  3. Protein kinase C-beta and oxygen deprivation. A novel Egr-1-dependent pathway for fibrin deposition in hypoxemic vasculature. Yan, S.F., Lu, J., Zou, Y.S., Kisiel, W., Mackman, N., Leitges, M., Steinberg, S., Pinsky, D., Stern, D. J. Biol. Chem. (2000) [Pubmed]
  4. Deletion of Protein Kinase C-{beta} Isoform In Vivo Reduces Renal Hypertrophy but Not Albuminuria in the Streptozotocin-Induced Diabetic Mouse Model. Meier, M., Park, J.K., Overheu, D., Kirsch, T., Lindschau, C., Gueler, F., Leitges, M., Menne, J., Haller, H. Diabetes (2007) [Pubmed]
  5. PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. Su, T.T., Guo, B., Kawakami, Y., Sommer, K., Chae, K., Humphries, L.A., Kato, R.M., Kang, S., Patrone, L., Wall, R., Teitell, M., Leitges, M., Kawakami, T., Rawlings, D.J. Nat. Immunol. (2002) [Pubmed]
  6. Protein kinase C beta II mRNA levels decrease in the striatum and cortex of transgenic Huntington's disease mice. Harris, A.S., Denovan-Wright, E.M., Hamilton, L.C., Robertson, H.A. Journal of psychiatry & neuroscience : JPN. (2001) [Pubmed]
  7. Interleukin-2 induces proliferation of T lymphocyte mutants lacking protein kinase C. Mills, G.B., Girard, P., Grinstein, S., Gelfand, E.W. Cell (1988) [Pubmed]
  8. PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1. Shinohara, H., Yasuda, T., Aiba, Y., Sanjo, H., Hamadate, M., Watarai, H., Sakurai, H., Kurosaki, T. J. Exp. Med. (2005) [Pubmed]
  9. Epidermal protein kinase C-beta 2 is highly sensitive to downregulation and is exclusively expressed in Langerhans cells: downregulation is associated with attenuated contact hypersensitivity. Goodell, A.L., Oh, H.S., Meyer, S.A., Smart, R.C. J. Invest. Dermatol. (1996) [Pubmed]
  10. Palmitoylcarnitine modulates interaction protein kinase C delta-GAP-43. Sobiesiak-Mirska, J., Nałecz, K.A. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  11. Inhibition of degranulation and interleukin-6 production in mast cells derived from mice deficient in protein kinase Cbeta. Nechushtan, H., Leitges, M., Cohen, C., Kay, G., Razin, E. Blood (2000) [Pubmed]
  12. Erythropoietin stimulates nuclear localization of diacylglycerol and protein kinase C beta II in B6SUt.EP cells. Mallia, C.M., Smith, M., Clejan, S., Beckman, B.S. Journal of lipid mediators and cell signalling. (1997) [Pubmed]
  13. Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates. Bowman, J.C., Steinberg, S.F., Jiang, T., Geenen, D.L., Fishman, G.I., Buttrick, P.M. J. Clin. Invest. (1997) [Pubmed]
  14. PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization. Kang, S.W., Wahl, M.I., Chu, J., Kitaura, J., Kawakami, Y., Kato, R.M., Tabuchi, R., Tarakhovsky, A., Kawakami, T., Turck, C.W., Witte, O.N., Rawlings, D.J. EMBO J. (2001) [Pubmed]
  15. Retinoic acid-induced transition from protein kinase C beta to protein kinase C alpha in differentiated F9 cells: correlation with altered regulation of proto-oncogene expression by phorbol esters. Khuri, F.R., Cho, Y., Talmage, D.A. Cell Growth Differ. (1996) [Pubmed]
  16. Protein kinase C activation in human monocytes: regulation of PKC isoforms. Chang, Z.L., Beezhold, D.H. Immunology (1993) [Pubmed]
  17. Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a. Wada, H., Ohno, S., Kubo, K., Taya, C., Tsuji, S., Yonehara, S., Suzuki, K. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  18. Characterization of conventional protein kinase C (PKC) isotype expression during F9 teratocarcinoma differentiation. Overexpression of PKC alpha alters the expression of some differentiation-dependent genes. Kindregan, H.C., Rosenbaum, S.E., Ohno, S., Niles, R.M. J. Biol. Chem. (1994) [Pubmed]
  19. Overexpression of protein kinase C isoforms protects RAW 264.7 macrophages from nitric oxide-induced apoptosis: involvement of c-Jun N-terminal kinase/stress-activated protein kinase, p38 kinase, and CPP-32 protease pathways. Jun, C.D., Oh, C.D., Kwak, H.J., Pae, H.O., Yoo, J.C., Choi, B.M., Chun, J.S., Park, R.K., Chung, H.T. J. Immunol. (1999) [Pubmed]
  20. Mobilization of protein kinase C in macrophages induced by Listeria monocytogenes affects its internalization and escape from the phagosome. Wadsworth, S.J., Goldfine, H. Infect. Immun. (2002) [Pubmed]
  21. Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion. Kawakami, Y., Nishimoto, H., Kitaura, J., Maeda-Yamamoto, M., Kato, R.M., Littman, D.R., Leitges, M., Rawlings, D.J., Kawakami, T. J. Biol. Chem. (2004) [Pubmed]
  22. Evidence for a role of protein kinase C-alpha in urine concentration. Yao, L., Huang, D.Y., Pfaff, I.L., Nie, X., Leitges, M., Vallon, V. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  23. B cell immunity regulated by the protein kinase C family. Saijo, K., Mecklenbräuker, I., Schmedt, C., Tarakhovsky, A. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  24. Different regulation of Purkinje cell dendritic development in cerebellar slice cultures by protein kinase Calpha and -beta. Gundlfinger, A., Kapfhammer, J.P., Kruse, F., Leitges, M., Metzger, F. J. Neurobiol. (2003) [Pubmed]
  25. Ceramide promotes calpain-mediated proteolysis of protein kinase C beta in murine polymorphonuclear leukocytes. Tanabe, F., Cui, S.H., Ito, M. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  26. Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behavior. Birikh, K.R., Sklan, E.H., Shoham, S., Soreq, H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  27. Loss of mouse epidermal protein kinase C isozyme activities following treatment with phorbol ester and non-phorbol ester tumor promoters. Wang, X.J., Warren, B.S., Rupp, T., Beltrán, L.M., DiGiovanni, J. Carcinogenesis (1994) [Pubmed]
  28. Inhibition of IFN-alpha signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway. Du, Z., Shen, Y., Yang, W., Mecklenbrauker, I., Neel, B.G., Ivashkiv, L.B. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  29. Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis. Yoshiji, H., Kuriyama, S., Ways, D.K., Yoshii, J., Miyamoto, Y., Kawata, M., Ikenaka, Y., Tsujinoue, H., Nakatani, T., Shibuya, M., Fukui, H. Cancer Res. (1999) [Pubmed]
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