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MeSH Review

Acanthosis Nigricans

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Disease relevance of Acanthosis Nigricans


High impact information on Acanthosis Nigricans


Chemical compound and disease context of Acanthosis Nigricans


Biological context of Acanthosis Nigricans


Anatomical context of Acanthosis Nigricans

  • Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans [1].
  • In this study, major steps in the insulin action cascade, receptor binding, kinase activity, and glucose transport activity were evaluated in isolated adipocytes prepared from PCO subjects (n = 8) without acanthosis nigricans and in a group of age and weight-matched controls [normal cycling (NC) n = 8] [20].
  • The physical features most often associated with this condition include hypertrichosis, pachyderma, acanthosis nigricans, prominent genitalia, and elfin-like facial characteristics of prominent eyes, wide nostrils, thick lips, and large, low-set ears [21].

Gene context of Acanthosis Nigricans


Analytical, diagnostic and therapeutic context of Acanthosis Nigricans


  1. Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans. Meyers, G.A., Orlow, S.J., Munro, I.R., Przylepa, K.A., Jabs, E.W. Nat. Genet. (1995) [Pubmed]
  2. Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13. Magré, J., Delépine, M., Khallouf, E., Gedde-Dahl, T., Van Maldergem, L., Sobel, E., Papp, J., Meier, M., Mégarbané, A., Bachy, A., Verloes, A., d'Abronzo, F.H., Seemanova, E., Assan, R., Baudic, N., Bourut, C., Czernichow, P., Huet, F., Grigorescu, F., de Kerdanet, M., Lacombe, D., Labrune, P., Lanza, M., Loret, H., Matsuda, F., Navarro, J., Nivelon-Chevalier, A., Polak, M., Robert, J.J., Tric, P., Tubiana-Rufi, N., Vigouroux, C., Weissenbach, J., Savasta, S., Maassen, J.A., Trygstad, O., Bogalho, P., Freitas, P., Medina, J.L., Bonnicci, F., Joffe, B.I., Loyson, G., Panz, V.R., Raal, F.J., O'Rahilly, S., Stephenson, T., Kahn, C.R., Lathrop, M., Capeau, J. Nat. Genet. (2001) [Pubmed]
  3. The molecular and genetic basis of fibroblast growth factor receptor 3 disorders: the achondroplasia family of skeletal dysplasias, Muenke craniosynostosis, and Crouzon syndrome with acanthosis nigricans. Vajo, Z., Francomano, C.A., Wilkin, D.J. Endocr. Rev. (2000) [Pubmed]
  4. Insulin resistance associated with androgen excess in women with autoantibodies to the insulin receptor. Taylor, S.I., Dons, R.F., Hernandez, E., Roth, J., Gorden, P. Ann. Intern. Med. (1982) [Pubmed]
  5. Selective insulin action on skin, ovary, and heart in insulin-resistant states. Geffner, M.E., Golde, D.W. Diabetes Care (1988) [Pubmed]
  6. Fibroblast growth factor receptor 2 mutations in Beare-Stevenson cutis gyrata syndrome. Przylepa, K.A., Paznekas, W., Zhang, M., Golabi, M., Bias, W., Bamshad, M.J., Carey, J.C., Hall, B.D., Stevenson, R., Orlow, S., Cohen, M.M., Jabs, E.W. Nat. Genet. (1996) [Pubmed]
  7. Detection of an alteration in the insulin-receptor gene in a patient with insulin resistance, acanthosis nigricans, and the polycystic ovary syndrome (type A insulin resistance). Moller, D.E., Flier, J.S. N. Engl. J. Med. (1988) [Pubmed]
  8. Antibody against the insulin receptor causes disappearance of insulin receptors in 3T3-L1 cells: a possible explanation of antibody-induced insulin resistance. Grunfeld, C. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  9. Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice. Iwata, T., Li, C.L., Deng, C.X., Francomano, C.A. Hum. Mol. Genet. (2001) [Pubmed]
  10. The effects of hyperinsulinemia on serum testosterone, progesterone, dehydroepiandrosterone sulfate, and cortisol levels in normal women and in a woman with hyperandrogenism, insulin resistance, and acanthosis nigricans. Nestler, J.E., Clore, J.N., Strauss, J.F., Blackard, W.G. J. Clin. Endocrinol. Metab. (1987) [Pubmed]
  11. Bimodal correlation between the circulating insulin level and the production rate of dehydroepiandrosterone: positive correlation in controls and negative correlation in the polycystic ovary syndrome with acanthosis nigricans. Farah, M.J., Givens, J.R., Kitabchi, A.E. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  12. Resolution of nicotinic acid-induced acanthosis nigricans by substitution of an analogue (acipimox) in a patient with type V hyperlipidaemia. Coates, P., Shuttleworth, D., Rees, A. Br. J. Dermatol. (1992) [Pubmed]
  13. The hyperandrogenic-insulin-resistant acanthosis nigricans syndrome: therapeutic response. Azziz, R. Fertil. Steril. (1994) [Pubmed]
  14. Insulin resistance Type A and short 5th metacarpals. Patel, V.K., Davies, H.A. Diabet. Med. (2003) [Pubmed]
  15. A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene. Tavormina, P.L., Bellus, G.A., Webster, M.K., Bamshad, M.J., Fraley, A.E., McIntosh, I., Szabo, J., Jiang, W., Jabs, E.W., Wilcox, W.R., Wasmuth, J.J., Donoghue, D.J., Thompson, L.M., Francomano, C.A. Am. J. Hum. Genet. (1999) [Pubmed]
  16. The insulin resistant subphenotype of polycystic ovary syndrome: clinical parameters and pathogenesis. Mor, E., Zograbyan, A., Saadat, P., Bayrak, A., Tourgeman, D.E., Zhang, C., Stanczyk, F.Z., Paulson, R.J. Am. J. Obstet. Gynecol. (2004) [Pubmed]
  17. Pregnancy following preimplantation genetic diagnosis for Crouzon syndrome. Abou-Sleiman, P.M., Apessos, A., Harper, J.C., Serhal, P., Delhanty, J.D. Mol. Hum. Reprod. (2002) [Pubmed]
  18. Case report: acanthosis nigricans in association with primary biliary cirrhosis: resolution after liver transplantation. Pham, T.H., Kaushik, S., Lin, B.P., Jones, D.B. J. Gastroenterol. Hepatol. (1996) [Pubmed]
  19. Acanthosis nigricans, hyperinsulinaemia and risk factors for cardiovascular disease. Bener, A., Lestringant, G.G., Nyomba, B.L., Frossard, P., Saadi, H. Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ. (2000) [Pubmed]
  20. Cellular mechanisms of insulin resistance in polycystic ovarian syndrome. Ciaraldi, T.P., el-Roeiy, A., Madar, Z., Reichart, D., Olefsky, J.M., Yen, S.S. J. Clin. Endocrinol. Metab. (1992) [Pubmed]
  21. Ocular manifestations of Donohue's syndrome. Gable, E.M., Brandonisio, T.M. Optometry and vision science : official publication of the American Academy of Optometry. (2003) [Pubmed]
  22. Prominent basal emissary foramina in syndromic craniosynostosis: correlation with phenotypic and molecular diagnoses. Robson, C.D., Mulliken, J.B., Robertson, R.L., Proctor, M.R., Steinberger, D., Barnes, P.D., McFarren, A., Müller, U., Zurakowski, D. AJNR. American journal of neuroradiology. (2000) [Pubmed]
  23. Further evidence that acanthosis nigricans maligna is linked to enhanced secretion by the tumour of transforming growth factor alpha. Wilgenbus, K., Lentner, A., Kuckelkorn, R., Handt, S., Mittermayer, C. Arch. Dermatol. Res. (1992) [Pubmed]
  24. Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans. Logié, A., Dunois-Lardé, C., Rosty, C., Levrel, O., Blanche, M., Ribeiro, A., Gasc, J.M., Jorcano, J., Werner, S., Sastre-Garau, X., Thiery, J.P., Radvanyi, F. Hum. Mol. Genet. (2005) [Pubmed]
  25. Pathophysiology of obesity. Bray, G.A. Am. J. Clin. Nutr. (1992) [Pubmed]
  26. Costello syndrome. Philip, N., Sigaudy, S. J. Med. Genet. (1998) [Pubmed]
  27. Type 2 diabetes and impaired glucose tolerance in European children and adolescents with obesity -- a problem that is no longer restricted to minority groups. Wiegand, S., Maikowski, U., Blankenstein, O., Biebermann, H., Tarnow, P., Grüters, A. Eur. J. Endocrinol. (2004) [Pubmed]
  28. Pregnancy after treatment with the insulin-sensitizing agent troglitazone in an obese woman with the hyperandrogenic, insulin-resistant acanthosis nigricans syndrome. Elkind-Hirsch, K.E., McWilliams, R.B. Fertil. Steril. (1999) [Pubmed]
  29. Long-term octreotide treatment reduced hyperinsulinemia, excess body weight and skin lesions in severe obesity with acanthosis nigricans. Lunetta, M., Di Mauro, M., Le Moli, R., Burrafato, S. J. Endocrinol. Invest. (1996) [Pubmed]
  30. Acanthosis nigricans: clinical predictor of abnormal glucose tolerance in Asian women with polycystic ovary syndrome. Charnvises, K., Weerakiet, S., Tingthanatikul, Y., Wansumrith, S., Chanprasertyothin, S., Rojanasakul, A. Gynecol. Endocrinol. (2005) [Pubmed]
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