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Gene Review

ITGAV  -  integrin, alpha V

Homo sapiens

Synonyms: CD51, Integrin alpha-V, MSK8, VNRA, VTNR, ...
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Disease relevance of ITGAV


High impact information on ITGAV

  • These cells were shown to have vitronectin beta-receptors using a specific monoclonal antibody, i.e., 23C6 (CD51), which reacts with osteoclasts in human bone biopsy samples [6].
  • Intact P. falciparum-infected erythrocytes can bind directly to CD36 and indirectly to CD51 [7].
  • Anti-integrin alphavbeta3 MoAb (CD51/CD61; 23C6) only slightly inhibited colony size (P < .05) [8].
  • High surface expression of CD49e, CD51, and CD61 along with kit was apparent by 4 weeks of culture, whereas expression of each at day 0 was low to undetectable [9].
  • Human mast cells derived from fetal liver cells cultured with stem cell factor express a functional CD51/CD61 (alpha v beta 3) integrin [9].

Biological context of ITGAV


Anatomical context of ITGAV


Associations of ITGAV with chemical compounds


Regulatory relationships of ITGAV

  • RA SF presented more cell surface integrins, and monoclonal antibodies against CD51 inhibited the adhesion to COMP by 80% [22].
  • CD51 is only weakly expressed by malpighian epithelial cells and does not colocalize with TSP [23].

Other interactions of ITGAV


Analytical, diagnostic and therapeutic context of ITGAV


  1. In vivo distribution of integrins in renal cell carcinoma: integrin-phenotype alteration in different degrees of tumor differentiation and VLA-2 involvement in tumor metastasis. Anastassiou, G., Duensing, S., Steinhoff, G., Kirchner, H., Ganser, A., Atzpodien, J. Cancer Biother. (1995) [Pubmed]
  2. Expression of epithelial markers in nocturnal asthma. Kraft, M., Striz, I., Georges, G., Umino, T., Takigawa, K., Rennard, S., Martin, R.J. J. Allergy Clin. Immunol. (1998) [Pubmed]
  3. Effect of eptifibatide for acute coronary syndromes: rapid versus late administration--therapeutic yield on platelets (The EARLY Platelet Substudy). Gurbel, P.A., Galbut, B., Bliden, K.P., Bahr, R.D., Roe, M.T., Serebruany, V.L., Gibler, W.B., Christenson, R.H., Ohman, E.M. J. Thromb. Thrombolysis (2002) [Pubmed]
  4. A novel integrin beta subunit is associated with the vitronectin receptor alpha subunit (alpha v) in a human osteosarcoma cell line and is a substrate for protein kinase C. Freed, E., Gailit, J., van der Geer, P., Ruoslahti, E., Hunter, T. EMBO J. (1989) [Pubmed]
  5. Decoy receptor 3 (DcR3) induces osteoclast formation from monocyte/macrophage lineage precursor cells. Yang, C.R., Wang, J.H., Hsieh, S.L., Wang, S.M., Hsu, T.L., Lin, W.W. Cell Death Differ. (2004) [Pubmed]
  6. Bone marrow-derived osteoclast-like cells from a patient with craniometaphyseal dysplasia lack expression of osteoclast-reactive vacuolar proton pump. Yamamoto, T., Kurihara, N., Yamaoka, K., Ozono, K., Okada, M., Yamamoto, K., Matsumoto, S., Michigami, T., Ono, J., Okada, S. J. Clin. Invest. (1993) [Pubmed]
  7. A role for CD36 in the regulation of dendritic cell function. Urban, B.C., Willcox, N., Roberts, D.J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  8. Influence of monoclonal antiplatelet glycoprotein antibodies on in vitro human megakaryocyte colony formation and proplatelet formation. Takahashi, R., Sekine, N., Nakatake, T. Blood (1999) [Pubmed]
  9. Human mast cells derived from fetal liver cells cultured with stem cell factor express a functional CD51/CD61 (alpha v beta 3) integrin. Shimizu, Y., Irani, A.M., Brown, E.J., Ashman, L.K., Schwartz, L.B. Blood (1995) [Pubmed]
  10. Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51. Sims, M.A., Field, S.D., Barnes, M.R., Shaikh, N., Ellington, K., Murphy, K.E., Spurr, N., Campbell, D.A. Cytogenet. Cell Genet. (2000) [Pubmed]
  11. Regional localization of the human vitronectin receptor alpha subunit gene (VNRA) to chromosome 2q31-->q32. Fernández-Ruiz, E., Pardo-Manuel de Villena, F., Rodríguez de Córdoba, S., Sánchez-Madrid, F. Cytogenet. Cell Genet. (1993) [Pubmed]
  12. Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors. Jacques, C., Baris, O., Prunier-Mirebeau, D., Savagner, F., Rodien, P., Rohmer, V., Franc, B., Guyetant, S., Malthiery, Y., Reynier, P. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  13. Amino acid sequence of the vitronectin receptor alpha subunit and comparative expression of adhesion receptor mRNAs. Suzuki, S., Argraves, W.S., Arai, H., Languino, L.R., Pierschbacher, M.D., Ruoslahti, E. J. Biol. Chem. (1987) [Pubmed]
  14. Could coenzyme Q10 affect hemostasis by inhibiting platelet vitronectin (CD51/CD61) receptor? Serebruany, V.L., Gurbel, P.A., Ordoñez, J.V., Herzog, W.R., Rohde, M., Mortensen, S.A., Folkers, K. Mol. Aspects Med. (1997) [Pubmed]
  15. Interaction of human Thy-1 (CD 90) with the integrin alphavbeta3 (CD51/CD61): an important mechanism mediating melanoma cell adhesion to activated endothelium. Saalbach, A., Wetzel, A., Haustein, U.F., Sticherling, M., Simon, J.C., Anderegg, U. Oncogene (2005) [Pubmed]
  16. Human skin mast cells adhere to vitronectin via the alphavbeta3 integrin receptor (CD51/CD61). Columbo, M., Bochner, B.S. J. Allergy Clin. Immunol. (2001) [Pubmed]
  17. Macrophage colony-stimulating factor is required for human monocyte survival and acts as a cofactor for their terminal differentiation to macrophages in vitro. Brugger, W., Kreutz, M., Andreesen, R. J. Leukoc. Biol. (1991) [Pubmed]
  18. Differences between scar and dermal cultured fibroblasts derived from a patient with recurrent abdominal incision wound herniation. Boemi, L., Allison, G.M., Graham, W.P., Krummel, T.M., Ehrlich, H.P. Plast. Reconstr. Surg. (1999) [Pubmed]
  19. Dietary coenzyme Q10 supplementation alters platelet size and inhibits human vitronectin (CD51/CD61) receptor expression. Serebruany, V.L., Ordonez, J.V., Herzog, W.R., Rohde, M., Mortensen, S.A., Folkers, K., Gurbel, P.A. J. Cardiovasc. Pharmacol. (1997) [Pubmed]
  20. Analysis of rodent platelet glycoprotein IIb: evidence for evolutionarily conserved domains and alternative proteolytic processing. Poncz, M., Newman, P.J. Blood (1990) [Pubmed]
  21. High affinity interactions of Coxsackievirus A9 with integrin alphavbeta3 (CD51/61) require the CYDMKTTC sequence of beta3, but do not require the RGD sequence of the CAV-9 VP1 protein. Triantafilou, M., Triantafilou, K., Wilson, K.M., Takada, Y., Fernandez, N. Hum. Immunol. (2000) [Pubmed]
  22. Galectin-3 is induced in rheumatoid arthritis synovial fibroblasts after adhesion to cartilage oligomeric matrix protein. Neidhart, M., Zaucke, F., von Knoch, R., Jüngel, A., Michel, B.A., Gay, R.E., Gay, S. Ann. Rheum. Dis. (2005) [Pubmed]
  23. Localization of thrombospondin, CD36 and CD51 during prenatal development of the human mammary gland. Péchoux, C., Clezardin, P., Dante, R., Serre, C.M., Clerget, M., Bertin, N., Lawler, J., Delmas, P.D., Vauzelle, J.L., Frappart, L. Differentiation (1994) [Pubmed]
  24. In vitro effect of transforming growth factor-beta on adhesion molecule expression by human gingival fibroblasts cultured in the presence of a titanium abutment. Schierano, G., Bellone, G., Manzella, C., Preti, G., Emanuelli, G. J. Periodontol. (2001) [Pubmed]
  25. Expression of thrombospondin-1 and its receptor CD36 in human osteoarthritic cartilage. Pfander, D., Cramer, T., Deuerling, D., Weseloh, G., Swoboda, B. Ann. Rheum. Dis. (2000) [Pubmed]
  26. Quantitation and kinetics of CD51 surface receptor expression: implications for targeted delivery. Smith, R.A., Giorgio, T.D. Annals of biomedical engineering. (2004) [Pubmed]
  27. PDGF-B producing cells and PDGF-B gene expression in normal gingival and cyclosporine A-induced gingival overgrowth. Plemons, J.M., Dill, R.E., Rees, T.D., Dyer, B.J., Ng, M.C., Iacopino, A.M. J. Periodontol. (1996) [Pubmed]
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