Disease relevance of nitridosilicon

• Experimentally measured force-extension curves revealed a unique pair of "sawtooth" features that were present when a bond formed between a silicon nitride surface (atomic force microscopy tip) and E. coli cells expressing the OmpA-AmCyan protein [1].
• In this study, the authors attempted to correlate microscopic adhesion of a collection of nine Streptococcus mitis strains to the negatively charged, hydrophilic silicon nitride tip of an atomic force microscope (AFM) with macroscopic adhesion of the strains to a negatively charged, hydrophilic glass in a parallel-plate flow chamber [2].
• We present qualitative detection of specific Salmonella enterica strains using a functionalized silicon nitride microcantilever [3].

High impact information on nitridosilicon

• We have produced single, synthetic nanometer-diameter pores by using a tightly focused, high-energy electron beam to sputter atoms in 10-nm-thick silicon nitride membranes [4].
• In this report we characterized the longitudinal elasticity of single actin filaments manipulated by novel silicon-nitride microfabricated levers [5].
• Adherent mouse fibroblast cells were grown on silicon nitride windows serving as biocompatible XRF support substrate, and labeled with FluoroNanogold in combination with primary antibodies specific for mitochondria or the Golgi apparatus, respectively [6].
• Nevertheless, a small group of materials, incorporating substantial amounts of quartz or silicon nitride filler particles, exhibited high rates of thermal diffusion, up to three times the level exhibited by dentin [7].
• Force/distance curves for silicon nitride tip/flat silica or alumina coated by a layer of mixed micelles of cationic/anionic surfactant are measured by using AFM [8].

Chemical compound and disease context of nitridosilicon

• Adhesion between a silicon nitride tip and Escherichia coli JM109 was measured in water and 0.01 M phosphate-buffered saline (PBS) on untreated cells and on a sample of E. coli treated with 100 mM ethylenediaminetetraacetic acid (EDTA), which removes approximately 80% of the LPS molecules [9].

Biological context of nitridosilicon

• The in vivo inflammatory and wound healing response of MEMS drug delivery component materials, metallic gold, silicon nitride, silicon dioxide, silicon, and SU-8(TM) photoresist, were evaluated using the cage implant system [10].
• Atomic force microscopy (AFM) was used to investigate both bacterial surface characteristics and adhesion forces between a probe surface (silicon nitride) and the bacteria, providing a direct evaluation of bacterial adhesion and interaction forces [11].
• Micromechanical measurement of active sites on silicon nitride using surface free energy variation [12].
• Lipid adsorption kinetics was primarily studied on plain silicon supports in an ellipsometric cell or on a silicon nitride surface in a resonant mirror system (IAsys), using the systematic approach [13].
• This study attempts to investigate the cytotoxicity of different qualities of industrial silicon nitride ceramics applying an L929-cell culture model in a direct contact assay combined with a cell viability assessment [14].

Anatomical context of nitridosilicon

• Immunocytochemistry was performed to verify the presence of neurons and quantitatively assess astrocytes using antibodies against glial fibrillary acidic protein on the silicon nitride substrates [15].
• By pressing adhering live cells onto the nanostructured SiN surface and then removing them, planar cell membrane sheets (CMSs) were transferred in a well-defined orientation onto the SiN support [16].
• The biocompatibility of silicon nitride (Si3N4) was assessed in an in vitro model using the human osteoblast-like MG-63 cell line [17].
• Embryonic day 15 rat spinal cord cells were plated on trimethoxysilyl-propyldiethylenetriamine coated microelectrode arrays comprised of gold recording sites passivated with silicon nitride [15].
• In vitro effects of fibrous and nonfibrous silicon nitride on bovine pulmonary macrophages [18].

Associations of nitridosilicon with other chemical compounds

• Five methods for protein immobilization were evaluated, comprising two methods of linker attachment to a silicon nitride surface (CNBr, silanization) and three methods of linker attachment to the protein (via primary amines, carboxyl groups, and the aromatic rings of tyrosine and histidine) [19].
• We used an atomic force microscope to investigate silicon nitride tip interactions with various materials (copper, nickel, silicon carbide) as a function of pH [20].
• Here we show the results from the application of the atomic force microscopy (AFM) technique to study the forces between silica or silicon nitride (AFM tips) and polyurethane surfaces in aqueous solutions of different acidity [21].
• Prior to membrane filtrations, an antifouling polymer based on poly(ethylene glycol), poly(TMSMA-r-PEGMA) was synthesized and applied on silicon-based surfaces like silicon, silicon nitride, and glass [22].

Gene context of nitridosilicon

• OPN protein was covalently bound to silicon nitride AFM tips and adsorption and adhesion forces were measured in an electrolyte with a composition similar to that of physiological fluids [23].
• Proinflammatory cytokine expression of IL-1beta and TNF-alpha by human osteoblast-like MG-63 cells upon exposure to silicon nitride in vitro [24].
• In this second part, cumulative particle size distributions of silicon and silicon nitride agglomerates, produced in a laser reactor, were determined from TEM pictures and compared to the distributions calculated from this self-preserving theory for power law particles [25].
• Biological-to-electronic interface with pores of ATP synthase subunit C in silicon nitride barrier [26].
• The cMEAs have 50 or 60 microm center-to-center inter-electrode distances and were manufactured on glass substrates by photolithographically defining ITO leads, insulating them with silicon nitride and SU-8 2000 epoxy-based photoresist and coating the etched electrode tips with gold or platinum [27].

Analytical, diagnostic and therapeutic context of nitridosilicon

• Quantum confinement in amorphous silicon quantum dots embedded in silicon nitride [28].
• A silicon nitride (Si(3)N(4) reaction surface also resulted in consistent inhibition of PCR [29].
• The transducer monolithically integrates silicon avalanche diodes as light sources, silicon nitride optical fibers, and p/n junction detectors and efficiently intercouples these elements through a self-alignment technique [30].
• METHODS: A drug delivery system was microfabricated based on a 5- or 10- microm aperture in a 500-nm thick silicon nitride membrane to localize and limit transmitter release [31].
• The platform for cell culture is equipped with an array of 16 silicon nitride micropipet-based ion-selective microelectrodes with a diameter of either 2 or 6 mum [32].

References