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Gene Review

GIPC1  -  GIPC PDZ domain containing family, member 1

Homo sapiens

Synonyms: C19orf3, GAIP C-terminus-interacting protein, GIPC, GLUT1CBP, Hs.6454, ...
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Disease relevance of GIPC1


High impact information on GIPC1


Biological context of GIPC1


Anatomical context of GIPC1

  • Expression of human GIPC1 in normal tissues, cancer cell lines, and primary tumors [1].
  • Expression level of GIPC1 mRNA was relatively lower in bone marrow and peripheral blood leukocytes [1].
  • Dynamic translocation of GAIP to the plasma membrane and coassembly in a protein complex in which GIPC was a required component was dictated by D2R activation and physical interactions [9].
  • In line with this activity of TIP-2/GIPC, we observed that depletion of this protein in HeLa cells hampers induction of the Id3 gene by TGF-beta treatment and also diminishes the antiproliferative effect of this cytokine [3].
  • Our data suggest that GIPC/SEMCAP-1 plays a role in biosynthetic sorting of proteins, specifically gp75, to melanosomes [10].

Associations of GIPC1 with chemical compounds

  • The alpha(6) integrin and TIP-2/GIPC co-localize in retraction fibers in carcinoma cells plated on laminin, a finding suggesting a functional interaction in vivo [11].
  • Interactions of GIPC with dopamine D2, D3 but not D4 receptors define a novel mode of regulation of G protein-coupled receptors [12].
  • Using the yeast two-hybrid system and an in vitro glutathione S-transferase fusion protein-binding assay, the binding of GIPC to the CYTO was shown to involve a newly identified class I PDZ-binding domain in the CD93 carboxyl terminus [13].
  • Gel filtration, sucrose gradient centrifugation and chemical cross-linking showed that whereas bulk of cytosolic GIPC was present as monomer, oligomers with an estimated molecular mass corresponding to GIPC homotrimer were readily detectable in the membrane fraction [14].
  • Using functional complementation and a yeast mutant deficient in ammonium (NH4+) transport (Deltamep1-3), three wheat (Triticum aestivum) TIP2 aquaporin homologues were isolated that restored the ability of the mutant to grow when 2 mM NH4+ was supplied as the sole nitrogen source [15].

Physical interactions of GIPC1


Other interactions of GIPC1


Analytical, diagnostic and therapeutic context of GIPC1


  1. Expression of human GIPC1 in normal tissues, cancer cell lines, and primary tumors. Kirikoshi, H., Katoh, M. Int. J. Mol. Med. (2002) [Pubmed]
  2. GIPC gene family (Review). Katoh, M. Int. J. Mol. Med. (2002) [Pubmed]
  3. Human papillomavirus type 18 E6 protein binds the cellular PDZ protein TIP-2/GIPC, which is involved in transforming growth factor beta signaling and triggers its degradation by the proteasome. Favre-Bonvin, A., Reynaud, C., Kretz-Remy, C., Jalinot, P. J. Virol. (2005) [Pubmed]
  4. BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Yano, H., Ninan, I., Zhang, H., Milner, T.A., Arancio, O., Chao, M.V. Nat. Neurosci. (2006) [Pubmed]
  5. Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles. Naccache, S.N., Hasson, T., Horowitz, A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  6. GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP. De Vries, L., Lou, X., Zhao, G., Zheng, B., Farquhar, M.G. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  7. APPL1 Associates with TrkA and GIPC1 and Is Required for Nerve Growth Factor-Mediated Signal Transduction. Lin, D.C., Quevedo, C., Brewer, N.E., Bell, A., Testa, J.R., Grimes, M.L., Miller, F.D., Kaplan, D.R. Mol. Cell. Biol. (2006) [Pubmed]
  8. Molecular cloning and characterization of human GIPC2, a novel gene homologous to human GIPC1 and Xenopus Kermit. Kirikoshi, H., Katoh, M. Int. J. Oncol. (2002) [Pubmed]
  9. GIPC recruits GAIP (RGS19) to attenuate dopamine D2 receptor signaling. Jeanneteau, F., Guillin, O., Diaz, J., Griffon, N., Sokoloff, P. Mol. Biol. Cell (2004) [Pubmed]
  10. PDZ domain protein GIPC interacts with the cytoplasmic tail of melanosomal membrane protein gp75 (tyrosinase-related protein-1). Liu, T.F., Kandala, G., Setaluri, V. J. Biol. Chem. (2001) [Pubmed]
  11. PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B. Tani, T.T., Mercurio, A.M. J. Biol. Chem. (2001) [Pubmed]
  12. Interactions of GIPC with dopamine D2, D3 but not D4 receptors define a novel mode of regulation of G protein-coupled receptors. Jeanneteau, F., Diaz, J., Sokoloff, P., Griffon, N. Mol. Biol. Cell (2004) [Pubmed]
  13. CD93 interacts with the PDZ domain-containing adaptor protein GIPC: implications in the modulation of phagocytosis. Bohlson, S.S., Zhang, M., Ortiz, C.E., Tenner, A.J. J. Leukoc. Biol. (2005) [Pubmed]
  14. TRP1 interacting PDZ-domain protein GIPC forms oligomers and is localized to intracellular vesicles in human melanocytes. Kedlaya, R.H., Bhat, K.M., Mitchell, J., Darnell, S.J., Setaluri, V. Arch. Biochem. Biophys. (2006) [Pubmed]
  15. Aquaporin homologues in plants and mammals transport ammonia. Jahn, T.P., Møller, A.L., Zeuthen, T., Holm, L.M., Klaerke, D.A., Mohsin, B., Kühlbrandt, W., Schjoerring, J.K. FEBS Lett. (2004) [Pubmed]
  16. GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation. Hu, L.A., Chen, W., Martin, N.P., Whalen, E.J., Premont, R.T., Lefkowitz, R.J. J. Biol. Chem. (2003) [Pubmed]
  17. GIPC binds to the human lutropin receptor (hLHR) through an unusual PDZ domain binding motif, and it regulates the sorting of the internalized human choriogonadotropin and the density of cell surface hLHR. Hirakawa, T., Galet, C., Kishi, M., Ascoli, M. J. Biol. Chem. (2003) [Pubmed]
  18. GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function. Lou, X., McQuistan, T., Orlando, R.A., Farquhar, M.G. J. Am. Soc. Nephrol. (2002) [Pubmed]
  19. 5T4 interacts with TIP-2/GIPC, a PDZ protein, with implications for metastasis. Awan, A., Lucic, M.R., Shaw, D.M., Sheppard, F., Westwater, C., Lyons, S.A., Stern, P.L. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  20. Assignment of PDZ domain-containing protein GIPC gene (C19orf3) to human chromosome band 19p13.1 by in situ hybridization and radiation hybrid mapping. Von Kap-Herr, C., Kandala, G., Mann, S.S., Hart, T.C., Pettenati, M.J., Setaluri, V. Cytogenet. Cell Genet. (2000) [Pubmed]
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