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Npy6r  -  neuropeptide Y receptor Y6

Mus musculus

Synonyms: NPY6-R, Neuropeptide Y receptor type 6, Npy5r, PP2, Pancreatic polypeptide receptor 2, ...
 
 
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Disease relevance of Npy6r

 

High impact information on Npy6r

  • TCR microcluster formation is resistant to inhibition by Src family kinase inhibitor PP2, but is abrogated by actin polymerization inhibitor latrunculin A [3].
  • Inhibition of SFKs with PP2 decreased PYK2 tyrosine phosphorylation dramatically, but not its autophosphorylation on Tyr-402 [4].
  • In contrast, ERK activation was unaltered by PP2, Fyn knock-out, or LY294002, a phosphatidyl-inositol-3-kinase inhibitor [4].
  • Src tyrosine kinase inhibitor PP2 markedly enhances Ras-independent activation of Raf-1 protein kinase by phorbol myristate acetate and H2O2 [5].
  • Transient transfection studies with a dominant-negative mutant of Ras (N19Ras) indicated that this PP2-induced activation of Raf-1 was Ras-independent [5].
 

Biological context of Npy6r

 

Anatomical context of Npy6r

 

Associations of Npy6r with chemical compounds

 

Analytical, diagnostic and therapeutic context of Npy6r

  • Podosome assembly was dependent on both PKA and tyrosine kinase activities because their formation was impaired after treatment with specific inhibitors [myristoylated PKI (mPKI) or PP2, respectively] previous to ACTH/8-Br-cAMP stimulation [19].
  • Additionally, immunoblotting analysis with PP2-treated cell extract demonstrated that, compared to other protein kinase C (PKC) isotypes, the translocation of novel PKC isotypes from the cytosol to membrane fraction was sustained for a longer time [16].

References

  1. Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells. Duxbury, M.S., Ito, H., Zinner, M.J., Ashley, S.W., Whang, E.E. Clin. Cancer Res. (2004) [Pubmed]
  2. Lipopolysaccharide-induced c-Src expression plays a role in nitric oxide and TNFalpha secretion in macrophages. Leu, T.H., Charoenfuprasert, S., Yen, C.K., Fan, C.W., Maa, M.C. Mol. Immunol. (2006) [Pubmed]
  3. Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. Campi, G., Varma, R., Dustin, M.L. J. Exp. Med. (2005) [Pubmed]
  4. Depolarization activates ERK and proline-rich tyrosine kinase 2 (PYK2) independently in different cellular compartments in hippocampal slices. Corvol, J.C., Valjent, E., Toutant, M., Enslen, H., Irinopoulou, T., Lev, S., Hervé, D., Girault, J.A. J. Biol. Chem. (2005) [Pubmed]
  5. Src tyrosine kinase inhibitor PP2 markedly enhances Ras-independent activation of Raf-1 protein kinase by phorbol myristate acetate and H2O2. Lee, M., Kim, J.Y., Anderson, W.B. J. Biol. Chem. (2004) [Pubmed]
  6. Src family kinases are required for prolactin induction of cell proliferation. Fresno Vara , J.A., Cáceres, M.A., Silva, A., Martín-Pérez, J. Mol. Biol. Cell (2001) [Pubmed]
  7. Temporal and spatial expression of tissue inhibitors of metalloproteinases during the natural ovulatory cycle of the mouse. Inderdeo, D.S., Edwards, D.R., Han, V.K., Khokha, R. Biol. Reprod. (1996) [Pubmed]
  8. Focal adhesion kinase signaling regulates cardiogenesis of embryonic stem cells. Hakuno, D., Takahashi, T., Lammerding, J., Lee, R.T. J. Biol. Chem. (2005) [Pubmed]
  9. Effect of tyrosine kinase inhibitors on clathrin-coated pit recruitment and internalization of epidermal growth factor receptor. Sorkina, T., Huang, F., Beguinot, L., Sorkin, A. J. Biol. Chem. (2002) [Pubmed]
  10. Oxidative stress induces protein kinase C-mediated activation loop phosphorylation and nuclear redistribution of protein kinase D. Waldron, R.T., Rey, O., Zhukova, E., Rozengurt, E. J. Biol. Chem. (2004) [Pubmed]
  11. CD44-initiated cell spreading induces Pyk2 phosphorylation, is mediated by Src family kinases, and is negatively regulated by CD45. Li, R., Wong, N., Jabali, M.D., Johnson, P. J. Biol. Chem. (2001) [Pubmed]
  12. Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis. Huang, Z.Y., Barreda, D.R., Worth, R.G., Indik, Z.K., Kim, M.K., Chien, P., Schreiber, A.D. J. Leukoc. Biol. (2006) [Pubmed]
  13. Tyrosine kinase modulation of protein kinase C activity regulates G protein-linked Ca2+ signaling in leukemic hematopoietic cells. Vichalkovski, A., Kotevic, I., Gebhardt, N., Kaderli, R., Porzig, H. Cell Calcium (2006) [Pubmed]
  14. Bombesin and angiotensin II rapidly stimulate Src phosphorylation at Tyr-418 in fibroblasts and intestinal epithelial cells through a PP2-insensitive pathway. Wu, S.S., Yamauchi, K., Rozengurt, E. Cell. Signal. (2005) [Pubmed]
  15. The osmotic shock-induced glucose transport pathway in 3T3-L1 adipocytes is mediated by gab-1 and requires Gab-1-associated phosphatidylinositol 3-kinase activity for full activation. Janez, A., Worrall, D.S., Imamura, T., Sharma, P.M., Olefsky, J.M. J. Biol. Chem. (2000) [Pubmed]
  16. Apoptotic effect of PP2 a Src tyrosine kinase inhibitor, in murine B cell leukemia. Lee, M., Kim, J.Y., Koh, W.S. J. Cell. Biochem. (2004) [Pubmed]
  17. Tyrosine phosphorylation of clathrin heavy chain under oxidative stress. Ihara, Y., Yasuoka, C., Kageyama, K., Wada, Y., Kondo, T. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  18. Regulation of K-Cl cotransport by protein phosphatase 1alpha in mouse erythrocytes. Franceschi, L.D., Villa-Moruzzi, E., Biondani, A., Siciliano, A., Brugnara, C., Alper, S.L., Lowell, C.A., Berton, G. Pflugers Arch. (2006) [Pubmed]
  19. ACTH-induced caveolin-1 tyrosine phosphorylation is related to podosome assembly in Y1 adrenal cells. Colonna, C., Podestá, E.J. Exp. Cell Res. (2005) [Pubmed]
 
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