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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Tularemia


High impact information on Tularemia

  • The present study explores the interactions between lymphocytes and monocytes that are required for expression of procoagulant activity (PCA) by monocytes in response to purified protein derivative of the tubercle bacillus (PPD) or tularemia antigen [6].
  • These findings suggest that rapid presumptive aminoglycoside therapy (gentamicin sulfate or streptomycin sulfate) should be considered soon after tularemia is suspected, especially for patients with serious underlying medical disorders [7].
  • Tularemia and once-daily gentamicin [8].
  • These results demonstrate that exogenous IL-12 delivered intranasally can prevent respiratory tularemia through a mechanism that is at least partially dependent upon the expression of IFN-gamma and CD8 T cells [9].
  • The highest levels of interleukin-2 and gamma interferon were recorded during the second and third weeks, respectively, after tularemia onset [10].

Chemical compound and disease context of Tularemia


Anatomical context of Tularemia


Gene context of Tularemia


Analytical, diagnostic and therapeutic context of Tularemia


  1. Modulation of delayed-type hypersensitivity and cellular immunity to microbial vaccines: effects of cyclophosphamide on the immune response to tularemia vaccine. Ascher, M.S., Parker, D., Turk, J.L. Infect. Immun. (1977) [Pubmed]
  2. Microagglutination test for early and specific serodiagnosis of tularemia. Sato, T., Fujita, H., Ohara, Y., Homma, M. J. Clin. Microbiol. (1990) [Pubmed]
  3. Similar pleural fluid findings in pleuropulmonary tularemia and tuberculous pleurisy. Pettersson, T., Nyberg, P., Nordström, D., Riska, H. Chest (1996) [Pubmed]
  4. Guillain-Barré syndrome and tularemia pleuritis with high adenosine deaminase activity in pleural fluid. Syrjälä, H., Koskela, P., Kujala, P., Myllylä, V. Infection (1989) [Pubmed]
  5. In vitro susceptibility of Francisella tularensis to fluoroquinolones and treatment of tularemia with norfloxacin and ciprofloxacin. Syrjälä, H., Schildt, R., Räisäinen, S. Eur. J. Clin. Microbiol. Infect. Dis. (1991) [Pubmed]
  6. Antigen-induced monocyte procoagulant activity. Requirement for antigen presentation and histocompatibility leukocyte antigen-DR molecules. Schwartz, B.S. J. Clin. Invest. (1985) [Pubmed]
  7. Factors associated with a poor outcome in tularemia. Penn, R.L., Kinasewitz, G.T. Arch. Intern. Med. (1987) [Pubmed]
  8. Tularemia and once-daily gentamicin. Hassoun, A., Spera, R., Dunkel, J. Antimicrob. Agents Chemother. (2006) [Pubmed]
  9. Intranasal interleukin-12 treatment for protection against respiratory infection with the Francisella tularensis live vaccine strain. Duckett, N.S., Olmos, S., Durrant, D.M., Metzger, D.W. Infect. Immun. (2005) [Pubmed]
  10. Development of Francisella tularensis antigen responses measured as T-lymphocyte proliferation and cytokine production (tumor necrosis factor alpha, gamma interferon, and interleukin-2 and -4) during human tularemia. Surcel, H.M., Syrjälä, H., Karttunen, R., Tapaninaho, S., Herva, E. Infect. Immun. (1991) [Pubmed]
  11. Murine model for study of cell-mediated immunity: protection against death from fully virulent Francisella tularensis infection. Eigelsbach, H.T., Hunter, D.H., Janssen, W.A., Dangerfield, H.G., Rabinowitz, S.G. Infect. Immun. (1975) [Pubmed]
  12. Treatment of tularemia with ciprofloxacin. Chocarro, A., Gonzalez, A., Garcia, I. Clin. Infect. Dis. (2000) [Pubmed]
  13. Tularemia epidemic in northwestern Spain: clinical description and therapeutic response. Pérez-Castrillón, J.L., Bachiller-Luque, P., Martín-Luquero, M., Mena-Martín, F.J., Herreros, V. Clin. Infect. Dis. (2001) [Pubmed]
  14. Treatment of tularemia with fluoroquinolones: two cases and review. Limaye, A.P., Hooper, C.J. Clin. Infect. Dis. (1999) [Pubmed]
  15. Modifying effects of exercise on clinical course and biochemical response of the myocardium in influenza and tularemia in mice. Ilbäck, N.G., Friman, G., Beisel, W.R., Johnson, A.J., Berendt, R.F. Infect. Immun. (1984) [Pubmed]
  16. Naturally occurring tularemia in a dog. Meinkoth, K.R., Morton, R.J., Meinkoth, J.H. J. Am. Vet. Med. Assoc. (2004) [Pubmed]
  17. Peripheral blood leukocyte counts, erythrocyte sedimentation rate and C-reactive protein in tularemia caused by the type B strain of Francisella tularensis. Syrjälä, H. Infection (1986) [Pubmed]
  18. Sudden death caused by myocardial tuberculosis: case report and review of the literature. Dada, M.A., Lazarus, N.G., Kharsany, A.B., Sturm, A.W. The American journal of forensic medicine and pathology : official publication of the National Association of Medical Examiners. (2000) [Pubmed]
  19. Interleukin 2 and gamma interferon production, interleukin 2 receptor expression, and DNA synthesis induced by tularemia antigen in vitro after natural infection or vaccination. Karttunen, R., Andersson, G., Ekre, H.P., Juutinen, K., Surcel, H.M., Syrjälä, H., Herva, E. J. Clin. Microbiol. (1987) [Pubmed]
  20. Relationship of serum beta-glucuronidase and lysozyme to pathogenesis of tularemia in immune and nonimmune rats. Canonico, P.G., Powanda, M.C., Cockerell, G.L., Moe, J.B. Infect. Immun. (1975) [Pubmed]
  21. Sequential metabolic alterations in the myocardium during influenza and tularemia in mice. Ilbäck, N.G., Friman, G., Beisel, W.R., Johnson, A.J. Infect. Immun. (1984) [Pubmed]
  22. Histologic and molecular diagnosis of tularemia: a potential bioterrorism agent endemic to North America. Lamps, L.W., Havens, J.M., Sjostedt, A., Page, D.L., Scott, M.A. Mod. Pathol. (2004) [Pubmed]
  23. Cell-mediated immunity against Francisella tularensis after natural infection. Koskela, P., Herva, E. Scand. J. Infect. Dis. (1980) [Pubmed]
  24. The development of tools for diagnosis of tularemia and typing of Francisella tularensis. Johansson, A., Forsman, M., Sjöstedt, A. APMIS (2004) [Pubmed]
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