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PLCG2  -  phospholipase C, gamma 2...

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Disease relevance of PLCG2


High impact information on PLCG2

  • Here we report the cloning of a bovine brain complementary DNA encoding an enzyme PLC-148 that is characterized by calcium-dependent and phosphatidylinositol-specific phospholipase C activity when expressed in mammalian cells [6].
  • The production of the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate is mediated by activated phosphatidylinositol-specific phospholipase C (PLC) enzymes [6].
  • Together, these data suggest that permanent sequential activation of both PI3K and PI-PLC is necessary for the dramatic reorganization of the actin cytoskeleton in oncogene-transformed fibroblasts, resulting in constitutive ruffling and macropinocytosis [7].
  • Implied in these observations are the following: (i) in powerful inhibitors an active site residue probably interacts with the equatorially oriented fluoro substituent; (ii) substrate recognition requires a negative charge on the phosphoryl at the Ins-1 position, and (iii) a GPI is better substrate than PI, for PI-PLC [3].
  • Aminoglycoside antibiotics kanamycin A, gentamycin, and G418 stimulated PI-PLC cleavage of the GPI anchor of variant surface glycoprotein (VSG) from Trypanosoma brucei 2- to 4-fold [3].

Chemical compound and disease context of PLCG2


Biological context of PLCG2


Anatomical context of PLCG2


Associations of PLCG2 with chemical compounds


Regulatory relationships of PLCG2


Other interactions of PLCG2


Analytical, diagnostic and therapeutic context of PLCG2


  1. Insulin stimulates the generation from hepatic plasma membranes of modulators derived from an inositol glycolipid. Saltiel, A.R., Cuatrecasas, P. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  2. Membrane-bound aminopeptidase P from bovine lung. Its purification, properties, and degradation of bradykinin. Simmons, W.H., Orawski, A.T. J. Biol. Chem. (1992) [Pubmed]
  3. Phosphatidylinositol phospholipase C is activated allosterically by the aminoglycoside G418. 2-deoxy-2-fluoro-scyllo-inositol-1-O-dodecylphosphonate and its analogs inhibit glycosylphosphatidylinositol phospholipase C. Morris, J.C., Ping-Sheng, L., Zhai, H.X., Shen, T.Y., Mensa-Wilmot, K. J. Biol. Chem. (1996) [Pubmed]
  4. Characterization of the phosphatidylinositol-specific phospholipase C isozymes present in the bovine parathyroid and in human kidney HEK293 cells stably transfected with the human parathyroid Ca2+-sensing receptor. Darè, E., Kifor, O., Brown, E.M., Weber, G. J. Mol. Endocrinol. (1998) [Pubmed]
  5. High-level expression in Escherichia coli and rapid purification of phosphatidylinositol-specific phospholipase C from Bacillus cereus and Bacillus thuringiensis. Koke, J.A., Yang, M., Henner, D.J., Volwerk, J.J., Griffith, O.H. Protein Expr. Purif. (1991) [Pubmed]
  6. Sequence similarity of phospholipase C with the non-catalytic region of src. Stahl, M.L., Ferenz, C.R., Kelleher, K.L., Kriz, R.W., Knopf, J.L. Nature (1988) [Pubmed]
  7. Constitutive macropinocytosis in oncogene-transformed fibroblasts depends on sequential permanent activation of phosphoinositide 3-kinase and phospholipase C. Amyere, M., Payrastre, B., Krause, U., Van Der Smissen, P., Veithen, A., Courtoy, P.J. Mol. Biol. Cell (2000) [Pubmed]
  8. Identification of the lipid moiety and further characterization of the novel lipophosphoglycan-like glycoconjugates of Trichomonas vaginalis and Trichomonas foetus. Singh, B.N., Beach, D.H., Lindmark, D.G., Costello, C.E. Arch. Biochem. Biophys. (1994) [Pubmed]
  9. Increase in osmotic fragility of bovine erythrocytes induced by bacterial phospholipases C. Taguchi, R., Mizuno, M., Inoue, M., Ikezawa, H. J. Biochem. (1983) [Pubmed]
  10. Phosphatidic acid, lysophosphatidic acid, and lipid A are inhibitors of glycosylphosphatidylinositol-specific phospholipase D. Specific inhibition of a phospholipase by product analogues? Low, M.G., Huang, K.S. J. Biol. Chem. (1993) [Pubmed]
  11. Isoform-specific transforming growth factor-beta binding proteins with membrane attachments sensitive to phosphatidylinositol-specific phospholipase C. Cheifetz, S., Massagué, J. J. Biol. Chem. (1991) [Pubmed]
  12. Functional significance of beta gamma-subunit carboxymethylation for the activation of phospholipase C and phosphoinositide 3-kinase. Parish, C.A., Smrcka, A.V., Rando, R.R. Biochemistry (1995) [Pubmed]
  13. A multisample assay for inhibitors of phosphatidylinositol phospholipase C: identification of naturally occurring peptide inhibitors with antiproliferative activity. Hill, S.R., Bonjouklian, R., Powis, G., Abraham, R.T., Ashendel, C.L., Zalkow, L.H. Anticancer Drug Des. (1994) [Pubmed]
  14. Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms. Seidenbecher, C.I., Richter, K., Rauch, U., Fässler, R., Garner, C.C., Gundelfinger, E.D. J. Biol. Chem. (1995) [Pubmed]
  15. Bovine membranous dopamine beta-hydroxylase is not anchored via covalently attached phosphatidylinositol. Stewart, L.C., Klinman, J.P. J. Biol. Chem. (1988) [Pubmed]
  16. The erythrocyte receptor for the channel-forming toxin aerolysin is a novel glycosylphosphatidylinositol-anchored protein. Cowell, S., Aschauer, W., Gruber, H.J., Nelson, K.L., Buckley, J.T. Mol. Microbiol. (1997) [Pubmed]
  17. Identification of a cell surface component of Swiss 3T3 cells associated with an inhibition of cell division. Lakshmanarao, S.S., Toole-Simms, W.E., Fattaey, H.K., Leach, R.J., Johnson, T.C. Exp. Cell Res. (1991) [Pubmed]
  18. Glycosylphosphatidylinositol is involved in the membrane attachment of proteins in granules of chromaffin cells. Fouchier, F., Bastiani, P., Baltz, T., Aunis, D., Rougon, G. Biochem. J. (1988) [Pubmed]
  19. A 57-kDa phosphatidylinositol-specific phospholipase C from bovine brain. Tompkins, T.A., Moscarello, M.A. J. Biol. Chem. (1991) [Pubmed]
  20. Are D- and L-chiro-phosphoinositides substrates of phosphatidylinositol-specific phospholipase C? Bruzik, K.S., Hakeem, A.A., Tsai, M.D. Biochemistry (1994) [Pubmed]
  21. Characterization of a 66-kilodalton surface glycoprotein of the human corneal endothelium. Srivastava, O.P., Srivastava, K., Shukla, S.D. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  22. Phospholipids chiral at phosphorus. Stereochemical mechanism for the formation of inositol 1-phosphate catalyzed by phosphatidylinositol-specific phospholipase C. Bruzik, K.S., Morocho, A.M., Jhon, D.Y., Rhee, S.G., Tsai, M.D. Biochemistry (1992) [Pubmed]
  23. Chondrocyte-mediated catabolism of aggrecan: evidence for a glycosylphosphatidylinositol-linked protein in the aggrecanase response to interleukin-1 or retinoic acid. Sandy, J.D., Thompson, V., Verscharen, C., Gamett, D. Arch. Biochem. Biophys. (1999) [Pubmed]
  24. Tyrosine hydroxylase in secretory granules from bovine adrenal medulla. Evidence for an integral membrane form. Kuhn, D.M., Arthur, R., Yoon, H., Sankaran, K. J. Biol. Chem. (1990) [Pubmed]
  25. Phosphatidylinositol-specific phospholipase C solubilized G2 acetylcholinesterase from plasma membranes of chromaffin cells. Prieto, A.L., Fuentes, M.E., Arqueros, L., Inestrosa, N.C. J. Neurosci. Res. (1989) [Pubmed]
  26. Presence of ectonucleotidases in cultured chromaffin cells: hydrolysis of extracellular adenine nucleotides. Torres, M., Pintor, J., Miras-Portugal, M.T. Arch. Biochem. Biophys. (1990) [Pubmed]
  27. Evidence for the direct interaction of chicken gizzard 5'-nucleotidase with laminin and fibronectin. Stochaj, U., Dieckhoff, J., Mollenhauer, J., Cramer, M., Mannherz, H.G. Biochim. Biophys. Acta (1989) [Pubmed]
  28. The p29 and p35 immunodominant antigens of Neospora caninum tachyzoites are homologous to the family of surface antigens of Toxoplasma gondii. Howe, D.K., Crawford, A.C., Lindsay, D., Sibley, L.D. Infect. Immun. (1998) [Pubmed]
  29. Cytotoxicity of Clostridium septicum alpha-toxin: its oligomerization in detergent resistant membranes of mammalian cells. Hang'ombe, M.B., Mukamoto, M., Kohda, T., Sugimoto, N., Kozaki, S. Microb. Pathog. (2004) [Pubmed]
  30. Purification and characterization of phosphatidylinositol-specific phospholipase C from bovine platelets. Hakata, H., Kambayashi, J., Kosaki, G. J. Biochem. (1982) [Pubmed]
  31. The ecto-5'-nucleotidase subunits in dimers are not linked by disulfide bridges but by non-covalent bonds. Martínez-Martínez, A., Muñoz-Delgado, E., Campoy, F.J., Flores-Flores, C., Rodríguez-López, J.N., Fini, C., Vidal, C.J. Biochim. Biophys. Acta (2000) [Pubmed]
  32. Purification and characterization of phosphatidylinositol-specific phospholipase C from bovine spermatozoa. Vanha-Perttula, T., Kasurinen, J. Int. J. Biochem. (1989) [Pubmed]
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