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Gene Review

Npy6r  -  neuropeptide Y receptor Y6

Mus musculus

Synonyms: NPY6-R, Neuropeptide Y receptor type 6, Npy5r, PP2, Pancreatic polypeptide receptor 2, ...
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Disease relevance of Npy6r


High impact information on Npy6r

  • TCR microcluster formation is resistant to inhibition by Src family kinase inhibitor PP2, but is abrogated by actin polymerization inhibitor latrunculin A [3].
  • Inhibition of SFKs with PP2 decreased PYK2 tyrosine phosphorylation dramatically, but not its autophosphorylation on Tyr-402 [4].
  • In contrast, ERK activation was unaltered by PP2, Fyn knock-out, or LY294002, a phosphatidyl-inositol-3-kinase inhibitor [4].
  • Src tyrosine kinase inhibitor PP2 markedly enhances Ras-independent activation of Raf-1 protein kinase by phorbol myristate acetate and H2O2 [5].
  • Transient transfection studies with a dominant-negative mutant of Ras (N19Ras) indicated that this PP2-induced activation of Raf-1 was Ras-independent [5].

Biological context of Npy6r


Anatomical context of Npy6r


Associations of Npy6r with chemical compounds


Analytical, diagnostic and therapeutic context of Npy6r

  • Podosome assembly was dependent on both PKA and tyrosine kinase activities because their formation was impaired after treatment with specific inhibitors [myristoylated PKI (mPKI) or PP2, respectively] previous to ACTH/8-Br-cAMP stimulation [19].
  • Additionally, immunoblotting analysis with PP2-treated cell extract demonstrated that, compared to other protein kinase C (PKC) isotypes, the translocation of novel PKC isotypes from the cytosol to membrane fraction was sustained for a longer time [16].


  1. Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells. Duxbury, M.S., Ito, H., Zinner, M.J., Ashley, S.W., Whang, E.E. Clin. Cancer Res. (2004) [Pubmed]
  2. Lipopolysaccharide-induced c-Src expression plays a role in nitric oxide and TNFalpha secretion in macrophages. Leu, T.H., Charoenfuprasert, S., Yen, C.K., Fan, C.W., Maa, M.C. Mol. Immunol. (2006) [Pubmed]
  3. Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. Campi, G., Varma, R., Dustin, M.L. J. Exp. Med. (2005) [Pubmed]
  4. Depolarization activates ERK and proline-rich tyrosine kinase 2 (PYK2) independently in different cellular compartments in hippocampal slices. Corvol, J.C., Valjent, E., Toutant, M., Enslen, H., Irinopoulou, T., Lev, S., Hervé, D., Girault, J.A. J. Biol. Chem. (2005) [Pubmed]
  5. Src tyrosine kinase inhibitor PP2 markedly enhances Ras-independent activation of Raf-1 protein kinase by phorbol myristate acetate and H2O2. Lee, M., Kim, J.Y., Anderson, W.B. J. Biol. Chem. (2004) [Pubmed]
  6. Src family kinases are required for prolactin induction of cell proliferation. Fresno Vara , J.A., Cáceres, M.A., Silva, A., Martín-Pérez, J. Mol. Biol. Cell (2001) [Pubmed]
  7. Temporal and spatial expression of tissue inhibitors of metalloproteinases during the natural ovulatory cycle of the mouse. Inderdeo, D.S., Edwards, D.R., Han, V.K., Khokha, R. Biol. Reprod. (1996) [Pubmed]
  8. Focal adhesion kinase signaling regulates cardiogenesis of embryonic stem cells. Hakuno, D., Takahashi, T., Lammerding, J., Lee, R.T. J. Biol. Chem. (2005) [Pubmed]
  9. Effect of tyrosine kinase inhibitors on clathrin-coated pit recruitment and internalization of epidermal growth factor receptor. Sorkina, T., Huang, F., Beguinot, L., Sorkin, A. J. Biol. Chem. (2002) [Pubmed]
  10. Oxidative stress induces protein kinase C-mediated activation loop phosphorylation and nuclear redistribution of protein kinase D. Waldron, R.T., Rey, O., Zhukova, E., Rozengurt, E. J. Biol. Chem. (2004) [Pubmed]
  11. CD44-initiated cell spreading induces Pyk2 phosphorylation, is mediated by Src family kinases, and is negatively regulated by CD45. Li, R., Wong, N., Jabali, M.D., Johnson, P. J. Biol. Chem. (2001) [Pubmed]
  12. Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis. Huang, Z.Y., Barreda, D.R., Worth, R.G., Indik, Z.K., Kim, M.K., Chien, P., Schreiber, A.D. J. Leukoc. Biol. (2006) [Pubmed]
  13. Tyrosine kinase modulation of protein kinase C activity regulates G protein-linked Ca2+ signaling in leukemic hematopoietic cells. Vichalkovski, A., Kotevic, I., Gebhardt, N., Kaderli, R., Porzig, H. Cell Calcium (2006) [Pubmed]
  14. Bombesin and angiotensin II rapidly stimulate Src phosphorylation at Tyr-418 in fibroblasts and intestinal epithelial cells through a PP2-insensitive pathway. Wu, S.S., Yamauchi, K., Rozengurt, E. Cell. Signal. (2005) [Pubmed]
  15. The osmotic shock-induced glucose transport pathway in 3T3-L1 adipocytes is mediated by gab-1 and requires Gab-1-associated phosphatidylinositol 3-kinase activity for full activation. Janez, A., Worrall, D.S., Imamura, T., Sharma, P.M., Olefsky, J.M. J. Biol. Chem. (2000) [Pubmed]
  16. Apoptotic effect of PP2 a Src tyrosine kinase inhibitor, in murine B cell leukemia. Lee, M., Kim, J.Y., Koh, W.S. J. Cell. Biochem. (2004) [Pubmed]
  17. Tyrosine phosphorylation of clathrin heavy chain under oxidative stress. Ihara, Y., Yasuoka, C., Kageyama, K., Wada, Y., Kondo, T. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  18. Regulation of K-Cl cotransport by protein phosphatase 1alpha in mouse erythrocytes. Franceschi, L.D., Villa-Moruzzi, E., Biondani, A., Siciliano, A., Brugnara, C., Alper, S.L., Lowell, C.A., Berton, G. Pflugers Arch. (2006) [Pubmed]
  19. ACTH-induced caveolin-1 tyrosine phosphorylation is related to podosome assembly in Y1 adrenal cells. Colonna, C., Podestá, E.J. Exp. Cell Res. (2005) [Pubmed]
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