Disease relevance of Hemosiderosis

• Despite the iron overload, HFE gene mutations were uncommon in patients with hepatic explant hemosiderosis [1].
• The disorders that are most often associated with AH include antibasement membrane antibodies (ABMA) disease, idiopathic pulmonary hemosiderosis, systemic lupus erythematosus, systemic vasculitides, and idiopathic rapidly progressive glomerulonephritis [2].
• Eight patients (16 eyes) developed ocular toxicity while undergoing intravenous deferoxamine mesylate (Desferal) chelation therapy for transfusional hemosiderosis [3].
• Amyloidosis, hemochromatosis/hemosiderosis, and atherosclerosis have been recognized in Phoenicopteriformes and other marine or aquatic birds [4].
• In addition to the patient's age and the site of the tumor, other unusual features of this case were as follows: positive staining of tumor cells with neuron-specific enolase, the presence of chronic, active, hepatitis that apparently developed coincident with the sarcoma, and the presence of widespread hemosiderosis [5].

High impact information on Hemosiderosis

• DESIGN--Retrospective autopsy study of CAD in cases of hemochromatosis and multiorgan hemosiderosis [6].
• The administration of benzidine dihydrochloride in water to mice for up to 39 weeks resulted in hemosiderosis of the spleen, focal vacuolization of the transitional epithelium of the urinary bladder, and chronic inflammation and cytologic and neoplastic changes in the liver [7].
• Enhanced class I MHC expression correlated significantly with portal inflammation, limiting plate erosion, vascular abnormalities, and hemosiderosis [8].
• Also, coexisting haptoglobin deficiency might alleviate hemosiderosis [9].
• Clearance of calcium pyrophosphate dihydrate crystals in vivo. III. Effects of synovial hemosiderosis [10].

Chemical compound and disease context of Hemosiderosis

• Adult patients with transfusional hemosiderosis were given ascorbic acid and treated with the iron chelator, desferrioxamine B [11].
• Idiopathic pulmonary hemosiderosis: ultrastructural studies and responses to azathioprine [12].
• Calcium oxalate and amyloid arthropathy with synovial hemosiderosis was diagnosed, and therapy with desferal and high-flux membrane dialysis was started [13].
• The 3000 microg/kg VA diet induced increased plasma retinol, splenic hemosiderosis and altered vocalization patterns (P < 0.05), although not as striking as those induced by the 30,000 microg/kg VA diet [14].
• Hemosiderosis in rodents and the effect of acetohydroxamic acid on urinary iron excretion [15].

Biological context of Hemosiderosis

• N-acetyl-D-methionine in excess depressed growth only slightly, due entirely to a depression in voluntary food intake, and no evidence of splenic hemosiderosis was observed from this addition [16].
• Pharmacokinetics of the iron chelator desperrioxamine as affected by liposome encapsulation: potential in treatment of chronic hemosiderosis [17].
• Histopathologic evaluation of selected tissues revealed splenic congestion, increased hematopoiesis and hemosiderosis, and bone marrow hyperplasia in aniline- and o-toluidine-treated animals [18].
• The non-neoplastic dose-related lesions were left atrial thrombosis, bladder urothelial hyperplasia, splenic hemosiderosis and splenic erythropoiesis [19].

Anatomical context of Hemosiderosis

• In young patients with intact spleens, a higher dose of deferoxamine may be use in order to prevent hemosiderosis [20].
• High prevalence of CSF-containing cysts in superficial hemosiderosis of the central nervous system [21].
• Terminal ileum hemosiderosis in association with hereditary hemochromatosis [22].
• A chronic hemodialysis case, a 46-year-old woman with secondary hemosiderosis induced by parenteral iron and blood transfusion due to a refractory anemia, was effectively treated with recombinant human erythropoietin and the removal of red blood cells [23].
• To our knowledge, increased echogenicity of the pancreas secondary to hemosiderosis (2 degrees hemochromatosis) in sickle cell patients has not been reported in the radiologic literature [24].

Gene context of Hemosiderosis

• Of 4 patients with a raised transferrin saturation level, 2 had raised serum ferritin levels and hemochromatosis, 1 had raised serum ferritin and hemosiderosis on liver biopsy, and 1 had a normal transferrin saturation level on repeat testing [25].
• In thalassemic patients lower IGF-1 circulating levels appear to be negatively correlated with both aspartate aminotransferase and alanine aminotransferase as well as with ferritin circulating levels indicating a probable role of hepatic hemosiderosis in IGF-1 production [26].
• The oral iron chelator deferiprone (1,2-dimethyl-3-hydroxy-pyrid-4-one, DMHP, LT or CP20) can be a useful drug in patients with transfusional hemosiderosis [27].
• Asymptomatic IgA nephropathy associated with pulmonary hemosiderosis [28].
• We discuss a young adult with recent onset RA following idiopathic pulmonary hemosiderosis, and review the 3 cases previously reported [29].

Analytical, diagnostic and therapeutic context of Hemosiderosis

• Ours are the first published results of a preliminary short-term trial of combined therapy with deferoxamine and hemofiltration in a dialysis patient with hemosiderosis [30].
• When polytransfused RDT patients with severe hemosiderosis cannot be transplanted and submitted consecutively to phlebotomy, DFO treatment is indicated [31].
• Low-dose dobutamine stress echocardiography may complement resting echocardiography and identify preclinical myocardial dysfunction caused by early cardiac hemosiderosis [32].
• Iron chelation by deferoxamine in sickle cell patients with severe transfusion-induced hemosiderosis: a randomized, double-blind study of the dose-response relationship [33].
• Deferoxamine for the treatment of hemosiderosis during CAPD [34].

References