Gene Review:
Cyp17a1 - cytochrome P450, family 17, subfamily a,...
Mus musculus
Synonyms:
17-alpha-hydroxyprogesterone aldolase, CYPXVII, Cyp17, Cytochrome P450 17A1, Cytochrome P450-C17, ...
- Endogenous estrogens inhibit mouse fetal Leydig cell development via estrogen receptor alpha. Delbès, G., Levacher, C., Duquenne, C., Racine, C., Pakarinen, P., Habert, R. Endocrinology (2005)
- Characterization of adrenal autoantigens recognized by sera from patients with autoimmune polyglandular syndrome (APS) type I. Uibo, R., Perheentupa, J., Ovod, V., Krohn, K.J. J. Autoimmun. (1994)
- Müllerian Inhibiting Substance lowers testosterone in luteinizing hormone-stimulated rodents. Trbovich, A.M., Sluss, P.M., Laurich, V.M., O'Neill, F.H., MacLaughlin, D.T., Donahoe, P.K., Teixeira, J. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Deletion of the mouse P450c17 gene causes early embryonic lethality. Bair, S.R., Mellon, S.H. Mol. Cell. Biol. (2004)
- Müllerian inhibiting substance blocks the protein kinase A-induced expression of cytochrome p450 17alpha-hydroxylase/C(17-20) lyase mRNA in a mouse Leydig cell line independent of cAMP responsive element binding protein phosphorylation. Laurich, V.M., Trbovich, A.M., O'Neill, F.H., Houk, C.P., Sluss, P.M., Payne, A.H., Donahoe, P.K., Teixeira, J. Endocrinology (2002)
- Developmentally regulated expression of adrenal 17 alpha-hydroxylase cytochrome P450 in the mouse embryo. Keeney, D.S., Jenkins, C.M., Waterman, M.R. Endocrinology (1995)
- Isolation and characterization of the mouse P450 17 alpha-hydroxylase/C17-20-lyase gene (Cyp17): transcriptional regulation of the gene by cyclic adenosine 3',5'-monophosphate in MA-10 Leydig cells. Youngblood, G.L., Payne, A.H. Mol. Endocrinol. (1992)
- Repression of cAMP-induced expression of the mouse P450 17 alpha-hydroxylase/C17-20 lyase gene (Cyp17) by androgens. Burgos-Trinidad, M., Youngblood, G.L., Maroto, M.R., Scheller, A., Robins, D.M., Payne, A.H. Mol. Endocrinol. (1997)
- The role of tumor necrosis factor-alpha in the regulation of mouse Leydig cell steroidogenesis. Xiong, Y., Hales, D.B. Endocrinology (1993)
- Novel role for the nuclear phosphoprotein SET in transcriptional activation of P450c17 and initiation of neurosteroidogenesis. Compagnone, N.A., Zhang, P., Vigne, J.L., Mellon, S.H. Mol. Endocrinol. (2000)
- Tumor necrosis factor-alpha inhibition of 17 alpha-hydroxylase/C17-20 lyase gene (Cyp17) expression. Li, X., Youngblood, G.L., Payne, A.H., Hales, D.B. Endocrinology (1995)
- Ontogeny of expression of the genes for steroidogenic enzymes P450 side-chain cleavage, 3 beta-hydroxysteroid dehydrogenase, P450 17 alpha-hydroxylase/C17-20 lyase, and P450 aromatase in fetal mouse gonads. Greco, T.L., Payne, A.H. Endocrinology (1994)
- Wnt-4 deficiency alters mouse adrenal cortex function, reducing aldosterone production. Heikkilä, M., Peltoketo, H., Leppäluoto, J., Ilves, M., Vuolteenaho, O., Vainio, S. Endocrinology (2002)
- Androgen-regulated transcripts in the neonatal mouse testis as determined through microarray analysis. Zhou, Q., Shima, J.E., Nie, R., Friel, P.J., Griswold, M.D. Biol. Reprod. (2005)
- Consensus sequence of transcription factor SF-1 binding site and putative binding site in the 5' flanking regions of genes encoding mouse steroidogenic enzymes 3betaHSDI and Cyp17. Busygina, T.V., Ignatieva, E.V., Osadchuk, A.V. Biochemistry Mosc. (2003)
- Feedback inhibition of steroidogenic acute regulatory protein expression in vitro and in vivo by androgens. Houk, C.P., Pearson, E.J., Martinelle, N., Donahoe, P.K., Teixeira, J. Endocrinology (2004)
- Arginine vasopressin inhibition of cytochrome P450c17 and testosterone production in mouse Leydig cells. Hales, D.B., Greene, R. Endocrine (1998)
- Characterization of the hypothalamic-pituitary-gonadal axis in estrogen receptor (ER) Null mice reveals hypergonadism and endocrine sex reversal in females lacking ERalpha but not ERbeta. Couse, J.F., Yates, M.M., Walker, V.R., Korach, K.S. Mol. Endocrinol. (2003)
- Pubertal and adult Leydig cell function in Mullerian inhibiting substance-deficient mice. Wu, X., Arumugam, R., Baker, S.P., Lee, M.M. Endocrinology (2005)
- Scraggly, a new hair loss mutation on mouse chromosome 19. Herron, B.J., Bryda, E.C., Heverly, S.A., Collins, D.N., Flaherty, L. Mamm. Genome (1999)
- Effects of 3,3',4,4',5-pentachlorobiphenyl, a coplanar polychlorinated biphenyl congener, on cultured neonatal mouse testis. Fukuzawa, N.H., Ohsako, S., Nagano, R., Sakaue, M., Baba, T., Aoki, Y., Tohyama, C. Toxicology in vitro : an international journal published in association with BIBRA. (2003)
- Nitric oxide is a mediator of the inhibitory effect of activated macrophages on production of androgen by the Leydig cell of the mouse. Pomerantz, D.K., Pitelka, V. Endocrinology (1998)