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Chemical Compound Review

pantethine     N-[2-[2-[2-[3-[(2,4- dihydroxy-3,3-dimethyl...

Synonyms: Bis-pantethine, Pantosin (TN), AG-D-77241, ACMC-20mx7k, NSC-759269, ...
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Disease relevance of pantethine


Psychiatry related information on pantethine

  • Dose- and time-response effects of pantethine on open-field behavior, and on central neurotransmission in rats [6].
  • It might be that the striatal dopaminergic transmission, modified by administration of pantethine, plays some role in the higher locomotor activity induced by the substance [7].

High impact information on pantethine


Chemical compound and disease context of pantethine


Biological context of pantethine


Anatomical context of pantethine


Associations of pantethine with other chemical compounds


Gene context of pantethine


Analytical, diagnostic and therapeutic context of pantethine

  • In the lenses of animals protected from protein aggregation and opacification by administration of 1.5 mmol kg-1 pantethine, the pattern of proteins in SDS-PAGE gels resembled the pattern for proteins from transparent lenses of normal untreated animals and loss of cytoskeletal proteins was prevented [24].
  • Pantethine improves the lipid abnormalities of chronic hemodialysis patients: results of a multicenter clinical trial [25].
  • In several animal models, preliminary studies have indicated that pantethine may inhibit cataract formation [26].
  • Application of pantethine 5 X 10(-3) Gm/ml under hypoxic perfusion prolonged action potential duration and effective refractory period significantly [27].
  • Following pantethine, the ambulation increased during the later tests (60 min, 240 min, 24 hr) [28].


  1. Metabolism of pantethine in cystinosis. Wittwer, C.T., Gahl, W.A., Butler, J.D., Zatz, M., Thoene, J.G. J. Clin. Invest. (1985) [Pubmed]
  2. Effect of pantethine on cholesterol ester metabolism in rat arterial wall. Shinomiya, M., Matsuoka, N., Shirai, K., Morisaki, N., Sasaki, N., Murano, S., Saito, Y., Kumagai, A. Atherosclerosis (1980) [Pubmed]
  3. Purification and characterization of a Bacillus megaterium disulfide reductase specific for disulfides containing pantethine 4',4"-diphosphate. Swerdlow, R.D., Setlow, P. J. Bacteriol. (1983) [Pubmed]
  4. Effectiveness of long-term treatment with pantethine in patients with dyslipidemia. Arsenio, L., Bodria, P., Magnati, G., Strata, A., Trovato, R. Clinical therapeutics. (1986) [Pubmed]
  5. The depletion of plasma prolactin by pantethine in oestrogen-primed hyperprolactinaemic rats. Jeitner, T.M., Oliver, J.R. J. Endocrinol. (1990) [Pubmed]
  6. Dose- and time-response effects of pantethine on open-field behavior, and on central neurotransmission in rats. Vécsei, L., Widerlöv, E., Ekman, R., Alling, C. Pharmacol. Biochem. Behav. (1990) [Pubmed]
  7. Cysteamine and pantethine effects on passive avoidance behavior, shuttle box learning, open-field activity, striatal catecholamines and somatostatin. Vécsei, L., Widerlöv, E., Ekman, R., Alling, C. Archives internationales de pharmacodynamie et de thérapie. (1989) [Pubmed]
  8. An Arabidopsis mutant impaired in coenzyme A biosynthesis is sugar dependent for seedling establishment. Rubio, S., Larson, T.R., Gonzalez-Guzman, M., Alejandro, S., Graham, I.A., Serrano, R., Rodriguez, P.L. Plant Physiol. (2006) [Pubmed]
  9. Pantethine inhibits cholesterol and fatty acid syntheses and stimulates carbon dioxide formation in isolated rat hepatocytes. Cighetti, G., Del Puppo, M., Paroni, R., Fiorica, E., Galli Kienle, M. J. Lipid Res. (1987) [Pubmed]
  10. Pantethine, a cysteamine precursor, depletes immunoreactive somatostatin and prolactin in the rat. Reichlin, S., Bollinger-Gruber, J.A. Endocrinology (1985) [Pubmed]
  11. Hypolipidemic effect of pantothenic acid derivatives in mice with hypothalamic obesity induced by aurothioglucose. Naruta, E., Buko, V. Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie. (2001) [Pubmed]
  12. Pantethine lipomodulation: evidence for cysteamine mediation in vitro and in vivo. Wittwer, C.T., Graves, C.P., Peterson, M.A., Jorgensen, E., Wilson, D.E., Thoene, J.G., Wyse, B.W., Windham, C.T., Hansen, R.G. Atherosclerosis (1987) [Pubmed]
  13. Pantethine, a somatostatin depleting agent, increases food intake in rats. Abucham, J., Bollinger-Gruber, J., Reichlin, S. Pharmacol. Biochem. Behav. (1989) [Pubmed]
  14. Effects of pantethine supplementation to diets with different energy cereals on hepatic lipogenesis of laying hens. Hsu, J.C., Tanaka, K., Ohtani, S., Collado, C.M. Poult. Sci. (1987) [Pubmed]
  15. Effects of cysteamine and pantethine on open-field behavior, hypothalamic catecholamine concentrations, and somatostatin-induced barrel rotation in rats. Vécsei, L., Alling, C., Heilig, M., Widerlöv, E. Pharmacol. Biochem. Behav. (1989) [Pubmed]
  16. Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance. Coronel, F., Tornero, F., Torrente, J., Naranjo, P., De Oleo, P., Macia, M., Barrientos, A. American journal of nephrology. (1991) [Pubmed]
  17. Changes in oxytocin and vasopressin content in posterior pituitary and hypothalamus following pantethine treatment. Ong, G.L., Miaskowski, C., Haldar, J. Life Sci. (1990) [Pubmed]
  18. Effect of pantethine on post-heparin plasma lipolytic activities and adipose tissue lipoprotein lipase in rats. Noma, A., Kita, M., Okamiya, T. Horm. Metab. Res. (1984) [Pubmed]
  19. Preclinical and clinical studies with cysteamine and pantethine related to the central nervous system. Vécsei, L., Widerlöv, E. Prog. Neuropsychopharmacol. Biol. Psychiatry (1990) [Pubmed]
  20. Effects of pantethine on in-vitro peroxidation of low density lipoproteins. Bon, G.B., Cazzolato, G., Zago, S., Avogaro, P. Atherosclerosis (1985) [Pubmed]
  21. Effects of pantethine on cholesterol synthesis from mevalonate in isolated rat hepatocytes. Cighetti, G., Del Puppo, M., Paroni, R., Galli, G., Kienle, M.G. Atherosclerosis (1986) [Pubmed]
  22. Lowering of blood acetaldehyde but not ethanol concentrations by pantethine following alcohol ingestion: different effects in flushing and nonflushing subjects. Watanabe, A., Hobara, N., Kobayashi, M., Nakatsukasa, H., Nagashima, H. Alcohol. Clin. Exp. Res. (1985) [Pubmed]
  23. Lowering effect of pantethine on plasma beta-thromboglobulin and lipids in diabetes mellitus. Eto, M., Watanabe, K., Chonan, N., Ishii, K. Artery (1987) [Pubmed]
  24. Loss of cytoskeletal proteins and lens cell opacification in the selenite cataract model. Matsushima, H., David, L.L., Hiraoka, T., Clark, J.I. Exp. Eye Res. (1997) [Pubmed]
  25. Pantethine improves the lipid abnormalities of chronic hemodialysis patients: results of a multicenter clinical trial. Donati, C., Barbi, G., Cairo, G., Prati, G.F., Degli Esposti, E. Clin. Nephrol. (1986) [Pubmed]
  26. Reduction of pantethine in rabbit ocular lens homogenate. Fisher, D.H., Szulc, M.E. Journal of pharmaceutical and biomedical analysis. (1997) [Pubmed]
  27. Effects of pantethine on action potential of canine papillary muscle during hypoxic perfusion. Hayashi, H., Kobayashi, A., Terada, H., Nagao, B., Nishiyama, T., Kamikawa, T., Yamazaki, N. Japanese heart journal. (1985) [Pubmed]
  28. Comparative studies of intracerebroventricularly administered cysteamine and pantethine in different behavioral tests and on brain catecholamines in rats. Vécsei, L., Alling, C., Widerlöv, E. Archives internationales de pharmacodynamie et de thérapie. (1990) [Pubmed]
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