Chemical Compound Review:
Agreen ethyl5-[(4,6- dimethoxypyrimidin-2...
Synonyms:
Sirius, SureCN22006, NC-311, CHEMBL2313155, AC-18019, ...
Grimm,
Nickerson,
Gough,
McKenna,
Stern,
Jeffery,
Rush,
Stumpf,
Cao,
Klinge,
Klosterhalfen,
Junge,
Krones,
Schumpelick,
Sakaida,
Terai,
Yamamoto,
Aoyama,
Ishikawa,
Nishina,
Okita,
Rizzoni,
Paiardi,
Rodella,
Porteri,
De Ciuceis,
Rezzani,
Boari,
Zani,
Miclini,
Tiberio,
Giulini,
Rosei,
Bianchi,
Rosei,
Reifen,
Nur,
Ghebermeskel,
Zaiger,
Urizky,
Pines,
Rowshani,
Scholten,
Bemelman,
Eikmans,
Idu,
van Groningen,
Surachno,
Mallat,
Paul,
de Fijter,
Bajema,
ten Berge,
Florquin,
Pines,
Domb,
Ohana,
Inbar,
Genina,
Alexiev,
Nagler,
van Westerloo,
Florquin,
de Boer,
Daalhuisen,
de Vos,
Bruno,
van der Poll,
Roos-van Groningen,
Scholten,
Lelieveld,
Rowshani,
Baelde,
Bajema,
Florquin,
Bemelman,
de Heer,
de Fijter,
Bruijn,
Eikmans,
- Agnogenic myeloid metaplasia, portal hypertension, and sinusoidal abnormalities. Roux, D., Merlio, J.P., Quinton, A., Lamouliatte, H., Balabaud, C., Bioulac-Sage, P. Gastroenterology (1987)
- Fas enhances fibrogenesis in the bile duct ligated mouse: a link between apoptosis and fibrosis. Canbay, A., Higuchi, H., Bronk, S.F., Taniai, M., Sebo, T.J., Gores, G.J. Gastroenterology (2002)
- Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: a potential mechanism of lesion stabilization. Aikawa, M., Rabkin, E., Okada, Y., Voglic, S.J., Clinton, S.K., Brinckerhoff, C.E., Sukhova, G.K., Libby, P. Circulation (1998)
- An epidemiologic study of risk factors for deep vein thrombosis in medical outpatients: the Sirius study. Samama, M.M. Arch. Intern. Med. (2000)
- Untreated rejection in 6-month protocol biopsies is not associated with fibrosis in serial biopsies or with loss of graft function. Scholten, E.M., Rowshani, A.T., Cremers, S., Bemelman, F.J., Eikmans, M., van Kan, E., Mallat, M.J., Florquin, S., Surachno, J., ten Berge, I.J., Bajema, I.M., de Fijter, J.W. J. Am. Soc. Nephrol. (2006)
- Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis. Canbay, A., Guicciardi, M.E., Higuchi, H., Feldstein, A., Bronk, S.F., Rydzewski, R., Taniai, M., Gores, G.J. J. Clin. Invest. (2003)
- Altered fat differentiation and adipocytokine expression are inter-related and linked to morphological changes and insulin resistance in HIV-1-infected lipodystrophic patients. Jan, V., Cervera, P., Maachi, M., Baudrimont, M., Kim, M., Vidal, H., Girard, P.M., Levan, P., Rozenbaum, W., Lombès, A., Capeau, J., Bastard, J.P. Antivir. Ther. (Lond.) (2004)
- Portal hypertension and ascites in acute hepatitis: clinical, hemodynamic and histological correlations. Valla, D., Flejou, J.F., Lebrec, D., Bernuau, J., Rueff, B., Salzmann, J.L., Benhamou, J.P. Hepatology (1989)
- Cardiac metallothionein synthesis in streptozotocin-induced diabetic mice, and its protection against diabetes-induced cardiac injury. Song, Y., Wang, J., Li, Y., Du, Y., Arteel, G.E., Saari, J.T., Kang, Y.J., Cai, L. Am. J. Pathol. (2005)
- Therapeutic effects of troglitazone in experimental chronic pancreatitis in mice. van Westerloo, D.J., Florquin, S., de Boer, A.M., Daalhuisen, J., de Vos, A.F., Bruno, M.J., van der Poll, T. Am. J. Pathol. (2005)
- Measurement of fibrosis in needle liver biopsies: evaluation of a colorimetric method. Jimenez, W., Parés, A., Caballería, J., Heredia, D., Bruguera, M., Torres, M., Rojkind, M., Rodés, J. Hepatology (1985)
- Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. Yang, L., Bataller, R., Dulyx, J., Coffman, T.M., Ginès, P., Rippe, R.A., Brenner, D.A. J. Hepatol. (2005)
- Vitamin A deficiency exacerbates inflammation in a rat model of colitis through activation of nuclear factor-kappaB and collagen formation. Reifen, R., Nur, T., Ghebermeskel, K., Zaiger, G., Urizky, R., Pines, M. J. Nutr. (2002)
- Expression of pleiotrophin in hepatic nonparenchymal cells and preneoplastic nodules in carbon tetrachloride-induced fibrotic rat liver. Kohashi, T., Tateaki, Y., Tateno, C., Asahara, T., Obara, M., Yoshizato, K. Growth Factors (2002)
- Sirius red histophotometry and spectrophotometry of sections in the assessment of the collagen content of liver tissue and its application in growing rat liver. James, J., Bosch, K.S., Aronson, D.C., Houtkooper, J.M. Liver (1990)
- Halofuginone--an inhibitor of collagen type I synthesis--prevents postoperative formation of abdominal adhesions. Nagler, A., Rivkind, A.I., Raphael, J., Levi-Schaffer, F., Genina, O., Lavelin, I., Pines, M. Ann. Surg. (1998)
- Inhibition of p38 mitogen-activated protein kinase attenuates left ventricular dysfunction by mediating pro-inflammatory cardiac cytokine levels in a mouse model of diabetes mellitus. Westermann, D., Rutschow, S., Van Linthout, S., Linderer, A., Bücker-Gärtner, C., Sobirey, M., Riad, A., Pauschinger, M., Schultheiss, H.P., Tschöpe, C. Diabetologia (2006)
- Bradykinin differentiates human lung fibroblasts to a myofibroblast phenotype via the B2 receptor. Vancheri, C., Gili, E., Failla, M., Mastruzzo, C., Salinaro, E.T., Lofurno, D., Pistorio, M.P., La Rosa, C., Caruso, M., Crimi, N. J. Allergy Clin. Immunol. (2005)
- Cholestasis-induced fibrosis is reduced by interferon alpha-2a and is associated with elevated liver metalloprotease activity. Bueno, M.R., Daneri, A., Armendáriz-Borunda, J. J. Hepatol. (2000)
- Renal vascular endothelial growth factor in neonatal obstructive nephropathy. II. Exogenous VEGF. Burt, L.E., Forbes, M.S., Thornhill, B.A., Kiley, S.C., Minor, J.J., Chevalier, R.L. Am. J. Physiol. Renal Physiol. (2007)
- The role of the nuclear receptor constitutive androstane receptor in the pathogenesis of non-alcoholic steatohepatitis. Yamazaki, Y., Kakizaki, S., Horiguchi, N., Sohara, N., Sato, K., Takagi, H., Mori, M., Negishi, M. Gut (2007)
- Cardiac fibrosis occurs early and involves endothelin and AT-1 receptors in hypertension due to endogenous angiotensin II. Seccia, T.M., Belloni, A.S., Kreutz, R., Paul, M., Nussdorfer, G.G., Pessina, A.C., Rossi, G.P. J. Am. Coll. Cardiol. (2003)
- Left ventricular fibrosis in renovascular hypertensive rats. Effect of losartan and spironolactone. Nicoletti, A., Heudes, D., Hinglais, N., Appay, M.D., Philippe, M., Sassy-Prigent, C., Bariety, J., Michel, J.B. Hypertension (1995)
- Extracellular matrix and oscillatory mechanics of rat lung parenchyma in bleomycin-induced fibrosis. Dolhnikoff, M., Mauad, T., Ludwig, M.S. Am. J. Respir. Crit. Care Med. (1999)
- Changes in extracellular matrix in subcutaneous small resistance arteries of patients with primary aldosteronism. Rizzoni, D., Paiardi, S., Rodella, L., Porteri, E., De Ciuceis, C., Rezzani, R., Boari, G.E., Zani, F., Miclini, M., Tiberio, G.A., Giulini, S.M., Rosei, C.A., Bianchi, R., Rosei, E.A. J. Clin. Endocrinol. Metab. (2006)
- No difference in degree of interstitial Sirius red-stained area in serial biopsies from area under concentration-over-time curves-guided cyclosporine versus tacrolimus-treated renal transplant recipients at one year. Rowshani, A.T., Scholten, E.M., Bemelman, F., Eikmans, M., Idu, M., van Groningen, M.C., Surachno, J.S., Mallat, M.J., Paul, L.C., de Fijter, J.W., Bajema, I.M., ten Berge, I., Florquin, S. J. Am. Soc. Nephrol. (2006)
- Inflammatory cells and myocardial fibrosis: spatial and temporal distribution in renovascular hypertensive rats. Nicoletti, A., Heudes, D., Mandet, C., Hinglais, N., Bariety, J., Michel, J.B. Cardiovasc. Res. (1996)
- The role of purinergic P2X7 receptors in the inflammation and fibrosis of unilateral ureteral obstruction in mice. Gon??alves, R.G., Gabrich, L., Ros??rio, A., Takiya, C.M., Ferreira, M.L., Chiarini, L.B., Persechini, P.M., Coutinho-Silva, R., Leite, M. Kidney Int. (2006)
- Reduction in dermal fibrosis in the tight-skin (Tsk) mouse after local application of halofuginone. Pines, M., Domb, A., Ohana, M., Inbar, J., Genina, O., Alexiev, R., Nagler, A. Biochem. Pharmacol. (2001)
- Histologic analysis of thermal effects of laser thermokeratoplasty and corneal ablation using Sirius-red polarization microscopy. Asiyo-Vogel, M.N., Brinkmann, R., Notbohm, H., Eggers, R., Lubatschowski, H., Laqua, H., Vogel, A. Journal of cataract and refractive surgery. (1997)
- Human endothelial nitric oxide synthase gene delivery protects against cardiac remodeling and reduces oxidative stress after myocardial infarction. Smith, R.S., Agata, J., Xia, C.F., Chao, L., Chao, J. Life Sci. (2005)
- Reduced expression of collagen type I and increased expression of matrix metalloproteinases 1 in patients with Crohn's disease. Stumpf, M., Cao, W., Klinge, U., Klosterhalfen, B., Junge, K., Krones, C.J., Schumpelick, V. Journal of investigative surgery : the official journal of the Academy of Surgical Research. (2005)
- Molecular comparison of calcineurin inhibitor-induced fibrogenic responses in protocol renal transplant biopsies. Roos-van Groningen, M.C., Scholten, E.M., Lelieveld, P.M., Rowshani, A.T., Baelde, H.J., Bajema, I.M., Florquin, S., Bemelman, F.J., de Heer, E., de Fijter, J.W., Bruijn, J.A., Eikmans, M. J. Am. Soc. Nephrol. (2006)
- Kallikrein gene transfer reduces renal fibrosis, hypertrophy, and proliferation in DOCA-salt hypertensive rats. Xia, C.F., Bledsoe, G., Chao, L., Chao, J. Am. J. Physiol. Renal Physiol. (2005)
- Dual angiotensin-converting enzyme/neutral endopeptidase inhibition on cardiac and renal fibrosis and inflammation in DOCA-salt hypertensive rats. Pu, Q., Amiri, F., Gannon, P., Schiffrin, E.L. J. Hypertens. (2005)
- Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice. Sakaida, I., Terai, S., Yamamoto, N., Aoyama, K., Ishikawa, T., Nishina, H., Okita, K. Hepatology (2004)
- Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis. Haber, P.S., Keogh, G.W., Apte, M.V., Moran, C.S., Stewart, N.L., Crawford, D.H., Pirola, R.C., McCaughan, G.W., Ramm, G.A., Wilson, J.S. Am. J. Pathol. (1999)
- Impact of final stent dimensions on long-term results following sirolimus-eluting stent implantation: serial intravascular ultrasound analysis from the sirius trial. Sonoda, S., Morino, Y., Ako, J., Terashima, M., Hassan, A.H., Bonneau, H.N., Leon, M.B., Moses, J.W., Yock, P.G., Honda, Y., Kuntz, R.E., Fitzgerald, P.J. J. Am. Coll. Cardiol. (2004)
- Computerized image analysis of Sirius Red-stained renal allograft biopsies as a surrogate marker to predict long-term allograft function. Grimm, P.C., Nickerson, P., Gough, J., McKenna, R., Stern, E., Jeffery, J., Rush, D.N. J. Am. Soc. Nephrol. (2003)
- Osteoblasts generate harder, stiffer, and more delamination-resistant mineralized tissue on titanium than on polystyrene, associated with distinct tissue micro- and ultrastructure. Saruwatari, L., Aita, H., Butz, F., Nakamura, H.K., Ouyang, J., Yang, Y., Chiou, W.A., Ogawa, T. J. Bone Miner. Res. (2005)