Gene Review:
POLK - polymerase (DNA directed) kappa
Homo sapiens
Synonyms:
DINB protein, DINB1, DINP, DNA polymerase kappa, POLQ
- Byron Stookey: "the old lion"--an unsung giant of neurosurgery. Kaufman, H.H., Goodrich, J.T. Neurosurgery (1997)
- Elevated expression of DNA polymerase kappa in human lung cancer is associated with p53 inactivation: Negative regulation of POLK promoter activity by p53. Wang, Y., Seimiya, M., Kawamura, K., Yu, L., Ogi, T., Takenaga, K., Shishikura, T., Nakagawara, A., Sakiyama, S., Tagawa, M., O-Wang, J. Int. J. Oncol. (2004)
- Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene). Suzuki, N., Ohashi, E., Kolbanovskiy, A., Geacintov, N.E., Grollman, A.P., Ohmori, H., Shibutani, S. Biochemistry (2002)
- Prevalence and correlates of HIV infection among young injection drug users in San Francisco. Shafer, K.P., Hahn, J.A., Lum, P.J., Ochoa, K., Graves, A., Moss, A. J. Acquir. Immune Defic. Syndr. (2002)
- Establishing efficient interview periods for gonorrhea patients. Starcher, E.T., Kramer, M.A., Carlota-Orduna, B., Lundberg, D.F. American journal of public health. (1983)
- Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa. Ohashi, E., Ogi, T., Kusumoto, R., Iwai, S., Masutani, C., Hanaoka, F., Ohmori, H. Genes Dev. (2000)
- Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily. Gerlach, V.L., Aravind, L., Gotway, G., Schultz, R.A., Koonin, E.V., Friedberg, E.C. Proc. Natl. Acad. Sci. U.S.A. (1999)
- DNA polymerase kappa is specifically required for recovery from the benzo[a]pyrene-dihydrodiol epoxide (BPDE)-induced S-phase checkpoint. Bi, X., Slater, D.M., Ohmori, H., Vaziri, C. J. Biol. Chem. (2005)
- Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides. Fischhaber, P.L., Gerlach, V.L., Feaver, W.J., Hatahet, Z., Wallace, S.S., Friedberg, E.C. J. Biol. Chem. (2002)
- Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene. Ohashi, E., Bebenek, K., Matsuda, T., Feaver, W.J., Gerlach, V.L., Friedberg, E.C., Ohmori, H., Kunkel, T.A. J. Biol. Chem. (2000)
- Effects of di-isononyl phthalate, di-2-ethylhexyl phthalate, and clofibrate in cynomolgus monkeys. Pugh, G., Isenberg, J.S., Kamendulis, L.M., Ackley, D.C., Clare, L.J., Brown, R., Lington, A.W., Smith, J.H., Klaunig, J.E. Toxicol. Sci. (2000)
- Error-prone and inefficient replication across 8-hydroxyguanine (8-oxoguanine) in human and mouse ras gene fragments by DNA polymerase kappa. Jałoszyński, P., Ohashi, E., Ohmori, H., Nishimura, S. Genes Cells (2005)
- Adaptation to DNA damage and stimulation of genetic instability: the double-edged sword mammalian DNA polymerase kappa. Bavoux, C., Hoffmann, J.S., Cazaux, C. Biochimie (2005)
- Crystal structure of the catalytic core of human DNA polymerase kappa. Uljon, S.N., Johnson, R.E., Edwards, T.A., Prakash, S., Prakash, L., Aggarwal, A.K. Structure (Camb.) (2004)
- Absence of DNA polymerase theta results in decreased somatic hypermutation frequency and altered mutation patterns in Ig genes. Masuda, K., Ouchida, R., Hikida, M., Nakayama, M., Ohara, O., Kurosaki, T., O-Wang, J. DNA Repair (Amst.) (2006)
- Multiple PolK (POLK) transcripts in mammalian testis. Guo, C., Gao, T., Confer, N., Velasco-Miguel, S., Friedberg, E.C. DNA Repair (Amst.) (2005)
- Absorption, disposition and metabolism of di-isononyl phthalate (DINP) in F-344 rats. McKee, R.H., El-Hawari, M., Stoltz, M., Pallas, F., Lington, A.W. Journal of applied toxicology : JAT. (2002)
- The promoter of the human sodium/iodide symporter responds to certain phthalate plasticisers. Breous, E., Wenzel, A., Loos, U. Mol. Cell. Endocrinol. (2005)
- The role of inhibition of gap junctional intercellular communication in rodent liver tumor induction by phthalates: review of data on selected phthalates and the potential relevance to man. McKee, R.H. Regulatory toxicology and pharmacology : RTP. (2000)
- University of Louisville experience and contributions to pediatric trauma care. Bond, S., Fallat, M.E. Am. J. Surg. (2005)
- Current treatment of intraabdominal infections. Chong, A.J., Dellinger, E.P. Surgical technology international. (2005)