Gene Review:
LCN2 - lipocalin 2
Homo sapiens
Synonyms:
24p3, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, HNL, Lipocalin-2, MSFI, ...
- Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. Mori, K., Lee, H.T., Rapoport, D., Drexler, I.R., Foster, K., Yang, J., Schmidt-Ott, K.M., Chen, X., Li, J.Y., Weiss, S., Mishra, J., Cheema, F.H., Markowitz, G., Suganami, T., Sawai, K., Mukoyama, M., Kunis, C., D'Agati, V., Devarajan, P., Barasch, J. J. Clin. Invest. (2005)
- Lipocalin 2 diminishes invasiveness and metastasis of Ras-transformed cells. Hanai, J., Mammoto, T., Seth, P., Mori, K., Karumanchi, S.A., Barasch, J., Sukhatme, V.P. J. Biol. Chem. (2005)
- The matrix metalloproteinase-9/neutrophil gelatinase-associated lipocalin complex plays a role in breast tumor growth and is present in the urine of breast cancer patients. Fernández, C.A., Yan, L., Louis, G., Yang, J., Kutok, J.L., Moses, M.A. Clin. Cancer Res. (2005)
- Cloning and expression of human neutrophil lipocalin cDNA derived from bone marrow and ovarian cancer cells. Bartsch, S., Tschesche, H. FEBS Lett. (1995)
- Microarray and protein analysis of human pterygium. John-Aryankalayil, M., Dushku, N., Jaworski, C.J., Cox, C.A., Schultz, G., Smith, J.A., Ramsey, K.E., Stephan, D.A., Freedman, K.A., Reid, T.W., Carper, D.A. Mol. Vis. (2006)
- Urinary lipocalin-2 is associated with renal disease activity in human lupus nephritis. Pitashny, M., Schwartz, N., Qing, X., Hojaili, B., Aranow, C., Mackay, M., Putterman, C. Arthritis Rheum. (2007)
- Neutrophil gelatinase-associated lipocalin is a predictor of the course of global and renal childhood-onset systemic lupus erythematosus disease activity. Hinze, C.H., Suzuki, M., Klein-Gitelman, M., Passo, M.H., Olson, J., Singer, N.G., Haines, K.A., Onel, K., O'Neil, K., Silverman, E.D., Tucker, L., Ying, J., Devarajan, P., Brunner, H.I. Arthritis Rheum. (2009)
- Lymphadenopathy associated virus infection of a blood donor--recipient pair with acquired immunodeficiency syndrome. Feorino, P.M., Kalyanaraman, V.S., Haverkos, H.W., Cabradilla, C.D., Warfield, D.T., Jaffe, H.W., Harrison, A.K., Gottlieb, M.S., Goldfinger, D., Chermann, J.C. Science (1984)
- Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Barré-Sinoussi, F., Chermann, J.C., Rey, F., Nugeyre, M.T., Chamaret, S., Gruest, J., Dauguet, C., Axler-Blin, C., Vézinet-Brun, F., Rouzioux, C., Rozenbaum, W., Montagnier, L. Science (1983)
- Identification of the C-signal, a contact-dependent morphogen coordinating multiple developmental responses in Myxococcus xanthus. Lobedanz, S., Søgaard-Andersen, L. Genes Dev. (2003)
- The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Goetz, D.H., Holmes, M.A., Borregaard, N., Bluhm, M.E., Raymond, K.N., Strong, R.K. Mol. Cell (2002)
- Heterogeneous expression of the lipocalin NGAL in primary breast cancers. Stoesz, S.P., Friedl, A., Haag, J.D., Lindstrom, M.J., Clark, G.M., Gould, M.N. Int. J. Cancer (1998)
- Antibodies to the core protein of lymphadenopathy-associated virus (LAV) in patients with AIDS. Kalyanaraman, V.S., Cabradilla, C.D., Getchell, J.P., Narayanan, R., Braff, E.H., Chermann, J.C., Barré-Sinoussi, F., Montagnier, L., Spira, T.J., Kaplan, J. Science (1984)
- The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Fischbach, M.A., Lin, H., Zhou, L., Yu, Y., Abergel, R.J., Liu, D.R., Raymond, K.N., Wanner, B.L., Strong, R.K., Walsh, C.T., Aderem, A., Smith, K.D. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Urinary neutrophil gelatinase-associated lipocalin as a biomarker of nephritis in childhood-onset systemic lupus erythematosus. Brunner, H.I., Mueller, M., Rutherford, C., Passo, M.H., Witte, D., Grom, A., Mishra, J., Devarajan, P. Arthritis Rheum. (2006)
- Regulation of lipocalin-2 gene by the cancer chemopreventive retinoid 4-HPR. Caramuta, S., De Cecco, L., Reid, J.F., Zannini, L., Gariboldi, M., Kjeldsen, L., Pierotti, M.A., Delia, D. Int. J. Cancer (2006)
- Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans. Cowland, J.B., Borregaard, N. Genomics (1997)
- Neutrophil gelatinase-associated lipocalin is a marker for dysregulated keratinocyte differentiation in human skin. Mallbris, L., O'Brien, K.P., Hulthén, A., Sandstedt, B., Cowland, J.B., Borregaard, N., Ståhle-Bäckdahl, M. Exp. Dermatol. (2002)
- Glycosylation of natural human neutrophil gelatinase B and neutrophil gelatinase B-associated lipocalin. Rudd, P.M., Mattu, T.S., Masure, S., Bratt, T., Van den Steen, P.E., Wormald, M.R., Küster, B., Harvey, D.J., Borregaard, N., Van Damme, J., Dwek, R.A., Opdenakker, G. Biochemistry (1999)
- The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. Hvidberg, V., Jacobsen, C., Strong, R.K., Cowland, J.B., Moestrup, S.K., Borregaard, N. FEBS Lett. (2005)
- Studies of the release and turnover of a human neutrophil lipocalin. Axelsson, L., Bergenfeldt, M., Ohlsson, K. Scand. J. Clin. Lab. Invest. (1995)
- Neutrophil gelatinase-associated lipocalin, a siderophore-binding eukaryotic protein. Borregaard, N., Cowland, J.B. Biometals (2006)
- Sorting of the specific granule protein, NGAL, during granulocytic maturation of HL-60 cells. Le Cabec, V., Calafat, J., Borregaard, N. Blood (1997)
- Lipocalin 2 antagonizes the proangiogenic action of ras in transformed cells. Venkatesha, S., Hanai, J., Seth, P., Karumanchi, S.A., Sukhatme, V.P. Mol. Cancer Res. (2006)
- Human neutrophil lipocalin (HNL) and myeloperoxidase (MPO). Studies of lung lavage fluid and lung tissue. Schmekel, B., Seveus, L., Xu, S.Y., Venge, P. Respiratory medicine. (2000)
- Neutrophil gelatinase-associated lipocalin as a survival factor. Tong, Z., Wu, X., Ovcharenko, D., Zhu, J., Chen, C.S., Kehrer, J.P. Biochem. J. (2005)
- Comparative mapping of lipocalin genes in human and mouse: the four genes for complement C8 gamma chain, prostaglandin-D-synthase, oncogene-24p3, and progestagen-associated endometrial protein map to HSA9 and MMU2. Chan, P., Simon-Chazottes, D., Mattei, M.G., Guenet, J.L., Salier, J.P. Genomics (1994)
- The development of an assay for human neutrophil lipocalin (HNL)--to be used as a specific marker of neutrophil activity in vivo and vitro. Xu, S.Y., Petersson, C.G., Carlson, M., Venge, P. J. Immunol. Methods (1994)
- Molecular cloning and expression of a cDNA encoding NGAL: a lipocalin expressed in human neutrophils. Bundgaard, J.R., Sengeløv, H., Borregaard, N., Kjeldsen, L. Biochem. Biophys. Res. Commun. (1994)