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Gene Review

FHL1  -  four and a half LIM domains 1

Homo sapiens

Synonyms: FHL-1, FHL1A, FHL1B, FLH1A, Four and a half LIM domains protein 1, ...
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Disease relevance of FHL1


High impact information on FHL1


Biological context of FHL1


Anatomical context of FHL1


Associations of FHL1 with chemical compounds

  • We show that FHL-1 presents a higher binding affinity for S. pyogenes than factor H because it carries a hydrophobic, high-affinity, GAS binding site in addition to the heparin binding site in SCR7 [10].
  • Since the 25-HC, 9-cis RA and 15d-PGJ2 were ligands for the LXR, RXRalpha and PPARgamma respectively, there might be a functional positive cross-talk between LXR and RXRalpha pathways and a negative cross-talk between PPARgamma and LXR and/or RXRalpha pathways in the regulation of SLIM1 expression [11].
  • In addition, an over-production of SLIM1 in the cells resulted in a change in the cell-shape into a spindle-like form, which is identical to that observed after a prolonged treatment of the cells with cholesterol [11].
  • Up-regulation of skeletal muscle LIM protein 1 gene by 25-hydroxycholesterol may mediate morphological changes of rat aortic smooth muscle cells [11].
  • OBJECTIVE: To evaluate ease of insertion, acceptability and endometrial safety of a novel, miniature intrauterine, T-shaped, levonorgestrel (LNG)-releasing intrauterine system (IUS), Femilis Slim LNG-IUS (Contrel Research, Belgium), combined with parenteral estrogen substitution therapy (EST) in postmenopausal women [12].

Other interactions of FHL1


Analytical, diagnostic and therapeutic context of FHL1


  1. The influence of different isolation procedures and the use of target cells from melanoma cell lines and short-term cultures on the non-specific cytotoxic effects of lymphocytes from healthy donors. de Vries, J.E., Meyering, M., van Dongen, A., Rümke, P. Int. J. Cancer (1975) [Pubmed]
  2. Molecular markers for discrimination of benign and malignant follicular thyroid tumors. Fryknäs, M., Wickenberg-Bolin, U., Göransson, H., Gustafsson, M.G., Foukakis, T., Lee, J.J., Landegren, U., Höög, A., Larsson, C., Grimelius, L., Wallin, G., Pettersson, U., Isaksson, A. Tumour Biol. (2006) [Pubmed]
  3. Skeletal muscle LIM protein 1 (SLIM1/FHL1) induces alpha 5 beta 1-integrin-dependent myocyte elongation. McGrath, M.J., Mitchell, C.A., Coghill, I.D., Robinson, P.A., Brown, S. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  4. Characterization of a brain-specific nuclear LIM domain protein (FHL1B) which is an alternatively spliced variant of FHL1. Lee, S.M., Li, H.Y., Ng, E.K., Or, S.M., Chan, K.K., Kotaka, M., Chim, S.S., Tsui, S.K., Waye, M.M., Fung, K.P., Lee, C.Y. Gene (1999) [Pubmed]
  5. Discrimination of polycythemias and thrombocytoses by novel, simple, accurate clonality assays and comparison with PRV-1 expression and BFU-E response to erythropoietin. Liu, E., Jelinek, J., Pastore, Y.D., Guan, Y., Prchal, J.F., Prchal, J.T. Blood (2003) [Pubmed]
  6. The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor. Samson, T., Smyth, N., Janetzky, S., Wendler, O., Müller, J.M., Schüle, R., von der Mark, H., von der Mark, K., Wixler, V. J. Biol. Chem. (2004) [Pubmed]
  7. Characterization of two isoforms of the skeletal muscle LIM protein 1, SLIM1. Localization of SLIM1 at focal adhesions and the isoform slimmer in the nucleus of myoblasts and cytoplasm of myotubes suggests distinct roles in the cytoskeleton and in nuclear-cytoplasmic communication. Brown, S., McGrath, M.J., Ooms, L.M., Gurung, R., Maimone, M.M., Mitchell, C.A. J. Biol. Chem. (1999) [Pubmed]
  8. Chromosomal mapping, tissue distribution and cDNA sequence of four-and-a-half LIM domain protein 1 (FHL1). Lee, S.M., Tsui, S.K., Chan, K.K., Garcia-Barcelo, M., Waye, M.M., Fung, K.P., Liew, C.C., Lee, C.Y. Gene (1998) [Pubmed]
  9. The cardiac expression of striated muscle LIM protein 1 (SLIM1) is restricted to the outflow tract of the developing heart. Brown, S., Biben, C., Ooms, L.M., Maimone, M., McGrath, M.J., Gurung, R., Harvey, R.P., Mitchell, C.A. J. Mol. Cell. Cardiol. (1999) [Pubmed]
  10. Assessment of the interaction of human complement regulatory proteins with group A Streptococcus. Identification of a high-affinity group A Streptococcus binding site in FHL-1. Pérez-Caballero, D., Albertí, S., Vivanco, F., Sánchez-Corral, P., Rodríguez de Córdoba, S. Eur. J. Immunol. (2000) [Pubmed]
  11. Up-regulation of skeletal muscle LIM protein 1 gene by 25-hydroxycholesterol may mediate morphological changes of rat aortic smooth muscle cells. Kang, M.A., Jeoung, N.H., Kim, J.Y., Lee, J.E., Jung, U.J., Choi, M.S., Lee, W.H., Kwon, O.S., Lee, H., Park, Y.B. Life Sci. (2007) [Pubmed]
  12. Continuous combined parenteral estrogen substitution and intrauterine progestogen delivery: the ideal HST combination? Wildemeersch, D., Janssens, D., Weyers, S. Maturitas. (2005) [Pubmed]
  13. Characterization of tissue-specific LIM domain protein (FHL1C) which is an alternatively spliced isoform of a human LIM-only protein (FHL1). Ng, E.K., Lee, S.M., Li, H.Y., Ngai, S.M., Tsui, S.K., Waye, M.M., Lee, C.Y., Fung, K.P. J. Cell. Biochem. (2001) [Pubmed]
  14. Influence of age, sex, and strength training on human muscle gene expression determined by microarray. Roth, S.M., Ferrell, R.E., Peters, D.G., Metter, E.J., Hurley, B.F., Rogers, M.A. Physiol. Genomics (2002) [Pubmed]
  15. Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly. McGrath, M.J., Cottle, D.L., Nguyen, M.A., Dyson, J.M., Coghill, I.D., Robinson, P.A., Holdsworth, M., Cowling, B.S., Hardeman, E.C., Mitchell, C.A., Brown, S. J. Biol. Chem. (2006) [Pubmed]
  16. Genomic structure, tissue expression and chromosomal location of the LIM-only gene, SLIM1. Greene, W.K., Baker, E., Rabbitts, T.H., Kees, U.R. Gene (1999) [Pubmed]
  17. Seroepidemiologic survey of Orientia tsutsugamushi, Rickettsia typhi, and TT118 spotted fever group rickettsiae in rubber estate workers in Malaysia. Tee, T.S., Kamalanathan, M., Suan, K.A., Chun, S.S., Ming, H.T., Yasin, R.M., Devi, S. Am. J. Trop. Med. Hyg. (1999) [Pubmed]
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