The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Folimycin     [(2R,3S,4R,6R)-6- [(2R,4R,5S,6S)-2-[(2S,3R...

Synonyms: concanamycin a, CHEMBL1241239, CHEBI:73167, CPD-10323, LS-21275, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of X 4357 B


High impact information on X 4357 B

  • In contrast use of the vacuolar H+/ATPase inhibitor, concanamycin A, stabilized total cellular free oligosaccharides and enabled us to demonstrate a translocation of partially trimmed oligosaccharides from the cytosol into a membrane-bound compartment [6].
  • In addition, we detected autophagic bodies in the vacuoles of wild-type roots but not in those of atg4a4b-1 in the presence of concanamycin A, a V-ATPase inhibitor [7].
  • Although sensitive to concanamycin A and ethyleneglycotetraacetic acid, which inhibit cytotoxicity by granule exocytosis, the CD4(+) cytotoxic T lymphocytes (CTLs) did not express perforin, suggesting a cytotoxic mechanism independent of perforin although involving exocytosis [8].
  • Again, cyclosporin A, but not concanamycin A, strongly reduced activating receptor-mediated IFN-gamma production [9].
  • Conversely, concanamycin A, an inhibitor of vacuolar type H(+)-adenosine triphosphatase (H(+)-ATPase) of granules, inhibited activating receptor-induced NK cell cytolysis, suggesting that activating receptor-mediated apoptosis and cytolysis can use different intracellular pathways [9].

Chemical compound and disease context of X 4357 B


Biological context of X 4357 B


Anatomical context of X 4357 B


Associations of X 4357 B with other chemical compounds


Gene context of X 4357 B

  • The cytotoxicity was dose-dependently inhibited by either a Con A ligand, alpha-methyl mannoside, or a perforin inhibitor, concanamycin A (CMA), but not by anti-Fas ligand antiserum [24].
  • CMA treatment showed that while the cytotoxicity of IL-2-activated CHS PBL against K562 was largely dependent on perforin, that against Jurkat was largely not [25].
  • In contrast, the CHS PBL exhibited substantial cytotoxicity against Jurkat cells, which was only partially inhibited by CMA treatment but not by the addition of neutralizing anti-FasL or anti-TNF-alpha antibodies [25].
  • However, pretreatment with concanamycin A completely inhibited this IL-18- and/or IL-12-augmented NK activity [26].
  • Constitutive expression of Bcl-2 but not Bcl-XL inhibited concanamycin A-induced apoptosis [27].

Analytical, diagnostic and therapeutic context of X 4357 B


  1. Demethylation of promoter regulatory elements contributes to perforin overexpression in CD4+ lupus T cells. Kaplan, M.J., Lu, Q., Wu, A., Attwood, J., Richardson, B. J. Immunol. (2004) [Pubmed]
  2. Requirement for vacuolar proton-ATPase activity during entry of influenza virus into cells. Guinea, R., Carrasco, L. J. Virol. (1995) [Pubmed]
  3. Entry of poliovirus into cells is blocked by valinomycin and concanamycin A. Irurzun, A., Carrasco, L. Biochemistry (2001) [Pubmed]
  4. Entry of Semliki forest virus into cells: effects of concanamycin A and nigericin on viral membrane fusion and infection. Irurzun, A., Nieva, J.L., Carrasco, L. Virology (1997) [Pubmed]
  5. The vacuolar ATPase proton pump is required for the cytotoxicity of Bacillus anthracis lethal toxin. Ménard, A., Altendorf, K., Breves, D., Mock, M., Montecucco, C. FEBS Lett. (1996) [Pubmed]
  6. Transfer of free polymannose-type oligosaccharides from the cytosol to lysosomes in cultured human hepatocellular carcinoma HepG2 cells. Saint-Pol, A., Bauvy, C., Codogno, P., Moore, S.E. J. Cell Biol. (1997) [Pubmed]
  7. Processing of ATG8s, ubiquitin-like proteins, and their deconjugation by ATG4s are essential for plant autophagy. Yoshimoto, K., Hanaoka, H., Sato, S., Kato, T., Tabata, S., Noda, T., Ohsumi, Y. Plant Cell (2004) [Pubmed]
  8. Cytokine production and cytolytic mechanism of CD4(+) cytotoxic T lymphocytes in ex vivo expanded therapeutic Epstein-Barr virus-specific T-cell cultures. Sun, Q., Burton, R.L., Lucas, K.G. Blood (2002) [Pubmed]
  9. Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction. Spaggiari, G.M., Contini, P., Dondero, A., Carosio, R., Puppo, F., Indiveri, F., Zocchi, M.R., Poggi, A. Blood (2002) [Pubmed]
  10. Concanamycin A blocks influenza virus entry into cells under acidic conditions. Guinea, R., Carrasco, L. FEBS Lett. (1994) [Pubmed]
  11. CD40 activation does not protect chronic lymphocytic leukemia B cells from apoptosis induced by cytotoxic T lymphocytes. Chu, P., Wierda, W.G., Kipps, T.J. Blood (2000) [Pubmed]
  12. Cytosolic Ca2+ homeostasis is a constitutive function of the V-ATPase in Saccharomyces cerevisiae. Forster, C., Kane, P.M. J. Biol. Chem. (2000) [Pubmed]
  13. Specific inhibitors of vacuolar H(+)-ATPase trigger apoptotic cell death of osteoclasts. Okahashi, N., Nakamura, I., Jimi, E., Koide, M., Suda, T., Nishihara, T. J. Bone Miner. Res. (1997) [Pubmed]
  14. Intracellular apoptosis-inducing factor is induced by a vacuolar type H+-ATPase inhibitor in B lineage cells. Hashimoto, S., Ishisaki, A., Yamato, K., Aiko, K., Amagasa, T., Nishihara, T. J. Cell. Physiol. (2001) [Pubmed]
  15. Uptake of botulinum neurotoxin into cultured neurons. Keller, J.E., Cai, F., Neale, E.A. Biochemistry (2004) [Pubmed]
  16. CD8brightCD56+ T cells are cytotoxic effectors in patients with active Behcet's uveitis. Ahn, J.K., Chung, H., Lee, D.S., Yu, Y.S., Yu, H.G. J. Immunol. (2005) [Pubmed]
  17. Activated lymphocytes promote endothelial cell detachment from matrix: a role for modulation of endothelial cell beta 1 integrin affinity. Phan, C., McMahon, A.W., Nelson, R.C., Elliott, J.F., Murray, A.G. J. Immunol. (1999) [Pubmed]
  18. Mutations of pma-1, the gene encoding the plasma membrane H+-ATPase of Neurospora crassa, suppress inhibition of growth by concanamycin A, a specific inhibitor of vacuolar ATPases. Bowman, E.J., O'Neill, F.J., Bowman, B.J. J. Biol. Chem. (1997) [Pubmed]
  19. Enhancement of human cord blood CD34+ cell-derived NK cell cytotoxicity by dendritic cells. Yu, Y., Hagihara, M., Ando, K., Gansuvd, B., Matsuzawa, H., Tsuchiya, T., Ueda, Y., Inoue, H., Hotta, T., Kato, S. J. Immunol. (2001) [Pubmed]
  20. Visualization of effective tumor targeting by CD8+ natural killer T cells redirected with bispecific antibody F(ab')(2)HER2xCD3. Scheffold, C., Kornacker, M., Scheffold, Y.C., Contag, C.H., Negrin, R.S. Cancer Res. (2002) [Pubmed]
  21. Bafilomycin Induces the p21-Mediated Growth Inhibition of Cancer Cells under Hypoxic Conditions by Expressing Hypoxia-Inducible Factor-1{alpha}. Lim, J.H., Park, J.W., Kim, M.S., Park, S.K., Johnson, R.S., Chun, Y.S. Mol. Pharmacol. (2006) [Pubmed]
  22. Why green fluorescent fusion proteins have not been observed in the vacuoles of higher plants. Tamura, K., Shimada, T., Ono, E., Tanaka, Y., Nagatani, A., Higashi, S.I., Watanabe, M., Nishimura, M., Hara-Nishimura, I. Plant J. (2003) [Pubmed]
  23. V-type ATPase is involved in biogenesis of GLUT4 vesicles. Malikova, M., Shi, J., Kandror, K.V. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  24. Concanavalin A induces perforin-mediated but not Fas-mediated hepatic injury. Watanabe, Y., Morita, M., Akaike, T. Hepatology (1996) [Pubmed]
  25. Cytolytic mechanisms involved in non-MHC-restricted cytotoxicity in Chediak-Higashi syndrome. Nakazawa, T., Agematsu, K., Yasui, K., Onodera, T., Inoue, R., Kaneko, H., Kondo, N., Yamamoto, M., Kayagaki, N., Yagita, H., Okumura, K., Komiyama, A. Clin. Exp. Immunol. (1999) [Pubmed]
  26. IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor. Hyodo, Y., Matsui, K., Hayashi, N., Tsutsui, H., Kashiwamura, S., Yamauchi, H., Hiroishi, K., Takeda, K., Tagawa, Y., Iwakura, Y., Kayagaki, N., Kurimoto, M., Okamura, H., Hada, T., Yagita, H., Akira, S., Nakanishi, K., Higashino, K. J. Immunol. (1999) [Pubmed]
  27. Increase in Bcl-2 level promoted by CD40 ligation correlates with inhibition of B cell apoptosis induced by vacuolar type H(+)-ATPase inhibitor. Akifusa, S., Ohguchi, M., Koseki, T., Nara, K., Semba, I., Yamato, K., Okahashi, N., Merino, R., Núñez, G., Hanada, N., Takehara, T., Nishihara, T. Exp. Cell Res. (1998) [Pubmed]
  28. Specific inhibitors of vacuolar type H(+)-ATPases induce apoptotic cell death. Nishihara, T., Akifusa, S., Koseki, T., Kato, S., Muro, M., Hanada, N. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  29. The effects of repeated exposure to sub-toxic doses of plecomacrolide antibiotics on the endocrine pancreas. Hettiarachchi, K.D., Zimmet, P.Z., Myers, M.A. Food Chem. Toxicol. (2006) [Pubmed]
  30. ANG II-dependent HCO3- reabsorption in surviving rat distal tubules: expression/activation of H(+)-ATPase. Levine, D.Z., Iacovitti, M., Buckman, S., Hincke, M.T., Luck, B., Fryer, J.N. Am. J. Physiol. (1997) [Pubmed]
WikiGenes - Universities