Gene Review:
Mvp - major vault protein
Mus musculus
Synonyms:
2310009M24Rik, LRP, MVP, Major vault protein, VAULT1
- Disruption of the murine major vault protein (MVP/LRP) gene does not induce hypersensitivity to cytostatics. Mossink, M.H., van Zon, A., Fränzel-Luiten, E., Schoester, M., Kickhoefer, V.A., Scheffer, G.L., Scheper, R.J., Sonneveld, P., Wiemer, E.A. Cancer Res. (2002)
- Decreased expression and function of alpha-2 macroglobulin receptor/low density lipoprotein receptor-related protein in photodynamic therapy-resistant mouse tumor cells. Luna, M.C., Ferrario, A., Rucker, N., Gomer, C.J. Cancer Res. (1995)
- Differential recognition of alpha 1-antitrypsin-elastase and alpha 1-antichymotrypsin-cathepsin G complexes by the low density lipoprotein receptor-related protein. Poller, W., Willnow, T.E., Hilpert, J., Herz, J. J. Biol. Chem. (1995)
- Abnormal guanine nucleotide regulatory protein in MVP dysautonomia: evidence from reconstitution of Gs. Davies, A.O., Su, C.J., Balasubramanyam, A., Codina, J., Birnbaumer, L. J. Clin. Endocrinol. Metab. (1991)
- The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing. Pietrzik, C.U., Busse, T., Merriam, D.E., Weggen, S., Koo, E.H. EMBO J. (2002)
- LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation. Herz, J., Clouthier, D.E., Hammer, R.E. Cell (1992)
- Delayed catabolism of apoB-48 lipoproteins due to decreased heparan sulfate proteoglycan production in diabetic mice. Ebara, T., Conde, K., Kako, Y., Liu, Y., Xu, Y., Ramakrishnan, R., Goldberg, I.J., Shachter, N.S. J. Clin. Invest. (2000)
- Two receptor systems are involved in the plasma clearance of tissue-type plasminogen activator (t-PA) in vivo. Narita, M., Bu, G., Herz, J., Schwartz, A.L. J. Clin. Invest. (1995)
- The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling. Kolli, S., Zito, C.I., Mossink, M.H., Wiemer, E.A., Bennett, A.M. J. Biol. Chem. (2004)
- Vault mobility depends in part on microtubules and vaults can be recruited to the nuclear envelope. van Zon, A., Mossink, M.H., Houtsmuller, A.B., Schoester, M., Scheffer, G.L., Scheper, R.J., Sonneveld, P., Wiemer, E.A. Exp. Cell Res. (2006)
- The genomic sequence of the murine major vault protein and its promoter. Mossink, M., van Zon, A., Fränzel-Luiten, E., Schoester, M., Scheffer, G.L., Scheper, R.J., Sonneveld, P., Wiemer, E.A. Gene (2002)
- Analysis of MVP and VPARP promoters indicates a role for chromatin remodeling in the regulation of MVP. Emre, N., Raval-Fernandes, S., Kickhoefer, V.A., Rome, L.H. Biochim. Biophys. Acta (2004)
- The relationship between low density lipoprotein-related protein/alpha 2-macroglobulin (alpha 2M) receptors and the newly described alpha 2M signaling receptor. Misra, U.K., Chu, C.T., Gawdi, G., Pizzo, S.V. J. Biol. Chem. (1994)
- Apolipoprotein E receptors mediate neurite outgrowth through activation of p44/42 mitogen-activated protein kinase in primary neurons. Qiu, Z., Hyman, B.T., Rebeck, G.W. J. Biol. Chem. (2004)
- C1 inhibitor-C1s complexes are internalized and degraded by the low density lipoprotein receptor-related protein. Storm, D., Herz, J., Trinder, P., Loos, M. J. Biol. Chem. (1997)
- The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors. Bacskai, B.J., Xia, M.Q., Strickland, D.K., Rebeck, G.W., Hyman, B.T. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Cellular internalization and degradation of antithrombin III-thrombin, heparin cofactor II-thrombin, and alpha 1-antitrypsin-trypsin complexes is mediated by the low density lipoprotein receptor-related protein. Kounnas, M.Z., Church, F.C., Argraves, W.S., Strickland, D.K. J. Biol. Chem. (1996)
- Identification of a binding site in protease nexin I (PN1) required for the receptor mediated internalization of PN1-thrombin complexes. Knauer, M.F., Hawley, S.B., Knauer, D.J. J. Biol. Chem. (1997)
- Cryoelectron microscopy imaging of recombinant and tissue derived vaults: localization of the MVP N termini and VPARP. Mikyas, Y., Makabi, M., Raval-Fernandes, S., Harrington, L., Kickhoefer, V.A., Rome, L.H., Stewart, P.L. J. Mol. Biol. (2004)
- Cell surface heparan sulfate proteoglycans participate in factor VIII catabolism mediated by low density lipoprotein receptor-related protein. Sarafanov, A.G., Ananyeva, N.M., Shima, M., Saenko, E.L. J. Biol. Chem. (2001)
- Analysis of the binding of pro-urokinase and urokinase-plasminogen activator inhibitor-1 complex to the low density lipoprotein receptor-related protein using a Fab fragment selected from a phage-displayed Fab library. Horn, I.R., Moestrup, S.K., van den Berg, B.M., Pannekoek, H., Nielsen, M.S., van Zonneveld, A.J. J. Biol. Chem. (1995)