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Gene Review

Sct  -  secretin

Mus musculus

Synonyms: Secretin
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Disease relevance of Sct


High impact information on Sct


Chemical compound and disease context of Sct


Biological context of Sct


Anatomical context of Sct

  • These results suggest that most small intestinal endocrine cells are developmentally related and that a close developmental relationship exists between secretin-producing S cells and cholecystokinin-producing and L type enteroendocrine cells [3].
  • Targeted ablation of secretin-producing cells in transgenic mice reveals a common differentiation pathway with multiple enteroendocrine cell lineages in the small intestine [3].
  • The secretin-producing (S) cell is one of at least ten cell types belonging to the diffuse neuroendocrine system of the gut [3].
  • Consistent with the idea that secretin is a brain-gut peptide, its expressions are present in several developing brain regions such as cephalic mesenchyme, cerebellar primordium and choroid plexus as well as the epithelial villi lining and inner circular muscle of the developing intestine [12].
  • Other than these organs, secretin was also detected in the developing heart including the ventricular epicardium and myocardium and certain structures of the developing kidney like ureteric bud, collecting duct and glomerulus [12].

Associations of Sct with chemical compounds

  • VIP and secretin both potentiated glucose-induced insulin release [13].
  • Secretin inhibited insulin secretion induced by carbachol and L-IPNA, whereas VIP potentiated L-IPNA-induced insulin secretion and had no influence on the effect of carbachol [13].
  • The expression of these products was compared with that of substance P, serotonin, and secretin [14].
  • Existence of the gastro-intestinal peptide secretin in the CNS has been a matter of debate, and contrasting results have been reported, altogether indicating that the CNS is not a major site of production of this peptide [4].
  • In addition, the protective effect of secretin was compared with that of the cholecystokinin-receptor antagonists proglumide and benzotript [7].

Regulatory relationships of Sct

  • CCK and A23187 did not alter the increase of cAMP induced by secretin and the inhibitory effect of octreotide on cAMP production [15].
  • Secretin potentiates cholinergically induced glucagon secretion in the mouse [16].
  • Vasoactive intestinal peptide (VIP) and secretin are two related peptides that activate adenylate cyclase on membranes of striatal neurons and glial cells from embryonic mouse brain grown in primary culture [17].
  • Secretin is a gastrointestinal peptide belonging to the vasoactive intestinal peptide (VIP)/glucagon/pituitary adenylate cyclase-activating polypeptide (PACAP) family recently suggested to have therapeutic effects in autism [18].

Other interactions of Sct

  • The results suggest that VIP, secretin and gastrin display their effects on insulin secretion through different mechanisms [13].
  • Factors that affect intracellular cAMP concentration, such as secretin, somatostatin, VIP, DBcAMP, and forskolin, did not increase DNA synthesis in cultured pancreatic cells [19].
  • Octreotide also reduced synergistic amylase secretion by secretin or VIP in combination with calcium ionophore A23187 [15].
  • Fluid collections done in older mice (that are less sensitive to a high-fat diet) by ductal cannulation showed threefold increased pancreatic fluid flow in response to secretin/cholecystokinin, but volumes, pH, and amylase activities were affected little by AQP1 deletion, nor were bile flow rates and bile salt concentrations [20].
  • Natural glucagon, at concentrations that stimulated cAMP accumulation, did not react with vasoactive intestinal peptide or secretin radioimmunoassays [21].

Analytical, diagnostic and therapeutic context of Sct


  1. Beneficial effects of cholecystokinin-receptor blockade and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice. Evidence for cholecystokinin as a major factor in the development of acute pancreatitis. Niederau, C., Liddle, R.A., Ferrell, L.D., Grendell, J.H. J. Clin. Invest. (1986) [Pubmed]
  2. Establishment of a human gastrinoma in nude mice. Upp, J.R., Trudel, J.L., Townsend, C.M., Alexander, R.W., Rajaraman, S., Nealon, W.H., Greeley, G.H., Thompson, J.C. Surgery (1988) [Pubmed]
  3. Targeted ablation of secretin-producing cells in transgenic mice reveals a common differentiation pathway with multiple enteroendocrine cell lineages in the small intestine. Rindi, G., Ratineau, C., Ronco, A., Candusso, M.E., Tsai, M., Leiter, A.B. Development (1999) [Pubmed]
  4. Transient expression of secretin in serotoninergic neurons of mouse brain during development. Lossi, L., Bottarelli, L., Candusso, M.E., Leiter, A.B., Rindi, G., Merighi, A. Eur. J. Neurosci. (2004) [Pubmed]
  5. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Naya, F.J., Huang, H.P., Qiu, Y., Mutoh, H., DeMayo, F.J., Leiter, A.B., Tsai, M.J. Genes Dev. (1997) [Pubmed]
  6. Role of the amino-terminal domain of simian virus 40 early region in inducing tumors in secretin-expressing cells in transgenic mice. Ratineau, C., Ronco, A., Leiter, A.B. Gastroenterology (2000) [Pubmed]
  7. Caerulein-induced acute necrotizing pancreatitis in mice: protective effects of proglumide, benzotript, and secretin. Niederau, C., Ferrell, L.D., Grendell, J.H. Gastroenterology (1985) [Pubmed]
  8. Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior. Nishijima, I., Yamagata, T., Spencer, C.M., Weeber, E.J., Alekseyenko, O., Sweatt, J.D., Momoi, M.Y., Ito, M., Armstrong, D.L., Nelson, D.L., Paylor, R., Bradley, A. Hum. Mol. Genet. (2006) [Pubmed]
  9. Effect of kinin inhibition in experimental acute pancreatitis. Lerch, M.M., Weidenbach, H., Gress, T.M., Adler, G. Am. J. Physiol. (1995) [Pubmed]
  10. Role of CCK-A receptor for pancreatic function in mice: a study in CCK-A receptor knockout mice. Takiguchi, S., Suzuki, S., Sato, Y., Kanai, S., Miyasaka, K., Jimi, A., Shinozaki, H., Takata, Y., Funakoshi, A., Kono, A., Minowa, O., Kobayashi, T., Noda, T. Pancreas (2002) [Pubmed]
  11. cDNA sequence and genomic organization of mouse secretin. Lan, M.S., Kajiyama, W., Donadel, G., Lu, J., Notkins, A.L. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  12. Secretin, a known gastrointestinal peptide, is widely expressed during mouse embryonic development. Siu, F.K., Sham, M.H., Chow, B.K. Gene Expr. Patterns (2005) [Pubmed]
  13. Effects of vasoactive intestinal polypeptide (VIP), secretin and gastrin on insulin secretion in the mouse. Ahrén, B., Lundquist, I. Diabetologia (1981) [Pubmed]
  14. Immunohistochemical studies indicate multiple enteroendocrine cell differentiation pathways in the mouse proximal small intestine. Aiken, K.D., Kisslinger, J.A., Roth, K.A. Dev. Dyn. (1994) [Pubmed]
  15. The effect of somatostatin analogue octreotide on amylase secretion from mouse pancreatic acini. Ishiguro, H., Hayakawa, T., Kondo, T., Shibata, T., Kitagawa, M., Sakai, Y., Sobajima, H., Nakae, Y., Tanikawa, M. Digestion (1993) [Pubmed]
  16. Secretin potentiates cholinergically induced glucagon secretion in the mouse. Ahrén, B., Lundquist, I. Acta Physiol. Scand. (1986) [Pubmed]
  17. Do secretin and vasoactive intestinal peptide have independent receptors on striatal neurons and glial cells in primary cultures? Chneiweiss, H., Glowinski, J., Premont, J. J. Neurochem. (1986) [Pubmed]
  18. Differential transport of a secretin analog across the blood-brain and blood-cerebrospinal fluid barriers of the mouse. Banks, W.A., Goulet, M., Rusche, J.R., Niehoff, M.L., Boismenu, R. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  19. Stimulation of pancreatic acinar cell growth by CCK, epidermal growth factor, and insulin in vitro. Logsdon, C.D. Am. J. Physiol. (1986) [Pubmed]
  20. Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels. Ma, T., Jayaraman, S., Wang, K.S., Song, Y., Yang, B., Li, J., Bastidas, J.A., Verkman, A.S. Am. J. Physiol., Cell Physiol. (2001) [Pubmed]
  21. Action of natural glucagon on pancreatic acini: due to contamination by previously undescribed secretagogues. Pandol, S.J., Sutliff, V.E., Jones, S.W., Charlton, C.G., O'Donohue, T.L., Gardner, J.D., Jensen, R.T. Am. J. Physiol. (1983) [Pubmed]
  22. Development of neuroendocrine tumors in the gastrointestinal tract of transgenic mice. Heterogeneity of hormone expression. Rindi, G., Grant, S.G., Yiangou, Y., Ghatei, M.A., Bloom, S.R., Bautch, V.L., Solcia, E., Polak, J.M. Am. J. Pathol. (1990) [Pubmed]
  23. Vasoactive intestinal peptide (VIP)/pituitary adenylate cyclase-activating peptide receptor subtypes in mouse calvarial osteoblasts: presence of VIP-2 receptors and differentiation-induced expression of VIP-1 receptors. Lundberg, P., Lundgren, I., Mukohyama, H., Lehenkari, P.P., Horton, M.A., Lerner, U.H. Endocrinology (2001) [Pubmed]
  24. Temporal differentiation and migration of substance P, serotonin, and secretin immunoreactive enteroendocrine cells in the mouse proximal small intestine. Aiken, K.D., Roth, K.A. Dev. Dyn. (1992) [Pubmed]
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