Disease relevance of Pregnancy, High-Risk

• The use of aspirin to prevent pregnancy-induced hypertension and lower the ratio of thromboxane A2 to prostacyclin in relatively high risk pregnancies [1].
• Natural progesterone prevents preterm birth in high-risk pregnancies [2].
• In most instances, the need for continuous anticoagulation therapy constituted a major concern in the obstetric management of these high-risk pregnancies, particularly since coumarin has been implicated as causing an increased frequency of fetal wastage or birth defects (or both) [3].
• Ninety pregnant women admitted to the high-risk pregnancy unit with a diagnosis of acute pyelonephritis were randomized to receive either oral (cephalexin 500 mg every 6 hours) or intravenous (IV) (cephalothin 1 g every 6 hours) antibiotic therapy [4].
• The low incidence of fetal death after a negative CST supports continued use of the CST in evaluation of high-risk pregnancies [5].

Psychiatry related information on Pregnancy, High-Risk

• The High-Risk Pregnancy Stress Scale, Brown's Social Behaviors Inventory, and the Family Assessment Measure III Dyadic Relationships Scale were administered to the women at randomisation (T1) and at 1-week (T2) and 2-weeks (T3) after randomisation [6].

High impact information on Pregnancy, High-Risk

• Placental CRH, like hypothalamic CRH, may be stimulated in conditions of chronic stress and may modulate fetal pituitary-adrenal function in high risk pregnancies [7].
• In medical centers with many high risk pregnancies, the ability to perform a large number of urinary estriol measurements is required [8].
• We report on the use of LMW heparin (Fragmin) as thromboprophylaxis in thirty four high risk pregnancies [9].
• In fact, increased uterine vascular resistance and reduced uterine blood flow can be used as predictors of high risk pregnancies and are associated with fetal growth retardation [10].
• This case prompted retrospective examination of the sera from six other women with anti-D and anti-C who were referred to a high-risk pregnancy clinic [11].

Chemical compound and disease context of Pregnancy, High-Risk

• A biological carrier 'stick' for estriol measurements might serve as test of choice in the monitoring of high-risk pregnancy as well as for identifying pregnancies complicated by chromosomal abnormalities (e.g., Down's syndrome) [12].
• The use of diethylstilbestrol (DES) for high risk pregnancy has exposed millions of mothers to an increased risk of breast cancer, and also resulted in a generation of women with genital tract abnormalities, such as vaginal adenosis [13].

Biological context of Pregnancy, High-Risk

• The degree of maternal glucose control achieved during the third trimester of pregnancy was evaluated for 120 overtly diabetic women hospitalized on a high-risk pregnancy ward. "Rigid" blood glucose control, defined as a mean preprandial plasma glucose concentration less than 115 mg/dl was achieved in only 14% of these women [14].
• RESULTS: There was concordance of results with midtrimester ultrasound (US) imaging, home uterine activity monitoring (HUAM), Doppler velocimetry in high-risk pregnancy, short-term tocolysis, single-course antenatal corticosteroids (BMZ), thyroid-releasing hormone (TRH), and fetal fibronectin (fFN) [15].
• Our results suggest that the EPF determination has high prognostic value in patients with high risk pregnancies and in pregnancies which follow treatment for sterility [16].
• CONCLUSION: We recommend the use of multiple applications of 2 mg intravaginal prostaglandin E2 gel as a safe, effective and easy method for preinduction cervical ripening in high-risk pregnancies [17].
• Fetal activity determination and neosynephrine test for evaluation of fetal well-being in high risk pregnancies [18].

Anatomical context of Pregnancy, High-Risk

• Whether amniotic fluid cortisol can be used as an adjunct in the evaluation of high-risk pregnancies with "transitional" L/S ratios remains to be explored [19].
• PATIENTS AND METHODS: One hundred and ten women with high-risk pregnancy and unripe cervix received prostaglandin E2 gel 1 mg intravaginally (n=35), 2 mg intravaginally (n=36) and 0.5 mg intracervically (n=39), maximally three times at 6-hour intervals for cervical ripening prior to labor induction [17].
• Results in high-risk pregnancies demonstrated that S100B concentration increased in amniotic fluid and in cord blood of fetuses with brain damage [20].
• STUDY DESIGN: TNF-alpha and IL-6 levels were evaluated in maternal blood serum of 67 high-risk pregnancies [21].

Associations of Pregnancy, High-Risk with chemical compounds

• The relevance of diethylstilbestrol (DES) administration to neonatal mice as a model for human pathology attributed to the use of DES in high-risk pregnancies has been investigated, particularly with respect to cervical and vaginal changes in female offspring [22].
• Induction of labor with oral prostaglandin E2 in normal and high-risk pregnancies [23].
• Plasma oestriol and human placental lactogen measurements in patients with high risk pregnancies [24].
• In 12 normal and 50 high risk pregnancies fetal breathing and fetal trunk movements were measured by real time ultrasound after the mothers had been given oral glucose [25].
• The method is rapid enough to permit the monitoring of a high-risk pregnancy for plasma estradiol levels on a daily basis [26].

Gene context of Pregnancy, High-Risk

• The aim of this study was to evaluate if markers of tissue injury, i.e., tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) are related to signs of increased perinatal vascular impedance and/or fetal brain sparing in high-risk pregnancies [21].
• Using the 10th percentile of the normal range for amniotic fluid disaccharidase activities as an action line, the sensitivity of CF detection is estimated at 80 to 90 per cent, which could in high risk pregnancies reduce the risk of having another affected child from 1 in 4 to 1 in 20 [27].
• Carcinoembryonic antigen in high risk pregnancies [28].
• These results suggest that the measurement of CEA in high risk pregnancies is not useful in predicting fetal condition [28].
• It is concluded that maternal serum AFP screening defines a group of high risk pregnancies [29].

Analytical, diagnostic and therapeutic context of Pregnancy, High-Risk

• In this study, serial plasma unconjugated estriol (E3) concentrations determined by radioimmunoassay were evaluated in 321 patients with high-risk pregnancy for correlation with fetal and neonatal performance [30].
• OBJECTIVE: The aim of the study was too determine whether, in a low-dose aspirin trial in high-risk pregnancies, a decrease in maternal serum thromboxane B2 level predicted improved pregnancy outcomes [31].
• Maximizing in-utero steroid treatment in high-risk pregnancies, minimizing the days of mechanical ventilation and investment of efforts in prevention of bacteraemia may help to reduce the incidence of candidaemia in the NICU [32].
• Prenatal diagnosis to exclude FAP in a high risk pregnancy [33].
• OBJECTIVES: To examine whether pathological perfusion in the second trimester is characterized by an altered plasma antioxidant capacity and to investigate whether the total antioxidant capacity in maternal plasma is related to the clinical outcome of these high-risk pregnancies [34].

References