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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Colostomy

  • Subsequently, a retrograde whole-colon lavage with PVPI 5 per cent and Gastrografin 12 per cent was performed in 14 euthyroid, non-allergic patients with colorectal cancer using a colostomy irrigation set [1].
  • We report the case of a 49-year-old C6 ASIA B tetraplegic man who had received colostomy because of intractable ileus 10 years earlier [2].
  • The usual approach to this problem is simple incision and parenteral antibiotics but we have recently treated two patients with wide excision combined with a defunctioning colostomy which resulted in rapid and complete eradication of sepsis [3].
  • From 1977 to Nov 1, 1980, progress in immediate nursing and total parenteral nutrition made colostomy unnecessary in 19 neonates and infants with severe Hirschsprung's disease [4].
  • Distal colectomy is curative but the formation of a colostomy is undesirable in patients who already have a poor self-image due to the other manifestations of Klippel-Trenaunay syndrome such as multiple cutaneous hemangiomata, severe varicose veins, and prominent limb hypertrophy [5].

High impact information on Colostomy


Chemical compound and disease context of Colostomy


Anatomical context of Colostomy


Associations of Colostomy with chemical compounds

  • To determine if the effects of pinealectomy on the colon could be modified by the absence of colonic luminal contents, the crypt cell kinetic effects of combined pinealectomy and defunctioning of a colonic loop by colostomy for 6 months were examined by using a stathmokinetic technique [10].
  • Similar analyses of the colostomy contents of subjects revealed a total menaquinone content of 8.85 micrograms/g dry weight [18].
  • The emptying of the colon and the side-effects after intraluminal application of prostaglandin E2 and of bisacodyl in 14 patients was studied by employing colostomy irrigation [19].
  • Treatment included primary closure of the rectal perforation with colostomy diversion combined with parenteral antibiotics [20].
  • Chemical colostomy irrigation with glyceryl trinitrate solution [21].

Gene context of Colostomy

  • METHODS AND RESULTS: The expression of CD44v3, CD44v6, and MIB1 (proliferation marker) was studied by immunohistochemistry on surgical colonic samples of UC (n = 13), CD (n = 10), colostomy resections with non-specific mucosal inflammation (NSMI) (n = 3), and normal controls (N = 5) [22].
  • Functional results in 33 patients who underwent a coloanal anastomosis with reservoir were prospectively evaluated three months after colostomy closure and later (16.2 +/- 5.7 months) and were compared with those of 36 healthy controls [23].
  • Growth hormone treatment of rats with chronic diverting colostomy. Differential response on proximal functioning and distal atrophic colon [24].
  • A useful technique of paramedian skin incision for midline laparotomy in patients requiring colostomy in left lower abdomen [25].
  • Healing of a left colon anastomosis after early colostomy closure. An experimental study in the rat [26].

Analytical, diagnostic and therapeutic context of Colostomy

  • Use of total parenteral nutrition as a "medical colostomy" in management of severe lacerations of the sphincter: report of a case [27].
  • METHODS: In a cross-over study, 41 colostomy irrigators were randomly assigned to water or polyethylene glycol solution irrigation first and then the other regimen, each for one week [28].
  • The accelerated-stay program included preoperative information, no premedication, a surgical procedure without colostomy, single-dose prophylactic antibiotics, paracetamol for analgesia, free oral fluid and food immediately after the operation supplemented by laxatives, and enforced mobilization [29].
  • The number of in-hospital days required due to gastrointestinal (GI) complications and the number of days required for supplemental parenteral hyperalimentation were significantly higher in patients managed by terminal ileostomy than by colostomy (P less than .05 and P less than .03, respectively) [30].
  • Our modification of using tube cecostomy and parenteral nutrition instead of a temporary transverse colostomy warrants attention; it made the technique simpler and more attractive [31].


  1. Rectal washout with cytotoxic solution can be extended to the whole colon. Mariani, P.P., van Pelt, J.F., Ectors, N., Topal, B., D'Hoore, A., Penninckx, F. The British journal of surgery. (2002) [Pubmed]
  2. Diversion colitis: a cause of abdominal discomfort in spinal cord injury patients with colostomy. Lai, J.M., Chuang, T.Y., Francisco, G.E., Strayer, J.R. Archives of physical medicine and rehabilitation. (1997) [Pubmed]
  3. Defunctioning colostomy for perianal sepsis in acute leukaemia. Baglin, T.P., Fielding, J.W., Boughton, B.J. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. (1987) [Pubmed]
  4. Primary corrective operation without decompression in infants less thn three months of age with Hirschsprung's disease. Carcassonne, M., Morisson-Lacombe, G., Letourneau, J.N. J. Pediatr. Surg. (1982) [Pubmed]
  5. Treatment of colonic bleeding in Klippel-Trenaunay syndrome with combined partial colectomy and endoscopic laser. Myers, B.M. Dig. Dis. Sci. (1993) [Pubmed]
  6. Effect of colostomy on intestinal carcinogenesis by methylazoxymethanol acetate in rats. Matsubara, N., Mori, H., Hirono, I. J. Natl. Cancer Inst. (1978) [Pubmed]
  7. Colostomy closure promotes cell proliferation and dimethylhydrazine-induced carcinogenesis in rat distal colon. Terpstra, O.T., Dahl, E.P., Williamson, R.C., Ross, J.S., Malt, R.A. Gastroenterology (1981) [Pubmed]
  8. Addition of oxaliplatin to continuous fluorouracil, l-folinic acid, and concomitant radiotherapy in rectal cancer: the Lyon R 97-03 phase I trial. Freyer, G., Bossard, N., Romestaing, P., Mornex, F., Chapet, O., Trillet-Lenoir, V., Gérard, J.P. J. Clin. Oncol. (2001) [Pubmed]
  9. Rectal obstruction secondary to carcinoma of the prostate. Fry, D.E., Amin, M., Harbrecht, P.J. Ann. Surg. (1979) [Pubmed]
  10. The effect of pinealectomy on the crypts of defunctioned rat colon. Callaghan, B.D. J. Pineal Res. (1997) [Pubmed]
  11. Hospital outbreak of hepatitis A: risk factors for spread. Krober, M.S., Bass, J.W., Brown, J.D., Lemon, S.M., Rupert, K.J. Pediatric infectious disease. (1984) [Pubmed]
  12. Experience with 5-fluoro-uracil and levamisole in the management of advanced rectal carcinoma. Ajao, O.G., Soyannwo, O.A., Ladipo, J.K., Okeke, L.I., Adebamowo, C.A. African journal of medicine and medical sciences. (1996) [Pubmed]
  13. Indium-111-white blood cell scintigraphy in Crohn's patients with fistulae and sinus tracts. Even-Sapir, E., Barnes, D.C., Martin, R.H., LeBrun, G.P. J. Nucl. Med. (1994) [Pubmed]
  14. Changes in cell proliferation and morphology in the large intestine of normal and DMH-treated rats following colostomy. Barkla, D.H., Tutton, P.J. Dis. Colon Rectum (1987) [Pubmed]
  15. Changes in nitrergic innervation of defunctionalized rat colon after diversion colostomy. Chaudhury, A., Shariff, A., Srinivas, M., Sabherwal, U. Neurogastroenterol. Motil. (2004) [Pubmed]
  16. An unusual late radiotherapy-related complication requiring surgery in anal canal carcinoma. Cicchini, C., Stazi, A., Ciardi, A., Ghini, C., Indinnimeo, M. Journal of surgical oncology. (2000) [Pubmed]
  17. Rofecoxib: a possible cause of acute colitis. Freitas, J., Farricha, V., Nascimento, I., Borralho, P., Paramés, A. J. Clin. Gastroenterol. (2002) [Pubmed]
  18. Quantitative and qualitative measurements of K vitamins in human intestinal contents. Conly, J.M., Stein, K. Am. J. Gastroenterol. (1992) [Pubmed]
  19. Colostomy irrigation with prostaglandin E2 and bisacodyl. A double-blind cross-over study. Kjaergaard, J., Christensen, U., Stadil, F., Anderson, B. The British journal of surgery. (1984) [Pubmed]
  20. Pseudotorsion of testis. Lynch, D.F., Peterson, N.R., Powell, R.W. Urology (1983) [Pubmed]
  21. Chemical colostomy irrigation with glyceryl trinitrate solution. O'Bichere, A., Bossom, C., Gangoli, S., Green, C., Phillips, R.K. Dis. Colon Rectum (2001) [Pubmed]
  22. CD44 variant expression in inflammatory colonic mucosa is not disease specific but associated with increased crypt cell proliferation. Fromont Hankard, G., Cezard, J.P., Aigrain, Y., Navarro, J., Peuchmaur, M. Histopathology (1998) [Pubmed]
  23. Functional results of coloanal anastomosis with reservoir. Pélissier, E.P., Blum, D., Bachour, A., Bosset, J.F. Dis. Colon Rectum (1992) [Pubmed]
  24. Growth hormone treatment of rats with chronic diverting colostomy. Differential response on proximal functioning and distal atrophic colon. Kissmeyer-Nielsen, P., Christensen, H., Laurberg, S. Eur. J. Endocrinol. (1994) [Pubmed]
  25. A useful technique of paramedian skin incision for midline laparotomy in patients requiring colostomy in left lower abdomen. Chaturvedi, P., Quereshi, S.S., Shah, B. Journal of surgical oncology. (2004) [Pubmed]
  26. Healing of a left colon anastomosis after early colostomy closure. An experimental study in the rat. Udén, P., Blomquist, P., Jiborn, H., Zederfeldt, B. International journal of colorectal disease. (1988) [Pubmed]
  27. Use of total parenteral nutrition as a "medical colostomy" in management of severe lacerations of the sphincter: report of a case. Sohn, N., Weinstein, M.A. Dis. Colon Rectum (1977) [Pubmed]
  28. Randomized cross-over trial of polyethylene glycol electrolyte solution and water for colostomy irrigation. O'Bichere, A., Green, C., Phillips, R.K. Dis. Colon Rectum (2004) [Pubmed]
  29. Early discharge after external anal sphincter repair. Rosenberg, J., Kehlet, H. Dis. Colon Rectum (1999) [Pubmed]
  30. Management of the hindgut in cloacal exstrophy: terminal ileostomy versus colostomy. Husmann, D.A., McLorie, G.A., Churchill, B.M., Ein, S.H. J. Pediatr. Surg. (1988) [Pubmed]
  31. Continent urinary undiversion to modified ureterosigmoidostomy in bladder extrophy patients. Mansi, M.K. World journal of surgery. (1999) [Pubmed]
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