Gene Review:
GNB3 - guanine nucleotide binding protein (G...
Homo sapiens
Synonyms:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3, Transducin beta chain 3
Holtmann,
Siffert,
Haag,
Mueller,
Langkafel,
Senf,
Zotz,
Talley,
Rosskopf,
Manthey,
Habich,
Kielbik,
Eisenhardt,
Nikula,
Urban,
Kohnen,
Graf,
Ravens,
Siffert,
Rosskopf,
Busch,
Manthey,
Siffert,
Vormfelde,
Sehrt,
Bolte,
Pahl,
Tzvetkov,
Brockmöller,
Hegele,
Anderson,
Young,
Connelly,
Grossmann,
Dobrev,
Siffert,
Kirch,
Frey,
Aral,
Müller,
Siffert,
Haase,
Schmidt,
Faustmann,
Anttila,
Huuhka,
Huuhka,
Rontu,
Mattila,
Leinonen,
Lehtimäki,
Naber,
Baumgart,
Heusch,
Siffert,
Oldenburg,
Huesing,
Erbel,
Weinstein,
Chen,
Xie,
Liu,
Wenzel,
Siffert,
Bruck,
Philipp,
Schäfers,
von Beckerath,
Schusterschitz,
Koch,
Griesser,
Mehilli,
Gorchakova,
Schömig,
Kastrati,
Siffert,
Siffert,
Rosskopf,
Siffert,
Busch,
Moritz,
Erbel,
Sharma,
Ritz,
Wichmann,
Jakobs,
Horsthemke,
Andersen,
Overgaard,
Albrechtsen,
Glümer,
Borch-Johnsen,
Jørgensen,
Hansen,
Pedersen,
- Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study. Terra, S.G., McGorray, S.P., Wu, R., McNamara, D.M., Cavallari, L.H., Walker, J.R., Wallace, M.R., Johnson, B.D., Bairey Merz, C.N., Sopko, G., Pepine, C.J., Johnson, J.A. International journal of obesity (2005) (2005)
- G-protein beta 3 subunit 825 CC genotype is associated with unexplained (functional) dyspepsia. Holtmann, G., Siffert, W., Haag, S., Mueller, N., Langkafel, M., Senf, W., Zotz, R., Talley, N.J. Gastroenterology (2004)
- Genetic diseases associated with heterotrimeric G proteins. Weinstein, L.S., Chen, M., Xie, T., Liu, J. Trends Pharmacol. Sci. (2006)
- Polymorphisms of genes encoding components of the sympathetic nervous system but not the renin-angiotensin system as risk factors for orthostatic hypotension. Tabara, Y., Kohara, K., Miki, T. J. Hypertens. (2002)
- 825T allele of the G-protein beta3 subunit gene (GNB3) is associated with impaired left ventricular diastolic filling in essential hypertension. Jacobi, J., Hilgers, K.F., Schlaich, M.P., Siffert, W., Schmieder, R.E. J. Hypertens. (1999)
- Sildenafil response is influenced by the G protein beta 3 subunit GNB3 C825T polymorphism: a pilot study. Sperling, H., Eisenhardt, A., Virchow, S., Hauck, E., Lenk, S., Porst, H., Stief, C., Wetterauer, U., Rubben, H., Muller, N., Siffert, W. J. Urol. (2003)
- Association between a G-protein beta 3 subunit gene polymorphism and the symptomatology and treatment responses of major depressive disorders. Lee, H.J., Cha, J.H., Ham, B.J., Han, C.S., Kim, Y.K., Lee, S.H., Ryu, S.H., Kang, R.H., Choi, M.J., Lee, M.S. Pharmacogenomics J. (2004)
- Association analysis of a functional G protein beta3 subunit gene polymorphism (C825T) in mood disorders. Lin, C.N., Tsai, S.J., Hong, C.J. Neuropsychobiology (2001)
- Interaction between TPH1 and GNB3 genotypes and electroconvulsive therapy in major depression. Anttila, S., Huuhka, K., Huuhka, M., Rontu, R., Mattila, K.M., Leinonen, E., Lehtimäki, T. Journal of neural transmission (Vienna, Austria : 1996) (2007)
- Association study of C825T polymorphism of the G-protein b3 subunit gene with schizophrenia and mood disorders. Kunugi, H., Kato, T., Fukuda, R., Tatsumi, M., Sakai, T., Nanko, S. Journal of neural transmission (Vienna, Austria : 1996) (2002)
- Association of a human G-protein beta3 subunit variant with hypertension. Siffert, W., Rosskopf, D., Siffert, G., Busch, S., Moritz, A., Erbel, R., Sharma, A.M., Ritz, E., Wichmann, H.E., Jakobs, K.H., Horsthemke, B. Nat. Genet. (1998)
- G-protein beta3 subunit gene splice variant and body fat distribution in Nunavut Inuit. Hegele, R.A., Anderson, C., Young, T.K., Connelly, P.W. Genome Res. (1999)
- Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes. Andersen, G., Overgaard, J., Albrechtsen, A., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Hansen, T., Pedersen, O. Diabetologia (2006)
- GNB3 C825T polymorphism and response to interferon-alfa/ribavirin treatment in patients with hepatitis C virus genotype 1 (HCV-1) infection. Sarrazin, C., Berg, T., Weich, V., Mueller, T., Frey, U.H., Zeuzem, S., Gerken, G., Roggendorf, M., Siffert, W. J. Hepatol. (2005)
- Prediction of successful weight reduction under sibutramine therapy through genotyping of the G-protein beta3 subunit gene (GNB3) C825T polymorphism. Hauner, H., Meier, M., Jöckel, K.H., Frey, U.H., Siffert, W. Pharmacogenetics (2003)
- Role of the eNOS Glu298Asp variant on the GNB3825T allele dependent determination of alpha-adrenergic coronary constriction. Naber, C.K., Baumgart, D., Heusch, G., Siffert, W., Oldenburg, O., Huesing, J., Erbel, R. Pharmacogenetics (2003)
- G protein beta 3 gene: structure, promoter, and additional polymorphisms. Rosskopf, D., Busch, S., Manthey, I., Siffert, W. Hypertension (2000)
- Identification and characterization of G beta 3s2, a novel splice variant of the G-protein beta 3 subunit. Rosskopf, D., Manthey, I., Habich, C., Kielbik, M., Eisenhardt, A., Nikula, C., Urban, M., Kohnen, S., Graf, E., Ravens, U., Siffert, W. Biochem. J. (2003)
- Enhanced vasoconstriction to endothelin-1, angiotensin II and noradrenaline in carriers of the GNB3 825T allele in the skin microcirculation. Wenzel, R.R., Siffert, W., Bruck, H., Philipp, T., Schäfers, R.F. Pharmacogenetics (2002)
- G protein beta 3 subunit 825T allele carriage and risk of coronary artery disease. von Beckerath, N., Schusterschitz, Y., Koch, W., Griesser, K., Mehilli, J., Gorchakova, O., Schömig, A., Kastrati, A. Atherosclerosis (2003)
- Association of C825T polymorphism of G protein beta3 subunit with the autonomic nervous system in young healthy Japanese individuals. Matsunaga, T., Nagasumi, K., Yamamura, T., Gu, N., Nishikino, M., Ueda, Y., Moritani, T., Aoki, N., Tsuda, K., Yasuda, K. Am. J. Hypertens. (2005)
- C825T polymorphism in the human G protein beta 3 subunit gene and preeclampsia; a case control study. Jansen, M.W., Bertina, R.M., Vos, H.L., Bloemenkamp, K.W., Helmerhorst, F.M., Wladimiroff, J.W., de Groot, C.J. Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy. (2004)
- Heterogeneity in hand veins responses to acetylcholine is not associated with polymorphisms in the G-protein beta3-subunit (C825T) and endothelial nitric oxide synthase (G894T) genes but with serum low density lipoprotein cholesterol. Grossmann, M., Dobrev, D., Siffert, W., Kirch, W. Pharmacogenetics (2001)
- Cooperative effect of GNB3 825C>T and GPIIIa PI(A) polymorphisms in enhanced platelet aggregation. Frey, U.H., Aral, N., Müller, N., Siffert, W. Thromb. Res. (2003)
- Hydrochlorothiazide efficacy and polymorphisms in ACE, ADD1 and GNB3 in healthy, male volunteers. Vormfelde, S.V., Sehrt, D., Bolte, D., Pahl, S., Tzvetkov, M., Brockmöller, J. Eur. J. Clin. Pharmacol. (2006)
- Molecular genetics of G proteins and atherosclerosis risk. Siffert, W. Basic Res. Cardiol. (2001)
- Polymorphism in genes involved in adrenergic signaling associated with Alzheimer's. Bullido, M.J., Ramos, M.C., Ruiz-Gómez, A., Tutor, A.S., Sastre, I., Frank, A., Coria, F., Gil, P., Mayor, F., Valdivieso, F. Neurobiol. Aging (2004)
- ADD1 460W allele associated with cardiovascular disease in hypertensive individuals. Morrison, A.C., Bray, M.S., Folsom, A.R., Boerwinkle, E. Hypertension (2002)
- Frequencies of the G-protein beta3 subunit C825T polymorphism and the delta 32 mutation of the chemokine receptor-5 in patients with multiple sclerosis. Haase, C.G., Schmidt, S., Faustmann, P.M. Neurosci. Lett. (2002)
- Insulin-mediated venodilation is impaired in young, healthy carriers of the 825T allele of the G-protein beta3 subunit gene (GNB3). Mitchell, A., Pace, M., Nürnberger, J., Wenzel, R.R., Siffert, W., Philipp, T., Schäfers, R.F. Clin. Pharmacol. Ther. (2005)
- G protein polymorphisms do not predict weight loss and improvement of hypertension in severely obese patients. Potoczna, N., Wertli, M., Steffen, R., Ricklin, T., Lentes, K.U., Horber, F.F. J. Gastrointest. Surg. (2004)
- G-protein beta-3 subunit gene 825C>T dimorphism is associated with left ventricular hypertrophy but not essential hypertension. Mahmood, M.S., Mian, Z.S., Afzal, A., Frossard, P.M. Med. Sci. Monit. (2005)