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Gene Review

ZC3HAV1  -  zinc finger CCCH-type, antiviral 1

Homo sapiens

Synonyms: ADP-ribosyltransferase diphtheria toxin-like 13, ARTD13, FLB6421, FLJ13288, MGC48898, ...
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Disease relevance of ZC3HAV1


High impact information on ZC3HAV1


Chemical compound and disease context of ZC3HAV1

  • A 2432-bp cDNA for mouse FAD-linked glycerol-3-phosphate dehydrogenase, a nuclear-encoded enzyme associated with the inner mitochondrial membrane, was isolated from a Lambda ZAP phage library generated from brown adipocyte mRNA [7].
  • After double-strand cDNA synthesis, we fractionated it on a CHROMA APIN-400 column; ligated the longer than 500bp cDNA into a ZAP Express Vector; and performed a lambda: phage packaging reaction, library amplification, and titer [8].

Biological context of ZC3HAV1

  • The rat zinc-finger antiviral protein (ZAP) was recently identified as a host protein conferring resistance to retroviral infection [1].
  • A cDNA encoding mouse deoxycytidine kinase (dCK) (EC was cloned from a mouse T-cell lambda ZAP cDNA library [9].
  • A 1.4-kilobase DNA fragment amplified from genomic DNA was used to screen a genomic library constructed in ZAP [10].
  • Some of these waveforms were derived from barrages of postsynaptic potentials evoked by visual stimulation recorded in vivo; others were artificially created and contained various amounts of gamma range fluctuations; finally, others consisted of swept-sinewave current (ZAP current) functions [11].
  • DNA obtained from a human sputum isolate of Mycobacterium tuberculosis, NTI-64719, which showed extensive dissemination in the guinea pig model resulting in a high score for virulence was used to construct an expression library in the lambda ZAP vector [12].

Anatomical context of ZC3HAV1

  • While the presence of p56-Lck was required for ZAP YF-C-induced signaling, Syk YF-C showed enhanced functional activity in Lck-deficient JCaM1 Jurkat cells [13].
  • In the present study our aim was to 1) evaluate the impact of different antibodies, namely cytokeratin (CK) 7, 13, and 20, CaCO3/73, and FBB2/29, in order to differentiate between Barrett's esophagus and cardia intestinal metaplasia, and 2) explore the staining patterns in different ZAP grades [14].
  • Even among patients undergoing fundoplication (i.e., patients with an anatomically altered gastroesophageal junction), the ZAP classification is a feasible tool to characterize the Z-line appearance [15].
  • Intestinal metaplasia was found to be associated with age, more than 10 years of symptoms of gastroesophageal reflux disease preoperatively, tongues of columnar epithelium in the distal esophagus, carditis, and ZAP grade [15].

Associations of ZC3HAV1 with chemical compounds

  • We report here the characterization of novel mutants of ZAP-70 and Syk, in which conserved C-terminal tyrosine residues have been replaced by phenylalanines (ZAP YF-C, Syk YF-C) [13].
  • Histologically, pretreatment with pranlukast or MK-886 did not affect the ZAP-induced PMN infiltration [16].
  • Neither the antihistaminic agent diphenhydramine, nor the bradykinin B2 receptor antagonist, HOE140, affected the ZAP-induced, late-phase extravasation [16].
  • A clone (P2) coding for an allergen of Parietaria judaica (Pj) pollen has been isolated and sequenced from a cDNA library in lambda ZAP using a pool of 23 sera from Pj-allergic patients [17].
  • Complementary deoxyribonucleic acid was cloned into the ZAP Express lambda vector (Stratagene, La Jolla, Calif) [18].

Analytical, diagnostic and therapeutic context of ZC3HAV1


  1. Expression of the zinc-finger antiviral protein inhibits alphavirus replication. Bick, M.J., Carroll, J.W., Gao, G., Goff, S.P., Rice, C.M., MacDonald, M.R. J. Virol. (2003) [Pubmed]
  2. More ZAP for chronic lymphocytic leukemia (CLL). Wiestner, A. Blood (2005) [Pubmed]
  3. Derivation of clones from the choroideremia locus by preparative field inversion gel electrophoresis. van de Pol, T.J., Cremers, F.P., Brohet, R.M., Wieringa, B., Ropers, H.H. Nucleic Acids Res. (1990) [Pubmed]
  4. Cloning and characterization of complementary DNA for human tryptase. Miller, J.S., Westin, E.H., Schwartz, L.B. J. Clin. Invest. (1989) [Pubmed]
  5. The zinc-finger antiviral protein recruits the RNA processing exosome to degrade the target mRNA. Guo, X., Ma, J., Sun, J., Gao, G. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  6. Ig alpha and Ig beta are functionally homologous to the signaling proteins of the T-cell receptor. Burkhardt, A.L., Costa, T., Misulovin, Z., Stealy, B., Bolen, J.B., Nussenzweig, M.C. Mol. Cell. Biol. (1994) [Pubmed]
  7. Sequence and tissue-dependent RNA expression of mouse FAD-linked glycerol-3-phosphate dehydrogenase. Koza, R.A., Kozak, U.C., Brown, L.J., Leiter, E.H., MacDonald, M.J., Kozak, L.P. Arch. Biochem. Biophys. (1996) [Pubmed]
  8. Construction and characterization of a cDNA library from liver tissue of chinese banna minipig inbred line. Tan, W., Chen, Y., Zhang, L., Lu, Y., Li, S., Zeng, R., Zeng, Y., Li, Y., Cheng, J. Transplant. Proc. (2006) [Pubmed]
  9. 2 cloning and expression of mouse deoxycytidine kinase. Pure recombinant mouse and human enzymes show differences in substrate specificity. Karlsson, A., Johansson, M., Eriksson, S. J. Biol. Chem. (1994) [Pubmed]
  10. Galactose oxidase of Dactylium dendroides. Gene cloning and sequence analysis. McPherson, M.J., Ogel, Z.B., Stevens, C., Yadav, K.D., Keen, J.N., Knowles, P.F. J. Biol. Chem. (1992) [Pubmed]
  11. Influence of low and high frequency inputs on spike timing in visual cortical neurons. Nowak, L.G., Sanchez-Vives, M.V., McCormick, D.A. Cereb. Cortex (1997) [Pubmed]
  12. Analysis of a genomic DNA expression library of Mycobacterium tuberculosis using tuberculosis patient sera: evidence for modulation of host immune response. Amara, R.R., Satchidanandam, V. Infect. Immun. (1996) [Pubmed]
  13. T cell activation induced by novel gain-of-function mutants of Syk and ZAP-70. Zeitlmann, L., Knorr, T., Knoll, M., Romeo, C., Sirim, P., Kolanus, W. J. Biol. Chem. (1998) [Pubmed]
  14. Immunohistochemical markers for Barrett's esophagus and associations to esophageal Z-line appearance. Wallner, B., Sylvan, A., Janunger, K.G., Bozoky, B., Stenling, R. Scand. J. Gastroenterol. (2001) [Pubmed]
  15. A postfundoplication study on Z-line appearance and intestinal metaplasia in the gastroesophageal junction. Wallner, B., Sylvan, A., Stenling, R., Janunger, K.G. Surgical laparoscopy, endoscopy & percutaneous techniques. (2001) [Pubmed]
  16. Roles of leukocytosis and cysteinyl leukotriene in polymorphonuclear leukocyte-dependent plasma extravasation. Tokita, K., Uchida, Y., Yamamoto, T. J. Leukoc. Biol. (2006) [Pubmed]
  17. cDNA cloning, sequence analysis and allergological characterization of Par j 2.0101, a new major allergen of the Parietaria judaica pollen. Duro, G., Colombo, P., Costa, M.A., Izzo, V., Porcasi, R., Di Fiore, R., Locorotondo, G., Mirisola, M.G., Cocchiara, R., Geraci, D. FEBS Lett. (1996) [Pubmed]
  18. Genetic expression by fetal chorionic villi during the first trimester of human gestation. Dizon-Townson, D.S., Lu, J., Morgan, T.K., Ward, K.J. Am. J. Obstet. Gynecol. (2000) [Pubmed]
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