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Gene Review

Olfr66  -  olfactory receptor 66

Mus musculus

Synonyms: 5'[b]1, 5'beta1, GA_x6K02T2PBJ9-6620959-6620024, MOR1-3, ORL532
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Disease relevance of Olfr66


High impact information on Olfr66


Chemical compound and disease context of Olfr66


Biological context of Olfr66


Anatomical context of Olfr66


Associations of Olfr66 with chemical compounds


Regulatory relationships of Olfr66


Other interactions of Olfr66

  • However, the embryos progress significantly further than embryos null for fibronectin, for which alpha 5 beta 1 integrin is a receptor, suggesting the involvement of other fibronectin receptors [19].
  • Recent findings have also revealed heterophilic interactions between L1 and two "classical" integrin matrix receptors, murine alpha 5 beta 1 and human alpha V beta 3 [24].
  • We report that a beta 1 integrin (alpha 5 beta 1) can exist in different affinity states for its soluble ligand, fibronectin [16].
  • The alpha 5 beta 1, alpha 6 beta 4 and Mac-1 integrins all participate in the endocytotic cycle [11].
  • In short term adhesion assays, the GlcNAc-TV expressing cells were less adhesive on surfaces coated with fibronectin and collagen type IV, but no changes were observed in levels of cell surface alpha 5 beta 1 or alpha v beta 3 integrins [25].

Analytical, diagnostic and therapeutic context of Olfr66

  • Surprisingly, ligation of alpha 5 beta 1 on these cells by cell attachment to a fibronectin substrate not only reverses the growth inhibition and gas-1 gene induction but activates immediate early gene transcription [26].
  • Immunoblotting and immunomorphological findings in the cultures treated with anti-beta 1 antibody from day 1 to day 3 revealed a pattern of integrins and collagen composed of beta 1, alpha 1, alpha 5 beta 1 integrins and collagen type I. The cartilage-specific chondroitin sulfate proteoglycan (CSPG) could not be demonstrated in these cultures [27].
  • Properties of expressed recombinant alpha 5 beta X gamma 2L (where X = 1,2, or 3) GABARs were studied with the use of whole-cell, patch-clamp techniques [28].
  • As determined by immunofluorescence flow cytometry assay, both a-EAT and na-EAT cells express similar amounts of surface antigen(s) recognized by the same anti-alpha 5 beta 1 integrin polyclonal antibody that blocks a-EAT cells from adhering to laminin and fibronectin [29].
  • Localization and dynamic aspects of fibronectin receptor (alpha 5 beta 1 integrin) were investigated by immunoelectron microscopy on freshly isolated mouse peritoneal macrophages and after cultivation in vitro [30].


  1. Increased fibronectin-receptor expression in colon carcinoma-derived HT 29 cells decreases tumorigenicity in nude mice. Stallmach, A., von Lampe, B., Orzechowski, H.D., Matthes, H., Riecken, E.O. Gastroenterology (1994) [Pubmed]
  2. Extracellular matrix receptors and mouse skin carcinogenesis: altered expression linked to appearance of early markers of tumor progression. Tennenbaum, T., Yuspa, S.H., Grover, A., Castronovo, V., Sobel, M.E., Yamada, Y., De Luca, L.M. Cancer Res. (1992) [Pubmed]
  3. The capacity of human malignant B-lymphocytes to disseminate in SCID mice is correlated with functional expression of the fibronectin receptor alpha 5 beta 1 (CD49e/CD29). Blase, L., Daniel, P.T., Koretz, K., Schwartz-Albiez, R., Möller, P. Int. J. Cancer (1995) [Pubmed]
  4. Suprabasal alpha 5 beta1 integrin expression stimulates formation of epidermal squamous cell carcinomas without disrupting TGFbeta signaling or inducing spindle cell tumors. Owens, D.M., Broad, S., Yan, X., Benitah, S.A., Watt, F.M. Mol. Carcinog. (2005) [Pubmed]
  5. Elevated levels of the alpha 5 beta 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells. Giancotti, F.G., Ruoslahti, E. Cell (1990) [Pubmed]
  6. The pulmonary alveolar proteinosis in granulocyte macrophage colony-stimulating factor/interleukins 3/5 beta c receptor-deficient mice is reversed by bone marrow transplantation. Nishinakamura, R., Wiler, R., Dirksen, U., Morikawa, Y., Arai, K., Miyajima, A., Burdach, S., Murray, R. J. Exp. Med. (1996) [Pubmed]
  7. Beta 1 integrin-dependent and -independent polymerization of fibronectin. Wennerberg, K., Lohikangas, L., Gullberg, D., Pfaff, M., Johansson, S., Fässler, R. J. Cell Biol. (1996) [Pubmed]
  8. Transforming growth factor-beta 1 modulates beta 1 and beta 5 integrin receptors and induces the de novo expression of the alpha v beta 6 heterodimer in normal human keratinocytes: implications for wound healing. Zambruno, G., Marchisio, P.C., Marconi, A., Vaschieri, C., Melchiori, A., Giannetti, A., De Luca, M. J. Cell Biol. (1995) [Pubmed]
  9. Fibronectin co-stimulates via the alpha 5 beta 1 receptor IL-2, IL-4 production by splenic, granuloma lymphocytes of Schistosoma mansoni infected mice. Zhu, Y., Boros, D.L. Scand. J. Immunol. (1996) [Pubmed]
  10. Androgen therapy of aplastic anaemia. Gardner, F.H. Clinics in haematology. (1978) [Pubmed]
  11. Circulating integrins: alpha 5 beta 1, alpha 6 beta 4 and Mac-1, but not alpha 3 beta 1, alpha 4 beta 1 or LFA-1. Bretscher, M.S. EMBO J. (1992) [Pubmed]
  12. Alpha 5 beta 1 integrin activates an NF-kappa B-dependent program of gene expression important for angiogenesis and inflammation. Klein, S., de Fougerolles, A.R., Blaikie, P., Khan, L., Pepe, A., Green, C.D., Koteliansky, V., Giancotti, F.G. Mol. Cell. Biol. (2002) [Pubmed]
  13. Activation of microvascular endothelium by eicosanoid 12(S)-hydroxyeicosatetraenoic acid leads to enhanced tumor cell adhesion via up-regulation of surface expression of alpha v beta 3 integrin: a posttranscriptional, protein kinase C- and cytoskeleton-dependent process. Tang, D.G., Diglio, C.A., Honn, K.V. Cancer Res. (1994) [Pubmed]
  14. Role of alpha 5 beta 1 integrin in TGF-beta 1-costimulated CD8+ T cell growth and apoptosis. Rich, S., Van Nood, N., Lee, H.M. J. Immunol. (1996) [Pubmed]
  15. 5alpha-reduced glucocorticoids, novel endogenous activators of the glucocorticoid receptor. McInnes, K.J., Kenyon, C.J., Chapman, K.E., Livingstone, D.E., Macdonald, L.J., Walker, B.R., Andrew, R. J. Biol. Chem. (2004) [Pubmed]
  16. Affinity modulation of integrin alpha 5 beta 1: regulation of the functional response by soluble fibronectin. Faull, R.J., Kovach, N.L., Harlan, J.M., Ginsberg, M.H. J. Cell Biol. (1993) [Pubmed]
  17. Protein kinase C-dependent effects of 12(S)-HETE on endothelial cell vitronectin receptor and fibronectin receptor. Tang, D.G., Chen, Y.Q., Diglio, C.A., Honn, K.V. J. Cell Biol. (1993) [Pubmed]
  18. Macrophage-colony-stimulating factor regulates expression of the integrins alpha 4 beta 1 and alpha 5 beta 1 by murine bone marrow macrophages. Shima, M., Teitelbaum, S.L., Holers, V.M., Ruzicka, C., Osmack, P., Ross, F.P. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  19. Embryonic mesodermal defects in alpha 5 integrin-deficient mice. Yang, J.T., Rayburn, H., Hynes, R.O. Development (1993) [Pubmed]
  20. Fine tuning of the specificity of an anti-progesterone antibody by first and second sphere residue engineering. Dubreuil, O., Bossus, M., Graille, M., Bilous, M., Savatier, A., Jolivet, M., Ménez, A., Stura, E., Ducancel, F. J. Biol. Chem. (2005) [Pubmed]
  21. Regulatory role of GM3 ganglioside in alpha 5 beta 1 integrin receptor for fibronectin-mediated adhesion of FUA169 cells. Zheng, M., Fang, H., Tsuruoka, T., Tsuji, T., Sasaki, T., Hakomori, S. J. Biol. Chem. (1993) [Pubmed]
  22. Impact of beta and gamma variants on ligand-binding properties of gamma-aminobutyric acid type A receptors. Lüddens, H., Seeburg, P.H., Korpi, E.R. Mol. Pharmacol. (1994) [Pubmed]
  23. Adhesion of lymphoma cells to fibronectin: differential use of alpha 4 beta 1 and alpha 5 beta 1 integrins and stimulation by the 9EG7 mAb against the murine beta 1 integrin subunit. Driessens, M.H., Van Rijthoven, E.A., Kemperman, H., Roos, E. Cell Adhes. Commun. (1995) [Pubmed]
  24. The cell adhesion molecule L1: species- and cell-type-dependent multiple binding mechanisms. Kadmon, G., Altevogt, P. Differentiation (1997) [Pubmed]
  25. Reduced contact-inhibition and substratum adhesion in epithelial cells expressing GlcNAc-transferase V. Demetriou, M., Nabi, I.R., Coppolino, M., Dedhar, S., Dennis, J.W. J. Cell Biol. (1995) [Pubmed]
  26. Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin. Varner, J.A., Emerson, D.A., Juliano, R.L. Mol. Biol. Cell (1995) [Pubmed]
  27. Inhibition of chondrogenesis by integrin antibody in vitro. Shakibaei, M. Exp. Cell Res. (1998) [Pubmed]
  28. Properties of recombinant gamma-aminobutyric acid A receptor isoforms containing the alpha 5 subunit subtype. Burgard, E.C., Tietz, E.I., Neelands, T.R., Macdonald, R.L. Mol. Pharmacol. (1996) [Pubmed]
  29. Expression and function of beta 1 integrins on adherent and nonadherent Ehrlich ascites tumor cells. Song, Z., Varani, J., Goldstein, I.J. Exp. Cell Res. (1995) [Pubmed]
  30. Endocytosis of integrin alpha 5 beta 1 (fibronectin receptor) of mouse peritoneal macrophages in vitro: an immunoelectron microscopic study. Shakibaei, M., Zimmermann, B., Scheller, M. J. Struct. Biol. (1993) [Pubmed]
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