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PTCRA  -  pre T-cell antigen receptor alpha

Homo sapiens

Synonyms: PT-ALPHA, PTA, Pre T-cell antigen receptor alpha, pT-alpha, pT-alpha-TCR, ...
 
 
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Disease relevance of PTCRA

  • Development of new coronary aneurysms was reported in 3 patients for PTCA, 2 for PTCRA, 3 for DCA, and 1 for stents [1].
  • High gene frequency of factor XI (PTA) deficiency in Ashkenazi Jews [2].
  • This study was a prospective controlled open trial to evaluate whether prophylactic PTA of stenosis not associated with access dysfunction improves survival in native, virgin, radiocephalic forearm AVF [3].
  • There was no correlation between PT-alpha or c-myc messenger RNA expression and Dukes' stage of colorectal cancer; or between either of these two and actin messenger RNA expression [4].
  • We identified PT-alpha as being overexpressed in a human colon cancer minus normal mucosa subtraction cDNA library [4].
 

Psychiatry related information on PTCRA

  • Of the predictors, history of alcohol abuse (odds ratio [OR] 32.39; 95% CI 1.67-626.89), having a PAK or PTA (OR 13.6; 95% CI 2.20-84.01), and use of a nonlocal organ procurement center (OPO) (OR 4.51; 95% CI 0.78-25.96) were most closely associated with early graft loss [5].
  • RESULTS: In multiple logistic regression analyses controlling for potential confounders, moderate alcohol consumption (>140 grams/week) was inversely associated with hearing loss (PTA(.5,1,2,4 > 25 dB HL); odds ratio [OR] = .71, 95% confidence interval [CI] = .52, .97; where PTA is pure tone average) [6].
  • Class A hearing is socially useful hearing and is defined as a pure tone average (PTA; average of 500 Hz and 1, 2 and 4 kHz) of < 30 dB and speech discrimination scores (SDS) of > 70% [7].
  • The severity of trauma was assessed by the Glasgow Coma Scale (GCS) score (8 or less), posttraumatic amnesia (PTA, more than 24 hours), and initial computed tomography (CT) scan [8].
  • METHODS AND RESULTS: PTA was performed in external iliac arteries of 12 atherosclerotic Yucatan pigs, of which 6 pigs (7 vessels) received the MMPI batimastat and 6 pigs (10 vessels) served as controls [9].
 

High impact information on PTCRA

  • With help of a hCD25 reporter controlled by pre-T cell receptor alpha (Ptcra) regulatory elements, T cell precursors were identified in peripheral blood [10].
  • These analogues are also inhibitors for the hydrolysis of NAD(+) by PTA with K(i) values of 24-40 microM, but bind with similar affinity to the NAD(+) substrates [11].
  • As functional biomimics of the hydrogen-producing capability of the dinuclear active site in [Fe]H(2)ase, the Fe(I)Fe(I) organometallic complexes, (mu-pdt)[Fe(CO)(2)PTA](2), 1-PTA(2), (pdt = SCH(2)CH(2)CH(2)S; PTA = 1,3,5-triaza-7-phosphaadamantane), and (mu-pdt)[Fe(CO)(3)][Fe(CO)(2)PTA], 1-PTA, were synthesized and fully characterized [12].
  • METHODS: From December 16, 1966, to March 31, 2000, the authors performed 1,194 pancreas transplants (111 from living donors; 191 retransplants): 498 simultaneous pancreas-kidney (SPK) and 1 simultaneous pancreas-liver transplant; 404 pancreas after kidney (PAK) transplants; and 291 pancreas transplants alone (PTA) [13].
  • Transcription of PT-alpha has been reported to be regulated by the c-myc gene in vitro [4].
 

Chemical compound and disease context of PTCRA

  • (ii) To assess the pharmacokinetic-pharmacodynamic profile of various cefepime dosing regimens and to assess their expected probability of target attainment (= PTA expectation value) against common ICU pathogens such as Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii [14].
  • Four interventions showed a significant preventive effect on the development or severity of oral mucositis: PTA with an odds ratio (OR) = 0.61 (95% confidence interval [CI], 0.39-0.96); GM-CSF, OR = 0.53 (CI: 0.33-0.87); oral cooling, OR = 0.3 (CI: 0.16-0.56); and amifostine, OR = 0.37 (CI: 0.15-0.89) [15].
  • Conversely, six of the 15 patients in the group who underwent PTA-stenting with standard SDSA had significantly increased Cr values at 6 days (95% CI, 16.3-67.7) and two patients had progressive chronic renal insufficiency at 12 months [16].
 

Biological context of PTCRA

 

Anatomical context of PTCRA

 

Associations of PTCRA with chemical compounds

  • Moreover, the cumulative cyclophosphamide dose (26.86 vs 8.53 P < 0.01) was significantly increased in these patients, suggesting that PTA was associated with disease severity [20].
  • CONCLUSIONS: Carotid PTA results in a normalization of impaired hemodynamics, as assessed by CO2 reactivity [22].
  • For P. aeruginosa higher doses of cefepime (>4 g/day) are required to achieve the required PTA expectation value [14].
  • Purified rat liver glutathione S-transferases enhanced 6-MP formation from PTA by 1.8-fold, whereas human recombinant alpha, mu, and pi isozymes enhanced 6-MP formation by 1.7-, 1.3-, and 1.3-fold, respectively [24].
  • cis-3-(9H-Purin-6-ylthio)acrylic acid (PTA) is a structural analog of azathioprine, a prodrug of the antitumor and immunosuppressive drug 6-mercaptopurine (6-MP) [24].
 

Analytical, diagnostic and therapeutic context of PTCRA

  • The immediate success rate was 74% for PTCA, 100% for PTCRA, 100% for DCA, and 86% for stents [1].
  • We studied 14 patients undergoing PTCRA and compared them with 14 patients undergoing plain balloon angioplasty [25].
  • ET-1 increased in the angioplasty group from 6.3 +/- 3.2 pmol/L at baseline to 8.5 +/- 3.9 pmol/L at the end of the procedure (F = 3.83, P = .02), whereas it did not change in the PTCRA group [25].
  • Appropriate surgery allowed limb salvage in 23 of 36 early failures (less than 3 months) and 12 of 14 late failures (greater than 3 months), and usually consisted of the same operation that would have been performed had PTA not been attempted [21].
  • PTA was also associated with a significant decrease in access-related morbidity by approximately halving the risk of hospitalization, central venous catheterization, and thrombectomy (P < 0.05) [3].

References

  1. Catheter interventional treatment in Kawasaki disease: A report from the Japanese Pediatric Interventional Cardiology Investigation group. Akagi, T., Ogawa, S., Ino, T., Iwasa, M., Echigo, S., Kishida, K., Baba, K., Matsushima, M., Hamaoka, K., Tomita, H., Ishii, M., Kato, H. J. Pediatr. (2000) [Pubmed]
  2. High gene frequency of factor XI (PTA) deficiency in Ashkenazi Jews. Seligsohn, U. Blood (1978) [Pubmed]
  3. A prospective controlled trial on effect of percutaneous transluminal angioplasty on functioning arteriovenous fistulae survival. Tessitore, N., Mansueto, G., Bedogna, V., Lipari, G., Poli, A., Gammaro, L., Baggio, E., Morana, G., Loschiavo, C., Laudon, A., Oldrizzi, L., Maschio, G. J. Am. Soc. Nephrol. (2003) [Pubmed]
  4. Prothymosin-alpha mRNA expression correlates with that of c-myc in human colon cancer. Mori, M., Barnard, G.F., Staniunas, R.J., Jessup, J.M., Steele, G.D., Chen, L.B. Oncogene (1993) [Pubmed]
  5. A neural network model for predicting pancreas transplant graft outcome. Dorsey, S.G., Waltz, C.F., Brosch, L., Connerney, I., Schweitzer, E.J., Bartlett, S.T. Diabetes Care (1997) [Pubmed]
  6. Moderate alcohol consumption and hearing loss: a protective effect. Popelka, M.M., Cruickshanks, K.J., Wiley, T.L., Tweed, T.S., Klein, B.E., Klein, R., Nondahl, D.M. Journal of the American Geriatrics Society. (2000) [Pubmed]
  7. Audiovestibular results after surgery for cerebellopontine angle meningiomas. Grey, P.L., Baguley, D.M., Moffat, D.A., Hardy, D.G., Beynon, G.J. The American journal of otology. (1996) [Pubmed]
  8. Evidence for integrity of the growth hormone/insulin-like growth factor-1 axis in patients with severe head trauma during rehabilitation. Bondanelli, M., Ambrosio, M.R., Margutti, A., Boldrini, P., Basaglia, N., Franceschetti, P., Zatelli, M.C., Degli Uberti, E.C. Metab. Clin. Exp. (2002) [Pubmed]
  9. Shear-stress and wall-stress regulation of vascular remodeling after balloon angioplasty: effect of matrix metalloproteinase inhibition. Wentzel, J.J., Kloet, J., Andhyiswara, I., Oomen, J.A., Schuurbiers, J.C., de Smet, B.J., Post, M.J., de Kleijn, D., Pasterkamp, G., Borst, C., Slager, C.J., Krams, R. Circulation (2001) [Pubmed]
  10. Identification of a T lineage-committed progenitor in adult blood. Krueger, A., von Boehmer, H. Immunity (2007) [Pubmed]
  11. Inhibitors of ADP-ribosylating bacterial toxins based on oxacarbenium ion character at their transition states. Zhou, G.C., Parikh, S.L., Tyler, P.C., Evans, G.B., Furneaux, R.H., Zubkova, O.V., Benjes, P.A., Schramm, V.L. J. Am. Chem. Soc. (2004) [Pubmed]
  12. The hydrophilic phosphatriazaadamantane ligand in the development of H2 production electrocatalysts: iron hydrogenase model complexes. Mejia-Rodriguez, R., Chong, D., Reibenspies, J.H., Soriaga, M.P., Darensbourg, M.Y. J. Am. Chem. Soc. (2004) [Pubmed]
  13. Lessons learned from more than 1,000 pancreas transplants at a single institution. Sutherland, D.E., Gruessner, R.W., Dunn, D.L., Matas, A.J., Humar, A., Kandaswamy, R., Mauer, S.M., Kennedy, W.R., Goetz, F.C., Robertson, R.P., Gruessner, A.C., Najarian, J.S. Ann. Surg. (2001) [Pubmed]
  14. Pharmacokinetic-pharmacodynamic rationale for cefepime dosing regimens in intensive care units. Roos, J.F., Bulitta, J., Lipman, J., Kirkpatrick, C.M. J. Antimicrob. Chemother. (2006) [Pubmed]
  15. Preventive intervention possibilities in radiotherapy- and chemotherapy-induced oral mucositis: results of meta-analyses. Stokman, M.A., Spijkervet, F.K., Boezen, H.M., Schouten, J.P., Roodenburg, J.L., de Vries, E.G. J. Dent. Res. (2006) [Pubmed]
  16. Low-contrast medium doses for ultrasound imaging during renal revascularization by PTA-stenting. Cianci, R., Lavini, R., Letizia, C., Zaccaria, A., Manfredini, P., Cerroni, F., Ciano, G., Clemenzia, G., Coen, G. J. Nephrol. (2004) [Pubmed]
  17. Synaptonemal complex-associated centromeres and recombination nodules in plant meiocytes prepared by an improved surface-spreading technique. Albini, S.M., Jones, G.H. Exp. Cell Res. (1984) [Pubmed]
  18. The use of endovascular techniques for the treatment of complications of aortic dissection. Walker, P.J., Dake, M.D., Mitchell, R.S., Miller, D.C. J. Vasc. Surg. (1993) [Pubmed]
  19. Tissue concentrations of prothymosin alpha: a novel proliferation index of primary breast cancer. Dominguez, F., Magdalena, C., Cancio, E., Roson, E., Paredes, J., Loidi, L., Zalvide, J., Fraga, M., Forteza, J., Regueiro, B.J. Eur. J. Cancer (1993) [Pubmed]
  20. Persistent T-cell activation and clinical correlations in patients with ANCA-associated systemic vasculitis. Marinaki, S., Kälsch, A.I., Grimminger, P., Breedijk, A., Birck, R., Schmitt, W.H., Weiss, C., van der Woude, F.J., Yard, B.A. Nephrol. Dial. Transplant. (2006) [Pubmed]
  21. Management of angioplasty complications, unsuccessful procedures and early and late failures. Samson, R.H., Sprayregen, S., Veith, F.J., Scher, L.A., Gupta, S.K., Ascer, E. Ann. Surg. (1984) [Pubmed]
  22. Improvement in cerebral hemodynamics after carotid angioplasty. Markus, H.S., Clifton, A., Buckenham, T., Taylor, R., Brown, M.M. Stroke (1996) [Pubmed]
  23. Treatment of recurrent femoral or popliteal artery stenosis after percutaneous transluminal angioplasty. Treiman, G.S., Ichikawa, L., Treiman, R.L., Cohen, J.L., Cossman, D.V., Wagner, W.H., Levin, P.M., Foran, R.F. J. Vasc. Surg. (1994) [Pubmed]
  24. Glutathione-dependent metabolism of cis-3-(9H-purin-6-ylthio)acrylic acid to yield the chemotherapeutic drug 6-mercaptopurine: evidence for two distinct mechanisms in rats. Gunnarsdottir, S., Elfarra, A.A. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  25. Effect of rotational coronary atherectomy on peripheral endothelin-1, atrial natriuretic peptide, and cyclic adenosine monophosphate plasma levels. Kyriakides, Z.S., Markianos, M., Antoniadis, A., Sbarouni, E., Nikolaou, N., Zarvalis, E., Michalis, L., Triantafillou, K., Kremastinos, D.T. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. (1998) [Pubmed]
 
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