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Chemical Compound Review

SOT-Black 6     (2,2-dimethyl-1,3- dihydroperimidin-6-yl)...

Synonyms: ARONIS24132, Typogen Black, Sudan Black, NSC-11239, Fat Black HB, ...
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Disease relevance of CI 26150


High impact information on CI 26150

  • Positive myeloperoxidase and/or sudan black-B stainings and CD13 positivity in these cases were consistent with the presence of a myeloid involvement [5].
  • Mitoses were identified as being of erythroid lineage by immunofluorescent staining for surface glycophorin A and as being of granulocytic lineage by cytoplasmic staining for Sudan black B [6].
  • The phenotype of the leukemic cells was characterized by the presence of mature or early monocyte lineage antigens and intense Ia antigen expression detected by monoclonal antibodies, terminal deoxytransferase activity, and cytochemical features, including both Sudan black B and periodic acid-Schiff activity [7].
  • Renal and hepatocyte storage material stained intensely with oil red O and moderately with periodic acid-Schiff/alcian blue and Sudan black B stains [8].
  • A simple method was developed to identify large mononuclear (LMN) cells in human synovial fluid based on morphology and staining with Sudan black B [9].

Chemical compound and disease context of CI 26150


Biological context of CI 26150


Anatomical context of CI 26150

  • There is accumulation of autofluorescent, periodic acid-Schiff-, and Sudan black B-positive granules that are resistant to lipid solvents in the cytoplasm of most nerve cells and. to a lesser degree, of many other cell types [18].
  • Morphologically, after exposure to apoEko-VLDL/IDL, macrophages became strongly stained with Sudan black B [19].
  • In leukemic myeloblasts and promyelocytes stained with basic blue 93, variable numbers of black-colored lysosomes could be detected and usually paralleled the reactions for myeloperoxidase and Sudan black B in the same cells [20].
  • Mucicarminophilic histiocytes can be identified by the positive mucicarmine, colloidal iron, Gomori methenamine silver, Congo red, Sudan black B, Fontana-Masson argentaffin, and Victoria blue; but negative periodic acid-Schiff, alcian blue, and Giemsa stains [21].
  • A(0) induced a characteristic series of changes, hallmarked by the formation of eosin- and Sudan Black-B-negative vacuoles [22].

Associations of CI 26150 with other chemical compounds


Gene context of CI 26150

  • Leukemic cells were characterized by scanty cytoplasm with fine azurophilic granules, and were highly positive for myeloperoxidase and sudan black-B [28].
  • Anti-MPO was positive in all cases of AML (M1-M5) which were positive by Sudan Black B reaction in similar or higher percentage ratio for each case, although in some of them did not label with CD13/CD33 tested by IF and IPc techniques [29].
  • Surgical specimens of atherosclerosis and chronic panniculitis containing MCLs as well as experimentally formed MCLs were examined, using paraffin sections, by Sudan black B (SBB) stain and by immunostaining for CD68, Bax protein and advanced glycation end products (AGEs) [30].
  • Samples were separated by CITP combined with sudan black B staining [31].
  • Expression of fibronectin and transforming growth factor-beta was greater in the Sudan black B-positive than in the Sudan black B-negative vessels, suggesting that extracellular matrix production was increased in vessels with lipid deposition [32].

Analytical, diagnostic and therapeutic context of CI 26150


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  2. Negative stain for myeloid peroxidase and Sudan black B in acute promyelocytic leukemia (APL) cells: report of two patients with APL variant. Cui, W., Qing, S., Xu, Y., Hao, Y., Xue, Y., He, G. Haematologica (2002) [Pubmed]
  3. A novel screening method for isolating exopolysaccharide-deficient mutants. Liu, M., González, J.E., Willis, L.B., Walker, G.C. Appl. Environ. Microbiol. (1998) [Pubmed]
  4. Sudan black B and peroxidase positivity in cultured lymphoid cells from patients with B-type chronic lymphocytic leukemia. Lanza, F. Haematologica (1985) [Pubmed]
  5. Multipotent stem cell involvement in megakaryoblastic leukemia: cytologic and cytogenetic evidence in 15 patients. Cuneo, A., Mecucci, C., Kerim, S., Vandenberghe, E., Dal Cin, P., Van Orshoven, A., Rodhain, J., Bosly, A., Michaux, J.L., Martiat, P. Blood (1989) [Pubmed]
  6. The proportion of mitoses in different cell lineages changes during short-term culture of normal human bone marrow. Keinänen, M., Knuutila, S., Bloomfield, C.D., Elonen, E., de la Chapelle, A. Blood (1986) [Pubmed]
  7. TdT-positive acute leukemia with monocytoid characteristics: clinical, cytochemical, cytogenetic, and immunologic findings. Cuttner, J., Seremetis, S., Najfeld, V., Dimitriu-Bona, A., Winchester, R.A. Blood (1984) [Pubmed]
  8. The lesions of an ovine lysosomal storage disease. Initial characterization. Murnane, R.D., Prieur, D.J., Ahern-Rindell, A.J., Parish, S.M., Collier, L.L. Am. J. Pathol. (1989) [Pubmed]
  9. Mononuclear cells in human synovial fluid. Identification of lymphoblasts in rheumatoid arthritis. Traycoff, R.B., Pascual, E., Schumacher, H.R. Arthritis Rheum. (1976) [Pubmed]
  10. Reevaluation of the periodic acid-Schiff stain in acute leukemia with immunophenotypic analyses. Snower, D.P., Smith, B.R., Munz, U.J., McPhedran, P. Arch. Pathol. Lab. Med. (1991) [Pubmed]
  11. Lipid droplets are present in amyloid deposits in familial amyloidotic polyneuropathy and dialysis related amyloidosis. Sun, X., Ueda, M., Yamashita, T., Nakamura, M., Bergström, J., Zeledon Ramirez, M.E., Okajima, M., Misumi, S., Shoji, S., Motomiya, Y., Ando, Y. Amyloid (2006) [Pubmed]
  12. Staining methods applied to glycol methacrylate embedded tissue sections. Cerri, P.S., Sasso-Cerri, E. Micron (2003) [Pubmed]
  13. Bone marrow cytogenetics: the lineage of dividing cells changes during the first few hours in culture. Keinänen, M., Knuutila, S., Bloomfield, C.D., Elonen, E., de la Chapelle, A. Leukemia (1987) [Pubmed]
  14. Minor myeloid component in Ph chromosome-positive acute lymphoblastic leukaemia: correlation with cytogenetic pattern and implication for poor response to therapy. Cuneo, A., Demuynck, H., Ferrant, A., Louwagie, A., Doyen, C., Stul, M., Cassiman, J.J., Dal Cin, P., Negrini, M., Carli, M.G. Br. J. Haematol. (1994) [Pubmed]
  15. Expressions of resistance and cross-resistance in teniposide-resistant L1210 cells. Roberts, D., Lee, T., Parganas, E., Wiggins, L., Yalowich, J., Ashmun, R. Cancer Chemother. Pharmacol. (1987) [Pubmed]
  16. Rhodococcus opacus strain PD630 as a new source of high-value single-cell oil? Isolation and characterization of triacylglycerols and other storage lipids. Wältermann, M., Luftmann, H., Baumeister, D., Kalscheuer, R., Steinbüchel, A. Microbiology (Reading, Engl.) (2000) [Pubmed]
  17. Cytological and immunological study of 139 patients with acute leukemia. Minowada, J., Mathé, G., Barcos, M., Ginsbourg, M., Preisler, H., Canon, C., Reizenstein, P. Medical oncology and tumor pharmacotherapy. (1984) [Pubmed]
  18. The neuronal ceroid-lipofuscinoses. Haltia, M. J. Neuropathol. Exp. Neurol. (2003) [Pubmed]
  19. The very low- and intermediate-density lipoprotein fraction isolated from apolipoprotein E-knockout mice transforms macrophages to foam cells through an apolipoprotein E-independent pathway. Hakamata, H., Sakaguchi, H., Zhang, C., Sakashita, N., Suzuki, H., Miyazaki, A., Takeya, M., Takahashi, K., Kitamura, N., Horiuchi, S. Biochemistry (1998) [Pubmed]
  20. Basic blue 93. An alternative to the traditional myeloperoxidase stain. Kass, L. Am. J. Clin. Pathol. (1988) [Pubmed]
  21. Mucicarminophilic histiocytosis. A polyvinylpyrrolidone (PVP) storage disease simulating signet-ring cell carcinoma. Kuo, T.T., Hsueh, S. Am. J. Surg. Pathol. (1984) [Pubmed]
  22. Non-apoptotic programmed cell death induced by a copper(II) complex in human fibrosarcoma cells. Tardito, S., Bussolati, O., Gaccioli, F., Gatti, R., Guizzardi, S., Uggeri, J., Marchiò, L., Lanfranchi, M., Franchi-Gazzola, R. Histochem. Cell Biol. (2006) [Pubmed]
  23. Lipid and lipoprotein factors associated with variation in Lp(a) density. Rainwater, D.L., Ludwig, M.J., Haffner, S.M., VandeBerg, J.L. Arterioscler. Thromb. Vasc. Biol. (1995) [Pubmed]
  24. A cytochemical and ultrastructural study of acute myelomonocytic leukemia exhibiting the pseudo-Chediak-Higashi anomaly of leukemia and "splinter-type" Auer rods. Payne, C.M., Harrow, E.J. Am. J. Clin. Pathol. (1983) [Pubmed]
  25. Non-Hodgkin's lymphoma with immunologic phenotype similar to non-T, non-B acute lymphocytic leukemia. Castella, A., Neuberg, R.W., Kurec, A.S., Jones, D.B., Davey, F.R. Hum. Pathol. (1982) [Pubmed]
  26. The value of simple lipid stains for typing skeletal muscle fibres. Dux, L., Mészáros, M.G., Rohán, J., Gajdos, L., Jakab, G., Guba, F. Histochem. J. (1981) [Pubmed]
  27. Particle size analysis of high density lipoproteins in patients with genetic cholesteryl ester transfer protein deficiency. Arai, T., Tsukada, T., Murase, T., Matsumoto, K. Clin. Chim. Acta (2000) [Pubmed]
  28. Secondary myeloid/natural killer cell acute leukemia following T-cell lymphoma. Lee, J.J., Kim, H.J., Chung, I.J., Park, M.R., Ryang, D.W., Choi, C. Leuk. Lymphoma (2001) [Pubmed]
  29. Monoclonal antibody anti-MPO is useful in recognizing minimally differentiated acute myeloid leukaemia. Praxedes, M.K., De Oliveira, L.Z., Pereira, W.d.a. .V., Quintana, I.Z., Tabak, D.G., De Oliveira, M.S. Leuk. Lymphoma (1994) [Pubmed]
  30. Modes of participation of macrophages in the formation of membranocystic lesions. Nakamura, T., Fujiwara, M. APMIS (2002) [Pubmed]
  31. Characterization of modified low density lipoprotein subfractions by capillary isotachophoresis. Zorn, U., Haug, C., Celik, E., Wennauer, R., Schmid-Kotsas, A., Bachem, M.G., Grünert, A. Electrophoresis (2001) [Pubmed]
  32. The contribution of nitric oxide to renal vascular wall thickening in rats with L-NAME-induced hypertension. Yoneyama, T., Ohkawa, S., Watanabe, T., Odamaki, M., Kumagai, H., Kimura, M., Hishida, A. Virchows Arch. (1998) [Pubmed]
  33. A method for simultaneous study of the karyotype, morphology, and immunologic phenotype of mitotic cells in hematologic malignancies. Teerenhovi, L., Knuutila, S., Ekblom, M., Rossi, L., Borgström, G.H., Tallman, J.K., Andersson, L., de la Chapelle, A. Blood (1984) [Pubmed]
  34. Analysis of high density lipoproteins by a modified gradient gel electrophoresis method. Li, Z., McNamara, J.R., Ordovas, J.M., Schaefer, E.J. J. Lipid Res. (1994) [Pubmed]
  35. Agarose gel electrophoresis of plasma lipoproteins using the Durrum cell. Maguire, G.F., Breckenridge, W.C. Clin. Biochem. (1975) [Pubmed]
  36. Quantification of sinking pre beta lipoprotein in human plasma. Breckenridge, W.C., Maquire, G.F. Clin. Biochem. (1981) [Pubmed]
  37. Differential cytochemical staining characteristics of channel catfish leukocytes identify cell populations in lymphoid organs. Petrie-Hanson, L., Ainsworth, A.J. Vet. Immunol. Immunopathol. (2000) [Pubmed]
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