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Gene Review

PTPRJ  -  protein tyrosine phosphatase, receptor...

Homo sapiens

Synonyms: CD148, DEP-1, DEP1, Density-enhanced phosphatase 1, HPTP eta, ...
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Disease relevance of PTPRJ


Psychiatry related information on PTPRJ

  • METHODS: Ten normal males slept for 6 nights in the laboratory: 1 adaptation (AD), 2 baseline (BSL, BSL-A), 2 selective Slow-Wave Sleep (SWS) deprivation (DEP-1, DEP-2), and 1 recovery night (REC) [5].

High impact information on PTPRJ


Chemical compound and disease context of PTPRJ


Biological context of PTPRJ


Anatomical context of PTPRJ

  • To investigate the cellular function of DEP-1, stable cell lines inducibly expressing DEP-1 were generated [12].
  • These results demonstrate that DEP-1 is a negative regulator of cell proliferation, cell-substratum contacts, motility and chemotaxis in fibroblasts [12].
  • Together these data suggest an important role for DEP-1 in the function of cell-cell contacts and adherens junctions [13].
  • Time-lapse interference reflection microscopy of live cells revealed that although small focal contacts at the leading edge were generated in DEP-1-expressing cells, they failed to mature into stable focal adhesions, as found in control cells [12].
  • Using a tetracycline-inducible expression system, we show that the TCR-mediated activation of both the Ras and calcium pathways was inhibited by expression of CD148 at levels that approximate those found in activated primary T cells [14].

Associations of PTPRJ with chemical compounds


Physical interactions of PTPRJ


Enzymatic interactions of PTPRJ

  • Pulldown and in vitro dephosphorylation assays confirmed our prediction and demonstrated an overall specificity of DEP-1 in targeting the phosphorylated tyrosine 204 of ERK1/2 [19].

Regulatory relationships of PTPRJ

  • Overexpression of CD148 in the Jurkat T-cell line inhibited activation of the transcription factor nuclear factor of activated T cells following T-cell receptor (TCR) stimulation but not following stimulation through a heterologously expressed G protein-coupled receptor, the human muscarinic receptor subtype 1 [14].
  • Somatostatin treatment increased the activity of DEP-1/PTPeta and inhibited ERK1/2 activation [10].
  • CD148 has been shown to regulate density-dependent inhibition of cell growth as well as cellular differentiation in nonhematopoietic cells and has been shown to regulate signal transduction processes in several nonlymphoid hematopoietic cell types [17].

Other interactions of PTPRJ


Analytical, diagnostic and therapeutic context of PTPRJ


  1. Allelic association of the human homologue of the mouse modifier Ptprj with breast cancer. Lesueur, F., Pharoah, P.D., Laing, S., Ahmed, S., Jordan, C., Smith, P.L., Luben, R., Wareham, N.J., Easton, D.F., Dunning, A.M., Ponder, B.A. Hum. Mol. Genet. (2005) [Pubmed]
  2. The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis. Iuliano, R., Le Pera, I., Cristofaro, C., Baudi, F., Arturi, F., Pallante, P., Martelli, M.L., Trapasso, F., Chiariotti, L., Fusco, A. Oncogene (2004) [Pubmed]
  3. LOH of PTPRJ occurs early in colorectal cancer and is associated with chromosomal loss of 18q12-21. Ruivenkamp, C., Hermsen, M., Postma, C., Klous, A., Baak, J., Meijer, G., Demant, P. Oncogene (2003) [Pubmed]
  4. Genetic ablation of Ptprj, a mouse cancer susceptibility gene, results in normal growth and development and does not predispose to spontaneous tumorigenesis. Trapasso, F., Drusco, A., Costinean, S., Alder, H., Aqeilan, R.I., Iuliano, R., Gaudio, E., Raso, C., Zanesi, N., Croce, C.M., Fusco, A. DNA Cell Biol. (2006) [Pubmed]
  5. Time-course of sleep inertia upon awakening from nighttime sleep with different sleep homeostasis conditions. Ferrara, M., De Gennaro, L., Bertini, M. Aviation, space, and environmental medicine. (2000) [Pubmed]
  6. Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers. Ruivenkamp, C.A., van Wezel, T., Zanon, C., Stassen, A.P., Vlcek, C., Csikós, T., Klous, A.M., Tripodis, N., Perrakis, A., Boerrigter, L., Groot, P.C., Lindeman, J., Mooi, W.J., Meijjer, G.A., Scholten, G., Dauwerse, H., Paces, V., van Zandwijk, N., van Ommen, G.J., Demant, P. Nat. Genet. (2002) [Pubmed]
  7. The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions. Berset, T.A., Hoier, E.F., Hajnal, A. Genes Dev. (2005) [Pubmed]
  8. Autoantibodies to inner ear and endothelial antigens in Cogan's syndrome. Lunardi, C., Bason, C., Leandri, M., Navone, R., Lestani, M., Millo, E., Benatti, U., Cilli, M., Beri, R., Corrocher, R., Puccetti, A. Lancet (2002) [Pubmed]
  9. The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling. Lin, J., Weiss, A. J. Cell Biol. (2003) [Pubmed]
  10. The expression of the phosphotyrosine phosphatase DEP-1/PTPeta dictates the responsivity of glioma cells to somatostatin inhibition of cell proliferation. Massa, A., Barbieri, F., Aiello, C., Arena, S., Pattarozzi, A., Pirani, P., Corsaro, A., Iuliano, R., Fusco, A., Zona, G., Spaziante, R., Florio, T., Schettini, G. J. Biol. Chem. (2004) [Pubmed]
  11. CD148 is a membrane protein tyrosine phosphatase present in all hematopoietic lineages and is involved in signal transduction on lymphocytes. de la Fuente-García, M.A., Nicolás, J.M., Freed, J.H., Palou, E., Thomas, A.P., Vilella, R., Vives, J., Gayá, A. Blood (1998) [Pubmed]
  12. The tyrosine phosphatase DEP-1 induces cytoskeletal rearrangements, aberrant cell-substratum interactions and a reduction in cell proliferation. Kellie, S., Craggs, G., Bird, I.N., Jones, G.E. J. Cell. Sci. (2004) [Pubmed]
  13. The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn). Holsinger, L.J., Ward, K., Duffield, B., Zachwieja, J., Jallal, B. Oncogene (2002) [Pubmed]
  14. Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation. Baker, J.E., Majeti, R., Tangye, S.G., Weiss, A. Mol. Cell. Biol. (2001) [Pubmed]
  15. Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density. Ostman, A., Yang, Q., Tonks, N.K. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  16. The receptor-like protein-tyrosine phosphatase DEP-1 is constitutively associated with a 64-kDa protein serine/threonine kinase. Jallal, B., Mossie, K., Vasiloudis, G., Knyazev, P., Zachwieja, J., Clairvoyant, F., Schilling, J., Ullrich, A. J. Biol. Chem. (1997) [Pubmed]
  17. Evaluating function of transmembrane protein tyrosine phosphatase CD148 in lymphocyte biology. Harrod, T.R., Justement, L.B. Immunol. Res. (2002) [Pubmed]
  18. Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells. Sallee, J.L., Burridge, K. J. Biol. Chem. (2009) [Pubmed]
  19. Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases. Sacco, F., Tinti, M., Palma, A., Ferrari, E., Nardozza, A.P., Hooft van Huijsduijnen, R., Takahashi, T., Castagnoli, L., Cesareni, G. J. Biol. Chem. (2009) [Pubmed]
  20. The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins. Iervolino, A., Iuliano, R., Trapasso, F., Viglietto, G., Melillo, R.M., Carlomagno, F., Santoro, M., Fusco, A. Cancer Res. (2006) [Pubmed]
  21. Different classes of EGFR inhibitors may have different potential to improve local tumour control after fractionated irradiation: a study on C225 in FaDu hSCC. Krause, M., Schütze, C., Petersen, C., Pimentel, N., Hessel, F., Harstrick, A., Baumann, M. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (2005) [Pubmed]
  22. Molecular cloning, characterization, and chromosomal localization of a novel protein-tyrosine phosphatase, HPTP eta. Honda, H., Inazawa, J., Nishida, J., Yazaki, Y., Hirai, H. Blood (1994) [Pubmed]
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